WO1995021628B1 - Treatment of antibiotic associated diarrhea - Google Patents

Treatment of antibiotic associated diarrhea

Info

Publication number
WO1995021628B1
WO1995021628B1 PCT/CA1995/000060 CA9500060W WO9521628B1 WO 1995021628 B1 WO1995021628 B1 WO 1995021628B1 CA 9500060 W CA9500060 W CA 9500060W WO 9521628 B1 WO9521628 B1 WO 9521628B1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
oligosaccharide sequence
oligosaccharide
treatment
associated diarrhea
Prior art date
Application number
PCT/CA1995/000060
Other languages
French (fr)
Other versions
WO1995021628A1 (en
Filing date
Publication date
Priority claimed from US08/195,009 external-priority patent/US5484773A/en
Application filed filed Critical
Priority to CA002181359A priority Critical patent/CA2181359C/en
Priority to AT95907526T priority patent/ATE267614T1/en
Priority to AU15727/95A priority patent/AU698275B2/en
Priority to JP52086995A priority patent/JP4122052B2/en
Priority to NZ279180A priority patent/NZ279180A/en
Priority to DE69533084T priority patent/DE69533084T2/en
Priority to EP95907526A priority patent/EP0744959B1/en
Publication of WO1995021628A1 publication Critical patent/WO1995021628A1/en
Publication of WO1995021628B1 publication Critical patent/WO1995021628B1/en
Priority to NO963378A priority patent/NO963378D0/en

Links

Abstract

This invention relates to treatment of antibiotic associated diarrhea, including Clostridium difficile associated diarrhea (CDAD) and pseudomembranous colitis (PMC), using oligosaccharide compositions which bind C. difficile toxin A. More specifically, the invention concerns neutralization of C. difficile toxin A associated with CDAD.

Claims

AMENDED CLAIMS
[received by the International Bureau on 9 August 1995 (09.08.95);
original claims 14 and 15 amended; remaining claims unchanged (1 page)] support through a non-peptidyl compatible linker arm, wherein said oligosaccharide sequence binds toxin A; and b) a pharmaceutically acceptable carrier, wherein said composition is capable of being eliminated from the gastrointestinal tract.
14. The composition of Claim 13 wherein said oligosaccharide sequence has from 2 to 10 saccharide units. 15. The composition of Claim 13 wherein said oligosaccharide sequence has from 3 to 5 saccharide units.
16. The composition of Claim 13 wherein said oligosaccharide sequence is selected from the group consisting of the oligosaccharide structures numbers 1-3, 5-7, and 9-13 set forth in Table 1.
17. The composition of Claim 13 wherein said oligosaccharide sequence covalently attached to said pharmaceutically acceptable solid, inert support through a non-peptidyl compatible linker arm is selected from the group consisting of the SYNSCRBs 2, 5, 9, 51, 52, 68, 90, 104, 105, 115, and 134 set forth in Table 1,
18. The composition of Claim 13 wherein said linker arm is -{CH2)8C{O)-.
PCT/CA1995/000060 1994-02-14 1995-02-09 Treatment of antibiotic associated diarrhea WO1995021628A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA002181359A CA2181359C (en) 1994-02-14 1995-02-09 Treatment of antibiotic associated diarrhea
AT95907526T ATE267614T1 (en) 1994-02-14 1995-02-09 TREATMENT OF ANTIBIOTIC-ASSOCIATED DIARRHEA
AU15727/95A AU698275B2 (en) 1994-02-14 1995-02-09 Treatment of antibiotic associated diarrhea
JP52086995A JP4122052B2 (en) 1994-02-14 1995-02-09 Treatment of antibiotic-related diarrhea
NZ279180A NZ279180A (en) 1994-02-14 1995-02-09 Treating clostridium difficile associated diarrhea (cdad) and other antibiotic associated diarrhea using oligosaccharide compositions which bind toxin a
DE69533084T DE69533084T2 (en) 1994-02-14 1995-02-09 TREATMENT OF ANTIBIOTIC ASSOCIATED DIARRHOME
EP95907526A EP0744959B1 (en) 1994-02-14 1995-02-09 Treatment of antibiotic associated diarrhea
NO963378A NO963378D0 (en) 1994-02-14 1996-08-13 Treatment of antibiotic-associated diarrhea

