WO1995027517A1 - Pharmaceutical agent for local application and a method of obtaining same - Google Patents

Pharmaceutical agent for local application and a method of obtaining same Download PDF

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Publication number
WO1995027517A1
WO1995027517A1 PCT/RU1994/000073 RU9400073W WO9527517A1 WO 1995027517 A1 WO1995027517 A1 WO 1995027517A1 RU 9400073 W RU9400073 W RU 9400073W WO 9527517 A1 WO9527517 A1 WO 9527517A1
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WO
WIPO (PCT)
Prior art keywords
mixture
gelatin
furacilin
treatment
water
Prior art date
Application number
PCT/RU1994/000073
Other languages
French (fr)
Russian (ru)
Inventor
Evgeny Alexeevich Selivanov
Maria Abelevna Dembo
Emilia Yanovna Lambakakhar
Valentina Fedorovna Imshenetskaya
Leonid Feodosievich Linnik
Vladimir Anatolievich Maksimov
Natalya Ivanovna Sukhareva
Ljudmila Sergeevna CHABROVA
Evgeny Viktorovich Belov
Liya Izrailevna Sorina
Original Assignee
Lyzion Australia Pty. Ltd.
Rossiisky Nauchno-Issledovatelsky Institut Gematologii I Transfuziologii (Rniigit)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lyzion Australia Pty. Ltd., Rossiisky Nauchno-Issledovatelsky Institut Gematologii I Transfuziologii (Rniigit) filed Critical Lyzion Australia Pty. Ltd.
Priority to AU64390/94A priority Critical patent/AU6439094A/en
Priority to PCT/RU1994/000073 priority patent/WO1995027517A1/en
Publication of WO1995027517A1 publication Critical patent/WO1995027517A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Definitions

  • This product is equipped with components that are identical to those used in its manufacture and that it is not suitable for the manufacture of raw materials. Otherwise, the use of the product is very troublesome, as it is very difficult to use and could result in a loss of life.
  • There is a curative preparation for local use which is in possession. hemostatic and antibacterial action / ⁇ in ⁇ ; _ 1E2397 /.
  • the following components are included in the composition of the product: gelatin, furacilin, Calcium coolant-35 reed, sulfonyl, water.
  • the preparation is prepared in the following way: gelatine is dissolved in water at a temperature of 40-50 ° C when mixed; in addition add furatsilin, water ⁇ ⁇ 95/27517 ⁇ / ⁇ 9
  • the product received in the form of a preparation in the form of a sponge possesses a small hemostatic activity, since there is an inadequate addiction to 10 This is explained by the fact that in the process of irradiating, the foam is emitted from the air, which is not emitted, that is not emitted, The amount of moisture in the appliance, in such a large amount, significantly reduces the discharge of its storage. Otherwise, this product does not possess the long-acting antibacterial action.
  • the proposed appliance does not include sponge with ⁇ 94 / 00073
  • the high-speed industrial structure of the sponge is indicated by the system ensures the mechanism of the hemostatic effect of the drug 5 in the country. Hemostatic spongy is ensured by its adhesive properties, stimulation of the formation of the process and the activation of coagulation.
  • the sponge thanks to the long-term antibacterial interactions, removes the indicated inhibitory effect and facilitates the treatment
  • Gelatin is a basic white drug, which is necessary for the reception of the intended action. Other than that, it is known that gelatin
  • Calcium chloride is a means of repairing and accepting participation in the formation of hemostasis. With a decrease in the amount of calcium, less than less
  • Genetamycin has a wide range of antibiotic - 4 - sectoral action. With this antibiotic, sensible belypins of mixtures of Rana. A well-known quantity of anti-biotics is sufficient to ensure the antibiotic 5 drug's effect.
  • Sulphon is a traditional drug-active substance that prevents the drug / sponge /.
  • P ⁇ i is ⁇ lz ⁇ vanii ⁇ as ⁇ v ⁇ a zhela ⁇ ina in ⁇ u ⁇ atsiline s ⁇ vmes ⁇ n ⁇ with d ⁇ ugimi ⁇ m ⁇ nen ⁇ ami in chas ⁇ n ⁇ s ⁇ i with ⁇ - 5 maldegid ⁇ m in ⁇ tsesse vs ⁇ enivaniya s ⁇ zdayu ⁇ sya usl ⁇ viya for ⁇ lucheniya ⁇ e ⁇ a ⁇ a ⁇ a, ⁇ bladayuscheg ⁇ ⁇ l ⁇ ngi ⁇ vannym an ⁇ iba ⁇ e ⁇ ialnym deys ⁇ viem. This is due to the fact that partly free bonds of gelatine enter into a viable reversible interaction with antibiotics. ⁇ note ⁇ ,
  • the obtained product is better, which increases its hematostatic effect.
  • the machine is equipped with a stable appliance.
  • the temperature of the freezing temperature is minus 50 ° ⁇ . With this temperature 5, the stabilization of native foam is already taking place. The lower the temperature, the greater the speed of freezing foam. The lower temperature freezing section of the foam is connected with the facilities used.
  • the diameter of the approved vessels was adjusted from 0.02-0.6 mm to 1, 0-1, 2 mm.
  • Table 2 contains the results of the treatment of the patient in combination with the treatment of the other
  • the long-term antimicrobial activity of the preparation was studied in an experiment for 50 cases.
  • the dose of gentamicin sulfate in the brain was maximal and amounted to 29 ⁇ g / g.
  • the concentration of antibiotic was quite high - 22 mkg / g. 14
  • the gentamicin sulphate had already stopped after 30 minutes after the administration of the drug. and consisted of this mixture was maximum and amounted to 12 ⁇ g / ml. 15 After 15 following observation periods, from 1 hour to 4 days, the content of hematamycin sulphate was gradually reduced, and after 7 days the antibiotics were not found in the blood.
  • the antibiotic in the extracted preparation was still divided and was 350 micrograms, and after 21 days it was not detected in the drug.
  • ⁇ ezul ⁇ a ⁇ y ⁇ v ⁇ denny ⁇ issl ⁇ d ⁇ vany ⁇ azali, ch ⁇ 30 to 14 days ⁇ cheni ⁇ ⁇ is ⁇ di ⁇ ⁇ s ⁇ e ⁇ enn ⁇ selection gene ⁇ amitsina sul ⁇ a ⁇ a of ⁇ e ⁇ a ⁇ a ⁇ a in ⁇ uzhayuschuyu s ⁇ edu ⁇ ga- nism, s ⁇ zdavaya an ⁇ iba ⁇ e ⁇ ialny ⁇ ⁇ nts ⁇ n ⁇ atsii in m ⁇ zg ⁇ - v ⁇ : ⁇ ⁇ ani, s ⁇ inn ⁇ -m ⁇ zg ⁇ v ⁇ zhid ⁇ s ⁇ i and ⁇ vi.
  • the proposed product is available for purchase with 35 wired anti-shipments.
  • the ratio of the product was studied in an experiment at 30 cases / in two experiments /.
  • the claimed preparation was used in the clinic of the clinic and various individual medical conditions. Clinical studies were carried out for 2813 patients. The method of use of the device and its use depends on the purpose and area of its application. All cases to achieve a hemostatic effect of the drug on a vacant place for 1-2 minutes. .If the flow does not stop, then try - 18 - Again, they are laying down, so that they will not be able to reach the full hemostasis. In order to prevent the occurrence of infectious complications, the patient is to be reminded of any request to stop any injuries. It is immediately absorbed within 14 days, and therefore it can be sewn up in a wound.
  • the preparation was also used for biological treatment of obstructed burns / burns, acute ulcers, acute ulcers /.
  • the medicine used for the treatment and treatment of the neuropsychiatric process is controlled by the endocrine
  • the total content of sulphate genetamycin and the use of the drug should not exceed 2 g when using the drug
  • Non-hazardous products which are suitable for biological treatment, are divided by the size of the disposed devices.
  • a 5-motor device provided all cases of hemostatic effect within 1-2 minutes.
  • the treatment of the drug was also used in the integrated treatment of 282 patients with burns of heat.
  • the results of treatment depended on the depth, area of the burn and the time of the start of treatment from the moment of the accident, which was caused by
  • the drug was very effective because it was not harmful to the patient / 896 patients /.
  • 35 groups / 120 patients / use of conventional methods of treatment, including the parenteral administration of antibiotics, dull complications occurred in all 20 cases
  • P ⁇ l ⁇ zhi ⁇ zlny ⁇ ⁇ zul ⁇ a ⁇ y / 100 ⁇ / ⁇ a ⁇ zhe were ⁇ lu- cheny ⁇ i ⁇ imen ⁇ nii ⁇ e ⁇ a ⁇ a ⁇ a 63-x b ⁇ lny ⁇ with gn ⁇ ynymi ⁇ tsessa ⁇ li che ⁇ e ⁇ a and g ⁇ l ⁇ vn ⁇ g ⁇ m ⁇ zga, ⁇ ye v ⁇ zni ⁇ ali 5 b ⁇ lshins ⁇ ve cases ⁇ dalenny ⁇ s ⁇ i ⁇ sle che ⁇ e ⁇ n ⁇ - m ⁇ zg ⁇ v ⁇ - ⁇ ⁇ avmy, ⁇ i e ⁇ m ⁇ s ⁇ e ⁇ m ⁇ eli ⁇ ⁇ s ⁇ ey che ⁇ a nab- there were 18 patients with pain, abscesses, subdural and internal medications - in 32 patients, and impaired black and cerebral wounds - in 13 patients. 10 In all sick,
  • the ophthalmic treatment is also used in patients with an easy-to-use glance for the treatment of the illness / 300 patients /.
  • the unit is dia.
  • a good way to prevent moisture from the waste heat is because of the favorable conditions for the improvement of the laser.
  • 15 In general, we offer you the best ... of life.
  • hemostatic and antibiotic delivery With the use of charging, reliable and effective effect is achieved within 0.5-2 minutes. It is also effective for incidents of 20 cases / inconsequential complications and for the treatment of indefinitely differentiated values.
  • the duration of the drug is stored for up to 14 days.
  • the proposed product is also available with a high quality access / facilitates the process of repairing and / or ensuring that it is free of any problems. Thanks to the good practices, the drug is stimulated by the therapeutic processes in Rana and the healing _-: it healing.
  • the method of receiving the product allows you to receive the device with a high output / 90% /. It doesn’t require a dicarious raw materials, environmentally friendly.
  • the products of the desired gelatin in faracilin by a well-known method.
  • a large amount of gelatin is added to the preparation of faracilin for its swelling.
  • the resulting mixture is heated at a temperature of 8 ⁇ -90 ° C for a complete degradation of the iron.
  • the resulting solution cools and mixes it with other products Calcium chloride, phosphate and sulphide.
  • the mixture is placed in a container equipped with a stirrer, and defoamed for the production of foam volume, which rises above the initial volume by at least 2 times.
  • the antibiotic-aqueous solution of the gene of sulfate is added.
  • Concentrate consisting of ⁇ ml of distilled 5 water, 0.098 g of furacilin and 24 g of calcined gelatin, taken up 0.6 ml of 10% calcium sulfate, 0% sulphide, 0% sulphide, 0% - burning dry matter 0.9378 g in 5 ml of distilled water.
  • P ⁇ luchennuyu mixture ⁇ meschayu ⁇ in em ⁇ s ⁇ equipped meshal ⁇ y 10 and vs ⁇ enivayu ⁇ d ⁇ ⁇ lucheniya ⁇ bema ⁇ eny, ⁇ evy- shayuscheg ⁇ ⁇ e ⁇ nachalny ⁇ bem mixture 2 ⁇ aza and za ⁇ em ⁇ chen medlenn ⁇ malen ⁇ y s ⁇ uy ⁇ y ⁇ i ⁇ s ⁇ yann ⁇ m vs ⁇ e- nivanii vv ⁇ dya ⁇ 50 ml v ⁇ dn ⁇ g ⁇ ⁇ as ⁇ v ⁇ a gen ⁇ amitsina sulfonic ⁇ a ⁇ a / s ⁇ d ⁇ zhanie gen ⁇ amitsina sulphate of 7.148 g in 50 ml of 5 distilled water.
  • the resulting foam is quickly discharged into cooled cuvettes and placed in a mobile closure, where the temperature is minus 60 ° C, and it lasts 4 times. Under these conditions, the foam is frozen with the formation of a crystalline structure. Subsequently, suites with 20 refrigerated ports are placed in a vacuum dryer, which is less than 40 ° C / 38 ° C dry / minus 40 ° C. The product received cuts into the plates the necessary values, packs them with plastic and stores 25 lyses with the radiative method. For example, 2.
  • Diluent 3 composed of ⁇ ml of dostilled water, 0.088 g of furacilin and 26 g of calcined zhlatin, 0.8 ml of 10 ml of calcium sulfate / water is diluted with 1.2 ml of hydrochloride, - zhanyz dry weight 1.5 g s 8 ml distilled dy.
  • the resulting mixture is placed in a container equipped with a mixer .., ⁇ it is possible to obtain the best value, which exceeded the initial volume of the mixture by 2.5 times.
  • P ⁇ luchennuyu mixture ⁇ meschayu ⁇ in em ⁇ s ⁇ equipped m ⁇ shal- ⁇ y and vs ⁇ e ⁇ ivayu ⁇ d ⁇ ⁇ lucheniya ⁇ b ⁇ ma ⁇ ny, ⁇ evyshayusch ⁇ - g ⁇ ⁇ z ⁇ nachalny ⁇ bem mixture of 3 ⁇ aza, ⁇ ⁇ luchennuyu 30 ⁇ enu vv ⁇ dya ⁇ , ⁇ a ⁇ u ⁇ azan ⁇ in ⁇ im ⁇ ⁇ .v ⁇ dny ⁇ as ⁇ v ⁇ g ⁇ n ⁇ amitsina sul ⁇ a ⁇ a / 6,880 g in gen ⁇ amitsina sul ⁇
  • Foam freezing is essentially ⁇ :: temperature minus 56 ° C for 4 days. Freeze-drying is carried out at a temperature of 35 ° C to 38 ° C / drying cycle 36 hours /. Further developments with an excellent product exist, as in Example 1.
  • Freezing of foam has a temperature of minus 60 ° ⁇ for 4 days. Freeze-drying is controlled at a temperature of minus 45 ° C to 40 ° C / drying cycle of the ⁇ clock /. Further operations with the resulting product: .. of course, as in Example 1. 2 ⁇ Intended use
  • Medication can be used for all areas of arthritis - general chirurgia, neuropathy, cerebrovascular disease, and irregular disease.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Engineering & Computer Science (AREA)
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Abstract

The proposed haemostatic and bactericidal pharmaceutical agent for local application consists of gelatin, furacilin, gentamycin sulphate, calcium chloride, sulphonol and water in the following proportions (wt %): gelatin 60-80; furacilin 0.1-0.4; calcium chloride 0.1-0.4; gentamycin sulphate 10.0-30.0; sulphonol 0.7-3.0; water the balance. The method of obtaining the proposed pharmaceutical substance involves mixing a solution of gelatin in an aqueous solution of furacilin with an aqueous solution of calcium chloride, formaldehyde and sulphonol, and making the mixture froth until a volume of foam at least twice that of the original mixture is obtained. An aqueous solution of gentamycin sulphate is then added to the foam as the frothing process continues. The resulting foam is frozen at a temperature of -50 °C or below to form a crystalline structure. The resulting product is dried by sublimation at an initial temperature of between -50 and -30 °C and a final temperature of 38-40 °C before being sterilized by irradiation.

Description

95/27517 ΡСΤЛШ94ΛЮ073 ϊаЧЗБΗЫЙ ПΡΕПΑΡΑΤ ДЯЯ ЛΟΚΑЛЬΗΟГΟ ПΡИΜЙΗЯΗИЯ и СПΟСΟБ _ЗГ0 ПΟЛУЧΕΗЖ Οбласτь τеχниκи Ηасτοящее изοбρеτение οτнοсиτся κ οбласτи меди- 5 цины, а именнο κ лечебным πρеπаρаτам гемοсτаτичесκοгο и анτибаκτеρиальнοгο дейсτвия для лοκальнοгο πρимене- ния и сποсοбам иχ ποлучения.95/27517 ΡSΤLSH94ΛYU073 ϊaChZBΗY PΡΕPΑΡΑΤ AJ LΟΚΑLΗΟGΟ PΡIΜYΗYAΗIYA and SPΟSΟB _ZG0 PΟLUCHΕΗZH Οblasτ τeχniκi Ηasτοyaschee izοbρeτenie οτnοsiτsya κ οblasτi copper- 5 Ch'ing and imennο κ medical πρeπaρaτam gemοsτaτichesκοgο and anτibaκτeρialnοgο deysτviya for lοκalnοgο πρimene- Nia and sποsοbam iχ ποlucheniya.
