WO1995029708B1 - TECHNETIUM-99m LABELED IMAGING AGENTS - Google Patents
TECHNETIUM-99m LABELED IMAGING AGENTSInfo
- Publication number
- WO1995029708B1 WO1995029708B1 PCT/US1995/005340 US9505340W WO9529708B1 WO 1995029708 B1 WO1995029708 B1 WO 1995029708B1 US 9505340 W US9505340 W US 9505340W WO 9529708 B1 WO9529708 B1 WO 9529708B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- amide
- hcy
- cyclo
- methyl
- ggc
- Prior art date
Links
- 229940056501 Technetium 99m Drugs 0.000 title claims abstract 4
- GKLVYJBZJHMRIY-OUBTZVSYSA-N technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 title claims abstract 4
- 239000012216 imaging agent Substances 0.000 title abstract 4
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract 13
- 238000003384 imaging method Methods 0.000 claims abstract 2
- 150000001408 amides Chemical class 0.000 claims 23
- 125000006357 methylene carbonyl group Chemical group [H]C([H])([*:1])C([*:2])=O 0.000 claims 23
- 239000003638 reducing agent Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- -1 dithionite ion Chemical class 0.000 claims 1
- CWYNVVGOOAEACU-UHFFFAOYSA-N fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 claims 1
- 229910001448 ferrous ion Inorganic materials 0.000 claims 1
- 229910021526 gadolinium-doped ceria Inorganic materials 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 230000000536 complexating Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
Abstract
This invention relates to radiolabeled scintigraphic imaging agents and reagents for preparing such imaging agents and methods for producing and using such reagents. Specifically, the invention relates to reagents for preparing scintigraphic imaging agents for imaging sites in a mammalian body comprising a specific binding compound including specific-binding peptide embodiments thereof, covalently linked to a radiolabel complexing moiety. Reagents, methods and kits for making such reagents, and methods for using such reagents labeled with technetium-99m (Tc-99m) via Tc-99m complexing moieties comprising said reagents, are provided.
Claims
AMENDED CLAIMS
[received by the International Bureau on 8 November 1995 (08.11.95);
original claim 17 amended; remaining claims unchanged (1 page)] comprising a sealed vial containing a predetermined quantity of the reagent of Claim 1 and a sufficient amount of reducing agent to label the reagent with technetium-99m.
15. A method for labeling a reagent according to Claim 1 comprising reacting the reagent with technetium-99m in the presence of a reducing agent.
16. The method of Claim 15, wherein the reducing agent is selected from the group consisting of a dithionite ion, a sxannous ion and a ferrous ion.
17. Use of the reagent of Claim 2 for preparing a medicament for imaging a site within a mammalian body, wherein the medicament comprises an effective diagnostic amount of the reagent of Claim 2.
18. A composition of matter having formula:
cyclo(N-methyl)FY WDKV,Hcy. (CH2CO.GGC.amide)
cyclo(N-methyl)FY WDKV,Hcy. (CH2CO.GGCK.am ide)
cyclo(N-methyl)FY WDKV,Hcy. (CH2CO.GGCR.amide)
cyclo(N-methyl)FY WDKV,Hcy. (CH2CO.GGCRD.amide)
cyclo(N-methyl)FY WDKV,Hcy. (CH2CO.GGCRK.amide)
cyclo(N-methyl)FY WDKV,Hcy. (CH2CO. GGCRR. amide)
cyclo(N-methyl)FY WDKV,Hcy. (CH2CO.GQCKK.amide)
cyclo(N-methyl)FY WDKV,Hcy. (CH2CO.GGCKKK.amide)
cyclo(N-methyl)FY WDKV,Hcy. (CH2CO.GGC.Oen.amide)
cyclo(N-methyl)FY WDKV,Hcy. (CH2CO.GGCKDK.amide)
cyclo(N-methyl)FY WDKV,Hcy. (CH2CO.GGC.Orn.D.Orn.amide)
cyclo(N-methyl)FY WDKV,Hcy. (CH2CO.GGC.Orn .D.amide)
cyclo(N-methyl)FY WDKV,Hcy. (CH2CO.KKC.am ide)
cyclo(N-methyl)FY WDKV,Hcy. (CH2CO.KRC.amide)
cyclo(N-methyl)FY WDKV,Hcy. (CH2CO.RRC.amide)
cyclo(N-methyl)FY WDKV,Hcy. (CH2CO.KKCK.amide)
cyclo(N-methyl)FY WDKV,Hcy. (CH2CO.GRCK.amide)
cyclo(N-methyl)FY WDKV,Hcy. (CH2CO.GKCR .amide)
CH2CO,YD,Apc,GDCGGCAcmGCAcmGGC.amide
CH2CO,YD,Apc,GDCGGCAcmGCAcmGGCG.amide
CH2CO,YD,Apc,GDCGGSSGGCG.amide
CH2CO,YD,Apc,GDCGGCG. amide
CH2CO,YD,Apc,GDC KGCG.ami de
GRGDGGC
GLFCGC.amide
GRGDGGGGC
FDFYWDKTFTGGC.amide
aceryl. CGGY.(CH2)4-pipridine
or
β-glucan-(=NNHCO.(CH2),CO.)GGC.amide
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT95918875T ATE234639T1 (en) | 1994-05-02 | 1995-05-01 | TECHNETIUM-99M LABELED IMAGE-FORMING AGENTS |
| DE69529988T DE69529988T2 (en) | 1994-05-02 | 1995-05-01 | TECHNETIUM-99M MARKED IMAGING AGENT |
| AU24633/95A AU704460B2 (en) | 1994-05-02 | 1995-05-01 | Technetium-99m labeled imaging agents |
| DK95918875T DK0772459T3 (en) | 1994-05-02 | 1995-05-01 | Technetium-99m labeled imaging agents. |
| JP7528440A JPH09512555A (en) | 1994-05-02 | 1995-05-01 | Technetium-99m labeled imaging agent |
