WO1995028840A1

WO1995028840A1 - Hydrogen peroxide composition formulated for the preventive and curative treatment of diseases affecting the foliage and aerial parts of plants

Info

Publication number: WO1995028840A1
Application number: PCT/FR1995/000516
Authority: WO
Inventors: Jean-Louis Soyez
Original assignee: Soyez, Anne; Soyez, Jean-Eric; Soyez, Marie-Laure
Priority date: 1994-04-22
Filing date: 1995-04-20
Publication date: 1995-11-02
Also published as: FR2718924B1; FR2718924A1

Abstract

The composition of the invention comprises hydrogen peroxide, at least one surface active agent, at least one peroxide stabilizing agent, at least one evaporation retarder, at least one adhesiveness enhancing agent and at least one anticorrosion agent or a sequestering agent, and provides, at the time of use, 10-20,000 ppm of hydrogen peroxide. The composition can also contain other conventional compatible fungicides. The invention also concerns a sporicide-fungicide made from said composition and a method of treating plants with said sporicide or said composition. The invention provides a formulation for combatting the spores and mycelium of numerous parasitic fungi more effectively than non-formulated hydrogen peroxide.

Description

Composition based on hydrogen peroxide formulated for the preventive and curative treatment of leaf and air diseases of plants.

Since its identification in 1818 by Thénard, hydrogen peroxide has received numerous applications, mainly in chemistry because of its oxidizing or reducing power, depending on the pH of the medium, as well as in the medical field where it is used per se. or in combination with alcohols, other antimicrobial agents and acids (see for example US-A-4,900,721), and in various industrial fields, such as the manufacture of textiles and pulp where it is used as a bleach and pollution control agent, and that of metallurgy. It has also been used as an energy source (propellant oxidizer).

Hydrogen peroxide has also been used in agriculture, in applications relating to the bactericidal role which is recognized in the medical field. It has thus been studied as such in the treatment of seeds or fruits after harvest, but also in combination with other compounds in the fight against parasitic fungi of plants. Thus, the document JP-5 229 910 discloses the combination of hydrogen peroxide with an antimicrobial agent effective against Plasmodiophora brassicae, the fungus responsible for the hernia of cabbage; and document US-A-5,079,868 discloses the combination of hydrogen peroxide with urea to fight in particular against Peronospora and Phytophtora, two fungi affecting the vine. Hydrogen peroxide has also been used alone for this type of application.

It will be noted that, because of its liquid presentation and its solubility in water, it is not necessary to formulate it in a particular manner in order to be able to use it. Thus, European patent application EP-A-0 347 731 discloses a process for combating plant bacteria and parasites, and in particular Botrytis, oidium and downy mildew, which consists of spraying, after the start of infection, on the aerial parts of plants, a solution containing 0.05 to 5% by weight of 35% hydrogen peroxide, possibly associated with compounds believed to enhance the fight against parasites, such as calcium compounds, and / or compounds promoting plant growth, such as magnesium compounds, and / or organic peracids and / or sulfur. The major drawback of this known process is that the quantities of sprayed hydrogen peroxide, except in the particular case of inflorescence botrytis, range from 19.5 to 45 l / ha, the preferred quantities being close to 19, 5 to 30 1 / ha, that is to say much higher than the limits acceptable in phytosanitary practice, which must remain, at best, less than 5 1 / ha and, in any case, below 10 1 / ha to reduce as much as possible the quantities of product to be transported to the place of treatment.

