WO1995021628B1 - Treatment of antibiotic associated diarrhea - Google Patents
Treatment of antibiotic associated diarrheaInfo
- Publication number
- WO1995021628B1 WO1995021628B1 PCT/CA1995/000060 CA9500060W WO9521628B1 WO 1995021628 B1 WO1995021628 B1 WO 1995021628B1 CA 9500060 W CA9500060 W CA 9500060W WO 9521628 B1 WO9521628 B1 WO 9521628B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- oligosaccharide sequence
- oligosaccharide
- treatment
- associated diarrhea
- Prior art date
Links
- 206010012735 Diarrhoea Diseases 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 claims abstract 7
- 150000002482 oligosaccharides Polymers 0.000 claims abstract 7
- 101700023105 3L21 Proteins 0.000 claims abstract 3
- 101700012833 3S11 Proteins 0.000 claims abstract 3
- 101700057439 TOXA Proteins 0.000 claims abstract 3
- 101700041767 ctxA Proteins 0.000 claims abstract 3
- 150000001720 carbohydrates Chemical group 0.000 claims 2
- 125000001151 peptidyl group Chemical group 0.000 claims 2
- 210000001035 Gastrointestinal Tract Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 241000193163 Clostridioides difficile Species 0.000 abstract 3
- 206010009657 Clostridium difficile colitis Diseases 0.000 abstract 2
- 206010037128 Pseudomembranous colitis Diseases 0.000 abstract 2
- 230000005591 charge neutralization Effects 0.000 abstract 1
- 201000008286 diarrhea Diseases 0.000 abstract 1
- 230000001264 neutralization Effects 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 229920001542 oligosaccharide Polymers 0.000 abstract 1
Abstract
This invention relates to treatment of antibiotic associated diarrhea, including Clostridium difficile associated diarrhea (CDAD) and pseudomembranous colitis (PMC), using oligosaccharide compositions which bind C. difficile toxin A. More specifically, the invention concerns neutralization of C. difficile toxin A associated with CDAD.
Claims
AMENDED CLAIMS
[received by the International Bureau on 9 August 1995 (09.08.95);
original claims 14 and 15 amended; remaining claims unchanged (1 page)] support through a non-peptidyl compatible linker arm, wherein said oligosaccharide sequence binds toxin A; and b) a pharmaceutically acceptable carrier, wherein said composition is capable of being eliminated from the gastrointestinal tract.
14. The composition of Claim 13 wherein said oligosaccharide sequence has from 2 to 10 saccharide units. 15. The composition of Claim 13 wherein said oligosaccharide sequence has from 3 to 5 saccharide units.
16. The composition of Claim 13 wherein said oligosaccharide sequence is selected from the group consisting of the oligosaccharide structures numbers 1-3, 5-7, and 9-13 set forth in Table 1.
17. The composition of Claim 13 wherein said oligosaccharide sequence covalently attached to said pharmaceutically acceptable solid, inert support through a non-peptidyl compatible linker arm is selected from the group consisting of the SYNSCRBs 2, 5, 9, 51, 52, 68, 90, 104, 105, 115, and 134 set forth in Table 1,
18. The composition of Claim 13 wherein said linker arm is -{CH2)8C{O)-.
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002181359A CA2181359C (en) | 1994-02-14 | 1995-02-09 | Treatment of antibiotic associated diarrhea |
AT95907526T ATE267614T1 (en) | 1994-02-14 | 1995-02-09 | TREATMENT OF ANTIBIOTIC-ASSOCIATED DIARRHEA |
AU15727/95A AU698275B2 (en) | 1994-02-14 | 1995-02-09 | Treatment of antibiotic associated diarrhea |
JP52086995A JP4122052B2 (en) | 1994-02-14 | 1995-02-09 | Treatment of antibiotic-related diarrhea |
NZ279180A NZ279180A (en) | 1994-02-14 | 1995-02-09 | Treating clostridium difficile associated diarrhea (cdad) and other antibiotic associated diarrhea using oligosaccharide compositions which bind toxin a |
DE69533084T DE69533084T2 (en) | 1994-02-14 | 1995-02-09 | TREATMENT OF ANTIBIOTIC ASSOCIATED DIARRHOME |
EP95907526A EP0744959B1 (en) | 1994-02-14 | 1995-02-09 | Treatment of antibiotic associated diarrhea |
NO963378A NO963378D0 (en) | 1994-02-14 | 1996-08-13 | Treatment of antibiotic-associated diarrhea |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/195,009 US5484773A (en) | 1994-02-14 | 1994-02-14 | Treatment of antibiotic associated diarrhea |
US08/195,009 | 1994-02-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1995021628A1 WO1995021628A1 (en) | 1995-08-17 |
