WO1995030420A1 - Use of vitamin e tocopheryl derivatives in ophthalmic compositions - Google Patents
Use of vitamin e tocopheryl derivatives in ophthalmic compositions Download PDFInfo
- Publication number
- WO1995030420A1 WO1995030420A1 PCT/US1995/005730 US9505730W WO9530420A1 WO 1995030420 A1 WO1995030420 A1 WO 1995030420A1 US 9505730 W US9505730 W US 9505730W WO 9530420 A1 WO9530420 A1 WO 9530420A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- vitamin
- composition
- ophthalmic
- tocopheryl
- ester
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
Definitions
- the present invention relates generally to ophthalmic compositions.
- the present invention relates to the use of certain vitamin E tocopheryl derivatives to provide comfortable, non-irritating ophthalmic compositions.
- the present invention relates to the use of these vitamin E tocopheryl derivatives to increase the solubility of poorly soluble ophthalmic agents in aqueous compositions.
- the vitamin E tocopheryl derivatives useful in the present invention shall be referred to as "vitamin E tocopheryl derivatives" or “vitamin E derivatives” or "TPGS.”
- Stinging and burning sensations, as well as general discomfort, are often associated with the topical ophthalmic application of certain types of ophthalmic agents. It is believed that such ocular discomfort is due to the presence of certain functional groups in these agents.
- agents which produce ocular discomfort include, but are not limited to: -blockers such as betaxolol; prostaglandins and prostaglandin derivatives; muscarinics such as pilocarpine; ⁇ - adrenergics such as epinephrine, clonidine and apraclonidine; cholinergics such as carbachol; and non-steroidal anti-inflammatory drugs ("NSAIDs”) such as diclofenac and suprofen.
- NSAIDs non-steroidal anti-inflammatory drugs
- US 4,960,799 discloses storage stable aqueous ophthalmic compositions containing diclofenac and/or its pharmaceutically acceptable salts.
- the Nagy compositions include EDTA and a solubilizer such as ethoxylated castor oil.
- vitamin E tocopheryl derivatives renders such compositions very comfortable and non-irritating. It has also been discovered that these vitamin E derivatives greatly enhance the aqueous solubility of many compounds which are only sparingly soluble in aqueous compositions.
- Vitamin E tocopheryl derivatives are water-soluble, biologically-active vitamin E analogues. These vitamin E derivatives have been used as alternatives to vitamin E, especially where water-solubility is desired.
- US Patent No.3, 102,078 describes the use of these derivatives to solubilize naturally-occurring water-insoluble vitamins, such as vitamins A, D and E. The use of these vitamin E derivatives to enhance the absorption of vitamin A and cyclosporin have also been reported. See, for example, Sokol, R.J. et al., "Improvement of Cyclosporin Absorption in Children after Liver Transplantation by Means of Water-soluble Vitamin E," The Lancet. 338:212-215 (1991), and Argao, E.A. et al., "d- - Tocopheryl Polyethylene Glycol-1000 Succinate Enhances the Absorption of
- the vitamin E tocopheryl derivatives useful in the compositions of the present invention are highly water-soluble polyoxyalkylene glycol esters of vitamin E tocopheryl esters of a dicarboxylic acid.
- Representative esters of this type include the polyoxyethylene glycol esters of vitamin E tocopheryl esters of a dicarboxylic acid wherein the polyoxyethylene glycol moiety of the ester (sometimes merely referred to as the polyoxyethylene glycol moiety of the ester) has a molecular weight in the range from about 600 to about 6000, preferably in the range from about 600 to about 1500.
- Such esters and methods for their preparation are disclosed in US Patent No. 2,680,749 (Cawley et al.).
- the most preferred ester is the ⁇ -tocopheryl polyoxyethylene glycol (1000) succinate, a polyoxyethylene glycol ester of ⁇ -tocopheryl succinate wherein the polyoxyethylene glycol moiety of the molecule has an average molecular weight of about 1000.
- one or more vitamin E derivatives are used in the compositions of the present invention in an amount less than about 30 percent by weight (wt%). If the vitamin E derivatives are used as solubilizing agents, it is preferred to use an amount between about 0.1 and about 20 wt%, most preferably between about 0.1 and about 5 wt%. When the vitamin E derivatives are used to enhance comfort, it is preferred to use an amount between about 0.1 and about 20 wt%, most preferably between about 0.5 and about 10 wt%.