Пροблема προφилаκτиκи и лечения ρаневοй инφеκции вο всеχ οбласτяχ χиρуρгии являеτся весьма аκτуальнοй и 10 τеснο связана с неοбχοдимοсτью οбесπечения бысτροгο и сτοйκοгο гемοсτаза, τем бοлее, чτο неποлный гемοсτаз мοжеτ явиτься дοποлниτельнοй πρичинοй сеπτичесκиχ οс- лοжнений. Ηаρяду с πаρенτеρалъными меτοдами введения анτибаκτеρиальныχ πρеπаρаτοв немалοважнοе значение име- 15 еτ иχ лοκальнοе πρименение для сοздания в ρане дοсτа- τοчнο высοκиχ κοнценτρаций эτиχ πρеπаρаτοв. Β связи с эτим πеρсπеκτивным являеτся πρименение πρеπаρаτοв с προ- лοнгиροванным προτивοмиκροбным деисτвием. Пρедшесτвующий уροвень τеχниκи 20 Извесτен гемοсτаτичесκий πρеπаρаτ для лοκальнοгο πρименения / £[7, Ш 83093/, κοτορый πρедсτавляеτ сοбοй губκу, в сοсτав κοτοροй вχοдиτ πлазма κροви челοвеκа и τροмбοπласτин /τκань мοзга челοвеκа/. Эτοτ πρеπаρаτ οбладаеτ κροвοοсτанавливающими свοйсτвами, οднаκο πρи 25 егο изгοτοвлении τρебуеτся деφициτнοе сыρье - мοзг τρуπа челοвеκа. Κροме τοгο, исποльзοвание πρеπаρаτа весьма заτρудниτельнο, τаκ κаκ οн χρуποκ, легκο πρевρа- щаеτся в ποροшοκ и мοжеτ заκуπορиваτь κροвенοсные сοсу- ды, чτο сοздаеτ благοπρияτные услοвия для ρазвиτия миκ- 30 ροбοв. йзвесτен лечебный πρеπаρаτ для лοκальнοгο πρимене- ния, οбладающиϊ. гемοсτаτичесκим и анτибаκτеρиальным дейсτвием / ϋу Μ;_ 1Э2397/. Β сοсτав πρеπаρаτа вχοдяτ следующие κοмποненτы: желаτин, φуρацилин, κальции χлο- 35 ρид, сульφοнοл, вοда. Пρеπаρаτ ποлучаюτ следующим οбρа- зοм: желаτин ρасτвορяюτ в вοде πρи τемπеρаτуρе 40-50°С πρи πеρемешπвании; в ρасτвορ дοбавляюτ φуρацилин, вοдный \УΟ 95/27517 ΡСΤ/ΚΙΙ9Pροblema προφilaκτiκi and treatment ρanevοy inφeκtsii vο vseχ οblasτyaχ χiρuρgii yavlyaeτsya very aκτualnοy τesnο and 10 associated with neοbχοdimοsτyu οbesπecheniya bysτροgο and sτοyκοgο gemοsτaza, τem bοlee, chτο neποlny gemοsτaz mοzheτ yaviτsya dοποlniτelnοy πρichinοy seπτichesκiχ οs- lοzhneny. In addition to the parenteral methods of administering antibacterial drugs, the importance of 15 has a significant value for the creation of a high rate of growth in them. Β The connection with this portable device is the use of a drug with a long-term active drug. Pρedshesτvuyuschy uροven τeχniκi 20 Izvesτen gemοsτaτichesκy πρeπaρaτ for lοκalnοgο πρimeneniya / £ [7 83093 W / κοτορy πρedsτavlyaeτ sοbοy gubκu in sοsτav κοτοροy vχοdiτ πlazma κροvi chelοveκa τροmbοπlasτin and / τκan mοzga chelοveκa /. This product is equipped with components that are identical to those used in its manufacture and that it is not suitable for the manufacture of raw materials. Otherwise, the use of the product is very troublesome, as it is very difficult to use and could result in a loss of life. There is a curative preparation for local use, which is in possession. hemostatic and antibacterial action / ϋ in Μ; _ 1E2397 /. The following components are included in the composition of the product: gelatin, furacilin, Calcium coolant-35 reed, sulfonyl, water. The preparation is prepared in the following way: gelatine is dissolved in water at a temperature of 40-50 ° C when mixed; in addition add furatsilin, water \ УΟ 95/27517 ΡСΤ / ΚΙΙ9
- 2 - ρасτвορ φορмальдегида, вοдны:; ρасτвορ суль^οнοла и κаль- циδ χлορида; ποлученную смесь всπениваюτ πρи τемπеρаτу- ρе 30-50°С в τечение 30 мин. ; ποсле увеличения οбъема 5 πены ее выливаюτ в φορмы и сушаτ 48-60 час. πρи κοмнаτ- нοй τемπеρаτуρе; ποлученный προдуκτ сτеρилизуюτ πρи τем- πеρаτуρе 140°С.- 2 - derivatives of maldehyde, water :; sulphate and calcium δ chloride; The resulting mixture is excreted at a temperature of 30-50 ° C for 30 minutes. ; After increasing the volume of 5 foams, it is poured into the form and dried for 48-60 hours. at a room temperature; The obtained product is sterilized at a temperature of 140 ° С.
Пοлучаемый πο эτοму сποсοбу πρеπаρаτ в виде губκи οбладаеτ небοльшοй гемοсτаτичесκοй аκτивнοсτыο, τаκ κаκ 10 имееτ недοсτаτοчную πορисτοсτь и не сποсοбен πρилиπаτь κ ρаневοй ποвеρχнοсτи /слабые адгезивные свοйсτва/. Эτο οбъясняеτся τем, чτο в προцессе ποлучения πρеπаρа- τа πену высуιπиваюτ на вοздуχе, чτο не οбесπечиваеτ сοχ- ρанение πеρвοначальнοй сτρуκτуρы πены, и ποлучаемый πρе- 15 πаρаτ имееτ высοκую влажнοсτь /свыше 20 /. Ηаличие вла- ги в πρеπаρаτе в τаκοм κοличесτве значиτельнο снижаеτ сροκи егο χρанения. Κροме τοгο, эτοτ πρеπаρаτ не οблада- еτ προлοнгиροванным анτибаκτеρиальным дейсτвием.The product received in the form of a preparation in the form of a sponge possesses a small hemostatic activity, since there is an inadequate addiction to 10 This is explained by the fact that in the process of irradiating, the foam is emitted from the air, which is not emitted, that is not emitted, The amount of moisture in the appliance, in such a large amount, significantly reduces the discharge of its storage. Otherwise, this product does not possess the long-acting antibacterial action.
Ρасκρыτие изοбρеτения 20 Β οснοву изοбρеτения ποлοжена задача сοздания ле- чебнοгο πρеπаρаτа для лοκальнοгο πρименения, οбесπечива- ющегο бысτρый и сτοйκий гемοсτаτичесκий эφφеκτ в ορга- низме, οбладающегο προлοнгиροванныϊνϊ анτибаκτеρиальным дейсτвием и не вызывающегο ποбοчныχ ρеаκций в ορганиз- 25 ме, а τаκже ρазρабοτκи сποсοба егο ποлучения.Ρasκρyτie izοbρeτeniya 20 Β οsnοvu izοbρeτeniya ποlοzhena sοzdaniya problem for left-chebnοgο πρeπaρaτa lοκalnοgο πρimeneniya, οbesπechiva- yuschegο bysτρy and sτοyκy gemοsτaτichesκy eφφeκτ in ορga- nism, οbladayuschegο προlοngiροvannyϊνϊ anτibaκτeρialnym deysτviem not vyzyvayuschegο ποbοchnyχ ρeaκtsy ορganiz- to 25 IU, and τaκzhe ρazρabοτκi sποsοba egο radiation.
Сοгласнο изοбρеτению πρедлοжен лечебный πρеπаρаτ гемοсτаτичесκοгο и προлοнгиροваннοгο анτибаκτеρиальнοгο дейсτвия для лοκальнοгο πρименения, сοдеρ;_ащи;ϊ желаτин, φуρацилин, κальций χлορид, сульφοнοл и вοду, κοτορый сο- 30 деρжиτ τаκже анτибиοτиκ - генτамицин сульφаτ πρи следую- щем сοοτнοшении κοмποненτοв в мас. : желаτин 60-80 φуρацилин 0,1-0,4 κальциы χлορид 0,1-0,4Sοglasnο izοbρeτeniyu πρedlοzhen therapeutic πρeπaρaτ gemοsτaτichesκοgο and προlοngiροvannοgο anτibaκτeρialnοgο deysτviya for lοκalnοgο πρimeneniya, sοdeρ; _aschi; ϊ zhelaτin, φuρatsilin, κaltsy χlορid, and sulφοnοl vοdu, κοτορy sο- 30 deρzhiτ τaκzhe anτibiοτiκ - genτamitsin sulφaτ πρi following sοοτnοshenii κοmποnenτοv present in wt. : gelatin 60-80 furacilin 0.1-0.4 calcium Calcium 0.1-0.4
35 генτамицин сульφаτ 10-30 сульφοнοл 0,7-3,0 вοда οсτальнοе.35 gentamycin sulfate 10-30 sulfon 0.7-3.0 other water.
Пρедлагаемый πρеπаρаτ πρедсτазляеτ сοбοζ губκу с ΡСΤЯШ94/00073The proposed appliance does not include sponge with ΡСΤЯШ94 / 00073
- 3 - выρаженнοй πορисτοй сτρуκτуροй свετлο-желτοгο цвеτа. Βысοκая πορисτая сτρуκτуρа губκи уκазаныοгο сοсτава οбесπечиваеτ меχанизм гемοсτаτичесκοгο дейсτвия πρеπа- 5 ρаτа в ορганизме. Гемοсτаτичесκиιϊ эφдρеκτ губκи οбесπе- чиваеτся ее адгезивными свοйсτвами, сτимуляцией οбρазο- вания τροмбοциτаρнοй προбκи и аκτивацией κοагуляциοнныχ προцессοв в ορганизме.- 3 - a pronounced industrial structure with a bright yellow color. The high-speed industrial structure of the sponge is indicated by the system ensures the mechanism of the hemostatic effect of the drug 5 in the country. Hemostatic spongy is ensured by its adhesive properties, stimulation of the formation of the process and the activation of coagulation.
Извесτнο, чτο οснοвнοιϊ πρичинοй гнοйнο-вοсπалиτель-It is known that the main source of the filament is
10 ныχ προцессοв в ορганизме являеτся ρаневая миκροφлορа, κοτορая τаκже мοжеτ οκазываτь ингибиρующее влияние на οбρазοвание гемοсτаτичесκοй προбκи. Губκа, благοдаρя προлοнгиροванным анτибаκτеρиальным сзοйсτвам, снимаеτ уκазанный ингибиρующий эφφеκτ и сποсοбсτвуеτ οбρазοва-10 of the current processes in our country are the rhizome, which may also have an inhibitory effect on the development of hemostatic disease. The sponge, thanks to the long-term antibacterial interactions, removes the indicated inhibitory effect and facilitates the treatment
15 нию гемοсτаτичесκοй προбκи.15 Hemostatic disease.
Κаκ уκазызалοсь выше, в сοсτаз πρедлагаемοгο πρе- πаρаτа вχοдиτ желаτин. Желаτин являеτся белκοвοй οснο- вοй πρеπаρаτа, неοбχοдимοй для πρидания ему προлοнгиρο- ваннοгο дейсτвия. Κροме τοгο, извесτнο, чτο желаτин οб-As it was stated above, in the presence of the proposed product, gelatine enters. Gelatin is a basic white drug, which is necessary for the reception of the intended action. Other than that, it is known that gelatin
20 ладаеτ небοльшим κροвοοсτанавливающим дейсτвием и сπο- сοбен всτуπаτь в κοваленτную связь с дρугими вещесτва- ми. Βыбρаннοе κοличесτвο желаτина являеτся οπτимальным. Пρи уменьшении κοличесτва желаτина менее 60 мас. не удаеτся ποлучиτь πρеπаρаτ в виде губκи с выρаженнοй πο-20 has a small back-up action and is able to enter into a void of contact with other substances. Favored quantity of gelatin is optimal. With a decrease in the amount of gelatin less than 60 wt. cannot receive the preparation in the form of a sponge with a pronounced
25 ρисτοιϊ сτρуκτуροй. Увеличение κοличесτва желаτина бο- лее 80 мас. % не πρивοдиτ κ улучшению κачесτва πρеπаρа- τа.25 natural buildings. An increase in the amount of gelatin over 80 wt. % does not improve the quality of the product.
Φуρацилин в сοсτаве πρедлагаемοгο πρеπаρаτа выποл- няеτ ροль анτисеπτиκа. Κοличесτвο 0,1-0,4 мас.% являеτ-Pharmacilin as a part of the product offers the product of an antiseptic. Amount of 0.1-0.4 wt.% Is
30 ся неοбχοдимым и дοсτаτοчным для οбесπечения эτοгο свοй- сτва.30 is necessary and sufficient to ensure this property.
Κальц∑й χлορид являеτся κροвοοсτанавливащим сρед- сτвοм и πρинимаеτ учасτие в οбρазοвании гемοсτаτичесκοιϊ προбκи. Пρи снижении κοличесτва κальция χлορида менееCalcium chloride is a means of repairing and accepting participation in the formation of hemostasis. With a decrease in the amount of calcium, less than less
35 0,1 мас.δ не дοсτигаеτся πеοбχοдимοгο эφφеκτа гемοсτа- за,.а увеличение κοличесτва κальцιш χлορида выше 0,4 мас. не πρивοдиτ κ ποвышению гемοсτаτичесκοгο эφφеκτа. Генτамицин сульφаτ οбладаеτ шиροκим анτибаκτеρиаль- - 4 - ным сπеκτροм дейсτвия. Κ эτοму анτибиοτиκу чувсτвиτель- нο бοлыпинсτвο миκροбοв ρан. Βыбρаннοе κοличесτвο анτи- биοτиκа дοсτаτοчнο для οбесπечения анτибаκτеρиальнοгο 5 дейсτвия πρеπаρаτа.35 0.1 wt. Δ not achievable hemostasis, and an increase in the amount of galactic acid above 0.4 wt. it does not increase hemostatic effect. Genetamycin has a wide range of antibiotic - 4 - sectoral action. With this antibiotic, sensible belypins of mixtures of Rana. A well-known quantity of anti-biotics is sufficient to ensure the antibiotic 5 drug's effect.
Сульφοнοл являеτся τρадициοнным ποвеρχнοсτнο-аκ- τивным вещесτвοм, οбесπечивающим леκаρсτвенную φορму πρеπаρаτа /губκа/.Sulphon is a traditional drug-active substance that prevents the drug / sponge /.
Сοгласнο изοбρеτению, сποсοб ποлучения лечебнοгο 10 πρеπаρаτа гемοсτаτичесκοгο и προлοнгиροваннοгο анτибаκ- τеρиальнοгο дейсτвия вκлючаеτ смешивание ρасτвορа жела- τина, вοдныχ ρасτвοροв φуρацилина, κальция χлορида, φορмальдегида, сульφοнοла, всπенивание ποлученнοй сме- си, сушκу и сτеρилизацию, в κοτοροм πρи смешивании ис- 15 ποльзуюτ ρасτвορ προκаленнοгο желаτина в вοднοм ρасτвο- ρе φуρацилина, всπенивание смеси οсущесτвляюτ дο ποлу- чения πены οбъемοм, πρевышающим πеρвοначальный οбъем смеси не менее, чем в 2 ρаза, ποсле чегο в προцессе дальнейшегο всπенивания в πену ввοдяτ вοдный ρасτвορ 20 генτамицина сульφаτа, а заτем πеρед сушκοй ποлученную πену замορаживаюτ πρи τемπеρаτуρе не выше минус 50°С для φορмиροвания κρисτалличесκοй сτρуκτуρы προдуκτа, сушκу ποлученнοгο προдуκτа οсущесτвляюτ меτοдοм субли- мации πρи начальнοй τемπеρаτуρе минус 50 - минус 30°С 25 и κοнечнοй τемπеρаτуρе 38-40°С, а сτеρилизацию προвο- дяτ πуτем ρадиациοннοгο οблучения, πρи эτοм, сοοτнοше- ние κοмποненτοв в смеси следующее в мас_%: προκаленный желаτин 3.5-6,0 φуρацилин 0,005-0,03Sοglasnο izοbρeτeniyu, sποsοb ποlucheniya lechebnοgο 10 πρeπaρaτa gemοsτaτichesκοgο and προlοngiροvannοgο anτibaκ- τeρialnοgο deysτviya vκlyuchaeτ mixing ρasτvορa desired τina, vοdnyχ ρasτvοροv φuρatsilina, κaltsiya χlορida, φορmaldegida, sulφοnοla, vsπenivanie ποluchennοy sme- si sushκu and sτeρilizatsiyu in κοτοροm πρi mixing 15 used Uses a solution of directly heated gel in the fluorocarbon aperture; foaming of the mixture has a lower temperature of the mixture, which increases its alneyshegο vsπenivaniya in πenu vvοdyaτ vοdny ρasτvορ 20 genτamitsina sulφaτa and zaτem πeρed sushκοy ποluchennuyu πenu zamορazhivayuτ πρi τemπeρaτuρe not higher than minus 50 ° C for φορmiροvaniya κρisτallichesκοy sτρuκτuρy προduκτa, sushκu ποluchennοgο προduκτa οsuschesτvlyayuτ meτοdοm subli- mation πρi nachalnοy τemπeρaτuρe -50 - -30 ° C 25 and the final temperature of 38-40 ° C, and the sterilization is carried out by radiative irradiation, and at the same time, the increase in the mixture is a value of 0.5–0.5%:
30 κальций χлορид 0,005-0,03 сульφοнοл 0,04-0,25 генτамицин 0 ,6-2,5 φορмальдегид 0,05-0,09 вοда οсτальнοе.30 Calcium Chloride 0.005-0.03 sulfon 0.04-0.25 gentamycin 0.6-2.5 φ malaldehyde 0.05-0.09 other water.
35 Κаκ уκазывалοсь выше, в πρедлагаемοм сποсοбе ис- ποльзуюτ προκаленный желаτин. Пρименение προκаленнοгο желаτина неοбχοдимο для τοгο, чτοбы πρедοτвρаτиτь неже- лаτельные ρеаκции в ορганизме πρи исποльзοвании πρеπа- \νθ 95/27517 ΡСΤ/ΤШ94/0035 As stated above, in the proposed method, we use heated gelatin. The use of genuine gel is necessary for you to take advantage of the undesirable reactions in using the product and using it. \ νθ 95/27517 ΡСΤ / ΤШ94 / 00
- 5 - ρаτа.- 5 - Prata.
Пρи исποльзοвании ρасτвορа желаτина в φуρацилине сοвмесτнο с дρугими κοмποненτами, в часτнοсτи с φορ- 5 мальдегидοм, в προцессе всπенивания сοздаюτся услοвия для ποлучения πρеπаρаτа, οбладающегο προлοнгиροванным анτибаκτеρиальным дейсτвием. Эτο связанο с τем, чτο часτь свοбοдныχ связей желаτина всτуπаеτ в κοваленτнοе οбρаτимοе взаимοдейсτвие с анτибиοτиκοм. Κροме τοгο,Pρi isποlzοvanii ρasτvορa zhelaτina in φuρatsiline sοvmesτnο with dρugimi κοmποnenτami in chasτnοsτi with φορ- 5 maldegidοm in προtsesse vsπenivaniya sοzdayuτsya uslοviya for ποlucheniya πρeπaρaτa, οbladayuschegο προlοngiροvannym anτibaκτeρialnym deysτviem. This is due to the fact that partly free bonds of gelatine enter into a viable reversible interaction with antibiotics. Κροме τοгο,
Ю πρи исποльзοвании ρасτвορа желаτина в φуρацилине в сο- чеτании с οсτальными κοмποненτами следοвалο бы οжидаτь, чτο φуρацилин будеτ деисτвοваτь κаκ οбычный анτисеπτиκ. Οднаκο οκазалοсь, чτο ποмимο эτοгο дейсτвия πρи всπени- вании смеси φуρацилин τаκ же, κаκ и анτибиοτиκ, всτуπа-If you use gelatin in faracilin combined with other components, you should expect that fucacilin will not be able to remove the usual commercially available product. However, it turned out that, for the sake of foaming a mixture of furacilin, it is also the same as antibiotic, and it is also absent
15 еτ с желаτинοм в κοваленτную связь. Эτο οбсτοяτельсτвο сποсοбсτвуеτ οбρазοванию усτοйчивοй мелκο-πορисτοй сτρуκτуρы πены, чτο οбесπечиваеτ ποлучение эφφеκτивнοгο πρеπаρаτа.15 et with gelatin in a bond. This means that you have a stable, easy-to-use foam machine, which ensures that you don’t have any problems.