| EP95918875A EP0772459B1 (en) | 1994-05-02 | 1995-05-01 | TECHNETIUM-99m LABELED IMAGING AGENTS |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23640294A | 1994-05-02 | 1994-05-02 | |
| US08/236,402 | 1994-05-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1995029708A1 WO1995029708A1 (en) | 1995-11-09 |
| WO1995029708B1 true WO1995029708B1 (en) | 1995-12-07 |
Family
ID=22889343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/005340 WO1995029708A1 (en) | 1994-05-02 | 1995-05-01 | TECHNETIUM-99m LABELED IMAGING AGENTS |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0772459B1 (en) |
| JP (1) | JPH09512555A (en) |
| CN (1) | CN1087955C (en) |
| AT (1) | ATE234639T1 (en) |
| AU (1) | AU704460B2 (en) |
| CA (1) | CA2189420A1 (en) |
| DE (1) | DE69529988T2 (en) |
| DK (1) | DK0772459T3 (en) |
| ES (1) | ES2194908T3 (en) |
| PT (1) | PT772459E (en) |
| WO (1) | WO1995029708A1 (en) |
| ZA (1) | ZA953494B (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
| JP2774378B2 (en) * | 1991-02-08 | 1998-07-09 | ダイアテク，インコーポレイテッド | Technetium-99m labeled polypeptide for imaging |
| US7238340B1 (en) * | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
| US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5645815A (en) | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
| US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
| US5783170A (en) * | 1991-11-27 | 1998-07-21 | Diatide, Inc. | Peptide-metal chelate conjugates |
| US5989519A (en) * | 1992-03-13 | 1999-11-23 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
| US5968476A (en) * | 1992-05-21 | 1999-10-19 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
| US6017512A (en) * | 1992-06-23 | 2000-01-25 | Diatide, Inc. | Radiolabeled peptides |
| CN1768862A (en) * | 2004-10-26 | 2006-05-10 | 北京诺思兰德生物技术有限责任公司 | Protein marked by Tc-99 capable of specifically combined with GnRH-receptor expressed cancer cell |
| EP2271373B1 (en) * | 2008-03-10 | 2018-10-31 | The Medical College Of Wisconsin, Inc. | 99mtc-labeled 19 amino acid containing peptide for use as phosphatidylethanolamine binding molecular probe and radiopharmaceutical |
| RU2454931C1 (en) * | 2011-03-02 | 2012-07-10 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт онкологии имени Н.Н. Петрова" Министерства здравоохранения и социального развития Российской Федерации | Method of diagnosing tumour process dissemination in patients with non-small-cell lung carcinoma |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8914020D0 (en) * | 1989-06-19 | 1989-08-09 | Antisoma Ltd | Synthetic peptides for use in thrombus detection |
| JP2860157B2 (en) * | 1990-10-31 | 1999-02-24 | 日本メジフィジックス株式会社 | Method for producing radioactively labeled technetium chelate injection for renal function measurement |
| US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
| JP2774378B2 (en) * | 1991-02-08 | 1998-07-09 | ダイアテク，インコーポレイテッド | Technetium-99m labeled polypeptide for imaging |
| CA2127284C (en) * | 1992-01-03 | 2002-02-05 | Buck A. Rhodes | Protein- and peptide-metal ion pharmaceutical applications |
| AU687080B2 (en) * | 1993-04-08 | 1998-02-19 | Cis Bio International | Radiolabeled compounds for thrombus imaging |
| DK0641222T3 (en) * | 1992-05-21 | 2000-12-11 | Diatide Inc | Peptides labeled with technetium-99m for thrombus imaging |
| US5716596A (en) * | 1992-06-23 | 1998-02-10 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
| US5620675A (en) * | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
| US5464934A (en) * | 1993-05-14 | 1995-11-07 | Mallinckrodt Medical, Inc. | Metal chelates as spacer compounds in biologically active peptides |
| EP0720621B1 (en) * | 1993-06-23 | 2001-02-07 | Diatide, Inc. | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
-
1995
- 1995-05-01 DE DE69529988T patent/DE69529988T2/en not_active Revoked
- 1995-05-01 EP EP95918875A patent/EP0772459B1/en not_active Revoked
- 1995-05-01 DK DK95918875T patent/DK0772459T3/en active
- 1995-05-01 CN CN95193737A patent/CN1087955C/en not_active Expired - Fee Related
- 1995-05-01 CA CA002189420A patent/CA2189420A1/en not_active Abandoned
- 1995-05-01 AU AU24633/95A patent/AU704460B2/en not_active Ceased
- 1995-05-01 PT PT95918875T patent/PT772459E/en unknown
- 1995-05-01 AT AT95918875T patent/ATE234639T1/en not_active IP Right Cessation
- 1995-05-01 ES ES95918875T patent/ES2194908T3/en not_active Expired - Lifetime
- 1995-05-01 WO PCT/US1995/005340 patent/WO1995029708A1/en not_active Application Discontinuation
- 1995-05-01 JP JP7528440A patent/JPH09512555A/en not_active Ceased
- 1995-05-02 ZA ZA953494A patent/ZA953494B/en unknown
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