- Suitable ophthalmic agents which may be included in the compositions of the present invention and administered via the method of the present invention include, but are not limited to, the racemic and enantiomeric forms and ophthalmically acceptable salts and esters of following types of compounds:
- - glaucoma agents such as: -blockers (e.g., betaxolol, timolol, and carteolol); ⁇ -agonists (e.g., apraclonidine and related 2-substituted amino imidazolines); carbonic anhydrase inhibitors; dopamine agonists and antagonists; miotic cholinergics (e.g., pilocarpine and carbachol); prostaglandins and prostaglandin derivatives; ACE inhibitors; steroids (e.g., glucocorticoids and angiostatic steroids); and calcium channel blockers; anti-hypertensives; - non-steroidal anti-inflammatory agents, including but not limited to those classified as aryl- or heteroaryl- alkanoic acids such as diclofenac, flurbiprofen, suprofen, ketorolac, indomethacin and ketoprofen; steroidal anti-inflammatory agents, such as fluorometholone
- cephalosporins such as cefamandole
- anti-fungals such as natamycin
- anti-virals such as acyclovir and ganciclovir
- - anti-cataract agents and anti-oxidants anti-allergies
- anti-metabolites such as 5-fluorouracil (5-FU) and methotrexate
- immunosuppressants such as cyclosporin, FK-506 and leflunimide
- growth factors such as EGF, FGF, PDGF
- Combinations of ophthalmic agents may also be used in the compositions of the present invention. Further, in formulations without ophthalmic agents, the present invention may also serve to supplement tears in the prevention or treatment of dry eye.
- compositions of the present invention may additionally include other ophthalmically acceptable components: for example, buffers (e.g., phosphate, borate and citrate), chelating agents (e.g., EDTA), preservatives, (e.g., benzalkonium chloride, Polyquad ® and Dymed ® ) and tonicity agents (e.g., sodium chloride and mannitol).
- buffers e.g., phosphate, borate and citrate
- chelating agents e.g., EDTA
- preservatives e.g., benzalkonium chloride, Polyquad ® and Dymed ®
- tonicity agents e.g., sodium chloride and mannitol
- compositions of the present invention may also include viscosity modifying agents such as: cellulosic ethers, such as, hydroxypropyl methyl cellulose (HPMC), hydroxyethyl cellulose (HEC), ethyl hydroxyethyl cellulose, hydroxypropyl cellulose, methyl cellulose, and carboxymethyl cellulose; carbomers (Carbopol ); polyvinyl alcohol; polyvinyl pyrrolidone; alginates; carrageenans; and guar, karaya, agarose, locust bean, tragacanth and xanthan gums.
- concentration of such viscosity modifiers will vary between about 0.1 to about 5 wt%, but such formulations will generally have a viscosity between about 10 and about 1000 centipoise.
- the ophthalmic compositions containing TPGS may additionally contain polymers which will undergo sol-to-gel transition upon exposure to physical or chemical stimuli, such as changes in pH, ion concentration, and/or temperature.
- the ophthalmic agents contained in the compositions of the present invention may optionally be encapsulated in microparticles. These loaded microparticles can be dispersed in aqueous vehicles containing TPGS to improve comfort.
- water-soluble or water-insoluble complexes of the ophthalmic agent can be incorporated in a vehicle containing TPGS.
- Example of water-soluble complexes include traditional complexes formed between the ophthalmic agent and caffeine, cyclodextrins, salicylates, benzoates.
- Examples of water insoluble complexes include ophthalmic agent - drug resin complexes.
- Vitamin E TPGS (1000) 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0
- Formulation D was prepared as follows, and Formulations A-C and E-G were prepared similarly.
- a 10% (w/v) stock solution of vitamin E TPGS was prepared as follows.
- Approximately 150 g of vitamin E TPGS was melted in a beaker by heating on a hot plate with stirring to ensure homogeneity. About 100 grams (g) of the molten TPGS was then added into 800 milliliters (mL) of near-boiling double distilled water. This mixture was stirred and allowed to cool to room temperature to ensure complete dissolution. Sufficient water was then added to the above solution to make a liter of stock solution.