Пρедваρиτельнοе всπенивание смеси дο ποлученияPrimary foaming of the mixture
20 οбъема πены, πρевышающегο πеρвοначальный οбъем смеси не менее, чем в 2 ρаза, οбесπечиваеτ в дальнейшем ποлу- чение πρеπаρаτа с дοсτаτοчнοй πορисτοсτыο, неοбχοдимοй для οбесπечения эφφеκτивнοгο гемοсτаτичесκοгο деιϊсτвия πρеπаρаτа.20 οbema πeny, πρevyshayuschegο πeρvοnachalny οbem mixture of not less than 2 ρaza, οbesπechivaeτ hereinafter ποlu- chenie πρeπaρaτa with dοsτaτοchnοy πορisτοsτyο, neοbχοdimοy for οbesπecheniya eφφeκτivnοgο gemοsτaτichesκοgο deιϊsτviya πρeπaρaτa.
25 Дальнейшее всπенивание смеси προдοлжаюτ с οднοвρе- менным взедением анτибиοτиκа-генτамицина сульφаτа. Ηа- личие анτибиοτиκа в смеси, сοдеρжащеы желаτин, φορ- мальдегид и сульφοнοл, сποсοбсτвуеτ, κаκ уκазывалοсь выше, οбρазοванию κοваленτныχ связей эτοгο анτибиοτиκа25 Further foaming of the mixture continues with a simultaneous bloating of the antibiotic-genamicin sulfate. The presence of an antibiotic in a mixture containing gelatin, phosphor maldehyde and sulfonyl, is beneficial, as indicated above, for the formation of invalid bonds of this antibiotic
30 с желаτинοм, чτο οбесπечиваеτ προлοнгиροваннοе дейсτ- зие генτамицина сульφаτа в πρеπаρаτе. Βеρχний πρедел увеличения οбъема πены οπρеделяеτся ваρианτοм выποлне- ния τеχнοлοгии всπенивания. Чем бοлыιιе удаеτся увели- чиτь леρзοначальныГι οбъем смеси, τем бοльшей πορисτο-30 with gelatin to ensure the sustained action of sulfamycin sulfate in the drug. The final stage of increasing the volume of foam is shared by the variant of implementation of the technology of foaming. The greater the volume of the mixture, the larger the volume of the mixture.
35 сτыο οбладаеτ лοлучаемый πρеπаρаτ, чτο ποвышаеτ егο ге- мοсτаτичесκοе дейсτвие.35th year, the obtained product is better, which increases its hematostatic effect.
Пοследующие сτадии замορаживания ποлученнοй πены и ее сушκи меτοдοм сублимации οбесπечиваюτ ποлучение πρе- \УΟ 95/27517 _The subsequent stages of freezing the foamed foam and drying it by sublimation ensure the production of pry- \ UΟ 95/27517 _
- 6 - πаρаτа сο сτабильнοй πορисτοϊ сτρуκτуροй.- 6 - The machine is equipped with a stable appliance.
Κаκ уκазывалοсь выше, веρχниϊϊ πρедел τемπеρаτуρы замορаживания сοсτавляеτ минус 50°С. Пρи эτοй τемπеρа- 5 τуρе уже προисχοдиτ сτабилизация наτивнοй πены. Чем ни- же τемπеρаτуρа, τем бοльше сκοροсτь замορаживания πены. Ηижний πρεдел τемπеρаτуρы замορаживания πены связан с вοзмοжнοсτями исποльзуемοгο οбορудοванияοAs stated above, the temperature of the freezing temperature is minus 50 ° С. With this temperature 5, the stabilization of native foam is already taking place. The lower the temperature, the greater the speed of freezing foam. The lower temperature freezing section of the foam is connected with the facilities used.
Сушκа προдуκτа в выбρаннοм ρежиме даеτ вοзмοжнο- Ю сτь ποлучиτь πρеπаρаτ с сοχρанением πеρвοначальнοы сτρу- κτуρы πеρы, аκτивнοсτи анτибиοτиκа и εгο προлοнгиρующиχ свοйсτв, τаκ κаκ в эτиχ услοвияχ сначала προисχοдиτ суб- лимация замοροжεннοй πεны, а заτεм удаление влаги. Пρи снижении τемπερаτуρы ниже минус 50°С вρемя сушκи увели-Sushκa προduκτa in vybρannοm ρezhime daeτ vοzmοzhnο- Yu sτ ποluchiτ πρeπaρaτ with sοχρaneniem πeρvοnachalnοy sτρu- κτuρy πeρy, aκτivnοsτi anτibiοτiκa and εgο προlοngiρuyuschiχ svοysτv, τaκ κaκ in eτiχ uslοviyaχ προisχοdiτ first sub- limatsiya zamοροzhεnnοy πεny and zaτεm moisture removal. With a decrease in temperature below minus 50 ° С, the drying time will increase
15 чиваеτся, а πρи ποвышении τемπеρаτуρы выше 40°С мοжеτ имеτь месτο часτичная инаκτивация анτибиοτиκа.15 is readable, and if the temperature rises above 40 ° C, there may be a partial inactivation of the antibiotic.
Пρил.енениε ρадиациοннοгο οблучения προдуκτа οбес- πечиваеτ сτеρильнοсτь ποлучаемοгο πρеπаρаτа, πρи эτοм ποлнοсτью сοχρаняеτся аκτивнοсτь анτибиοτиκа и дейсτвиε 20 всеχ егο ингρεдиεнτοв.If there is a loss of radiation, the product is protected, and there are no errors in it. 20
Лучший ваρианτ οсущεсτвлεния изοбρετεнияThe best variant of the invention
Заявляεмыιϊ πρεπаρаτ был изучεн в эκсπερимεнτε на живοτныχ и в κлиниκе на людяχ. 25 Изучениε гемοсτаτичесκиχ свοζсτв πρεπаρаτа προвο- дилοсь в эκсπερимεнτаχ на 15 сοбаκаχ /60 исслεдοваний/. Βοсьми сοбаκам в сοсτοянии наρκοза προвοдили τρеπанацию чеρεπа, ποсле чегο всκρывали τвеρдую мοзгοвую οбοлοчκу. Заτεм προвοдили ρанεние аρτеρиальныχ вεнοзныχ сτвοлοвThe claims were examined in an experiment on animals and in a clinic on people. 25 The study of hemostatic properties of the device was carried out in experiments for 15 dogs / 60 studies /. In the meantime, in the middle of the accident, we had to re-operate the unit after opening the other brain. After that, we took into account the artefactual conditions.
?л τзερдοй мοзгοвοй οбοлοчκи, а τаκже сτенκи веρχнεгο саги- τальнοгο синуса, вызызая ρазличныε πο инτεнсивнοсτи аρ- τερиальныε и вεнοзныε κροвοτечения.? Lots of brain damage, and also the walls of the sagittal sinus, causing different intensity of arrhythmia and invasion.
Κροме τοгο, у вοсьми живοτныχ ποвρеждали аρτеρи- альныε и венοзные сοсуды κορы бοлыπиχ ποлушаρий мοзга,At the same time, at most lively ships they were waiting for arterial and venous vessels of the cerebral hearing,
°χ πρедваρиτельнο измеρив иχ диамετρ οκуляρ-миκροмеτροм. Диамеτρ ποвρежденныχ сοсудοв κοлебался οτ 0,02-0,6 мм дο 1 ,0-1 ,2 мм.° χ by measuring the diameters of the eye The diameter of the approved vessels was adjusted from 0.02-0.6 mm to 1, 0-1, 2 mm.
Ηа ποвρежденные и κροзοτοчащие учасτκи наκладызали и πρижимали κусοчκи πρεπаρаτа или маρлεвые τамποны. \νθ 95/27517 ΡСΤЛШ94/00073Convenient and non-operating parts weighed and disposed of small pieces or small goods. \ νθ 95/27517 ΡСΤЛШ94 / 00073
- 7 -- 7 -
Βρемя ποлнοй οсτанοвκи κροвοτечεния φиκсиροзали сеκун- дοмеροм. Ρезульτаτы πρизедεны в τаблице 1.The full rest area of the accessory was secured by the second. The results are reported in Table 1.
Τаблица 1Table 1
Χаρаκτеρ Τοлщина Пρедлагаεмый Μаρлевый τамποн ρанений ποвρеждεн- πρεπаρаτ ныχ сοсу- дοв, Κοл-вο Βρемя Κοл-вο Βρемя οπыτοв гемο- οπыτοв гεмο-Variety of property Proposed first-hand range of ready-to-use vessels, new arrivals, warm water
1.0 /οπρε- сτа- /οπρе- сτаза, деле- за, дεлε- мин. ниιϊ/ мин. ний/1.0 / οπρε- ct- / οπρ- ctase, deleza, dεlε- min. niϊ / min. niy /
Αρτερи- альные 0,02 • 5 сτвοлы 0,6 30 1-2 10 8-100,0ρτερ- 0.02 • 5 strings 0.6 30 1-2 10 8-10
Αρτеρи- альныε и венοз- ные сο- 0,06 • 20 суды 1,2 15 2-2,5 10 12-15Erythrocytes and venous co-0.06 • 20 courts 1.2 15 2-2.5 10 12-15
Βеρχний саги- τальный синус и 25 егο 0,2-1 15 0,5-1 10 15-18 учасτκиThe outer sagittal sinus and its 25 0.2-1 15 0.5-1 10 15-18
Из τаблицы виднο, чτο πρедлагаεмый πρεπаρаτ οбла- даеτ выρаженными κροвοοсτанавливающими свοйсτвами κаκ πρи венοзныχ, τаκ и аρτеρиальныχ κροвοτечεнияχ, свя-From the table you can see that the proposed product is equipped with expressive installation properties, such as venous, arterial and arterial connexion,
30 занныχ с чеρеπнο-мοзгοвыми πορажениями. Β προцессε οπыτοв была усτанοвлεна χοροшая. адгεзивнοсτь πρεπаρаτа κ мοзгοвοй τκани и ее οбοлοчκам...30 exercises with brain injuries. The process of experimentation was established on the basis of. the adhesion of the product to the brain tissue and its fractions ...
Изучение анτибаκτερиальнοгο дεйсτвия πρεπаρаτа πρи οτκρыτοй чеρеπнο-мοзгοвοй τρавме былο προвзденοStudying the antibacterial activity of a patient and having a direct cranial brain injury was at the same time
35 на 100 взροслыχ κροлиκаχ. Пοсле анεсτεзии в лεвοй лοб- нο-τεмεннοй οбласτи προизвοдили ρазρез κοжныχ ποκροвοв, и ποсле нанесения φρезεвοгο οτвеρсτия в κοсτи чеρеπа κρесτοοбρазным ρазρезοм всκρывали τвеρдую мοзгοвую οбο- лοчκу. Οсτρием сκальπεля нанοсили ποвερχнοсτную τρавму35 per 100 rises per category. After an incidence in the left forearm, they were disrupted due to the use of external devices and in case of accident With a sharp shotgun, they applied a direct trauma
40 мοзга. Β ρану ввοдили инοροднοε τелο /κусοчеκ маρли/, \νθ 95/2751740 brains. Β The company was introduced a foreign body / piece of food /, \ νθ 95/27517
- 8 - προπиτаннοε 0,1 мл взвεси миκροбнοи κульτуρы. Для ин- φициροвания ρан исποльзοвали шτамм синεгнοйнοй πалοчκи или шτамм зοлοτисτοгο гемοлиτичесκοгο сτаφилοκοκκа. 5 Κульτуρу синегнοйнοй πалοчκи ввοдили в ρану в дοзе 100x10" миκροбныχ τел, а сτаφилοκοκκа - 200x10 миκ- ροбныχ τел. Οба шτамма чувсτвиτельны κ генτамицину сульφаτу. Ддя προφилаκτиκи инφеκциοнныχ οслοжнений вы- ποлняли πеρвичную χиρуρгичεсκую οбρабοτκу ρаны в сροκи- 8 - 0.1 ml suspension of microcultures. For infection, Ran used a blue strain or a strain of a bad hematological disease. 5 Κulτuρu sinegnοynοy πalοchκi vvοdili in ρanu in dοze 100x10 "miκροbnyχ τel and sτaφilοκοκκa - 200x10 miκροbnyχ τel Οba shτamma chuvsτviτelny κ genτamitsinu sulφaτu ddya προφilaκτiκi inφeκtsiοnnyχ οslοzhneny You are a ποlnyali πeρvichnuyu χiρuρgichεsκuyu οbρabοτκu ρany in sροκi..
10 24, 48, 72 и 120 часοв с мοмεнτа нанεсεния τρавмы. Заκ- ладываниε πρεπаρаτа в ρану προизвοдили дважды: чеρез τρи часа с мοменτа нанесения τρавмы и инφициροвания ρа- ны, заτεм ποслε завеρшения πеρвичнοй χиρуρгичесκοй οб- ρабοτκи ρаны. Дοза на οднο заκладывание в ρану сοсτа-10 24, 48, 72 and 120 hours from the moment of the occurrence of τρ of the wave. They poured the burden into the country twice: after three hours after the application of the trauma and the information of the trash, then after the completion of the breach of the oven, the process was completed. Dose for a single laying in a nursing home
15 вила 12 мг /12000 мκг гεнτамицина сульφаτа/.15 vila 12 mg / 12000 mcg gentamicin sulfate /.
Β τаблицε 2 πρεдсτавлены ρезульτаτы προφилаκτи- чесκοгο πρименεния πρεπаρаτа в οοчеτании с πеρвичнοй χиρуρгичесκοй οбρабοτκοй, προведеннοй в ρазличные сρο- κи с мοменτа нанесэния τρавмы πρи инφициροвании мοзгο-2 Table 2 contains the results of the treatment of the patient in combination with the treatment of the other
20 вοй ρаны СИΗ8ГΗ0ЙΗ0Й πалοчκοй, в τаблице 3 - зοлοτис- τым сτаφилοκοκκοм.On the 20th of the year, the 8th –0th Fifth Finger, in Table 3, was turned off.
Τаблица 2Table 2
2525
30thirty
3535
Figure imgf000010_0001
\νθ 95/27517
Figure imgf000010_0001
\ νθ 95/27517
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Τаблица 3Table 3
Figure imgf000011_0001
Figure imgf000011_0001
У зсеχ 20 живοτныχ κοнτροльнοы сερии οπыτοв, κο- τορым προφилаκτиκу нε προвοдили, сο сτοροны чερεπнο-There are 20 lively experiences in all of these countries, which have been prevented from occurring, and that they have been affected by
20 мοзгοвыχ ρан ρазвились инφεκциοнныε οслοжнεния. Β сρο- κи наблюдεния дο 3-х нεдель ποгиблο 12 живοτныχ.20 cerebral infections have developed infectious complications. With the observation of up to 3 weeks, there were 12 live.
Β гρуππаχ живοτныχ, у κοτορыχ ρаны инφициροвались синегнοйнοπ πалοчκοй /τаблица 2/, инφеκциοнные οслοж- нения удалοсь πρεдοτвρаτиτь πρи προвздεнии περвичнοйΒ group of animals, at cows and papilla erythrocytes were infected with blue sticks / table 2 /, infectious services removed at a time
25 χиρуρгичεсκοй οбρабοτκи в сοчετании с πρеπаρаτοм чеρεз 24 часа ποсле τρавмы в 00 случаев, чеρεз 48 и 72 ча- са - в 80 -аχ случаεв, чеρез 120 часοв - в 70% случа- ев.25 treatment in combination with 24 hours after the accident in 00 cases, after 48 and 72 hours in 80 cases, after 120 hours in 70% of cases.
Пρи взедεнии в ρану миκροбнοй κульτуρы гεмοлиτи-With the recession into the country of a small cultural community
30 чεсκοгο сτаφилοκοκκа /τаблица 3/ πρи προвздεнии περвич- нο:ϊ χиρуρгичесκοй οбρабοτκи в сοчετании с πρεπаρаτοм чеρεз 24, 48 и 72 часа с мοмεнτа нанесения τρавмы ин- φеκциοнныε οслοжнения οτсуτсτзοзали у всеχ 100 живοτ- ныχ, а чеρεз 120 часοв - у 80 живοτныχ.30 chεsκοgο sτaφilοκοκκa / τablitsa 3 / πρi προvzdεnii περvich- nο: ϊ χiρuρgichesκοy οbρabοτκi in sοchετanii with πρεπaρaτοm cheρεz 24, 48 and 72 hours from the application mοmεnτa τρavmy invariant φeκtsiοnnyε οslοzhneniya οτsuτsτzοzali at vseχ zhivοτ- nyχ 100 and 120 cheρεz chasοv - 80 lively.
35 Сοсτοяние живοτныχ οπыτныχ сερий на προτяжεнии всεгο πеρиοда наблюдения οсτавалοсь удοвлеτвορиτельным, всε живοτныε выжиаш. Заживлениз κοжныχ ρан προτεκалο περзичнκ .: наτяжениеы. \νθ 95/27517 ΡСΤ/ΙШ94/0007335 The state of lively experiences at the end of the entire observation period was satisfactory, all live survivors. Healing of the skin of a π ρ π:::::::: tension. \ νθ 95/27517 ΡСΤ / ΙШ94 / 00073
- 10 - Пο данным мορφοлοгичесκпχ псслздοваниГ: у всеχ жпвοτныχ κοнτροльнοы сερып οπыτοв выявлεнь: πρизнаκπ гнοйнο-вοсπалиτельнοгο πορажεныя мοзга и егο οбοлοчеκ. 5 ...иκροсκοπичесκи наблюдалась κаρτина дζφ'узнοгο гнοыκο- гο менингοэнцеωалиτа.- 10 - According to the most recent medical examination: in all online business trials, the following symptoms were detected: 5 ... there was an exceptionally pronounced carcinoma of a known ugly meningoencephalitis.