The invention solves this problem by proposing a new specific formulation based on hydrogen peroxide which makes it possible to fight effectively against pathogenic fungi parasites of the aerial parts of plants, and in particular of the vine, a contact sporicide-fungicide constituted by said formulation, as well as a method of combating such fungi, which consists in spraying said formulation or said sporicide-fungicide on plants. It has been discovered that the particular formulation of the invention has an effectiveness such that the application of a quantity of hydrogen peroxide per hectare much lower than that sprayed according to the prior art makes it possible to destroy the fungi and spores (5 1 / ha of the proposed formulation, with extreme values ranging from 2 to 10 1 / ha). More specifically, the subject of the invention is:

- In general, a composition for the preventive and curative treatment of leaf and air diseases of plants, comprising: a) hydrogen peroxide; b) at least one surfactant; c) at least one peroxide stabilizing agent; d) at least one agent delaying evaporation; e) at least one tackifier; f) at least one anti-corrosion agent, which composition provides, at the time of use, from 10 to 20,000 ppm of hydrogen peroxide; and

- a contact sporicide-fungicide constituted by said formulation. As surface active agents, there can be used: alcohols: monalcohols, such as methanol, propanol, butanol; ethylene glycol; polyglycols, such as poly (ethylene glycol), and their esters; poly-glycerols and their fatty acid monoesters, sorbitol; oxyethylenic and oxypropylenic derivatives, such as mono- or di-esters of fatty acids; polyoxyethylene and polyoxypropylene ethers of fatty alcohols or acid-alcohols; mercaptan ethers; oxyethylene and oxypropylene derivatives of amines or amides of amino alcohols; al ylarylpolyal yleneoxide derivatives; fatty ester derivatives, such as derivatives of the polyol esters of sucrose, of sorbitol; and (poly) oxyethylene and (poly) oxypropylene ethers of phenols, cresols, alkylphenols and alkylnaphthols.

These surface active agents represent from about 0.05 to about 2% by weight of the formulation. They can be used alone or in combination. These compounds are available from a variety of suppliers, for example from BASF under the names PLURONIC ^R and TETRONIC ^R , from ICI under the name ATPLUS ^R , from RHONE-POULENC under the names RHODAMINE ^R , IGEPAL ^R , ALKAMUL ^R and ANTAR0X ^R , with O NICHEM under the name TENSIOFIX ^R , with UNION CARBIDE under the name TERGITOL ^R.

The formulation also contains from about 1 to about 5% by weight of at least one peroxide stabilizing agent, such as benzenesulfonic acid, trifluoroacetic acid, hydrochloric acid, nitric acid. , phosphoric acid and sulfuric acid, used alone or in combination, which are commonly available commercially. The formulation also contains from 0.05 to about 1% of at least one anti-corrosion agent and / or of one or more sequestrants, such as benzotriazole and / or ethylene diamine tetraacetic acid (EDTA).

As evaporation delaying agents, intended to prevent the formulation from evaporating when sprayed on the plant and to reduce the rate of decomposition of the active ingredient applied to the plant, it is possible to use from about 0.1 to about 5% either of one or more alcohols, such as glycol or isopropanol, or of hexanedioic acid, or of a mixture of these.

Tack improving agents or reducing rain leaching which can be used in the present invention include from about 0.1 to about 0.5% of pyrrolidone derivatives, such as, for example, AGRIMAX ^R , AGRISYNTH ^R or AGRIMER ^R , which are available from ISP.

The formulation according to the invention can also comprise compounds which have no influence on the effectiveness of the invention but are intended to warn the manipulator, such as dyes soluble in water (ACID RED, YELLOW SULPHONE , etc.) and / or odorants (olfactory denaturants) present up to about 5% by weight in the formulation (acetic acid, propionic acid, heptanoic acid or picric acid, for example, used alone or in combination).

According to another embodiment of the invention, the formulation also contains one or more compatible fungicides chosen from sulfur, benzimidazoles, dithiocarbamates, phenol derivatives, phthaliides, cyclic imides, amine derivatives. amides, diazine derivatives, morpholine heterocycles, imidazoles and triazoles. In this case, the formulation provides, at the time of use, from 500 to 5,000 ppm of hydrogen peroxide and a conventional concentration, or possibly reduced, of said fungicide (s). It was noted that the combination of the formulated hydrogen peroxide with another fungicide could have a synergistic effect.

Three examples of formulations according to the present invention are given below.