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/195,009 US5484773A (en) 1994-02-14 1994-02-14 Treatment of antibiotic associated diarrhea
US08/195,009 1994-02-14

Publications (2)

Publication Number Publication Date
WO1995021628A1 WO1995021628A1 (en) 1995-08-17
WO1995021628B1 true WO1995021628B1 (en) 1995-08-31

Family

ID=22719705

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1995/000060 WO1995021628A1 (en) 1994-02-14 1995-02-09 Treatment of antibiotic associated diarrhea

Country Status (15)

Country Link
US (2) US5484773A (en)
EP (1) EP0744959B1 (en)
JP (1) JP4122052B2 (en)
KR (1) KR970701064A (en)
CN (1) CN1131070C (en)
AT (1) ATE267614T1 (en)
AU (1) AU698275B2 (en)
CA (1) CA2181359C (en)
DE (1) DE69533084T2 (en)
IL (1) IL112428A (en)
MX (1) MX197129B (en)
NO (1) NO963378D0 (en)
NZ (1) NZ279180A (en)
WO (1) WO1995021628A1 (en)
ZA (1) ZA95630B (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1018342A3 (en) * 1991-10-18 2001-04-11 SYNSORB Biotech Inc. Diagnosis and treatment of bacterial dysentery
DE4428056A1 (en) * 1994-07-29 1996-02-08 Schering Ag Use of microparticle preparations to eliminate dissolved, non-renal substances from the blood
US6140045A (en) * 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
US5627163A (en) * 1995-06-05 1997-05-06 Synsorb Biotech, Inc. Treatment of traveller's diarrhea
US5661131A (en) * 1995-06-05 1997-08-26 Synsorb Biotech, Inc. Treatment of cholera
US5811409A (en) * 1995-06-05 1998-09-22 Synsorb Biotech, Inc. Treatment of cholera
US5637576A (en) * 1995-06-05 1997-06-10 Synsorb Biotech, Inc. Treatment of traveller's diarrhea
US5736533A (en) * 1995-06-07 1998-04-07 Neose Technologies, Inc. Bacterial inhibition with an oligosaccharide compound
US5891860A (en) * 1996-03-11 1999-04-06 Synsorb Biotech, Inc. Treatment of traveller's diarrhea
US6069137A (en) * 1996-03-11 2000-05-30 Synsorb Biotech, Inc. Treatment of traveller's diarrhea
JPH107575A (en) * 1996-06-21 1998-01-13 Synsorb Biotec Inc Treatment for bacillary dysentery
US5846943A (en) * 1996-11-08 1998-12-08 Synsorb Biotech, Inc. Solid support matricles containing a toxin binding oligosaccharide
US6013634A (en) * 1996-11-08 2000-01-11 Synsorb Biotech, Inc. Solid support matrices containing a toxin binding oligosaccharide
US5932554A (en) * 1996-11-14 1999-08-03 Synsorb Biotech, Inc. 1-galactose derivatives
US5968907A (en) * 1996-11-14 1999-10-19 Synsorb Biotech, Inc. 1-thiogalactose derivatives
US6087339A (en) * 1996-11-14 2000-07-11 Synsorb Biotech, Inc. Saccharide derivatives
US6063769A (en) * 1996-11-14 2000-05-16 Synsorb Biotech, Inc. 1-thiogalactose derivatives
WO1998022487A1 (en) * 1996-11-15 1998-05-28 Synsorb Biotech, Inc. Combinatorial synthesis of carbohydrate libraries
US5965719A (en) * 1996-11-15 1999-10-12 Sunsorb Biotech, Inc. Combinatorial synthesis of carbohydrate libraries
US6096725A (en) * 1997-07-02 2000-08-01 Neose Technologies, Inc. Methods of using αGal oligosaccharides as immune system targeting agents