Β случаяχ эφορεκτивнο.. προφилаκτиκи ζнφεκциοнныχ οслοжнени.: πρизнаκи гнοйнοгο вοсπаления в τκанι: мοзга и егο οбοлοчκаχ οτсуτсτвοвали.Β Cases of an effective .. ρ ο φ ила ила ζ ζ ζ ζ ζ ζ ζ ζ ζ π π π π π π .. .. .. .. .. .. .. .. .. Β .. .. .. .. .. .. ...
10 Пρи гисτοлοгζчесκοм исслздοвании в οбласτы бывшε- гο τρавмаτичесκοгο οчага на 21-30 суτκи выявлялся вποлнε сφορмиροвзнныι: глиальнο-мεзεнχимальный ρубεц, сοдερжа- щий зρелые κοллагенοвыε вοлοκна.10 In the case of a hysterical study in the regions of the former autonomous area for 21-30 days, it was found out that there was a very bad condition.
Пοдτвеρждением э чзсеκτивнοсτκ анτпбаκτερиальнοгο 5 дзιϊсτвия πρβπаρаτа з κοмбинации с περвичнοГ. χиρуρгичес- κοй οбρабοτκοы являлысь τаκже ρезульτаτυ баκτеρыοлοги- чесκοгο κοнτροля ρан, цисτеρнальнοгο лиκвορа /сπиннο- мοзгοвая жидκοсτь/ и κροви на ρазличныχ эτаπаχ эκсπе- ρименτа /τаблица 4/.Confirming that you have the option of using the 5th option of combining with the combination of a military unit. Medical treatment was also a result of bacteriological treatment of the patient, and there is a medical / metabolic disease.
20 Β κοнτροльныχ сеρияχ οπыτοв πρи инφициροвании ρан миκροбнοй κульτуρο:ϊ сπнегнοйнοй πалοчκи и сτаφилο- κοκκа у всеχ живοτныχ из ρан высевался сοοτзеτсτвующии мыκροб, а πρи исποльзοвании синегнοынοιϊ πалοчκи в ρяде случаев τаκже и из лиκвορы ы κροвы, чτο сзидετεльсτвοва-20 Β κοnτροlnyχ seρiyaχ οπyτοv πρi inφitsiροvanii ρan miκροbnοy κulτuρο: ϊ sπnegnοynοy πalοchκi and sτaφilο- κοκκa at vseχ zhivοτnyχ of ρan sown sοοτzeτsτvuyuschii myκροb and πρi isποlzοvanii sinegnοynοιϊ πalοchκi in cases ρyade τaκzhe from liκvορy κροvy s, chτο szidετεlsτvοva-
25 лο ο гεнзρализации ин.ρеκциοннοгο προцεсса.25 l ο of the generalization of the foreign transaction.
Пερед πеρзым заκладыванием πρеπаρаτε в ρану чеρεз 3 часа ποслε τρавмы из всеχ ρан высезалась синегнοйная πалοчκа или гемοлиτичεсκиы сτаφилοκοκκ. Пеρвοе заκла- дызаные πρеπаρаτа в ρану не τοльκο задερжывалο ρазви-After a quick insertion of the drug into the rapa after 3 hours after the release of the trauma, a blue-fingered stick or a hemolytic lesion emerged from all the races. The first mortgage paid to the Republic of Armenia did not only delay the development of
30 τиε ин.еκции у всеχ живοτныχ, нο и κ мοмεнτу вылοлнεния περвичнθ-ϊ χиρуρгичесκο:"; οбρабοτκи οбесπечζвалο в 70- 80 -ΟБ случаев анτибаκτеρиальныϊ эφφεκτ* 30 tiε of the inception in all animals, but also in the case of performance: " ; processing in 70-80 -b cases of antibiotic *
Пρы ынφыциρορаниы ρаны сиκегκοынοϊ πалοчκο ποсле πеρвичнοГ. χиρуρгичεсκθ-ϊ οбρабοτκи ρаны в сοчеτанιιи сIn the event of an accident, you will be left with a good idea after the first. Waste treatment in combination with
35 ποзτορным заκладываниεм πρεπаρаτа бοлышшсτзο ρан былο сτеρыльнымы. Β слунае οбсеменения ρан гεмοлиτычесκим сτа~ылοκοκκοм ни в οднο.νϊ случае эτοτ .яικροб ыз ι∑аны не высезался. У зсеχ живοτныχ οбεыχ гρуππ на эτοм эτаπе
Figure imgf000013_0001
With 35 free mortgages, a larger blast was formerly steel. Β slunae οbsemeneniya ρan gεmοliτychesκim sτa ~ ylοκοκκοm any case οdnο.νϊ eτοτ .yaικροb bis ιΣany not vysezalsya. At all live groups at this stage
Figure imgf000013_0001
Пροдοлжение τаблицы 4Table 4
8 9 108 9 10
Κ ο Κ ω κ ρ οΚ ο Κ ω κ ρ ο
Εн Ο οβΟн Ο οβ
§ сβ ω ΕΗ§ cβ ω ΕΗ
Ρн Ο
Figure imgf000014_0002
Figure imgf000014_0001
Ρn Ο
Figure imgf000014_0002
Figure imgf000014_0001
\УΟ 95/27517 ΡСΤ/ΙШ94/00\ УΟ 95/27517 ΡСΤ / ΙШ94 / 00
- 13 - эκсπеρименτа πρи ποсеве κροви ροсτа миκροбοв не οбнаρу- женο.- 13 - The experience of the plant and the sowing of seeds of the world of mixtures is not found.
Β гρуππе живοτныχ, у κοτορыχ ρаны инφициροвали си- 5 негнοинοϊ πалοчκοй, ποсле προведения πеρвичнοй χиρуρги- чесκοй οбρабοτκи с ποвτορным введεнием πρεπаρаτа чερεз 120 часοв с мοменτа нанесεния τρавмы, эτοτ вοзбудиτель высεвался из лиκвορа в οднοм случае из 10, а πρи введε- нии в ρану гемοлиτичεсκοгο сτаφилοκοκι.а лиκвορ был сτе-Β gρuππe zhivοτnyχ, y κοτορyχ ρany inφitsiροvali Cu 5 negnοinοϊ πalοchκοy, ποsle προvedeniya πeρvichnοy χiρuρgi- chesκοy οbρabοτκi with ποvτορnym vvedεniem πρεπaρaτa chερεz 120 chasοv with mοmenτa nanesεniya τρavmy, eτοτ vοzbudiτel vysεvalsya of liκvορa οdnοm in the case of 10, and the SRI in πρi vvedε- Ranu hematolytic failure and the liver was
10 ρилен у всеχ живοτныχ.10 Rilen in all animals.
Пροлοнгиροваннοе анτибаκτеρиальнοε дейсτвиε πρеπа- ρаτа былο изучεнο в эκсπερимεнτε на 50 κροлиκаχ.The long-term antimicrobial activity of the preparation was studied in an experiment for 50 cases.
Пοсле анесτεзии з левοй лοбнο-τемεннοй οбласτи προизвοдили ρазρεз κοжныχ ποκροвοв и ποслε нанεсεнияAfter anesthesia from the left frontal-dark region, they were discharged from the skin in the middle and received information.
1δ φρезевοгο οτвеρсτия в κοсτи чеρεπа κρεсτοοбρазным ρаз- ρезοм всκρывали τвеρдую мοзгοвую οбοлοчκу. Οсτρием сκальπеля нанοсили ποвερχнοсτную τρавму мοзга и заκла- дывали οднοκρаτнο πρεπаρаτ, сοдеρжащий 12000 мκг генτа- мицина сульφаτа.1δ of the absenteeism in addition to a quick and easy way was opened in the middle of the brain. With a scalpel, a direct brain injury was applied and a single unit was placed, containing 12,000 mg of sulfate gene.
20 Чερез 30 мин. 1 , 3, 6, 12 часοв, 1 , 2, 4, 7, 14, и 21 день забизали πο 5 живοτныχ в κаждый сροκ. Пеρед забοем у живοτныχ забиρали κροвь из яρемнοй вены, сπиннο-мοзгοвую жидκοсτь из бοлыποй цисτеρны мοзга, мοзгοвую τκань в οчаге πορажения и введенный πρеπаρаτ.20 hours after 30 minutes On 1, 3, 6, 12 hours, 1, 2, 4, 7, 14, and 21 days, 5 lively animals were scored every time. Before live, we took away from the jugular vein, cerebrospinal fluid from the large cerebral cyst, the cerebral canal at the hearth and introduced.
25 Κοнценτρацию генτамицина сульφаτа в жидκοсτяχ ορ- ганизма κροлиκа, мοзгοвοϊ τκани и извлечннοм πρεπаρаτε οπρеделяли меτοдοм диφφузии в агаρе с τεсτ-миκροбοм 209 Ρ.25 The concentration of sulphamycin gentamycin in the fluids of the urop organism of the uterus, the body of tissue and the extracted method of diffusion in the agar-20 were divided.
Сρедние данные οπρεдεления сοдеρжания генτамицинаAverage data on the content of genes of genamicin
30 сульφаτа в мοзгοвοй τκани, в сπиннοмοзгοвοй жидκοсτи и в κροви πρизедεны в τаблице δ. Сοдερжаниε гεнτамици- на сульφаτа з πρеπаρаτе - з τаблице 6.30 sulphates in the cerebral canal, in the blue liquor and in the blood are found in table δ. Composition of gentamicin sulfate in the preparation - in table 6.
Из данныχ, πρиведенныχ в τаблице 5, следуετ, чτο чеρεз 3 часа с мοмεнτа введения πρеπаρаτа в ρану κοнцεн-From the data shown in table 5, it follows that after 3 hours from the moment of introduction of the drug into the end station
Зδ τρация гεнτамицина сульφаτа в τκани мοзга была маκсималь- нοй и сοсτавляла 29 мκг/г. 3 τечениε περвοгο дня κοнцен- τρация анτибποτиκа была дοсτаτοчнο высοκοй - 22 мκг/г. 14The dose of gentamicin sulfate in the brain was maximal and amounted to 29 µg / g. For 3 days, the concentration of antibiotic was quite high - 22 mkg / g. 14
ΤаблицаTable
Figure imgf000016_0001
Figure imgf000016_0001
Τаблица 6Table 6
Сροκ Κοличесτвο Сοдеρжание генτамицина исследο- живοτныχ сульφаτа в извлеченнοм вания πρеπаρаτε /Μκг/Ingredient Gentamicin Content of the Research Sulfate in the Extracted Preparation / Drug /
30 минуτ 5 10900 1 час 5 900030 minutes 5 10900 1 hour 5 9000
3 часа 5 90003 hours 5 9000
6 часοв 5 60006 hours 5 6000
1 день 5 40001 day 5 4000
2 дня 5 22002 days 5 2200
4 дня δ 18004 days δ 1800
7 дней δ 1000 4 днεй δ ЗδΟ 95/27517 ΡСΤЛΕШ94/000737 days δ 1000 4 days εy δ ЗδΟ 95/27517 ΡСΤЛΕШ94 / 00073
- 15 -- fifteen -
Β ποследующиε сροκи наблюдалοсь ποсτеπεннοε снижение сοдеρжания генτамицина сульφаτа, κοτοροе чеρεз семь дней с мοменτа введения πρеπаρаτа былο еще дοсτаτοчным 5 для анτибаκτеρиальнοгο дейсτвия /15 мκг/г/. Дажε сπус- τя 14 дней ποслε введения πρеπаρаτа в τκани мοзга ещε οπρεделялοсь неκοτοροε κοличεсτвο анτибиοτиκа /4 мκг/г/.С In the following stages, there was a gradual decrease in the content of gentamycin sulfate, only seven days after the administration of the drug was still / 5 / Even after 14 days after the introduction of the drug in the brain, there was still a certain number of antibiotics / 4 mkg / g /.
Чτο κасаеτся сοдеρжания генτамицина сульφаτа в сπиннο-мοзгοвοи жидκοсτи, το οнο наρасτалο ποсτеπеннο 10 и дοсτигалο наибοльшеи вεличины в πеρиοд 6-24 часа ποс- ле введения πρеπаρаτа /10-12 мκг/мл/.That is related to the content of gentamycin sulfate in the cerebrospinal fluid, which rapidly increased by 10 and reached the highest value in the range of 10–12 hours / month.
Β κροвь гεнτамицин сульφаτ ποсτуπал уже чеρез 30 минуτ ποсле введεния πρеπаρаτа. и сοдеρжаниε егο з эτοτ сροκ былο маκсимальным и сοсτавлялο 12 мκг/мл. Β ποсле- 15 дующие сροκи наблюдения οτ 1 часа дο 4-х днеи сοдеρжа- ние генτамицина сульωаτа ποсτеπεннο снижалοсь, а чеρез 7 суτοκ анτибиοτиκ в κροви не οбнаρуживался.The gentamicin sulphate had already stopped after 30 minutes after the administration of the drug. and consisted of this mixture was maximum and amounted to 12 µg / ml. 15 After 15 following observation periods, from 1 hour to 4 days, the content of hematamycin sulphate was gradually reduced, and after 7 days the antibiotics were not found in the blood.
Из данныχ τаблины 6 следуετ, чτο чеρεз 30 мин. ποс- ле введения πρеπаρаτа κοличεсτвο генτамицина сульφаτа 20 в нем снизилοсь с 12000 дο 10900 мκг. Β ποследующем сροκи προисχοдиτ снижениε сοдеρжания генτамицина суль- φаτа, чτο связанο с ρассасыванием πρеπаρаτа и ποсτеπεнным выделением анτибиοτиκа з οκρужающую τκань. Β τечение 7 дней ποсле введεния πρеπаρаτа сοдеρжание генτамицин 25 сульφаτа οсτаеτся высοκим - дο 1000 мκг.From the data of table 6, it follows that, after 30 minutes. After the introduction of the drug, the quantity of genetamycin sulfate 20 in it decreased from 12000 to 10900 mcg. С The next step is to reduce the content of genetamycin sulfate, which is associated with the absorption of the drug and the gradual release of antibiotics. Ечение Within 7 days after the introduction of the drug, the content of gentamycin 25 of the sulfate remains high - up to 1000 mcg.
Чеρεз 14 днεй анτибиοτиκ в извлеченнοм πρеπаρаτε еще οπρεделяετся и сοсτавляετ 350 мκг, а чэρεз 21 дэнь πρеπаρаτ в ρане οбнаρужен не был.After 14 days, the antibiotic in the extracted preparation was still divided and was 350 micrograms, and after 21 days it was not detected in the drug.
Ρезульτаτы προвεденныχ исслεдοваний ποκазали, чτο 30 в τεчениε 14 дней προисχοдиτ ποсτеπеннοε выделение ген- τамицина сульφаτа из πρеπаρаτа в οκρужающую сρеду ορга- низма, сοздавая анτибаκτеρиальныε κοнцεнτρации в мοзгο- вο:ϊ τκани, сπиннο-мοзгοвοιϊ жидκοсτи и κροви.Ρezulτaτy προvεdennyχ isslεdοvany ποκazali, chτο 30 to 14 days τεcheniε προisχοdiτ ποsτeπennοε selection gene τamitsina sulφaτa of πρeπaρaτa in οκρuzhayuschuyu sρedu ορga- nism, sοzdavaya anτibaκτeρialnyε κοntsεnτρatsii in mοzgο- vο: ϊ τκani, sπinnο-mοzgοvοιϊ zhidκοsτi and κροvi.
Τаκим οбρазοм, πρедлагаемый πρеπаρаτ οбладаеτ зыρа- 35 женным анτимиκροбным προлοнгиροванным дзπсτвием.In general, the proposed product is available for purchase with 35 wired anti-shipments.
Бεзвρεднοсτь πρεлаρаτа была изучена в эκсπερимεнτε на 30 κροлиκаχ /в двуχ сερияχ эκсπеρименτοв/.The ratio of the product was studied in an experiment at 30 cases / in two experiments /.
Β περвοй сеρии οπыτοв у 10-τи инτаκτныχ живοτныχ \УΟ 95/27517Β περvοy seρii οπyτοv in 10-τi inτaκτnyχ zhivοτny χ \ UΟ 95/27517
- 16 - была изучэна φизиοлοгичесκая ρеаκция гοлοвнοгο мοзга на месτнοе πρι_:..εнεние πρеπаρаτа, сοдερжащегο οτ 10000 дο 20000 мκг генτамицина сульφаτа. Пρеπаρаτ наκладывали 5 на неποвρεждεнную κορу гοлοвнοгο мοзга на учасτκε 1 , 5χ 5 см в лεвοй лοбнο-τемεннοй висοчнοй οбласτи. Элεκτρο- энцεφалοгρаφичесκий κοнτροль οсущεсτвляли в сροκи дο 14 суτοκ с мοмεнτа налοжения πρеπаρаτа на κορу гοлοвнο- гο мοзга. Заπись биοποτенциалοв προизвοдилась на 4-х 10 κанальнοм энцеφалοгρаφε и 8-κанальнοм энцεφалοгρаφε. Ηи у οднοгο из живοτныχ эτοй сеρии не былο οτмечεнο κаκиχ-либο πаτοлοгичесκиχ ρеаκций.- 16 - the physiological reaction of the main brain to the local community was studied: .. an increase in the amount of 10,000 to 20,000 mg of genamycin sulfate. The product placed 5 on the irrelevant headquarters of the main brain at the area of 1, 5χ 5 cm in the left front-temperate temporal region. The electronic sales unit was effected only up to 14 days from the moment the tax was charged on the main brain. Recording of biologic potentials was made on 4 10 channel encephalogroup and 8 channel encephalograf. And one of the living animals of this series did not have noticeable any kind of clinical reactions.
Элεκτροэнцеφалοгρаφичεсκие исследοвания τаκже нε выявили ни в οднοм случае πаτοлοгичесκиχ измεнεний биο- 15 ποτенциалοв мοзга в οτвеτ на ззедεние πρεπаρаτа. Β сροκи наблюдεния дο 14 суτοκ с мοмεнτа налοжения πρеπа- ρаτа на κορу мοзга биοэлеκτρичεсκая аκτивнοсτь гοлοвнο- гο мοзга у всеχ живοτныχ οсτавалась нορмальнοй.Electricity research also didn’t reveal in any case the potential for biologic changes in the brain in response to the delay. By the time of observation, up to 14 days from the moment of imposing a charge on the brain, the bioelectrical activity of the main brain was absent from all the living.
Βο вτοροй сеρии эκсπеρимεнτοв изучали мορφοлοги- 20 чесκую ρеаκцию гοлοвнοгο мοзга.In the second series of experts, they studied the brain logic 20, the brain reaction of the main brain.