Formulation A hydrogen peroxide 32.5% wetting agent: ethylene diamine polyoxyethylene 1.0% acid stabilizer and anti¬ corrosion: EDTA / H ₃ P0 ₄ 10/90 mixture 1.0% agents delaying evaporation and improving adhesiveness : glycol / PVP 90/10 1.0% dye YELLOW SULFONE 0.14% odor denaturant acetic acid 0.5% water qs 100% Formulation B hydrogen peroxide 32.5% wetting agent: alkylphenolethoxylate 0.5% acid stabilizer and anti¬ corrosion: EDTA / nitric acid mixture 10/90 1.5% agents delaying evaporation and improving adhesiveness: alcohols / PVP 0.5% dye: ACID RED 0.10% odor denaturant: picric acid 0.10% water qs 100%

Formulation C 35% hydrogen peroxide 980 ml

TENSIOFIX ^R HS 5g

Ethylene glycol 50g

PVP 5g

^ -6 ^ 10 ^ 4 2g H3PO4 10g

CH ₃ CH ₂ COOH 3g any dye 0.7 to 1.4 g water qs 1 1

Formulation C, once diluted in distilled water to reduce the hydrogen peroxide concentration to 32.5%, will be designated by MRA in the following description. It is understood, however, that the formulations according to the invention may be more diluted, depending on the objective sought, and, ultimately, these formulations may contain from 20 to 32.5% of hydrogen peroxide, with correlative variations of formulating agents. The subject of the invention is also a process for the preventive or curative treatment of leaf and air diseases of plants, which consists in spraying on plants 50 to 400 l / ha, but preferably 100 to 250 l / ha, of the sporicide -fungicide or of the formulation defined in general terms above, or else a process which consists in subjecting said plants jointly to a treatment using said formulation, which provides, at the time of use, between 500 ppm and 5000 ppm of hydrogen peroxide and is applied at a rate of 50 to 400 l / ha, and to a treatment using one or more fungicides chosen from sulfur, benzimidazoles, dithiocarbamates, phenol derivatives, phthalides, cyclic imides, amine-amide derivatives, diazine derivatives, morpholine heterocycles, imidazoles and triazoles and phosethyl-Al.

It has been discovered that:

1 ") at concentrations of less than 500 ppm and sometimes as low as 10 to 20 ppm, the total destruction of the spores of these organisms is observed, which are completely and definitively prevented from germinating. No spore could be found which has not been destroyed by the formulation according to the invention in laboratory tests.

2 ^e ) at concentrations of between 5,000 and 20,000 ppm, the destruction of the vegetative forms of fungi, known as "mycelium" forms, is obtained more or less quickly and completely: these organisms are blocked in their development, then completely destroyed if the processing is duplicated. These two types of results make it possible to define hydrogen peroxide as a contact fungicide, rapid action and medium to low persistence (persistence of action).

3 °) At concentrations between 500 and 5000 ppm, hydrogen peroxide plays the role of an active adjuvant to current fungicide programs. We can send the hypothesis that this synergy results from the fact that hydrogen peroxide, by easily and totally destroying the spores at these doses, leaves to the current fungicides, generally specialized by disease, only the care of carrying out the destruction of the mycelium.

It is understood that the hydrogen peroxide concentrations indicated above correspond to volume or weight fractions of a formulation which is then applied in 50 to 400 liters of spray mixture per hectare. For example, 20,000 ppm or 2% of formulation in 400 l / ha of spray solution corresponds to 8 l / ha of sprayed formulated product.

The diseases susceptible to a sporicidal-fungicidal treatment by the formulation according to the invention are those where, at one stage or another, spores and / or mycelia have developed on the surface of the aerial organs of the plant. These diseases can be:

Oocetes: Pythium, Phytophtora, Plasmopara, Peronospora, Bremia and Albugo;

Basidiomycetes: Ustilago, Tilletia, Urocystis, Uro yces, Puccinia, Tranzchelia, Phragmidium, Gymnosporangium, Melampsora, Rhizoctonia, Stereu, Typhula, Phellinus;

