WO1995024896A3 - Use of antagonists of egf or tgf-alpha for the treatment and prophylaxis of acne - Google Patents

Use of antagonists of egf or tgf-alpha for the treatment and prophylaxis of acne Download PDF

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Publication number
WO1995024896A3
WO1995024896A3 PCT/EP1995/000877 EP9500877W WO9524896A3 WO 1995024896 A3 WO1995024896 A3 WO 1995024896A3 EP 9500877 W EP9500877 W EP 9500877W WO 9524896 A3 WO9524896 A3 WO 9524896A3
Authority
WO
WIPO (PCT)
Prior art keywords
egf
tgf
antagonists
acne
prophylaxis
Prior art date
Application number
PCT/EP1995/000877
Other languages
French (fr)
Other versions
WO1995024896A2 (en
Inventor
Alan Evenson
Walter Thomas Gibson
Martin Richard Green
Robert Guy
Terence George Evelyn Kealey
Original Assignee
Unilever Plc
Unilever Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Plc, Unilever Nv filed Critical Unilever Plc
Priority to AU20683/95A priority Critical patent/AU2068395A/en
Priority to EP95913074A priority patent/EP0750498A1/en
Priority to JP7523821A priority patent/JPH09510228A/en
Publication of WO1995024896A2 publication Critical patent/WO1995024896A2/en
Publication of WO1995024896A3 publication Critical patent/WO1995024896A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A61K8/315—Halogenated hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70—Biological properties of the composition as a whole

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compositions comprising one or more antagonists of EGF, TGF-α or EGF-receptor function for use in treating acne, spots and pimples are described.
PCT/EP1995/000877 1994-03-15 1995-03-08 Use of antagonists of egf or tgf-alpha for the treatment and prophylaxis of acne WO1995024896A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU20683/95A AU2068395A (en) 1994-03-15 1995-03-08 Use of antagonists of egf or tgf-alpha for the treatment and prophylaxis of acne
EP95913074A EP0750498A1 (en) 1994-03-15 1995-03-08 Use of antagonists of egf or tgf-alpha for the treatment and prophylaxis of acne
JP7523821A JPH09510228A (en) 1994-03-15 1995-03-08 Use of EGF or TGF-alpha antagonists for the treatment and prevention of blue

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9405046.5 1994-03-15
GB9405046A GB9405046D0 (en) 1994-03-15 1994-03-15 Skin treatment composition

Publications (2)

Publication Number Publication Date
WO1995024896A2 WO1995024896A2 (en) 1995-09-21
WO1995024896A3 true WO1995024896A3 (en) 1995-11-09

Family

ID=10751891

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1995/000877 WO1995024896A2 (en) 1994-03-15 1995-03-08 Use of antagonists of egf or tgf-alpha for the treatment and prophylaxis of acne

Country Status (7)

Country Link
EP (1) EP0750498A1 (en)
JP (1) JPH09510228A (en)
AU (1) AU2068395A (en)
CA (1) CA2185675A1 (en)
GB (1) GB9405046D0 (en)
WO (1) WO1995024896A2 (en)
ZA (1) ZA952120B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU737018B2 (en) * 1997-07-25 2001-08-09 Tsumura & Co. Pyridylacrylamide derivatives and nephritis remedies and TGF-beta inhibitors containing the same
AU2003216318B2 (en) 2002-02-19 2006-02-23 The Procter & Gamble Company Lipase inhibiting composition
CN102178930A (en) * 2011-05-17 2011-09-14 华南理工大学 Anti-acne composition containing epidermal growth factors and tea tree oil and preparation method thereof
CN113813369B (en) * 2021-11-09 2023-09-22 浙江省农业科学院 EGF/MMT complex for preventing/treating intestinal injury of piglets