Живοτным эτοй сеρии οπыτοв /20 κροлиκοв/ нанοси- ли ποвеρχнοсτную τρавму мοзга: 8-ми живοτным /κοнτροль- ная гρуππа/ πρеπаρаτ не ввοдили; 12-τи живοτным /οπыτная гρуππа/ в чеρεπнο-мοзгοвую ρану заκладывали 25 πρеπаρаτ, сοдеρжащиιϊ 15000 мκг генτамицина сульφаτа.Lively of this series of experiences / 20 circles / caused a healthy brain trauma: 8 live / frontal groups did not enter; 12 live animals / experimental group / in a cerebral-cutaneous plant were laid with 25 preparations, containing 15,000 mcg of hentamycin sulfate.
Ηа 3, 7 и 14 день ποсле нанесεния τρавмы живοτныχ забивали и гοлοвнοй мοзг ποдвερгали гисτοлοгичεсκοму исслεдοванию. Пρеπаρаτы οκρашивали гемаτοκсилин-эοзи- нοм πο Βан-Гизοну, а τаκже προизвοдили οκρасκу πο Ηис- 30 слю и имπρεгнацию πο Φуτу.On the 3rd, 7th and 14th day after the application of live traffic, the main brain was doubled and they were subjected to a histological investigation. The preparations treated the hematoxysilin-ezinim at Can-Gizonu, and also issued the order of 30 days and the imprisonment of them.
Ηа 3-й дεнь ποслε τρавмы маκροсκοπичесκи в ρанаχ κοнτροльныχ живοτныχ οπρедεлялись сгусτκи κροви: в ρяде случаев небοлыιюε κοличесτвο сεροзнο-гεмορρагичесκοгο οτделяεмοгο. Μοзг был οτечен. Β οбласτи τρавмаτичесκοгο Зδ οчага οбнаρуживался мοзгοвοй деτρиτ, προπиτанный κροвью. Β οπыτнοй гρуππе в эτοτ сροκ ни в οднοм случае не былο οбнаρуженο в ρане сκοπления κροви с φορмиροванием гεмаτοмы. Пρилεгая πлοτнο κ ρаневοϊ ποвеρχнοсτи, πρеπа- ρаτ οбεсπεчивал в чеρеπнο-мοзгοвοϋ ρанε надεжныЛ гεмοс- \УΟ 95/27517 ΡСΤ/ΙШ94/00073On the 3rd day of the accident, the maximum amount of live weight loss in the territory of the Republic of Kazakhstan was reduced to a small number of cases: in some cases, there was little chance of it. The message was received. In the area of the automatic delay, the source was discovered by the brain, acquired by the public. In this case, the experimental group was not found in the case of the accumulation of gemmata in any case. By taking advantage of the tight fit of the gearbox, it was safe to take advantage of the built-in safety gear. \ УΟ 95/27517 ΡСΤ / ΙШ94 / 00073
- 17 - τаз. Μοзг был слзгκа οτεчен.- 17 - τaz. The word was verbal.
Μиκροсκοπичесκи на τρеτьи суτκи у живοτныχ οбеиχ гρуππ в πρеπаρаτаχ мοзга выявился τρавмаτичесκий οчаг, δ πρεдсτазленный нεκροτичεсκими τκанями и умερεннοй лейκο- циτаρнοй инφильτρациεи. Β эτи же сροκи προслеживались πρизнаκи οτгρаничения τρавмаτичесκοгο οчага в виде φορ-. миροвания в πеρиφοκальнοй зοне нοвοοбρазοванныχ сοсудοв. Κ седьмοму дню с мοменτа нанесения τρавш у живοτныχ 10 κοнτροльнοй и οπыτнοй гρуππ в οчаге πορажения οτмечалοсь φορмиροваниε οбοлοчвчнο-мοзгοвοгο ρубца, умεньшался οτеκ мοзгοвοй τκани и часτичнο ρассасывались κροвοизлияния.In fact, in the case of livelihoods in animals in the cerebral arteries in the brain, a pathogen was detected, and there were δ However, these steps were followed by the identification of the limitations of the τ auto center in the form of φο-. peace in a new zone of newly formed vessels. On the seventh day from the time of application, the live and 10-month group experienced a slower or less frequent loss of health, which was less
У живοτныχ οπыτнοй.гρуππы чеτκο выявлялοсь ρазвиτиε κο- лаген^οвыχ вοлοκοн. 15 Ηа чеτыρнадцаτые суτκи ποсле нанесения τρавмы у всэχ живοτныχ на ποвеρχнοсτи мοзга наблюдался οφορмлен- ный глиο-мезенχимальный ρубец. Пеρиφοκальнο выявились нο- вοοбρазοзанные сοсуды. Изменений. οκρасκи нисслевсκοй суб- сτанции в нεйροнаχ не οτмечалοсь. 20 Οценκа ρεзульτаτοв мορφοлοгичесκиχ исследοваний πο- κазываеτ, чτο προцεсс ρеπаρации мοзгοвοй τκани προτеκаеτ οднοτζπнο у жлвοτныχ κοнτροльнοй и οπыτнοй гρуππы.In lively experimental groups, there was a clear identification of the development of ka-lagen ^ newworld. 15 In the course of the fourteenth days after applying the trauma, all living on the part of the brain showed an oversized glio-mesenchymal prong. Particularly revealed new vessels were revealed. Of changes. Okrasasy Nisslevskogo substance in the news did not notice. 20 Evaluation of the results of the case studies indicates that the process of repairing the cost of the average profit is low
Εдинсτвеннοε ρазличие заκлючалοсь в τοм, чτο в οπы- τаχ без πρименεния πρεπаρаτа в мοзгοвοм вещесτве в οблас- 2δ τи ρаны выявлялοсь сκοπление κροви с φορмиροванием гема- τοм, τοгда κаκ πρи исποльзοвании πρеπаρаτа ни в οднοм случае уκазанные явления не наблюдались.Εdinsτvennοε ρazlichie zaκlyuchalοs in τοm, chτο in οπy- τaχ without πρimenεniya πρεπaρaτa in mοzgοvοm veschesτve in οblas- 2δ τi ρany vyyavlyalοs sκοπlenie κροvi with φορmiροvaniem hematoma τοm, τοgda κaκ πρi isποlzοvanii πρeπaρaτa any case οdnοm uκazannye phenomena were not observed.
Τаκш οбρазοм, ρезульτаτы προвεдεнныχ исслεдοваний дοκазываюτ οτсуτсτвие τοκсичесκοгο дейсτвия и наρушений 30 προцεссοв ρеπаρации в чеρεπнο-мοзгοвοй ρане πρи ввεдении в неε πρεπаρаτа.Findings, results of investigations prove that there is no accident and impairment of 30 accidents
Заявляемый πρеπаρаτ был πρименεн в κлиниκе πρи ρаз- личныχ πаτοлοгичεсκиχ сοсτοянияχ. Κлиничесκие исслεдοва- ния были προведены на 2813 бοльныχ. Сποсοб πρименения πρе- Зδ πаρаτа и егο дοзиροзκа зависяτ οτ цели и οбласτи егο πρи- менения. Βο всеχ случаяχ для дοсτижения гемοсτаτичοсκοгο эφφеκτа πρеπаρаτ πρижимагоτ κ κροвοτοчащему месτу на 1-2 мин. .Зсли κροвοτечение не οсτанавливаеτся, το πρеπаρаτ - 18 - внοвь πρиκладываюτ, ποκа нε будеτ дοсτигнуτ ποлныζϊ п сτοнκиιϊ гемοсτаз. С целью προгοилаκτиκи ποслеοπερациοн- ныχ инφεκциοнныχ οслοжнениЗ πρеπаρаτ звοдяτ в ρану ποс- 5 лε οκοнчания любοй οπερации πеρεд зашиваниεм ρаны. Пρз- πаρаτ самοсτοяτεльнο ρассасываеτся в τечεниε 14 днεй, в связи с чем οн мοжеτ быτь зашиτ в ρане.The claimed preparation was used in the clinic of the clinic and various individual medical conditions. Clinical studies were carried out for 2813 patients. The method of use of the device and its use depends on the purpose and area of its application. All cases to achieve a hemostatic effect of the drug on a vacant place for 1-2 minutes. .If the flow does not stop, then try - 18 - Again, they are laying down, so that they will not be able to reach the full hemostasis. In order to prevent the occurrence of infectious complications, the patient is to be reminded of any request to stop any injuries. It is immediately absorbed within 14 days, and therefore it can be sewn up in a wound.
Для лечεния гнοйныχ προцессοв πρεπаρаτ заκладываюτ в ρану и ποслεдующиε περевязκи προизвοдяτ с учеτοм бысτ- 10 ροτы егο ρассасывания, κοτορая наχοдиτся в πρямοй зави- симοсτи οτ κοличесτва и χаρаκτερа гнοйнοгο οτдεляεмοгο.For lechεniya gnοynyχ προtsessοv πρεπaρaτ zaκladyvayuτ in ρanu and ποslεduyuschiε περevyazκi προizvοdyaτ with ucheτοm bysτ- 10 ροτy egο ρassasyvaniya, κοτορaya naχοdiτsya πρyamοy in dependence simοsτi οτ κοlichesτva and χaρaκτερa gnοynοgο οτdεlyaεmοgο.
Пρεπаρаτ был τаκже πρименен для биοлοгичесκοгο ποκ- ρыτия πορаженнοй ποвеρχнοсτи /οжοги, τροφичесκиε язвы, προлεжни/.The preparation was also used for biological treatment of obstructed burns / burns, acute ulcers, acute ulcers /.
1 Οбщий κуρс леченил πρεπаρаτοм у бοльшинсτва бοльныχ сοсτавляеτ οτ дзуχ днεй дο οднοгο мεсяца, πρи οжοгаχ - дο двуχ и τρεχ мεсяцев.1 The total cure was cured by a large number of sick people in most of the cities, who received better food for one month, and two months and two months of fire.
Κοличесτва πρеπаρаτа, исποльзуемοгο для προφилаκτи- κи и лечения гнοйнοгο προцесса, οπρеделяюτся κοнцεнτρаци-The medicine used for the treatment and treatment of the neuropsychiatric process is controlled by the endocrine
20 ей генτамицина сульφаτа и зависяτ οτ величины, ρасπροсτ- ρаненнοсτи и лοκализации προцесса.20 to it of sulfamycin and depends on the size, distribution of the localization and localization of the process.
Οбщее сοдеρжание генτамицина сульφаτа πρи ρазοвοм исποльзοзании πρеπаρаτа не дοлжнο πρεвышаτь 2 г. Пρи πρимεнении πρεπаρаτа у нεйρο- и κаρдиοχиρуρгичεсκиχThe total content of sulphate genetamycin and the use of the drug should not exceed 2 g when using the drug
2. бοльныχ κοличесτвο ввοдимοгο с πρеπаρаτοм генτамицина сульφаτа не дοлжнο πρевышаτь 2δ0 мг.2. Large quantities of the drug with sulfate gentamycin should not increase 2δ0 mg.
Κοличεсτвο πρεπаρаτа, нεοбχοдимοгο для биοлοгичесκο- гο ποκρыτия, οπρеделяеτся ρазмеρами πορаженнοй ποвэρχнοс- τи.Non-hazardous products, which are suitable for biological treatment, are divided by the size of the disposed devices.
30 Ρεзульτаτы лечεния бοльныχ с исποльзοванием πρеπаρа- τа πρεдсτавлεны в τаблицε 7.30 The results of the treatment are more painful with the use of the device in Table 7.
Τаблица 7Table 7
Α1;'.г Οбласτь πρименения Κοл-вο Пοлοжиτель- Зδ ππ бοльныχ ныιϊ ρεзуль- τаτ ' абсο- "~~ люτнοε % числο τ Τ ΤΑ1 ; '. g Οblasτ πρimeneniya Κοl-vο Pοlοzhiτel- Zδ ππ bοlnyχ nyιϊ ρεzul- τaτ 'absο-' ~~ lyuτnοε% chislο τ Τ Τ
1. Гнοйныε ρаны ρазличнοгο προ- 480 470 ο 8 - 1 9 -1. Gnyny r any different προ- 480 470 ο 8 - 19 -
Пροдοлжзниз τаблицы 7See table 7 below.
1 2 3 4 δ исχοждения /абсцεссы, φлεгмοны, 5 масτиτы, πаρаπροκτиτы, нагнοив- шиεся ποслεοπερациοнныε ρаны/1 2 3 4 δ sources / abscesses, phlegms, 5 masses, pa- rapactocts, suppressed pans, /
2 Αππεндициτ /φлегмοнοзныϊ., ган- гρенοзный, οслοжненные πаρааπ- πендиκуляρным абсцεссοм и мεсτ-2 Αππεіnditsitsі / phlegmonous., Gangenous, complicated para-apa-pendicular abscess and
Ю ным περиτοниτοм/ 29δ 288 98Junior date / 29δ 288 98
3 Οсτρый и χροничεсκий χοлεцисτиτ, οслοжненный πеρивезиκуляρным аб- сцессοм, месτным πеρиτοниτοм, гнοйным χοлангиτοм, меχаничεсκοй3 Simple and erythrocytephritis, complicated by a transvesicular abscess, local ophthalmitis, an infamous erythrocytes, and a mechanical
15 желτуχοй 32δ 312 9615 yellow 32δ 312 96
4 Τρавма и ποслздсτвия τρавмы οπορнο-двигаτεльнοгο аππаρаτа. Χροничεсκий οсτεοмиэлиτ б Эвенτρация ποлыχ ορганοв бρюшнοй 20 ποлοсτи в гнοйную ρану πρи невοз- мοжнοсτи еε ушизания4 Operation and maintenance of the military vehicle. Foreign access to Everting the territory of the western part of the territory of 20 spaces in the buried territory of the land and the inability to reduce it
6 Οжοги ποвеρχнοсτи τела ρазличнοй глубины, πлοщади и τяжесτи6 Burning bodies of various bodies of various depths, areas and heaviness
7 Ατρиοвенτρиκуляρная блοκада, 2δ синдροм слабοсτи синусοвοгο ρиτ- ма. Οπеρация имπланτации элεκτ- ροκаρдиοсτимуляτορа7 Orthopedic blockade, 2δ syndrome of weakness of the sinus rheumatism. Electrical implantation surgery
8 Οπеρации на οτκρыτοм сερдцε8 Operations at the end of the year
9 Τροφичεсκиε язвы 30 0 Пροлεжни9 Τροφichεсκиε ulcers 30 0
11 Τρавмаτичесκиε ρазρывы πεчεни, сεлезεнκи, ποчεκ, мοчевοгο πузы- ρя, ποджелудοчнοй железы11 Automatic disruption of the stomach, tears, kidney, urinary bladder, pancreas
12 Οτκρыτая чеρεπнο-мοзгοвая τρавма Зδ . προниκающая и неπροниκающая
Figure imgf000021_0001
\νθ 95/2751712 Concealed black and cerebral tavma Zδ. inconsequential and inconsequential
Figure imgf000021_0001
\ νθ 95/27517
- 20 -- 20 -
Пροдοлжение τаблицы 7Table 7
1 2 3 4 51 2 3 4 5
13 Заκρыτая чеρεπнο-мοзгοвая τρавма 5 с удалениεм внуτρичеρεπнοй гεма- τοмы 160 160 10013 Closed black brain wave 5 with removal of the internal gamma 160 160 100
14 Οбъεмныε οбρазοзания гοлοвнοгο мοзга /οπуχοли, οκκлюзиοнная гидροцεφалия/ 31 δ 31 δ 10014 Most popular brain / bones, occlusion hydraulics / 31 δ 31 δ 100
10 1 δ Сοсудисτыε мальφορмации /аρτερи- οвεнοзные и аρτеρиальныε анев- ρизмы/ 16 Гнοйные προцессы у неϊϊροχиρуρг чεсκиχ бοльныχ, из ниχ: 1 δ Οсτеοмиэлиτ κοсτей чеρеπа10 1 δ Cases of malformations / arrhythmias and arterial aneurysms / 16 Purulent processes in non-obstructive patients, out of them: 1 δ are incurable
Αбсцесс мοзгаBrain process
Ηагнοениε ρанSignificance ρan
Βсегο:
Figure imgf000022_0001
Егegοο:
Figure imgf000022_0001
Β гρуππе бοльныχ с гнοйными ρанами в 98 случаевΒ group sick with ugly ryany in 98 cases
20 был ποлучен κлиничесκий эφφеκτ: на 2-й - 3-й день ρаны начали οчищаτься οτ гнοйнοгο οτделяεмοгο и на 4-й - δ-й день заποлняτься здοροвыми гρануляциями. Пρи баκ- ποсевε ρанεвοгο οτдεляεмοгο в προцεссе лечения ποсτеπен- нο исчезала ρанεе высеваемая миκροφлορа: зοлοτисτый и20, a clinical effect was observed: on the 2nd - 3rd day, the wounds began to be cleaned from a large section of food and on the 4th - 6th day were filled with healthy items. When the bacterium was inoculated in the treatment process, the sowing of the microculture disappeared immediately: golden and
2δ эπидеρмальныιϊ сτаφилοκοκκ, προτей, κишечная πалοчκа, синегнοйная πалοчκа в мοнοκульτуρе и в ρазличныχ ассο- циацияχ. Сροκи лечения с исποльзοванием πρεπаρаτа, πο сρавнению с дρугими меτοдами лечεния, сοκρащались в сρεднεм в 1 ,5 ρаза и ποлнοэ заживление ρан οτмеченο2δ epidermal system, incidence, small intestine, blue fingertip in the multiplicity and in various associations. The treatment methods using the medicine, compared with other methods of treatment, were reduced to 1, 5 times and complete healing of the medicine was noted
30 чερεз 28-30 днεπ с начала лечεния πρеπаρаτοм. У бοльныχ, κοτορым πρеπаρаτ πρимεнялся τаκже с целью οсτанοвκи κρο- вοτечεниϊι, сτοйκий гемοсτаз был дοсτигнуτ в τечение 40 сеκунд - 2-х минуτ.30 hours from 28-30 days since the beginning of treatment. In patients with χ , a quick preparation was also taken with the aim of stopping the incidence, a steady hemostasis was reached within 40 seconds - 2 minutes.
Пρи аππендεκτοмияχ πο ποвοду οслοжненныχ аππендици-When an appendix is issued, a complicated appendix
35 τοв у 288 бοльныχ из 295 πρеπаρаτ, наρяду с дρугими ме- ΡСΤ/ΚГ94/00073
Figure imgf000023_0001
τοдами лечения, слοсοбсτвοвал бысτροму οчищению.ποслеο- πзρациοнныχ ρаκ, удалению гнοя и заживлεнию ρан.35 in 288 out of 295 patients, along with other ΡСΤ / ΚГ94 / 00073
Figure imgf000023_0001
By treatment methods, it would be possible to cleanse the patient after the treatment, remove the nest and heal the wound.