Ascomycetes; Taphrina, Penicillium, Aspergillus, Elsinoe, Erysiphe, Leveillula, Sphaerotheca, Microsphaera, Podospharea, Uncinula, Phyllactinia, Claviceps, Nectria, Gibberella, Guignardia, Mycosphaerella, Didymella, Ophiobolus Venturia, Ceratocystis, Botrytis, Sclerotinia, Monilia, Pseudopeziza, Phacidiella, Coccomyces;

Adelomycetes: Pho a, Phyllosticta, Aschochyta, Septoria, Fusicoccum, Coniothyrium, Gleosporium,

Colletotrichum, Kabathiella, Marssonina, Cylindrosporium,

Monilia, Botrytis, Ramularia, Powdery mildew, Thielaviopsis,

Fusicladium, Cladiosporium, Cylindrocarpon.

The formulation according to the invention can be used in sprayers suitable for reaching the diseased part of the plant: either alone (if the harvest is approaching, for example, and the objective sought is efficiency with no residue on the crop), or extemporaneously in addition to appropriate organic fungicides chosen from the following families. sulfur

. benzimidazoles, such as carbendazim. dithiocarbamates, such as mancozebe and thiurame. certain phenol derivatives, such as dinocap

. phthalimides, such as phaltane and captan. cyclic imides, such as iprodione. amine-amide derivatives, such as cymoxanil, metalaxyl, ofurace. diazine derivatives, such as nuarimol,. morpholine heterocycles (fenpropemorph) imidazoles (prochloraze) triazoles (triadimephon),

. phosethyl-Al among others; either in combination (co-formulation) with most fungicides from the families mentioned above, when compatibility is good (sulfur in particular).

The invention will be better understood by reference to the following examples which are given by way of illustration only and are not intended to limit the scope of the invention. EXAMPLES

EXAMPLE 1 In vitro test on Botrytis cinerea.

The in vitro efficacy of the formulation was compared

MRA and a commercial hydrogen peroxide solution at

35% which has been diluted with distilled water to a concentration of 32.5% (hereinafter MB), against

Botrytis cinerea. For this purpose, an S9 strain of Botrytis cinerea on a vine and kept in a 2% CRISTOMAT-agar liquid nutrient medium in Petri dishes, at a temperature of 19 ° C and in the dark.

The assay was performed on a 24-well cell culture plate. 1.5 ml of distilled water was added to each well, supplemented with either MB or MRA, at concentrations of 0; 0.002; 0.005; 0.01 and 0.02% by weight. Then added 50 μl of conidia suspension, at 10 ⁵ spores / ml, to each well. The germination of the conidia was evaluated after 24 hours of incubation at 19 ° C. The results are presented in Table 1 where DE 50 and DE 95 represent the effective dose for destroying 50% and 95% of the conidia population respectively.

Table 1

FROM 50 FROM 95

MB 0.0068 μg / ml 0.0240 μg / ml MRA 0.0028 μg / ml 0.0089 μg / ml

It appears from Table 1 above that the MRA formulation is 2.5 to 3 times more effective than the hydrogen peroxide taken separately. Other in vitro tests, carried out under conditions similar to those of Example 1, which account for the preventive activity of the formulation according to the invention, have shown that the MRA formulation diluted to 2% made it possible to kill the spores and mycelium of Erysiphe graminis (curative 48 hours) and diluted to 0.002% the spores of Septoria nodorum and tritici (preventive). EXAMPLE 2- In vitro test on Monilia fructigena.

The in vitro efficacy of the two products MB and MRA above was compared against two strains of Monilia fructigena (isolates 1519 and 1097 of Monilia fructigena isolated on apple). The strains were kept in incubation on a 2% DIAMALT-Agar nutrient medium, at a temperature of 19 ° C and in the dark.

More specifically, the product MB and the formulation MRA were used at concentrations of 0.002; 0.02; 0.2 and 2%.

Each Petri dish containing 20 ml of DIAMALT-Agar was seeded in the center with a growing mycelial implant, 4 mm in diameter.

After sowing, the diameters of the mycelial areas were measured and the effective dose for destroying 50% of the fungi (ED 50) and the effective dose for destroying 95% of the fungi (DE 95) were deduced therefrom.