- Sodium diclofenac (0.3 g) was added to 90 mL of 10% TPGS stock solution. After complete dissolution of the diclofenac, the each of following ingredients were sequentially added to the solution with stirring so that each ingredient was completely dissolved before the next ingredient was added: 1.5 g of arginine, 9.0 g of mannitol, 4.5 g of boric acid, 3.6 g of tromethamine and 0.3 g of edetate sodium. To the above solution was added 6.0 mL of 0.5% solution of benzalkonium chloride, followed by the addition of 15 mL of 2% solution of HPMC. An additional 150 mL of water were added and the pH of the formulation adjusted to 7.4 with HCI and/or NaOH. To the resulting solution, enough water was added to bring the total solution volume to 300 mL. The osmolality of the final solution was about 300mOsm/kg.
- composition is another representative composition of the present invention, wherein a prostaglandin complexed with cyclodextrin is formulated in accordance with the teachings of the present invention.
- the following formulation is another representative composition of the present invention, wherein a prostaglandin bound to Duolite® (cholestyramine resins, available from Rohm & Haas, Philadelphia, Pennsylvania) is formulated in accordance with the teachings of the present invention.
- Duolite® cholestyramine resins, available from Rohm & Haas, Philadelphia, Pennsylvania
- a prostaglandin (0.75 g) is dissolved in 200 mL of water. Finely divided Duolite (0.75 g) is added, and the solution allowed to equilibrate for 2 hours, during which time about 95% of the drug becomes bound to the resin.
- appropriate amounts of tromethamine, boric acid, BAC, edetate sodium and mannitol are added to 90 mL of the 10% TPGS stock solution. The two parts are then mixed and the pH adjusted to 7.4 with HCI and/or NaOH. Enough water is then added to the formulation to bring the final volume to 300 mL.
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- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
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Abstract
Description
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Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95919064A EP0708646A1 (en) | 1994-05-06 | 1995-05-08 | Use of vitamin e tocopheryl derivatives in ophthalmic compositions |
AU24762/95A AU684950B2 (en) | 1994-05-06 | 1995-05-08 | Use of vitamin E tocopheryl derivatives in ophthalmic compositions |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24005794A | 1994-05-06 | 1994-05-06 | |
US08/240,057 | 1994-05-06 |
Publications (1)
Publication Number | Publication Date |
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WO1995030420A1 true WO1995030420A1 (en) | 1995-11-16 |
Family
ID=22904935
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1995/005730 WO1995030420A1 (en) | 1994-05-06 | 1995-05-08 | Use of vitamin e tocopheryl derivatives in ophthalmic compositions |
Country Status (7)
Country | Link |
---|---|
US (1) | US5886030A (en) |
EP (1) | EP0708646A1 (en) |
JP (1) | JP2742333B2 (en) |
CN (1) | CN1129400A (en) |
AU (1) | AU684950B2 (en) |
CA (1) | CA2166722A1 (en) |
WO (1) | WO1995030420A1 (en) |
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WO1998041208A1 (en) * | 1997-03-17 | 1998-09-24 | Novartis Ag | Compositions and methods for reducing ocular hypertension |
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US6193985B1 (en) | 1994-05-16 | 2001-02-27 | A/S Dumex (Dumex Ltd) | Tocopherol compositions for delivery of biologically active agents |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60155111A (en) * | 1983-10-20 | 1985-08-15 | Hisamitsu Pharmaceut Co Inc | Stable pharmaceutical for external use containing "ketoprofen(r)" |
JPS6341421A (en) * | 1986-08-07 | 1988-02-22 | Sogo Yatsukou Kk | Anticataract agent |