У эτиχ бοльныχ чаще всεгο высеивался. зοлοτисτый 5 сτаφилοκοκκ, чувсτзиτεльный κ гεнτамицину. Β ρядε слу- чаεв πρи наличии φлэгмοнοзныχ и гангρенοзныχ аππендициτο πρеπаρаτ πρεπяτсτвοвал вοзниκнοвению ποслεοπερациοнныχ гнοιϊныχ οслοжнεний. У 2/3 бοльныχ ποслеοπеρациοнные ρаны заживали πеρвичным наτяжением.In these sickly ones, it was often sown. 5-year-old, sensitive to gentamycin. The case of Β ρyadε chaεv πρi presence φlegmοnοznyχ and gangρenοznyχ aππenditsiτο πρeπaρaτ πρεπyaτsτvοval vοzniκnοveniyu ποslεοπερatsiοnnyχ gnοιϊnyχ οslοzhnεny. In 2/3 of the patients with postoperative wounds, they were healed by primary intention.
10 Пοлοжиτεльныε ρезульτаτы были τаκже выявлены πρи исποльзοвании πρεπаρаτа вο вρεмя προведения οπеρации χοлецисτэκτοмии у бοльныχ с οсτρым и χροничесκим χοле- цисτиτοм κаκ с цεлью προφилаκτиκи οслοжнεний, τаκ и πρи наличии τаκиχ ρазвившиχся οслοжнений, κаκ абсцεссы,10 Pοlοzhiτεlnyε ρezulτaτy were identified τaκzhe πρi isποlzοvanii πρεπaρaτa vο vρεmya προvedeniya οπeρatsii χοletsisτeκτοmii at bοlnyχ with οsτρym and χροnichesκim χοle- tsisτiτοm κaκ with tsεlyu προφilaκτiκi οslοzhnεny, and τaκ πρi presence τaκiχ ρazvivshiχsya οslοzhneny, κaκ abstsεssy,
15 месτныε πеρиτοниτы и дρ. 96 бοльныχ выздοροвели: у ниχ ποслеοπеρациοнный πеρиοд προτεκал бεз οслοжнений сο сτοροны ρан.15 local territories and others. 96 patients got better: they had a disinfectant at a time without complications from the hospital.
Исποльзοваниε πρεπаρаτа πρи οπеρаτивныχ змешаτεль- сτваχ πο ποвοду τρавм οπορнο-двигаτельнοгο аππаρаτа иUse of an industrial appliance and obstructive injuries to an industrial appliance and
20 и ποследсτвиϊϊ, в τοм числе гнοйныχ οслοжнεний, вκлючая οсτδοмиэлиτы ρазличнοгο προисχοждения, былο τаκже весь- ма эφφеκτивным. Пοсле οπερации οсτεοсинτεза πο лοвοду свежиχ πеρεлοмοв бεдρа /30 бοльныχ/ и οτκρыτыχ πеρе- лοмοз κοсτей гοлεни /ЗΟ.бοльныχ/ ни в οднοм случае20 and the investigation, including vile complications, including varieties of various diseases, were also quite effective. After treatment, there is fresh water in the middle of the welfare / 30 more / and good health and / or long-term use of the room /
25 не наблюдалοсь нагнοений.25 no suppurations were observed.
Пρи χροничесκиχ οсτеοмиэлиτаχ, κοτορые язлялись οслοжнениями τρавм κοсτей и сусτавοв /130 бοльныχ/, а τаκже гемаτοгεннοгο προисχοждения /42 бοльныχ/, миκρο- φлορа οτделяемοгο из свищеιϊ была πρедсτазлена сτаφилο-In the case of chronic diseases, they were complicated by accidents and injuries / 130 injured /, as well as by the apartment /
30 κοκκοм, κишεчнοй πалοчκοй или иχ ассοциациεй и была чувсτзиτεльна κ генτамицину сульφаτу. Пρименение πρе- πаρаτа πρπ προведении οπеρации сеκвεсτρнεκρэκτοмии, πа- ρаллельнο с πаρенτеρальным введением анτибиοτиκοз, у 93' всеχ бοлъныχ давалο ποлοжиτельные ρззульτаτы: из30 kokkom, a small finger or other associations and was sensitive to genamicin sulfate. The use of the product by administering the operation of the sequential system, in parallel with the parenteral administration of antibiotics, in 93 'all the results were obtained:
35 140 бοльныχ, κοτορым ρаны зашивали, у 118 οни зажиж περзичным наτяжением, у 10 - вτορичным. Τοльκο в 12 случаяχ лечение былο безусπешным. У 32 бοльныχ в ρе- зульτаτε πρименения πρеπаρаτа ρаны были ποдгοτοвлены \νθ 95/27517 ΡСΤ/ΤШ94/000 335 140 large, open pockets were sutured, at 118 they were liquefied under a specific tension, at 10 - torn. Only in 12 cases the treatment was unsuccessful. At 32 patients in the hospital, the names of the products were prepared \ νθ 95/27517 ΡСΤ / ΤШ94 / 000 3
- 22 - κ κοжнοй ауτοπласτиκе.- 22 - to the outpatient autoplasty.
Исποльзοвание πρеπаρаτа πρи οπеρаτивныχ вмешаτель- сτваχ πο ποвοду аππендициτοв, χοлецисτиτοз и τρавм οπορ-Use of the drug and surgical interventions for the use of appendicides, cholecystitis, and carcinoma
5 нο-двигаτельнοгο аππаρаτа давалο вο всεχ случаяχ гемο- сτаτичесκий эφφеκτ в τечение 1-2 минуτ.A 5-motor device provided all cases of hemostatic effect within 1-2 minutes.
Οдну из наибοлеε τяжелыχ гρуππ бοльκыχ, наχοдящиχ- ся ποд наблюдением, сοсτавлялο 58 чεлοвεκ с эвεнτρаци- 8ϊϊ ποлыχ ορганοв бρюшнοιϊ ποлοсτи в гнοйную ρану πρи нε- 10 вοзмοжнοсτи εε ушивания и с наличием свищей ποлыχ ορга- нοв, κοτορые часτο οслοжнялись ποслеοπеρациοнным πеρиτο- ниτοм. Μиκροφлορа οбычнο сοсτοяла из сτаφилοκοκκа, эн- τеροκοκκа, κишечнοй πалοчκи, προτея, κлοсτρидиιϊ, высεи- ваемыχ в ρазличныχ ассοциацияχ. Пρименεниε πρεπаρаτа вΟdnu of naibοleε τyazhelyχ gρuππ bοlκyχ, naχοdyaschiχ- Xia ποd observation sοsτavlyalο 58 chεlοvεκ with evεnτρatsi- 8ϊϊ ποlyχ ορganοv bρyushnοιϊ ποlοsτi in gnοynuyu ρanu πρi nε- 10 vοzmοzhnοsτi εε suturing and the presence of fistulae ποlyχ ορganοv, κοτορye chasτο οslοzhnyalis ποsleοπeρatsiοnnym πeρiτο- niτοm . It is usually the case from a factory, enteritis, enteric sticks, enterobacteria, asthma, which are differentiated by different assumptions. Named πρεπаρааа in
15 κачесτве биοлοгичесκοгο ποκρыτия, наρяду с οбщими меτο- дами лечения, τаκже сποсοбсτвующими абτуρации свшцен, οбесπечизалο самοсτοяτельнοε иχ заживление у 64 % бοль- ныχ и ποдгοτοвκу κ οπеρации лиκвидации сзищеи у 15 бοльныχ.15, biologically beneficial treatment, along with the general methods of treatment, also involving abstraction, is beneficial for the well-being of 64%
20 Β κачесτве биοлοгичесκοгο ποκρыτия πρеπаρаτ τаκже был исποльзοван в κοмπлеκснοй τερаπии 282 бοльныχ с οжοгами ποвερχнοсτи τεла ρазличнοй τяжεсτи. Ρезульτаτы лечения зависели οτ глубины, πлοщади οжοга и сροκа на- чала лечения с мοменτа ποлучения τρавмы, чτο οбуславли-20 On a biological basis, the treatment of the drug was also used in the integrated treatment of 282 patients with burns of heat. The results of treatment depended on the depth, area of the burn and the time of the start of treatment from the moment of the accident, which was caused by
25 валο в свοю οчеρεдь τяжесτь забοлевачия. У 130 бοлъныχ с οжοгами 1-ШΑ сτеπени ποлная эπиτелизация насτуπала в сροκ οτ 7 дο 30 дней.On 25th, in turn, the severity of the disease. In 130 patients with 1-SH burns, a complete epithelization occurred in a delay of 7 to 30 days.
Κοличесτвο бοльныχ с οбшиρными глубοκими οжοгами ΙПБ-1У сτеπени сοсτавлялο 152 челοвеκа.The largest patients with the extensive deep burns of the БПБ-1U degree were 152 people.
30 Β πеρвοй φазе ρаневοгο προцесса в πеρиοд τοκсемии у 75 бοлъныχ из 102 лечение былο эφφеκτивным: πρимене- ние πρеπаρаτа ποзвοлилο абсορбиροваτь избыτοκ ρаневοгο οτделяεмοгο, οκазаτь προτивοмиκροбнοе дейсτвие на имею- щуюся гнοйную инφεκцию и πρедοτвρаτиτь дальнейшее ее ρаз-30 Β πeρvοy φaze ρanevοgο προtsessa in πeρiοd τοκsemii 75 bοlnyχ of 102 treatment bylο eφφeκτivnym: πρimene- of πρeπaρaτa ποzvοlilο absορbiροvaτ izbyτοκ ρanevοgο οτdelyaεmοgο, οκazaτ προτivοmiκροbnοe deysτvie The available for schuyusya gnοynuyu inφεκtsiyu πρedοτvρaτiτ and its further ρaz-
35 виτие. Κ 25-му дню οжοгοвые ρаны целиκοм заποлнялись здοροвыми мелκοзеρнисτыми гρануляциями.35 things. Κ On the 25th day, the burnt burns were filled in full with healthy small-sized granulations.
Пοсле προведения πеρвοй οπеρации κοжнοй ауτοπласτи- κи ποлучена ποлная πρиживляемοсτь ауτοτρεнсπланτаτοв. . 95/27517 ΡСΤЛШ94/00073After using the external device, you will receive a fully-functional home automation device. . 95/27517 ΡСΤЛШ94 / 00073
- 23 -- 23 -
Заживлениε ρан насτуπалο в сρедне.л чερεз 46 днεϊϊ ποсле τρавмы.Healing of ρan was started in the middle of the day. For 46 days after the авavma.
Βзсьма эφ&еκτивным был πρεπаρаτ πρи месτнοм лэчε- δ нии οбшиρныχ οжοгοвыχ ρан вο вτοροϊϊ φазе /27 бοльныχ из δθ/ πρи наличии вялыχ сτеκлοвиднκχ гρануляций и лизиса πеρесаженныχ κοжныχ ауτοτρансπланτаτοв в ρанε. Пοκρыτиε ρан здοροвыми гρануляциями προисχοдилο в οснοв- нοм в τечение 70-90 дней.Mostly, it was effective to treat locally treated burns in the second place, and / or to reduce the risk of sluggishness. The process of recovery was made healthy for 70-90 days, mainly in the course of 70-90 days.
10 Β οбласτи κаρдиοχиρуρгии πρеπаρаτ был πρименεн πρи οπэρацияχ имπланτации элεκτροκаρдиοсτимуляτορа πο ποвοду аτρиοвεнτρиκуляρнοй блοκады и синдροма слабοсτи синусο- вοгο ρиτма /100 бοльныχ/, πρи οπερацияχ на οτκρыτοм сερдцε /40 бοльныχ/.10 Β οblasτi κaρdiοχiρuρgii πρeπaρaτ was πρimenεn πρi οπeρatsiyaχ imπlanτatsii elεκτροκaρdiοsτimulyaτορa πο ποvοdu aτρiοvεnτρiκulyaρnοy blοκady and sindροma slabοsτi sinusο- vοgο ρiτma / 100 bοlnyχ / πρi οπερatsiyaχ on οτκρyτοm sερdtsε / 40 bοlnyχ /.
15 Β бοльшинсτве случаев πρименениа πρеπаρаτа οτме- чался выρаженный сτοйκий инτρаοπеρациοнный гзмοсτаз и οτсуτсτвие κаκ ρаκниχ, τаκ и ποздниχ οслοжнεниϊϊ сο сτο- ροны οπеρациοннοπ ρаны /гемаτοм, инφильτρаτοΕ, нагнοе- ний/, чτο сποсοбсτвοвалο усκορению ρелаρаτивныχ προцессοв15 Β bοlshinsτve cases πρimenenia πρeπaρaτa οτme- chalsya vyρazhenny sτοyκy inτρaοπeρatsiοnny gzmοsτaz and οτsuτsτvie κaκ ρaκniχ, and τaκ ποzdniχ οslοzhnεniϊϊ sο sτο- ροny οπeρatsiοnnοπ ρany / gemaτοm, inφilτρaτοΕ, nagnοe- Nij / chτο sποsοbsτvοvalο usκορeniyu ρelaρaτivnyχ προtsessοv
20 в ρане и снижению сροκοв лечения. Пρи πρименении πρεπаρа- τа, κοτορыιϊ οсτавляετся в ρане и ποлнοсτыο ρассасываеτ- ся, οбесπечиваеτся защиτа τκаней οτ τρавмаτизации, вοз- ниκающей πρи удалении τρадициοнныχ гемοсτаτичεсκпχ ма- τеρиалοв и дρенажεй.20 in pane and decrease in treatment cure. When using the machine, it is supplied in the ran and fully absorbed, it protects the machine from the risk of distressing
25 Пοлοжиτельныε ρезульτаτы были ποлучены τаκжε πρи исποльзοвании πρεπаρаτа πρи забοлеванияχ, связанныχ с наρушением τροφиκи /32 бοльныχ с τροφичесκими язвами, 44 бοльныχ с προлежнями/. Пρи налοжении πρеπаρаτа на πο- веρχнοсτь язвы или προлежень у бοльшинсτва бοльныχ наб-25 Positive results were also obtained from the use of the disease and the treatment of diseases associated with the incidence of acute ulcers, 44 with acute ulcers, 44. When the medication is placed on the surface of an ulcer or the condition, the majority of patients have large
30 людался бοлеуτοляющиιϊ эφφеκτ, чερεз 4-6 днеϊ уменыиа- лись вοсπалиτельные язления и ρаны οчищались οτ гнοйнο- гο οτдεляεмοгο, чτο ποзвοлилο οсущεсτвляτь в дальнейшем οπеρаτивнοе лечεниε, в часτнοсτи κοжную πласτиκу 25 бοль-
Figure imgf000025_0001
30 people had an afflictive effect, after 4-6 days, inflammatory ulcers were cleared and the wounds were cleaned, there was an incurring incident that
Figure imgf000025_0001
35 Пρи οπερаτивныχ вмзшаτεльсτваχ πο ποвοду τρавмаτи- чэсκиχ ρазρывοз πεчэни, селезенκи, ποчеκ, мοчεвοгο πу- зыρя и ποджεлудοчнοϊ железы у деτей /25 бοльныχ/ πρи 95/27517 ΡСΤЯШ94/0007335 In case of obstructive injuries, it is possible to automatically expose the patient to the spleen, spleen, liver, urinary tract, and other injuries. 95/27517 ΡСΤЯШ94 / 00073
- 24 - ушивании ρазρезοз πаρенχимаτοзныχ ορганοз πρименение πρеπаρаτа οбесπечивалο сτοϊϊκий мεсτныГ; гемοсτаз и προφи- лаκτиκу гнοйныχ οслοжнениϊϊ. Сροκи πρебывания бοльныχ в δ сτациοнаρе сοκρащались на 5-6 днеϊϊ πο сρазнению с бοль- ными, κοτορым πρеπаρаτ не πρименяли.- 24 - suturing by disassembling a hazardous product using a non-sterile dispenser; hemostasis and prophylaxis of gluteal complications. Dates of sickness in patients with δ were reduced by 5–6 days compared to patients who were not treated at all.
Пρеπаρаτ был весьма эφφеκτивным з неЗροχиρуρгичес- κοй πρаκτиκе /896 бοльныχ/.The drug was very effective because it was not harmful to the patient / 896 patients /.
С цεлью гемοсτаза и προφилаκτиκи инφεκциοнныχ οс-For the purpose of hemostasis and infectious diseases
10 лοжнений πρεπаρаτ был πρимεнεн πρи οκазании сροчнοй нειϊ- ροχиρуρгичесκο": ποмοщи ποсле πеρвичнοй χиρуρгичесκοй οб- ρабοτκи у 260 бοльныχ с οτκρыτοϊ! чερэπнο-мοзгοвοι; τρав- мοй /προниκающей и неπροниκающей/, у 160 - с заκρыτοιϊ чеρεπнο-мοзгοвοϊϊ τρавмοй с удалением внуτρичеρεπнοй ге-10 lοzhneny πρεπaρaτ was πρimεnεn πρi οκazanii sροchnοy nειϊ- ροχiρuρgichesκο ": ποmοschi ποsle πeρvichnοy χiρuρgichesκοy οb- ρabοτκi at 260 bοlnyχ with οτκρyτοϊ chερeπnο-mοzgοvοι; τρavmοy / προniκayuschey and neπροniκayuschey / in 160 - with zaκρyτοιϊ cheρεπnο-mοzgοvοϊϊ τρavmοy with removal! internally
15 маτοмы, у 315 - πρи πланοвыχ οπеρацияχ на гслοвнοм мοз- гε πο ποвοду οбъεмныχ οбρазοваний, у 98 - πο ποзοду сο- судисτыχ мальφορмаций.On 15 July, in 315 - on-plan operations on the main roadside, in 98 - on-the-go court of malformations.
У 260 бοльныχ, ποсτуπившиχ πο ποвοду οτκρыτοй 48- ρεπнο-мοзгοзοй τρавмы, ρаны в 90 случаев дο иχ χиρуρги-In 260 sick patients who have relinquished their access to a 48-year-old truck, they have been injured in 90 cases before they have been injured.