The results are presented in Table 2 below:

Table 2

MRA MB DE 50 DE 95 DE 50 DE 95 1519 0.12 μg / ml 5.05 μg / ml 0.2 μg / ml 11.2 μg / ml 1097 0.07 μg / ml 3.48 μg / ml 0, 11 μg / ml 5.35 μg / ml

Although isolate 1519 appears less sensitive than isolate 1097 to the two preparations, it is deduced from these results that the MRA formulation is approximately 1.8 to 2 times more active than the product MB (peroxide concentration about 1.8 to 2 times lower for the same result).

These results confirm the superiority of the MRA formulation compared to the unformulated hydrogen peroxide, already demonstrated in Example 1. EXAMPLE 3 Field test on Botrytis.

At the end of 1993, experimental sprays were carried out on vines in Champagne, using the MRA formulation at a concentration of 0.5%, 1% and 2%. 24 hours later, partial cleaning was observed Botrytis at 0.5% and 1%, and a total cleaning at 2%. The zone treated at 2% shows no significant recovery of the fungus, five days after the first control. The irregularities observed in the efficiencies noted at 0.5% and 1% are partially attributable to the imperfect quality of the spraying.

EXAMPLE 4 Field test on Botrytis: comparison with an untreated control.

In Languedoc, in Ledenon, a Carignan vine very affected by a violent storm (which constitutes a very favorable condition for the development of Botrytis) was treated by spraying 200 1 / ha of a "porridge" made up of MRA diluted to 2% , which corresponds to a dose of 41 / ha of MRA. Heavy rain of 26 mm occurred 5 days later and the harvest was carried out 5 days later. An untreated control (abbreviated as TNT) was compared to the MRA formulation. The results are given in Table 3.

Table 3

Before treatment At harvest

TNT MRA

% healthy clusters 33% 4.5% 20%

% average attack per cluster * 14% 56% 22%

* visually assessed

It will be noted that the kinetics of evolution of the botrytis on the untreated control is 4 times (56/14 = 4), against 1.5 times (22/14 = 1.5) on the vine treated with the formulation according to l 'invention. In addition, we obtain 8.3 tonnes of healthy harvest for the modality treated using MRA against 4.3 tonnes of healthy harvest for the untreated control, a healthy harvest almost doubled. EXAMPLE 5 Field trial on Botrytis: comparison with vinchlozoline.

In this example, a comparative test was carried out between the MRA formulation and a vinchlozoline preparation (used as a reference treatment), applied to the Pinot noir grape variety, in Champagne, in Aube. Four repetitions were carried out (on four different plots) of the same test, which consisted of spraying 400 1 / ha of the MRA formulation diluted up to 2% (ie 8 1 / ha of MRA), at the classic phenological stages D (3 weeks before harvest) and D + 8 (8 days later).

On the reference modality, four treatments were carried out with vinchlozoline, at the phenological stages A (flowering), B (closure of the cluster), C (veraison) and D of the vine, at the rate of 750 g of active ingredient per hectare, i.e. 1.5 kg / ha of RONILAN ^R supplied by BASF, which corresponds to the approved dose.

An untreated control (TNT) was also evaluated. The results recorded at the time of harvest are given in Table 4.

Table 4

vinchlozoline MRA TNT

Average% of healthy clusters 21% 29% 6%

% average attack per bunch 28% 17% 27% yield of healthy ven¬ 7670 kg / ha 10,100 kg / ha 6,200 kg / ha degree of alcohol in the pressed bunch 8.15 8.13 8.2

In conclusion, two treatments 8 days apart shortly before harvest, using the MRA formulation, give results far superior to those obtained with four treatments using the vinchlozoline reference. applied during the season. The difference in the quantity harvested is economically very significant (+ 2,500 kg). EXAMPLE 6 - Test on powdery mildew of the vine.