EP0380367A1 (en) * | 1989-01-27 | 1990-08-01 | Stafford-Miller Ltd. | Compositions and method for the treatment of disease |
US5013751A (en) * | 1989-01-10 | 1991-05-07 | Alcon Laboratories, Inc. | (+) Suprofen esters and amides as opthalmic anti-inflammatory agents |
WO1993003720A2 (en) * | 1991-08-16 | 1993-03-04 | Trevithick John R | Methods and compositions for treating sunburns |
JPH05271076A (en) * | 1992-03-26 | 1993-10-19 | Taisho Pharmaceut Co Ltd | Anti-inflammatory analgesic external preparation |
EP0578077A2 (en) * | 1992-07-10 | 1994-01-12 | F. Hoffmann-La Roche Ag | Compositions containing retinoic acids and tocopherol |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2680749A (en) * | 1951-12-01 | 1954-06-08 | Eastman Kodak Co | Water-soluble tocopherol derivatives |
US3102078A (en) * | 1961-01-13 | 1963-08-27 | Eastman Kodak Co | Water-dispersible vitamin preparations |
DE2530487A1 (en) * | 1975-07-09 | 1977-01-27 | Erfindergesellschaft Fresenius | WATER SANITIZER AND METHOD FOR MANUFACTURING THEREOF |
US4136173A (en) * | 1977-01-31 | 1979-01-23 | American Home Products Corp. | Mixed xanthan gum and locust beam gum therapeutic compositions |
US4136177A (en) * | 1977-01-31 | 1979-01-23 | American Home Products Corp. | Xanthan gum therapeutic compositions |
US4559343A (en) * | 1982-09-07 | 1985-12-17 | Alcon Laboratories, Inc. | Nonirritating aqueous ophthalmic compositions comfort formulation for ocular therapeutic agents |
US4911920A (en) * | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
JPS61184127A (en) * | 1985-02-08 | 1986-08-16 | Honda Motor Co Ltd | Device for driving steered wheels of vehicle |
FR2588189B1 (en) * | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | LIQUID-GEL PHASE TRANSITION PHARMACEUTICAL COMPOSITION |
US5093126A (en) * | 1987-09-26 | 1992-03-03 | Alcon Laboratories, Inc. | Glaucoma formulations comprising an anionic, polysulfonic acid polymer having mucomimetic properties and a polystyrene sulfonic polymer |
MX9203804A (en) * | 1987-10-19 | 1992-07-01 | Liposome Co Inc | PHARMACEUTICAL SYSTEMS BASED ON TOCOPHEROL. |
DE3883246T2 (en) * | 1987-10-19 | 1993-12-02 | Liposome Co Inc | MEDICINE SYSTEMS BASED ON TOCOPHEROL. |
JPH01128921A (en) * | 1987-11-12 | 1989-05-22 | Taisho Pharmaceut Co Ltd | Pharmaceutical for promoting absorption of vitamin a |
US5198432A (en) * | 1988-01-29 | 1993-03-30 | Center For Innovative Technology | Method of preventing chlorohydrocarbon toxicity using sterol derivatives |
US4960799A (en) * | 1988-09-13 | 1990-10-02 | Ciba-Geigy Corporation | Stabilized aqueous solutions of pharmaceutically acceptable salts of ortho-(2,6-dichlorophenyl)-aminophenylacetic acid for opthalmic use |
FR2685635B1 (en) * | 1991-12-27 | 1995-06-30 | Lvmh Rech | COMPLEX SOLID PARTICLES COMPRISING A BIOLOGICALLY ACTIVE SOLID SUBSTANCE, THEIR METHOD OF PREPARATION AND TOPICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF BIOLOGICAL SURFACES. |
JPH0468343A (en) * | 1990-07-10 | 1992-03-04 | Konica Corp | Antistatic plastic film |
JPH0537406A (en) * | 1990-11-28 | 1993-02-12 | Hitachi Ltd | Tuner circuit |
DK0495421T3 (en) * | 1991-01-15 | 1996-12-09 | Alcon Lab Inc | Use of carrageenans in topical ophthalmic compositions |
US5179122A (en) * | 1991-02-11 | 1993-01-12 | Eastman Kodak Company | Nutritional supplement containing vitamin e |
US5212162A (en) * | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
US5223268A (en) * | 1991-05-16 | 1993-06-29 | Sterling Drug, Inc. | Low solubility drug-coated bead compositions |
EP0724449A1 (en) * | 1991-09-20 | 1996-08-07 | Similasan Corporation | Preservative for pharmaceutical products |
NZ244862A (en) * | 1991-10-23 | 1995-07-26 | Block Drug Co | Use of vitamin e in topical pharmaceuticals to enhance penetration of the active agent |
JP2811036B2 (en) * | 1992-05-26 | 1998-10-15 | 参天製薬株式会社 | Vitamin E eye drops |
