WO1995028956A3 - Antifibrillatory agent in myocardial reperfusion - Google Patents

Antifibrillatory agent in myocardial reperfusion Download PDF

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Publication number
WO1995028956A3
WO1995028956A3 PCT/CA1995/000232 CA9500232W WO9528956A3 WO 1995028956 A3 WO1995028956 A3 WO 1995028956A3 CA 9500232 W CA9500232 W CA 9500232W WO 9528956 A3 WO9528956 A3 WO 9528956A3
Authority
WO
WIPO (PCT)
Prior art keywords
myocardial reperfusion
ceruloplasmin
relates
antifibrillatory agent
antifibrillatory
Prior art date
Application number
PCT/CA1995/000232
Other languages
French (fr)
Other versions
WO1995028956A2 (en
Inventor
Mircea Alexandru Mateescu
Marie-Josee Dumoulin
Roxana Atanasiu
Ramez Chahine
Reginald Nadeau
Original Assignee
Labopharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labopharm Inc filed Critical Labopharm Inc
Priority to AU23000/95A priority Critical patent/AU2300095A/en
Publication of WO1995028956A2 publication Critical patent/WO1995028956A2/en
Publication of WO1995028956A3 publication Critical patent/WO1995028956A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to a new use of a known chemical compound as a therapeutic agent having antiarrhythmic properties, the ceruloplasmin (a copper protein). More particularly, the Applicants have noted that ceruloplasmin generates antiarrhythmic effects during reperfusion in the ischemic heart. The invention also relates to a method for either preventing or treating heart arrhythmias.
PCT/CA1995/000232 1994-04-22 1995-04-24 Antifibrillatory agent in myocardial reperfusion WO1995028956A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU23000/95A AU2300095A (en) 1994-04-22 1995-04-24 Antifibrillatory agent in myocardial reperfusion

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23280494A 1994-04-22 1994-04-22
US232,804 1994-04-22

Publications (2)

Publication Number Publication Date
WO1995028956A2 WO1995028956A2 (en) 1995-11-02
WO1995028956A3 true WO1995028956A3 (en) 1995-12-14

Family

ID=22874663

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1995/000232 WO1995028956A2 (en) 1994-04-22 1995-04-24 Antifibrillatory agent in myocardial reperfusion

Country Status (2)

Country Link
AU (1) AU2300095A (en)
WO (1) WO1995028956A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2270853A1 (en) * 1999-05-05 2000-11-05 Unknown Ceruloplasmin and antioxidant compositions comprising the same and their uses as neuroprotective agent
CA2271192A1 (en) * 1999-05-05 2000-11-05 Unknown Cardioprotective compositions comprising ceruloplasmine and uses thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ATANASIU R. ET AL.: "Antiarrhythmic effects of ceruloplasmin as free radical scavenger in ischaemic isolated rat heart", FASEB JOURNAL FOR EXPERIMENTAL BIOLOGY, vol. 8, no. 5, 18 March 1994 (1994-03-18), BETHESDA, MD US, pages A606 *
BARON P ET AL: "Ceruloplasmin and deferoxamine prevent ischemia- reperfusion damage in kidney transplantation.", DAS, D. K. (ED.). ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, VOL. 723. CELLULAR, BIOCHEMICAL, AND MOLECULAR ASPECTS OF REPERFUSION INJURY;CONFERENCE, NEW YORK, NEW YORK, USA, JULY 11-14, 1993. XVI+506P. NEW YORK ACADEMY OF SCIENCES: NEW YORK, NEW YO *
BARON, PEDRO ET AL: "Renal preservation after warm ischemia using oxygen free radical scavengers to prevent reperfusion injury", J. SURG. RES. (1991), 51(1), 60-5 CODEN: JSGRA2;ISSN: 0022-4804 *
CHAHINE, RAMEZ ET AL: "Protective effects of ceruloplasmin against electrolysis-induced oxygen free radicals in rat heart", CAN. J. PHYSIOL. PHARMACOL. (1991), 69(10), 1459-64 CODEN: CJPPA3;ISSN: 0008-4212 *
MATEESCU, M. A. ET AL: "Protection of myocardial tissue against deleterious effects of oxygen free radicals by ceruloplasmin", ARZNEIM.-FORSCH. (1995), 45(4), 476-80 CODEN: ARZNAD;ISSN: 0004-4172 *
WANG, X. T. ET AL: "Joint chromatographic purification of bovine serum ceruloplasmin and amine oxidase", PREP. BIOCHEM. (1994), 24(3&4), 237-50 CODEN: PRBCBQ;ISSN: 0032-7484 *

Also Published As

Publication number Publication date
AU2300095A (en) 1995-11-16
WO1995028956A2 (en) 1995-11-02

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