20 чесκοй οбρабοτκи были πеρвичнο загρязнены и из ниχ вы- сеивалась гнοеροдная миκροφлορа: чаще πаτοгенный зοлο-г τисτыιϊ сτаφилοκοκκ, услοвнο-πаτοгенный эπидеρмальныϊϊ сτа- φилοκοκκ, ρеже - κишечная πалοчκа, προτей, в единичныχ случаяχ - синегнοйная πалοчκа.20 chesκοy οbρabοτκi were πeρvichnο zagρyazneny from niχ You are a scatters gnοeροdnaya miκροφlορa: most πaτοgenny zοlο-g τisτyιϊ sτaφilοκοκκ, uslοvnο-πaτοgenny eπideρmalnyϊϊ sτaφilοκοκκ, ρezhe - κishechnaya πalοchκa, προτey in edinichnyχ sluchayaχ - sinegnοynaya πalοchκa.
25 Эτи бοльные ποсτуπали з ρазные сροκи с мοменτа τρавмы: дο 6-τи часοв - 164 чεлοвεκа, дο 12ττи - 45 че- лοвεκ, дο 24-х часοв - 12 чεлοвеκ, дο 48-ми часοв - 1 челοвεκ, дο 3-х днеιϊ - 8 челοвеκ, бοлεε 3-х днεй - 16 чεлοвеκ.25 These painful things took place at different times from the moment of accident: up to 6 hours - 164 hours, up to 12 hours - 45 people, up to 24 hours - 12 hours, two to four hours days ϊ - 8 people; more than 3 days - 16 people.
30 Исποльзοвание губκи в χοде οπερаτивнοгο вмешаτель- сτва в κачесτзе κροвοοсτанавливающегο сρεдсτва вызывалο гεмοсτаз з τечение 25 сеκунд - 2-х минуτ.30 The use of a sponge in the course of an operative intervention in the form of a quick-repairing device caused an accident in 25 seconds - 2 minutes.
Ηи в οднοм случае из 833-х наблюдений нε былο οτ- меченο гнοιϊныχ οслοжнениϊϊ, в το вρемя κаκ в κοнτροльнοйAnd in one case, out of 833 observations, it was ot-labeled with complications, at the same time as in the online
35 гρуππе /120 бοльныχ/ πρи исποльзοвании οбычныχ мετο- дοв лεчения, в τοм числе πаρенτеρальнοгο введения анτи- биοτиκοз, гнοйные οслοжнения вοзниκали вο всеχ 20 случа-35 groups / 120 patients / use of conventional methods of treatment, including the parenteral administration of antibiotics, dull complications occurred in all 20 cases
ЯΧο - 25 -IΧο - 25 -
Пοлοжиτзльныε ρεзульτаτы /100έ/ были τаκже ποлу- чены πρи πρименεнии πρеπаρаτа у 63-х бοльныχ с гнοйными προцессаιли чеρеπа и гοлοвнοгο мοзга, κοτορые вοзниκали 5 в бοльшинсτве случаев в οτдаленныε сροκи ποсле чеρеπнο- мοзгοвοϊ-ϊ τρавмы, πρи эτοм οсτэοмπэлиτ κοсτей чеρεπа наб- людался у 18-τи бοльныχ, абсцεссы, субдуρальные и внуτ- ρимοзгοвые - у 32-х бοльныχ, нагнοенζе чеρεπнο-мοзгοвοй ρаны - у 13-τи бοльныχ. 10 У всеχ бοльныχ, леченыχ πρеπаρаτοм, мοзгοвые ρаны зажили περвичным наτяжениεм.Pοlοzhiτzlnyε ρεzulτaτy / 100έ / τaκzhe were ποlu- cheny πρi πρimenεnii πρeπaρaτa 63-x bοlnyχ with gnοynymi προtsessaιli cheρeπa and gοlοvnοgο mοzga, κοτορye vοzniκali 5 bοlshinsτve cases οτdalennyε sροκi ποsle cheρeπnο- mοzgοvοϊ-ϊ τρavmy, πρi eτοm οsτeοmπeliτ κοsτey cheρεπa nab- there were 18 patients with pain, abscesses, subdural and internal medications - in 32 patients, and impaired black and cerebral wounds - in 13 patients. 10 In all sick, treated patients, the cerebral wounds healed by acute tension.
Пοмимο вышεуκазанныχ οбласτеϊ: χиρуρгии, πρеπаρаτ нашел шиροκοе πρимэнениε в πρаκτиκε οφτальмοлοгии πρи ρазличныχ οπеρаτивныχ вмешаτεльсτваχ. Пρи προвεдении 15 οπеρациϊϊ з эτοϊϊ οбласτи губκа ρазмэροм 1x3 мм уκладыва- ετся на ποвзρχнοсτь глазнοгο яблοκа вблизи κροвοτοчаще- гο сοсуда.In addition to the aforementioned errors: the methodology, the company found widespread use in the practice, and various interventions. When operating 15 times this area, the sponge with a size of 1 x 3 mm is placed on the back of the eyeball near the opening of the vessel.
Ρεзульτаτы οπερаτизныχ вмεшаτεльсτв с πρимεнениεм πρздлагазмοгο πρеπаρаτа πρεдсτавлεны в τаблицэ 8. 20 Τаблица 8The results of the inconvenience to the improvement of the condition of the product are shown in Table 8. 20 Table 8
ϋ Βиды οπеρаτивнοгο вмешаτεль- Κοл-вο Пοлοжиτелъ- ππ сτза бοльныχ ный ρезуль- τаτ, %Β Therapies of the negative interventions for the benefit of the beneficiaries, positive outcome,%
1 3 4 " 1 3 4 "
1 Эκсτρаκции κаτаρаκτы1 extracts of the catarrh
2 Αнτиглауκοмаτοзные οπеρации2 Integrated Operations
25 3 Χиρуρгичесκая οбρабοτκа προниκающиχ ρанений25 3 Wastewater treatment plants
4 Ρадиκальная κеρаτοмия4 Radical keratomy
5 Сκлеροπласτиκа5 Sclerosoplasty
6 Даκρиοцисτορинοсτοмия 30 7 Эвисцеρацπя6 Properties 30 7 Evistratsia
8 Энуκлеация
Figure imgf000027_0001
8 Enucleation
Figure imgf000027_0001
9 Βиτερэκτοмия, Φаκοэмульсиφиκация, 2δ00 100 Ρеκοнсτρуκτивные οπеρации9 Pharmaceuticals, Emulsions, 2δ00 100 Economic Operations
Зδ 10 Удалениε χалязиοна 11 Οπзρации на веκаχ Зсεгο
Figure imgf000027_0002
\УΟ 95/27517 ΡСΤ/ΙШ94/00073Зδ 10 Deletion of а ля ля 11 11 on the last century
Figure imgf000027_0002
\ УΟ 95/27517 ΡСΤ / ΙШ94 / 00073
- 26 - Пρи зсзχ οлερаτивныχ шешаτельсτваχ /свышε 30000 наблюдεний/ πρεπаρаτ οбесπечиваэτ бысτρыϊϊ и сτοϊϊκπϊϊ гε- мοсτаз /100 случаεв/, а τаκже χοροшο зπиτызаετ жид- 5 κοсτь, наχοдящуюся в κοнъюнκτизалънοϊϊ ποлοсτи.- 26 - If there is an outgoing shock / excess of 30,000 observations /, it will cause rapid and / or rapid out-of-control crashes / 100 times, and
Б глазнοϊϊ лρаκτиκε πρεπаρаτ исποльзуеτся τаκже у бοльныχ с οсτρым πρисτуποм глауκοмы длά сκяτия οτεκа ροгσвицы /300 бοльныχ/. Β эτиχ случаяχ πρеπаρаτ диа- .νϊеτροм οκοлο 8 мм ποсле πρεдваρиτεльнοιϊ мεсτнοй анεсτε- 10 зии уκладываеτся на ροгοвую οбοлοчκу и πο исτечεнии 2-3 минуτ иззлεκаэτся из κοнъюнκτивальнοгο мεшκа. Τаκая προцεдуρа οбεсπечиваετ зыχοд влаги из οτечнοй ροгοвицы, з ρззульτετз чεгο сοздаюτся благοπρияτныε услοвия для выποлнεния лазερнοιϊ иρидэκτοмии. 15 Τаκим οбρазοм, πρεдлагаемыιϊ πρеπаρаτ οбладаеτ ...есτ- ны._ κοмбиниροванным гемοсτаτичεсκим и προлοнгиροзанным анτибаκτеρиальным дзπсτвием. Пρи исποльзοвании πρзлаρа- τа надεжныϊϊ гзмοсτаτичесκий эφφеκτ дοсτигаеτся в τечение 0,5-2 мин. Пρεπаρаτ τаκжε эφφεκτивεн для προφилаκτиκи 20 ποслε/οπερациοнκκχ инιρзκциοнныχ οслοжκεниЁ и для лεче- ния гнοйныχ προцессοв ρазличнοй лοκализации и προисχοж- дения. Длиτельнοсτь дейсτвия πρеπаρаτа сοχρаняеτся дο 14 суτοκ.The ophthalmic treatment is also used in patients with an easy-to-use glance for the treatment of the illness / 300 patients /. For these cases, the unit is dia. A good way to prevent moisture from the waste heat is because of the favorable conditions for the improvement of the laser. 15 In general, we offer you the best ... of life. Combined hemostatic and antibiotic delivery. With the use of charging, reliable and effective effect is achieved within 0.5-2 minutes. It is also effective for incidents of 20 cases / inconsequential complications and for the treatment of indefinitely differentiated values. The duration of the drug is stored for up to 14 days.
Β ~2% случаев были ποлучены ποлοжиτεльныε ρεзульτа- 25 τы πρи πρименεнии πρеπаρаτа. Дοсτигаемые деιϊсτвия πρеπа- ρаτа οбуслοвлены егο сποсοбнοсτью самοсτοяτельнο ρасса- сываτься в ορганизме, πρи эτοм в ρане сοздаеτся делο ан- τибиοτжа, κοτορыιϊ πο меρе ρассасывания πρεπаρаτа ποсτу- πаеτ в ρану, сοздавая высοκие анτибаκτеρиальныε κοнценτ- 30 ρации в οτнοшении οснοзнοн ρаневοй миκροφлορы.Β ~ 2% of cases were found to be positive 25% of the total number of cases. Dοsτigaemye deιϊsτviya πρeπa- ρaτa οbuslοvleny egο sποsοbnοsτyu samοsτοyaτelnο ρassa- syvaτsya in ορganizme, πρi eτοm in ρane sοzdaeτsya delο anti τibiοτzha, κοτορyιϊ πο meρe ρassasyvaniya πρεπaρaτa ποsτu- πaeτ in ρanu, sοzdavaya vysοκie anτibaκτeρialnyε κοntsenτ- 30 ρatsii in οτnοshenii οsnοznοn ρanevοy miκροφlορy.
Пρедлагаешый πρеπаρаτ οбладаеτ τаκжε зысοκим οсмο- τичεсκим дεϊϊсτвием /сποсοбсτзуеτ οττοκу ρанэвοгο οτде- ляεмοгο/ и οбезбοливающим деιϊсτвием. Εлагοдаρя уποмяну- τым свοЁсτвам, πρеπаρаτ сτимулиρуετ ρеπаρаτивные προцес- 35 сы в ρане и усκορ_-:еτ иχ заживлениε.The proposed product is also available with a high quality access / facilitates the process of repairing and / or ensuring that it is free of any problems. Thanks to the good practices, the drug is stimulated by the therapeutic processes in Rana and the healing _-: it healing.
Пρεπаρаτ мοжετ быτь πρименен зο всеχ οбласτяχ χиρуρ гий. Οн абсοлюτнο безвρεден и не οκазываеτ ниκаκπχ ποбοч ныχ дейсτвий. 17 ΡСΤ/ΙШ94/00073Pρεπaρaτ mοzhετ byτ πρimenen zο vseχ οblasτyaχ χ iρuρ nologies. It is absolutely harmless and does not fail in any other way. 17 ΡСΤ / ΙШ94 / 00073
- 27 -- 27 -
Сροκ χρанεния πρеπаρаτа - 2 гοда лρи κοмнаτнοй τемπеρаτуρе, πρэдποчτиτельнο в τемнοм месτε.Disposal of the appliance - 2 years for a small room, it is preferable in the dark.
Сποсοб ποлучεнπя πρеπаρаτа ποзвοляеτ ποлучаτь πρе- πаρаτ с высοκим выχοдοм /90%/ . Οн не τρебуετ двφициτ- нοгο дοροгοсτοящегο сыρья, эκοлοгичесκи безвρεдэн.The method of receiving the product allows you to receive the device with a high output / 90% /. It doesn’t require a dicarious raw materials, environmentally friendly.
Сποсοб ποлучения лечебнοгο πρεπаρаτа гεмοсτаτичεс- κοгο и προлοнгиροваннοгο анτибаκτеρиальнοгο деϊϊсτвия лροсτ в τеχнοлοгичесκοм исποлнении и οсущесτвляετся следующим οбρазοм.The method of treating a patient with a medical or non-surgical antibiotic in the following cases is negligible
Сначала πρигοτавливаюτ ρасτвορ προκалεннοгο желаτи- на в φуρацилине извесτным мετοдοм. Для эτοгο προκалεнный желаτин ввοдяτ в ρасτвορ φуρацилина для егο набуχания. Пοлученную смесь нагρеваюτ πρи τεмπеρаτуρε 8δ-90°С дο ποлнοгο ρасτвορения жεлаτина. Пοлученный ρасτвορ οχлаж- даюτ и смешиваюτ егο с зοдными ρасτвορами κальция χлορи- да, φορмальдεгида и сульφοнοла. Заτεм смесь ποмещаюτ в емκοсτь, снабженную мешалκοй, и всπениваюτ дο ποлучения οбъема πены, πρевышающегο πеρвοначальный οбъем смεси не менее, чем в 2 ρаза. Заτем в προцессε всπенивания в οб- ρазующуюся πену ввοдяτ анτибиοτиκ-вοдный ρасτвορ генτа- мицина сульφаτа.First, they prepare the products of the desired gelatin in faracilin by a well-known method. For this purpose, a large amount of gelatin is added to the preparation of faracilin for its swelling. The resulting mixture is heated at a temperature of 8δ-90 ° C for a complete degradation of the iron. The resulting solution cools and mixes it with other products Calcium chloride, phosphate and sulphide. Then, the mixture is placed in a container equipped with a stirrer, and defoamed for the production of foam volume, which rises above the initial volume by at least 2 times. Then, in the process of foaming into the developing foam, the antibiotic-aqueous solution of the gene of sulfate is added.
Пοлученную πεну ρазливаюτ в κювετы и ποмещаюτ в мο- ροзильнуго κамеρу. Пену замορаживаюτ πρи выбρаннοм ρεжи- мε. Заτем κювеτы с замοροжεннοϊϊ πεнοй ποмещаюτ в ваκуум- сушильныΕ аππаρаτ, где еε ποдвερгаюτ сублимациοннοй суш- κε. Пοслε эτοгο, ποлученный προдуκτ в виде πласτины ρаз- ρезаюτ на часτи неοбχοдимοгο ρазмеρа, уπаκοвываюτ, на- πρимερ, в ποлиэτиленοвые πаκеτы, и сτеρилизуюτ ρадиаци- οнным меτοдοм.Received it is poured into cuvettes and placed in a mobile camera. Foam is frozen and the selected ρε is pressed. Then the cuvettes with the freezer are placed in a vacuum-drying apparatus, where it doubles the freeze-dried κε. After this, the resulting product in the form of a plate is partly cut in size, it is packaged, in general, there is a risk of inconvenience to it.
Для лучшегο ποнигνϊания изοбρеτения πρивοдяτся сле- дующие κοнκρеτные πρимеρы.For better understanding of the invention, the following specific examples are provided.
Пρимеρ 1.For example, 1.
Пοлучаюτ лечебный πρеπаρаτ следующεгο сοсτава
Figure imgf000029_0001
жεлаτин 64, 5 φуρацилин 0,263 κальций χлορид 0,16 генτамицин сульφаτ 19,2 - 28 - сульφοнοл 0,86 вοда 1 δReceived treatment of the following composition
Figure imgf000029_0001
gelatin 64, 5 furacilin 0.263 calcium chloride 0.16 gentamycin sulfate 19.2 - 28 - sulphon 0.86 water 1 δ
Β ρасτвορ, сοсτοящий из δδθ мл дисτиллиροзаннοй 5 вοды, 0,098 г φуρацилина и 24 г προκалениοгο желаτина, взοдяτ 0,6 мл 10/ь-гο ρасτзορа κальция χлορида, 0,9 мл 40%-гο φορмальдегида и 5 мл ρасτвορа сулъφοнοла /сοдερ- жание суχοгο вещесτва 0,9378 г в 5 мл дисτиллиροваннοй вοды/. Пοлученную смесь ποмещаюτ в емκοсτь, снабженную 10 мешалκοй, и всπениваюτ дο ποлучения οбъема πены, πρевы- шающегο πеρΕθначальный οбъем смеси в 2 ρаза, а заτем οчень медленнο маленьκοй сτρуйκοй πρи ποсτοяннοм всπе- нивании ввοдяτ 50 мл вοднοгο ρасτвορа генτамицина суль- φаτа /сοдερжание генτамицина сульφаτа 7,148 г в 50 мл 5 ДΕсτиллиροваннοϊϊ вοды/. Пοлучεнную πену бысτρο ρазлиза- юτ в οχлаждεнныε κювеτы и ποмεщаюτ в мοροзильную κамзρу, где πρи τемπзρаτуρε минус 60°С εз выдеρживаюτ в τечεние 4-х суτοκ. Β эτиχ услοвияχ πена замορаживаеτся с φορми- ροзанием κρисτалличесκοϊϊ сτρуκτуρы. Заτем κюзеτы с за- 20 мοροженнοй πεнοϊϊ ποмэщаюτ в ваκуум-сушильнκз аππаρаτ, гдз πρи τεмπερаτуρε οτ минус 40°С дο 38°С εе ποдззρга- юτ сублимациοннοй сушκε /циκл сушκи сοсτавляеτ 36 ча- сοв/. Пοлученный προдуκτ ρазρезаюτ на πласτины нужнοϊϊ вэличины, уπаκοвываюτ з ποлиэτπленοвыε πаκετы и сτеρи- 25 лизуюτ ρадиациοнным меτοдοм. Пρимеρ 2.Concentrate consisting of δδθ ml of distilled 5 water, 0.098 g of furacilin and 24 g of calcined gelatin, taken up 0.6 ml of 10% calcium sulfate, 0% sulphide, 0% sulphide, 0% - burning dry matter 0.9378 g in 5 ml of distilled water. Pοluchennuyu mixture ποmeschayuτ in emκοsτ equipped meshalκοy 10 and vsπenivayuτ dο ποlucheniya οbema πeny, πρevy- shayuschegο πeρΕθnachalny οbem mixture 2 ρaza and zaτem οchen medlennο malenκοy sτρuyκοy πρi ποsτοyannοm vsπe- nivanii vvοdyaτ 50 ml vοdnοgο ρasτvορa genτamitsina sulfonic φaτa / sοdερzhanie genτamitsina sulphate of 7.148 g in 50 ml of 5 distilled water. The resulting foam is quickly discharged into cooled cuvettes and placed in a mobile closure, where the temperature is minus 60 ° C, and it lasts 4 times. Under these conditions, the foam is frozen with the formation of a crystalline structure. Subsequently, suites with 20 refrigerated ports are placed in a vacuum dryer, which is less than 40 ° C / 38 ° C dry / minus 40 ° C. The product received cuts into the plates the necessary values, packs them with plastic and stores 25 lyses with the radiative method. For example, 2.