A comparative test was carried out between the MRA formulation and wettable sulfur (that is to say a ^' sprayable powder consisting of sulfur with wetting agent) in Roussillon, at Sainte-Colombe, on a Syrah grape. For this purpose, four repetitions were carried out by spraying approximately 230 1 / ha of "slurry" of MRA diluted up to 2%, applied in six treatments spaced approximately 14 days apart from each other (dose / ha of MRA = 4.6 liters).

Wettable sulfur THIOVIT, supplied by SANDOZ, was tested in parallel, also at the rate of 6 sprays of 12.5 kg / ha. An untreated control (TNT) was also evaluated.

The results are collated in Table 5.

Table 5

THIOVIT MRA TNT

% average attack per cluster 1.13% 1.05% 16%

There is no significant difference between the two products. This example demonstrates that a relatively non-persistent product, such as suitably formulated hydrogen peroxide, can advantageously be compared to sulfur, a conventional product for combating powdery mildew. It is to its mode of action, both preventive and curative, that the MRA formulation must have had such effectiveness. Given its already demonstrated activity with respect to Botrytis, it can be deduced that the formulation of • MRA offers a certain interesting versatility on the economic level. EXAMPLE 7 Test on downy mildew of the vine compared with the association cymoxanil + mancozebe.

A trial was carried out in Languedoc, on six different plots, which were each subjected to 11 treatments spaced 10 days apart. The MRA formulation, diluted up to 2%, was applied to these vines by spraying progressive amounts of spray ranging from 140 to 200 l / ha.

The formulation according to the invention was compared with the combination cymoxanil + mancozebe, which is the reference

Plant Protection (REMILTINE PEPITE ^R , supplied by

SANDOZ), applied at the approved rate of 3 kg / ha (0.1 +

1.395 kg of active ingredient).

An untreated control (TNT) was also evaluated. The test, conducted under artificial contamination and misting, shows a moderate attack, but a control of the disease quite comparable for the two methods and this, statistically.

The results are summarized in Table 6 below.

Table 6

% average attack% average attack on leaf on cluster at veraison

TNT 28.85% (a) 8, 78% (a)

REMILTINE PEPITE ¹ 0.43% (b) 0.05% (b)

MRA 0.36% (b) 0.08% (b)

Ranking Very highly Very highly significant statistically significant

The difference between (a) and (b) is significant, unlike the difference between the results noted (b). EXAMPLE 8 - Gray mold test: synergistic effect of the MRA / vinchlozoline combination.

We compared, in the Loire Valley, in the resistant zone, the efficacy of vinchlozoline used alone and used with the MRA formulation playing here the role of an adjuvant to the basic fungicide. The results obtained are as follows:

vinchlozoline

750 g of active ingredient / ha 35% efficiency

vi + 67% efficiency fo

Despite the decrease in efficacy due to resistance phenomena present in many vineyards in Western Europe, the control of the disease by vinchlozoline can be almost doubled by the addition of the adjuvant based on hydrogen peroxide.

The above examples and the preceding description demonstrate that concentrations of 2% of the formulation according to the invention give very good results, both in the laboratory, in in vitro tests on:

Monilia (responsible for moniliosis), Botrytis (responsible for botrytis or rot), Erysiphe (responsible for powdery mildew in cereals) and Septoria nodorum (responsible for septoria blight in cereals), only in the vineyard, in tests on: Botrytis , Plasmopara (responsible for downy mildew) and Uncinula necator (responsible for powdery mildew). Similar results can be expected against the other microorganisms mentioned in this description.

In general, it has been demonstrated that the present invention makes it possible to significantly increase (more than 200%) and unexpected biological efficiency of industrial hydrogen peroxide (35%) by the use of various formulating agents, whose respective roles are still poorly defined to date, in the field of the fight against plant diseases such as vines, fruit trees, cereals, beets, potatoes, horticultural and flower crops.

It will be noted that, although in the foregoing description, reference has been made to an application of the sporicide or of the compositions according to the invention by spraying, other techniques can be used such as whitewash and inclusion in spray water. .