US20020019991A1 (en) * 1998-04-30 2002-02-14 Abbott Laboratories Compositions containing an alpha 1,2-fucose linkage and uses thereof
US6174867B1 (en) 1998-05-08 2001-01-16 Synsorb Biotech, Inc. 1-galactose derivatives having a carbon- or nitrogen-containing aglycon linkage
US6013635A (en) * 1998-05-28 2000-01-11 Synsorb Biotech, Inc. Treatment of C. difficile toxin B associated conditions
US6358930B1 (en) * 1998-05-28 2002-03-19 Synsorb Biotech Inc. Treatment of C. difficile toxin B associated conditions
US6291435B1 (en) * 1999-03-04 2001-09-18 The Governs Of The University Of Alberta Treatment of diarrhea caused by enteropathogenic Escherichia coli
US6290946B1 (en) * 1999-05-13 2001-09-18 Geltex Pharmaceuticals, Inc. Anionic polymers as toxin binders and antibacterial agents
US6270755B1 (en) 1999-05-13 2001-08-07 Geltex Pharmaceuticals, Inc. Anionic polymers as toxin binders
CA2314494A1 (en) 2000-05-02 2001-11-02 Geltex Pharmaceuticals, Inc. Anionic polymers as species specific antibacterial agents
US6596707B2 (en) * 2001-05-24 2003-07-22 Abbott Laboratories Monovalent saccharides and uses thereof
CA2492211A1 (en) * 2002-07-22 2004-01-29 Genzyme Corporation Poly(potassium and sodium styrene sulfonate), its manufacture and its uses
US7682631B2 (en) * 2003-10-01 2010-03-23 Clemson University Adhesin-specific nanoparticles and process for using same
WO2005055944A2 (en) * 2003-12-05 2005-06-23 Cincinnati Children's Hospital Medical Center Oligosaccharide compositions and use thereof in the treatment of infection
US20060078534A1 (en) * 2004-10-13 2006-04-13 Dominique Charmot Toxin binding compositions
EP1802349A1 (en) * 2004-10-13 2007-07-04 Ilypsa, Inc. Pharmaceutical compositions comprising a toxin-binding oligosaccharide and a polymeric particle
WO2006122835A1 (en) * 2005-05-18 2006-11-23 Da Volterra Colonic delivery of adsorbents
US7915235B2 (en) * 2006-03-20 2011-03-29 Brian Dieckgraefe High affinity ligands bind to clostridium difficile toxin A
WO2007114683A1 (en) * 2006-03-30 2007-10-11 N.V. Nutricia Milk oligosaccharides for stimulating the immune system
US8048413B2 (en) * 2006-05-17 2011-11-01 Helene Huguet Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules
US20080041643A1 (en) * 2006-08-17 2008-02-21 Khalife Tony N Wind-power vehicle aka WPV
JP5766947B2 (en) 2007-09-07 2015-08-19 チルドレンズ ホスピタル メディカル センター Use of secreted Lewis and sialylated antigen levels in clinical samples as predictors of disease risk
EP3248605A1 (en) 2009-07-06 2017-11-29 Children's Hospital Medical Center Inhibiting inflammation with milk oligosaccharides
WO2014130789A1 (en) 2013-02-21 2014-08-28 Children's Hospital Medical Center Use of glycans and glycosyltransferases for diagnosing/monitoring inflammatory bowel disease
WO2016176484A1 (en) 2015-04-28 2016-11-03 Children's Hospital Medical Center Use of oligosaccharide compositions to enhance weight gain
CN108977497A (en) * 2018-06-12 2018-12-11 深圳市领治医学科技有限公司 A method of acquisition and depositary's trace fecal sample