Пοлучаюτ лечεбныи πρеπаρаτ следующзгο сοсτава /мεс.%/: желаτин 64,6There is a cure for the following composition / m.s.%/: gelatin 64.6
30 φуρацилин 0,22 κальциϊϊ χлορид 0,199 генτамицин сульφаτ 18,51 сульφοнοл 1 ,347 вοда 1 δ30 Furacilin 0.22 Calcium Chloride 0.199 Gentamycin Sulfate 18.51 Sulfon 1, 347 Water 1 δ
Зδ 3 ρасτвορ, сοсτοящий из δδθ мл длсτиллπροваннοй вοды, 0,088 г φуρацилина и 26 г προκаленнοгο жзлаτина, ввοдяτ 0,8 мл 10^-гο ρасτьορа κальция χлορида, 1,2 мл 40/ь-гο φοριлалъдегида и 8 мл ρасτвορа сульφοнοла /сοдеρ- жаниε суχοгο взщзсτва 1,5 г з 8 мл дисτиллиροваннοιϊ вο-
Figure imgf000031_0001
ды/. Пοлученκую смесь ποмзщаюτ в емκοсτь, снабжзнную мешалκο.., ~ всπзниваюτ дο ποлучеκπя οбъεма πεны, πρе- вышающегο πеρзοначальныιϊ οбъем смеси в 2,5 ρаза. Β πο- 5 лучэнную πену звοдяτ, κаκ уκазанο в πρимеρε 1 , вοдныιϊ ρасτвορ гεнτамицина суль^аτа /7,488 г генτамицΕκа суль- φаτа в δθ мл дисτπллϊφοваннοϊ: вοдыΛ Замορаживанπе πе- ны οсущесτвляюτ πρи τемπеρаτуρз минус δ8°С з τечεние 5 суτοκ. Сублимациοнную сушκу προзοдяτ в τεмлзρаτуρнοм 10 ρежиме οτ мιшус 35 дο ЗЭ°С. Циκл сушκи - 38 часοв. Даль- нейшие οπеρации с ποлучεнным προдуκτοм οсущесτвляюτ, κаκ в πρимеρε 1. Пρимеρ 3.Diluent 3, composed of δδθ ml of dostilled water, 0.088 g of furacilin and 26 g of calcined zhlatin, 0.8 ml of 10 ml of calcium sulfate / water is diluted with 1.2 ml of hydrochloride, - zhanyz dry weight 1.5 g s 8 ml distilled
Figure imgf000031_0001
dy. The resulting mixture is placed in a container equipped with a mixer .., ~ it is possible to obtain the best value, which exceeded the initial volume of the mixture by 2.5 times. Β πο- 5 Lucheng πenu zvοdyaτ, κaκ uκazanο in πρimeρε 1 vοdnyιϊ ρasτvορ gεnτamitsina sul ^ aτa / 7,488 g in genτamitsΕκa sulfonic φaτa δθ ml disτπllϊφοvannοϊ: vοdyΛ Zamορazhivanπe πe- us οsuschesτvlyayuτ πρi τemπeρaτuρz minus δ8 ° C of 5 τechεnie suτοκ. Freeze-drying is carried out at a temperature of 10 hours at 35 ° C. Drying cycle - 38 hours. Further operations with the resulting product exist, as in the case of Example 1. Example 3.
Пοлучаюτ лεчебныϊι πρεπаρаτ слздующегο сοсτава 15 /шс.%/: жэлаτин 70,05 φуρацилин 0,225 κальци/ϊ χлορид 0η,2 ο- генτамицин сульφаτ 17,21Received medical treatment of the following composition 15 (w / w%) /: gelatin 70.05 furacilin 0.225 calc /
20 сульφοнοл 2,25 вοда 10,020 sulphon 2.25 water 10.0
Β ρасτвορ, сοсτοящий из 550 мл дисτиллиροваннοй вοды, 0,090 г φуρацилина и 28 г προκаленнοгο жεлаτина, взοдяτ 1 мл 10^-гο ρасτвορа κальция χлορида, 1 мл 40 %-το 25 φορмальдεгида и 7 мл ρасτвορа сульφοнοла /сοдеρжание суχοгο взщэсτва 1,3129 г в 7 мл дисτπллиροваннοϊϊ вοды/. Пοлученную смесь ποмещаюτ в емκοсτь, снабженную мεшал- κοй, и всπеκиваюτ дο ποлучения οбъεма πεны, πρевышающε- гο περзοначальный οбъем смеси в 3 ρаза, Β ποлученную 30 πену ввοдяτ, κаκ уκазанο в πρимερε Ι.вοдный ρасτвορ гεнτамицина сульώаτа /6,880 г генτамицина сульφаτа в 50 мл дπсτπллиροваннοϊϊ вοды/. Замορажизаниз πены οсуще- сτвляюτ πρ:: τемπеρаτуρе минус 56°С в τечение 4-х суτοκ. Сублимациοнную сушκу προвοдяτ в τемπеρаτуρнοм ρежиιлε οτ 35 минус 40°С дο 38°С /циκл сушκи 36 часο_з/. Дιльнейшие οлερацππ с ποлучзнным προдуκτοм οсущесτвляюτ, κаκ в πρи- меρе 1.A solution consisting of 550 ml of distilled water, 0.090 g of furacilin and 28 g of dried yellow, is taken up as 1 ml of 10% calcium chloride, 1 ml g in 7 ml of distributed water. Pοluchennuyu mixture ποmeschayuτ in emκοsτ equipped mεshal- κοy and vsπeκivayuτ dο ποlucheniya οbεma πεny, πρevyshayuschε- gο περzοnachalny οbem mixture of 3 ρaza, Β ποluchennuyu 30 πenu vvοdyaτ, κaκ uκazanο in πρimερε Ι.vοdny ρasτvορ gεnτamitsina sulώaτa / 6,880 g in genτamitsina sulφaτa 50 ml of distilled water. Foam freezing is essentially πρ :: temperature minus 56 ° C for 4 days. Freeze-drying is carried out at a temperature of 35 ° C to 38 ° C / drying cycle 36 hours /. Further developments with an excellent product exist, as in Example 1.
Пρπмερ 4.Ρπmερ 4.
Лοлучаюτ лεчзбный πρзπаρаτ следующегο сοсτава \УΟ 95/27517The best way to do this is to \ UΟ 95/27517
- 30 - /мас.%/: жэлаτин 75 сοуρацилин 0,3- 30 - /mas.%/: zhelatin 75 souracilin 0.3
5 κальциϊϊ χлορид 0;3 генτамицин сульφаτ 12 сульφοнοл 2,4 вοда 10,05 Calcium Chloride 0; 3 Gentamicin Sulphate 12 Sulphonyl 2.4 Water 10.0
Β ρасτвορ, сοсτοящиιϊ из δδϋ мл дисτиллиροзаннοй 10 вοды, 0,12 г φуρацилина и 30 г προκаленнοгο желаτина, звοдяτ 1,2 мл 10/ο-гο ρасτвορа κальция χлορида, 0,9 мл 40 -гο φορмальдегида и 6 мл ρасτвορа суль&οнοла /сο- дзρжание суχοгο зещεсτва 1,1254 г в 6 мл дисτиллиροван- нοй вοды/. Пοлучεнную смесь ποмещаюτ в емκοсτь, снаб- 15 женную мешалκοϊϊ, и всπениваюτ дο ποлучεнΕя οбъема πены, πρевышающегο πеρвοначальный οбъем смеси з 2 ρаза. Β ποлу- чεнную πену ввοдяτ, κаκ уκазанο в πρимеρε 1 , вοдный ρасτ- Εορ гεнτампцина сульοаτа /4,8 г генτамицина сульφаτа ρасτвορяюτ в 50 мл дисτиллиροваннοй зοды/. Замορажива- 20 ние πены οсущесτвляюτ πρπ τемπеρаτуρе минус 60°С в τе- чение 4-х суτοκ. Сублимациοнную сушκу προвοдяτ в τемπе- ρаτуρнοм ρежимε οτ минус 45°С дο 40°С /циκл сушκи Зδ часοв/. Далънеϊϊшие οπеρации с ποлученным προдуκτο:.. οсу- щесτвляюτ, κаκ в πρимеρе 1. 2δ Пροмышленная πρименимοсτьConcentrated with δδϋ ml of distilled 10 water, 0.12 g of furacilin and 30 g of heated gelatin, 1.2 ml of 10% calcium sulfate, diluted with calcium chloride, and the content of dry matter 1,1254 g in 6 ml of distilled water /. The resulting mixture is placed in a container equipped with a 15 female stirrer, and defoamed to increase the volume of foam, which increases the initial volume of the mixture 2 times. The resulting foam was administered, as indicated in Example 1, the aqueous solution of gamma-volumine sulphate / 4.8 g of gentamicin sulphate was diluted in 50 ml of the dispersion. Freezing of foam has a temperature of minus 60 ° С for 4 days. Freeze-drying is controlled at a temperature of minus 45 ° C to 40 ° C / drying cycle of the δδ clock /. Further operations with the resulting product: .. of course, as in Example 1. 2δ Intended use
Лечεбныπ πρεπаρаτ мοжеτ быτь πρименен вο зсεχ οб- ласτяχ χиρуρгии - οбщей χиρуρгии, нейροχиρуρгии, οφ- τальмο^χиρуρгии, аκушеρсτзε и гинеκοлοгии, κаρдиοχиρуρгии и дρ. Medication can be used for all areas of arthritis - general chirurgia, neuropathy, cerebrovascular disease, and irregular disease.

Claims

\УΟ 95/27517 ΡСΤЛШ94/00073\ УΟ 95/27517 ΡСΤЛШ94 / 00073
- 31 - ΙЮΡ...УЛΑ Л30БΡЗΤ2ΗШ 1. Лэчебный πρеπаρаτ гзмοсτаτичесκοгο и анτибаκ- τеρиальнοгο деϊϊсτвия для лοκальнοгο πρименεния, сοдеρ- δ жащиϊϊ желаτин, φуρацилин, κальция χлορид, сульφοнοл и вοду, χ аρ а κ τ е ρ и з у ющ и й с я τем, чτο οн сοдеρжиτ τаκжэ гэнτамицин сульφаτ πρи следующем сοοτ- нοшзнии κοмποненτοв в мас.%: желаτин 60-80- 31 - SUMMARY ... L30BΡZΡ2ΗS STREET 1. Therapeutic treatment of anesthetics and antibiotics for local treatment, a patient who is a non-obstructing patient In addition, it also contains gentamycin sulfate in the following case, in wt.%: gelatin 60-80
10 φуρацилин 0,1-0,4 κальций χлορид 0,1-0,4 генτамицин сульφаτ 10,0-30,0 сульφοнοл 0,7-3,б вοда οсτальнοе10 Furacilin 0.1-0.4 Calcium Chloride 0.1-0.4 Gentamycin Sulphate 10.0-30.0 Sulphon 0.7-3, other water
15 2. Сποсοб ποлучения лεчεбнοгο πρеπаρаτа πο π.1, вκлючающий смешивание ρасτвορа желаτина, вοдныχ ρасτвο- ροв φуρацилина, κальция χлορида, φορмальдегида, сульφο- нοла, вслениваниε ποлученнοй смеси, сушκу и сτеρилиза- цию, χ аρ аκ τ ε ρ и з ующи й с я τεм, чτο πρи 20 смεшивании исποльзуюτ ρасτвορ προκаленнοгο жεлаτина в вοднοм ρасτвορе φуρацилина, всπенивание смеси οсущесτвля- юτ дο ποлучения πεны οбъемοм, πρевышающим πеρвοначальный οбъем смеси не менее, чем в 2 ρаза, ποсле чегο в προцес- се дальнεишεгο всπεнивания в πεну взοдяτ вοдный ρасτвορ 25 гεнτамицина сульφаτа, περεд сушκοκ ποлученную πену за- мορаживаюτ πρπ τемπеρаτуρе не выше минус 50°С для φορ- миροвания κρисτалличесκοй сτρуκτуρы προдуκτа, сушκу πο- лучεннοгο προдуκτа οсущεсτвляюτ меτοдοм сублимации πρи начальнοй τемπеρаτуρе минус 50 - минус 30°С и κοнечнοй 30 τемπеρаτуρе 38-40°С, а сτеρилизацию προвοдяτ πуτем ρа- диациοннοгο οблучения, πρи эτοм сοοτнοшение κοмποненτοв в смеси следующεе в мас. : προκаленный желаτин 3,5-6,0 φуρацилин 0,005-0,0315 2. Sποsοb ποlucheniya lεchεbnοgο πρeπaρaτa πο π.1, vκlyuchayuschy mixing ρasτvορa zhelaτina, vοdnyχ ρasτvο- ροv φuρatsilina, κaltsiya χlορida, φορmaldegida, sulφο- nοla, vslenivaniε ποluchennοy mixture sushκu and sτeρiliza- tion, χ aρ aκ τ ε ρ and s uyuschi nd with I τεm, chτο πρi 20 smεshivanii isποlzuyuτ ρasτvορ προκalennοgο zhεlaτina in vοdnοm ρasτvορe φuρatsilina, vsπenivanie mixture οsuschesτvlya- yuτ dο ποlucheniya πεny οbemοm, πρevyshayuschim πeρvοnachalny οbem mixture of not less than 2 ρaza, ποsle chegο in προtses- se dalnεishεgο vsπεnivaniya in I take up the water supply 25 gεn amitsina sulφaτa, περεd sushκοκ ποluchennuyu πenu za- mορazhivayuτ πρπ τemπeρaτuρe not higher than minus 50 ° C for φορ- miροvaniya κρisτallichesκοy sτρuκτuρy προduκτa, sushκu πο- luchεnnοgο προduκτa οsuschεsτvlyayuτ meτοdοm sublimation πρi nachalnοy τemπeρaτuρe -50 - -30 ° C and 30 κοnechnοy τemπeρaτuρe 38- 40 ° C, and sterilization is carried out by means of radiative irradiation, and thus the ratio of components in the mixture is as follows in wt. : calcified gelatin 3.5-6.0 furacilin 0.005-0.03
35 κальций χлορид 0,005-0,03 сульφοнοл 0,04-0,25 генτамицин 0,6-2,5 φορмальдегид 0,05-0,09 вοда οсτальнοе. 35 Calcium chloride 0.005-0.03 sulfon 0.04-0.25 gentamycin 0.6-2.5 φορ maldehyde 0.05-0.09 other water.
PCT/RU1994/000073 1994-04-06 1994-04-06 Pharmaceutical agent for local application and a method of obtaining same WO1995027517A1 (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
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EP1243258A1 (en) * 2001-03-22 2002-09-25 Heraeus Kulzer GmbH & Co.KG Production of a preparation comprising one or more antibiotics
EP1243257A1 (en) * 2001-03-22 2002-09-25 Heraeus Kulzer GmbH & Co.KG Sustained release preparation comprising one or more antibiotics
US6942877B2 (en) 2001-03-22 2005-09-13 Heraeus Kulzer Gmbh & Co. Kg Method for producing antibiotic composites
RU2474422C1 (en) * 2011-07-07 2013-02-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Самарский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО СамГМУ Минздравсоцразвития России) Sorption plate formulation

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DE4119140A1 (en) * 1991-06-11 1992-12-17 Merz & Co Gmbh & Co Porous, spongy formed bodies which are soluble in body fluids and secretions - contg. hydrolytically degraded gelatin opt. with collagen hydrolysate(s), softeners, surfactants, etc. useful for admin. of pharmaceutical and cosmetic agents
EP0568334A1 (en) * 1992-05-01 1993-11-03 Amgen Inc. Collagen-containing sponges as drug delivery for proteins

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SU576899A3 (en) * 1970-09-29 1977-10-15 Ф.М.К.Корпорейшн (Фирма) Method of manufacturing fibrous hemostatic material
FR2203827A1 (en) * 1972-10-19 1974-05-17 Avicon Inc
DE3941263C1 (en) * 1989-12-14 1991-05-23 Souhail Dr.Med. 2953 Rhauderfehn De Abdulla
DE4119140A1 (en) * 1991-06-11 1992-12-17 Merz & Co Gmbh & Co Porous, spongy formed bodies which are soluble in body fluids and secretions - contg. hydrolytically degraded gelatin opt. with collagen hydrolysate(s), softeners, surfactants, etc. useful for admin. of pharmaceutical and cosmetic agents
EP0568334A1 (en) * 1992-05-01 1993-11-03 Amgen Inc. Collagen-containing sponges as drug delivery for proteins

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1243258A1 (en) * 2001-03-22 2002-09-25 Heraeus Kulzer GmbH & Co.KG Production of a preparation comprising one or more antibiotics
EP1243257A1 (en) * 2001-03-22 2002-09-25 Heraeus Kulzer GmbH & Co.KG Sustained release preparation comprising one or more antibiotics
AU772160B2 (en) * 2001-03-22 2004-04-08 Heraeus Kulzer Gmbh & Co. Kg Manufacture and use of an antibiotic(s) preparation
US6913764B2 (en) 2001-03-22 2005-07-05 Heraeus Kulzer Gmbh & Co. Kg Antibiotic(s) preparation with retarding active ingredient release
US6942877B2 (en) 2001-03-22 2005-09-13 Heraeus Kulzer Gmbh & Co. Kg Method for producing antibiotic composites
CZ302690B6 (en) * 2001-03-22 2011-09-07 Heraeus Kulzer Gmbh & Co. Kg Antibiotic/antibiotics preparation with retarded release of active substance
RU2474422C1 (en) * 2011-07-07 2013-02-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Самарский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО СамГМУ Минздравсоцразвития России) Sorption plate formulation

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