Claims

1- Composition for the preventive and curative treatment of leaf and air diseases of plants, comprising: a) hydrogen peroxide; b) at least one surfactant; c) at least one peroxide stabilizing agent; d) at least one agent delaying evaporation; e) at least one tackifier; f) at least one anti-corrosion agent and / or a sequestering agent, which composition provides, at the time of use, from 10 to 20,000 ppm of hydrogen peroxide.

2- Composition according to claim 1, characterized in that it contains from about 20 to about 32.5% by weight of hydrogen peroxide.

3- Composition according to claim 1 or 2, characterized in that it contains from about 0.05 to about 2% by weight of surface activity agent. 4- Composition according to any one of the preceding claims, characterized in that it contains from about 1 to about 5% by weight of stabilizing agent.

5- Composition according to any one of the preceding claims, characterized in that it contains from 0.05 to about 1% by weight of anti-corrosion agent and / or of sequestering agent.

6- Composition according to any one of the preceding claims, characterized in that it contains from about 0.1 to about 5% by weight of agent delaying evaporation.

7- Composition according to any one of the preceding claims, characterized in that it contains from about 0.1 to about 0.5% by weight of agent improving adhesiveness. 8- Composition according to one. Some of the preceding claims, characterized in that the surface activity agent is chosen from the group consisting of: monalcohols; ethylene glycol; polyglycols and their esters; polyglycerols and their fatty acid monoesters, sorbitol; oxyethylene and oxypropylene derivatives; polyoxyethylenic and polyoxypropylene ethers of fatty alcohols or acid-alcohols; mercaptan ethers; oxyethylene and oxypropylene derivatives of amines or amides of amino alcohols; alkylarylpolyalkyleneoxide derivatives; fatty ester derivatives; and the (poly) oxyethylene and (poly) oxypropylene ethers of phenols, cresols, alkylphenols and alkylnaphthols. 9- Composition according to any one of the preceding claims, characterized in that the peroxide stabilizing agent is chosen from the group consisting of: benzenesulfonic acid, trifluoroacetic acid, hydrochloric acid, nitric acid , phosphoric acid and sulfuric acid.

10- Composition according to any one of the preceding claims, characterized in that the agent delaying evaporation is chosen from the group consisting of: alcohols, such as isopropanol or glycol, and hexanedioic acid.

11- Composition according to any one of the preceding claims, characterized in that the tackifier improving agent is chosen from pyrrolidone derivatives. 12- Composition according to any one of the preceding claims, characterized in that the anti-corrosion agent is benzotriazole.

13- Composition according to any one of the preceding claims, characterized in that the sequestrant is ethylene diamine tetraacetic acid (EDTA). 14- Composition according to any one of the preceding claims, characterized in that it also contains one or more compatible fungicides chosen from sulfur, benzimidazoles, dithiocarbamates, phenol derivatives, phthalimides, cyclic imides, amine-amide derivatives, diazine derivatives, morpholine heterocycles, imidazoles and triazoles, and in that it provides, at the time of use, from 500 to 5,000 ppm of hydrogen peroxide and a conventional or reduced concentration of said or said fungicide (s).

15- Contact sporicide-fungicide constituted by the formulation according to any one of the preceding claims. 16- A method of preventive or curative treatment of leaf and air diseases of plants, characterized in that it consists in spraying on plants from 50 to 400 1 / ha, preferably from 100 to 250 1 / ha, of the formulation according to any one of claims 1 to 14 or the sporicide according to claim 15.

17- A method of preventive or curative treatment of leaf and air diseases of plants, characterized in that it consists in subjecting said plants jointly to a treatment using the formulation according to any one of claims 1 to 13, which formulation provides, at the time of use, between 500 and 5,000 ppm of hydrogen peroxide and is applied, at a rate of 50 to 400 1 / ha, and to a treatment using one or more fungicides chosen from sulfur, benzimidazoles, dithiocarbamates, phenol derivatives, phthalimides, cyclic imides, amine-amide derivatives, diazine derivatives, morpholine heterocycles, imidazoles and triazoles and phosethyl-Al.