CA2088927A1 (en) * | 1993-02-11 | 1994-08-12 | Donald Skeffington | Preservative system for vitamin e aqueous solution |
GB9409778D0 (en) * | 1994-05-16 | 1994-07-06 | Dumex Ltd As | Compositions |
US5558876A (en) * | 1995-03-29 | 1996-09-24 | Alcon Laboratories, Inc. | Topical ophthalmic acidic drug formulations |
CA2221145A1 (en) * | 1995-05-19 | 1996-11-21 | Abbott Laboratories | Self-emulsifying formulations of lipophilic drugs |
-
1995
- 1995-05-08 AU AU24762/95A patent/AU684950B2/en not_active Ceased
- 1995-05-08 JP JP7529163A patent/JP2742333B2/en not_active Expired - Lifetime
- 1995-05-08 CA CA002166722A patent/CA2166722A1/en not_active Abandoned
- 1995-05-08 CN CN95190533A patent/CN1129400A/en active Pending
- 1995-05-08 WO PCT/US1995/005730 patent/WO1995030420A1/en not_active Application Discontinuation
- 1995-05-08 EP EP95919064A patent/EP0708646A1/en not_active Withdrawn
- 1995-09-19 US US08/530,516 patent/US5886030A/en not_active Expired - Fee Related
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60155111A (en) * | 1983-10-20 | 1985-08-15 | Hisamitsu Pharmaceut Co Inc | Stable pharmaceutical for external use containing "ketoprofen(r)" |
JPS6341421A (en) * | 1986-08-07 | 1988-02-22 | Sogo Yatsukou Kk | Anticataract agent |
US5013751A (en) * | 1989-01-10 | 1991-05-07 | Alcon Laboratories, Inc. | (+) Suprofen esters and amides as opthalmic anti-inflammatory agents |
EP0380367A1 (en) * | 1989-01-27 | 1990-08-01 | Stafford-Miller Ltd. | Compositions and method for the treatment of disease |
WO1993003720A2 (en) * | 1991-08-16 | 1993-03-04 | Trevithick John R | Methods and compositions for treating sunburns |
JPH05271076A (en) * | 1992-03-26 | 1993-10-19 | Taisho Pharmaceut Co Ltd | Anti-inflammatory analgesic external preparation |
EP0578077A2 (en) * | 1992-07-10 | 1994-01-12 | F. Hoffmann-La Roche Ag | Compositions containing retinoic acids and tocopherol |
Non-Patent Citations (7)
Title |
---|
DATABASE WPI Week 8539, Derwent World Patents Index; AN 85-239345 * |
DATABASE WPI Week 8813, Derwent World Patents Index; AN 88-089177 * |
DATABASE WPI Week 9333, Derwent World Patents Index; AN 93-262882 * |
DATABASE WPI Week 9346, Derwent World Patents Index; AN 93-365145 * |
M.W. ADAMS: "d-Alpha tocopheryl polyethylene glycol 1000 succinate (Eastman vitamin E TPGS) as an emulsifier and bioenhancer for drugs and lipophilic compounds", CONGR. INT. TECHNOL. PHARM., 6TH, vol. 4, 1992, pages 254 - 262 * |
POPOVICI I. ET AL: "FORMULATION ET ESSAIS IN VIVO DE COLLYRES HUILEUX D'INDOMETACINE", STP PHARMA SCI. (FRANCE), 1993, VOL. 3, NO. 3, PAGE(S) 266-270, * |
R. CARINI ET AL.: "Comparative evaluation of the antioxidant activity of alpha-tocopherol, alpha-tocopherol polyethylene glycol 1000 succinate and alpha-tocopherol succinate in isolated hepatocytes and liver microsomal suspensions", BIOCHEMICAL PHARMACOLOGY, vol. 39, no. 10, 1990, pages 1597 - 1601 * |
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US9192577B2 (en) | 2002-11-29 | 2015-11-24 | Janssen Pharmaceutica Nv | Pharmaceutical compositions comprising a basic drug compound, a surfactant, and a physiologically tolerable water soluble acid |
KR20190098949A (en) * | 2016-12-19 | 2019-08-23 | 라이온 가부시키가이샤 | Ophthalmic composition and its manufacturing method |
KR102453524B1 (en) | 2016-12-19 | 2022-10-12 | 라이온 가부시키가이샤 | Ophthalmic composition and manufacturing method thereof |
Also Published As
Publication number | Publication date |
---|---|
JPH08508049A (en) | 1996-08-27 |
CA2166722A1 (en) | 1995-11-16 |
MX9600140A (en) | 1998-11-29 |
AU684950B2 (en) | 1998-01-08 |
AU2476295A (en) | 1995-11-29 |
JP2742333B2 (en) | 1998-04-22 |
EP0708646A1 (en) | 1996-05-01 |
CN1129400A (en) | 1996-08-21 |
US5886030A (en) | 1999-03-23 |
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