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6236305A (en) * 1985-08-08 1987-02-17 Kao Corp Cosmetic
WO1988003805A1 (en) * 1986-11-19 1988-06-02 Chemex Pharmaceuticals, Inc. Pharmacologically active compounds and mixtures thereof, organic compositions and metal salts
WO1991016892A1 (en) * 1990-04-27 1991-11-14 Rorer International (Holdings), Inc. Styryl compounds which inhibit egf receptor protein tyrosine kinase
WO1992006946A1 (en) * 1990-10-22 1992-04-30 Henkel Kommanditgesellschaft Auf Aktien Bicyclo-compounds with an anti-seborrhoeic action
JPH04266807A (en) * 1991-02-22 1992-09-22 Soken:Kk Skin improver
WO1992017206A1 (en) * 1991-03-28 1992-10-15 The Victoria University Of Manchester Wound healing
JPH05105620A (en) * 1991-10-15 1993-04-27 Kao Corp Beautifying cosmetic comprising p-hydroxycinnamic acid derivative as active ingredient
JPH05201846A (en) * 1992-01-30 1993-08-10 Pola Chem Ind Inc External agent for skin
EP0586002A2 (en) * 1992-08-18 1994-03-09 CENTRO de IMMUNOLOGIA MOLECULAR Monoclonal antibodies recognizing the epidermal growth factor receptor, cells and methods for their production and compositions containing them

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6236305A (en) * 1985-08-08 1987-02-17 Kao Corp Cosmetic
WO1988003805A1 (en) * 1986-11-19 1988-06-02 Chemex Pharmaceuticals, Inc. Pharmacologically active compounds and mixtures thereof, organic compositions and metal salts
WO1991016892A1 (en) * 1990-04-27 1991-11-14 Rorer International (Holdings), Inc. Styryl compounds which inhibit egf receptor protein tyrosine kinase
WO1992006946A1 (en) * 1990-10-22 1992-04-30 Henkel Kommanditgesellschaft Auf Aktien Bicyclo-compounds with an anti-seborrhoeic action
JPH04266807A (en) * 1991-02-22 1992-09-22 Soken:Kk Skin improver
WO1992017206A1 (en) * 1991-03-28 1992-10-15 The Victoria University Of Manchester Wound healing
JPH05105620A (en) * 1991-10-15 1993-04-27 Kao Corp Beautifying cosmetic comprising p-hydroxycinnamic acid derivative as active ingredient
JPH05201846A (en) * 1992-01-30 1993-08-10 Pola Chem Ind Inc External agent for skin
EP0586002A2 (en) * 1992-08-18 1994-03-09 CENTRO de IMMUNOLOGIA MOLECULAR Monoclonal antibodies recognizing the epidermal growth factor receptor, cells and methods for their production and compositions containing them

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 8712, Derwent World Patents Index; AN 87-084155 *
DATABASE WPI Week 9244, Derwent World Patents Index; AN 92-363064 *
DATABASE WPI Week 9321, Derwent World Patents Index; AN 93-172621 *
DATABASE WPI Week 9336, Derwent World Patents Index; AN 93-285353 *
GUY, R. ET AL: "Isolation and maintenace of the human pilosebaceous duct: 13-cis retinoic acid acts directly on the duct in vitro", BRITISH JOURNAL OF DERMATOLOGY, vol. 128, no. 3, pages 242 - 248 *
SUMMERLY R ET AL: "The in vitro incorporation of 14 C-acetate into the isolated sebaceous glands and appendage-freed epidermis of human skin. A technique for the study of lipid synthesis in the isolated sebaceous gland.", BR J DERMATOL, NOV 1971, 85 (5) P424-31, ENGLAND *

Also Published As

Publication number Publication date
EP0750498A1 (en) 1997-01-02
JPH09510228A (en) 1997-10-14
CA2185675A1 (en) 1995-09-21
ZA952120B (en) 1996-09-16
AU2068395A (en) 1995-10-03
WO1995024896A2 (en) 1995-09-21
GB9405046D0 (en) 1994-04-27

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