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1544908A (en) * 1975-07-08 1979-04-25 Chembiomed Ltd Artificial oligosaccharide antigenic determinants
DE2857790C2 (en) * 1977-04-14 1983-12-22 Chembiomed Ltd., Edmonton, Alberta Process for the preparation of O-protected 2-azido-2-deoxy-glycosyl halides, some such compounds as such and their use
US4362720A (en) * 1977-04-14 1982-12-07 Chembiomed Ltd. Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-deoxyglycosides from glycals
US4713240A (en) * 1985-04-04 1987-12-15 Research Corporation Vaccines based on insoluble supports
US4863852A (en) * 1985-07-03 1989-09-05 Virginia Tech Intellectual Properties, Inc. Method of detecting, isolating and purifying clostridium difficile toxin A and its receptors
US5079353A (en) * 1987-12-02 1992-01-07 Chembiomed, Ltd. Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation
US5098826A (en) * 1990-03-09 1992-03-24 Virginia Tech Intellectual Properties, Inc. Detection, isolation and purification of Clostridium difficile toxin A with toxin receptors
US5266315A (en) * 1990-05-07 1993-11-30 Kabushiki Kaisha Miyarisan Seibutsu Igaku Kenkyusho Composite for Clostridium difficile diarrhea and pseudomembranous colitis
EP1018342A3 (en) * 1991-10-18 2001-04-11 SYNSORB Biotech Inc. Diagnosis and treatment of bacterial dysentery

Similar Documents

Publication Publication Date Title
WO1995021628B1 (en) Treatment of antibiotic associated diarrhea
CA2181359A1 (en) Treatment of antibiotic associated diarrhea
Malabarba et al. Glycopeptide derivatives
CA2118757A1 (en) Aza cyclohexapeptide compounds
WO2000059528A8 (en) Desleucyl glycopeptide antibiotics and methods of making same
WO1994008624A3 (en) Therapeutic and diagnostic imaging compositions and methods
EP1089740B8 (en) Compositions for the treatment of cdad initiated by c. difficile toxin b
CA2243504A1 (en) New 19-nor-pregnene derivatives
HUT71678A (en) Polymer-bound camptothecin derivatives
IL134056A0 (en) Pharmaceutical compositions containing lysostaphin alone or in combination with an antibiotic for the treatment of staphylococcal infections
WO2001010951A8 (en) Antistatic styrene polymer compositions
CA2053832A1 (en) Stable Plasticizers for Nitrocellulose/Nitroguanidine-Type Compositions
IL117656A (en) Pharmaceutical compositions comprising a supported saccharide for the treatment of travellers' diarrhea caused by E.coli LT enterotoxin
WO1998056398A3 (en) A method for the treatment of diarrheal disease and for eliminating particular bacterial populations from the colon
ES8705893A1 (en) Basic monocarboxyamide derivatives of actagardine having antibiotic activity.
CA2251086A1 (en) Glycopeptide compounds
NZ332976A (en) Solid support matrices containing a toxin binding oligosaccharide
NZ302632A (en) Treatment of traveller's diarrhea using a pharmaceutical composition containing a saccharide sequence
Ahrendt et al. Identification of potent and broad-spectrum antibiotics from SAR studies of a synthetic vancomycin analogue
WO2004056849B1 (en) Methanobactin: a copper binding compound having antibiotic and antioxidant activity isolated from methanotrophic bacteria
WO2001032219A3 (en) Treatment of c. difficile toxin b associated conditions
CA2136438A1 (en) Anthracycline conjugates, their preparation and their use as antitumor agents
CA2106675A1 (en) Enzymatic process for the preparation of macrolactone
NZ504303A (en) Compounds and methods for the e coli mediated dysentery using antibiotics and shiga like toxin binding oligosaccharide compositions
EP0326873A3 (en) Teicoplanin hydrazides