WO1995021628B1 true WO1995021628B1 (en) | 1995-08-31 |
Family
ID=22719705
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA1995/000060 WO1995021628A1 (en) | 1994-02-14 | 1995-02-09 | Treatment of antibiotic associated diarrhea |
Country Status (15)
Country | Link |
---|---|
US (2) | US5484773A (en) |
EP (1) | EP0744959B1 (en) |
JP (1) | JP4122052B2 (en) |
KR (1) | KR970701064A (en) |
CN (1) | CN1131070C (en) |
AT (1) | ATE267614T1 (en) |
AU (1) | AU698275B2 (en) |
CA (1) | CA2181359C (en) |
DE (1) | DE69533084T2 (en) |
IL (1) | IL112428A (en) |
MX (1) | MX197129B (en) |
NO (1) | NO963378D0 (en) |
NZ (1) | NZ279180A (en) |
WO (1) | WO1995021628A1 (en) |
ZA (1) | ZA95630B (en) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1018342A3 (en) * | 1991-10-18 | 2001-04-11 | SYNSORB Biotech Inc. | Diagnosis and treatment of bacterial dysentery |
DE4428056A1 (en) * | 1994-07-29 | 1996-02-08 | Schering Ag | Use of microparticle preparations to eliminate dissolved, non-renal substances from the blood |
US6140045A (en) * | 1995-03-10 | 2000-10-31 | Meso Scale Technologies | Multi-array, multi-specific electrochemiluminescence testing |
US5627163A (en) * | 1995-06-05 | 1997-05-06 | Synsorb Biotech, Inc. | Treatment of traveller's diarrhea |
US5661131A (en) * | 1995-06-05 | 1997-08-26 | Synsorb Biotech, Inc. | Treatment of cholera |
US5811409A (en) * | 1995-06-05 | 1998-09-22 | Synsorb Biotech, Inc. | Treatment of cholera |
US5637576A (en) * | 1995-06-05 | 1997-06-10 | Synsorb Biotech, Inc. | Treatment of traveller's diarrhea |
US5736533A (en) * | 1995-06-07 | 1998-04-07 | Neose Technologies, Inc. | Bacterial inhibition with an oligosaccharide compound |
US5891860A (en) * | 1996-03-11 | 1999-04-06 | Synsorb Biotech, Inc. | Treatment of traveller's diarrhea |
US6069137A (en) * | 1996-03-11 | 2000-05-30 | Synsorb Biotech, Inc. | Treatment of traveller's diarrhea |
JPH107575A (en) * | 1996-06-21 | 1998-01-13 | Synsorb Biotec Inc | Treatment for bacillary dysentery |
US5846943A (en) * | 1996-11-08 | 1998-12-08 | Synsorb Biotech, Inc. | Solid support matricles containing a toxin binding oligosaccharide |
US6013634A (en) * | 1996-11-08 | 2000-01-11 | Synsorb Biotech, Inc. | Solid support matrices containing a toxin binding oligosaccharide |
US5932554A (en) * | 1996-11-14 | 1999-08-03 | Synsorb Biotech, Inc. | 1-galactose derivatives |
US5968907A (en) * | 1996-11-14 | 1999-10-19 | Synsorb Biotech, Inc. | 1-thiogalactose derivatives |
US6087339A (en) * | 1996-11-14 | 2000-07-11 | Synsorb Biotech, Inc. | Saccharide derivatives |
US6063769A (en) * | 1996-11-14 | 2000-05-16 | Synsorb Biotech, Inc. | 1-thiogalactose derivatives |
WO1998022487A1 (en) * | 1996-11-15 | 1998-05-28 | Synsorb Biotech, Inc. | Combinatorial synthesis of carbohydrate libraries |
US5965719A (en) * | 1996-11-15 | 1999-10-12 | Sunsorb Biotech, Inc. | Combinatorial synthesis of carbohydrate libraries |
US6096725A (en) * | 1997-07-02 | 2000-08-01 | Neose Technologies, Inc. | Methods of using αGal oligosaccharides as immune system targeting agents |
US20020019991A1 (en) * | 1998-04-30 | 2002-02-14 | Abbott Laboratories | Compositions containing an alpha 1,2-fucose linkage and uses thereof |
US6174867B1 (en) | 1998-05-08 | 2001-01-16 | Synsorb Biotech, Inc. | 1-galactose derivatives having a carbon- or nitrogen-containing aglycon linkage |
US6013635A (en) * | 1998-05-28 | 2000-01-11 | Synsorb Biotech, Inc. | Treatment of C. difficile toxin B associated conditions |
US6358930B1 (en) * | 1998-05-28 | 2002-03-19 | Synsorb Biotech Inc. | Treatment of C. difficile toxin B associated conditions |
US6291435B1 (en) * | 1999-03-04 | 2001-09-18 | The Governs Of The University Of Alberta | Treatment of diarrhea caused by enteropathogenic Escherichia coli |
US6290946B1 (en) * | 1999-05-13 | 2001-09-18 | Geltex Pharmaceuticals, Inc. | Anionic polymers as toxin binders and antibacterial agents |
US6270755B1 (en) | 1999-05-13 | 2001-08-07 | Geltex Pharmaceuticals, Inc. | Anionic polymers as toxin binders |
CA2314494A1 (en) | 2000-05-02 | 2001-11-02 | Geltex Pharmaceuticals, Inc. | Anionic polymers as species specific antibacterial agents |
US6596707B2 (en) * | 2001-05-24 | 2003-07-22 | Abbott Laboratories | Monovalent saccharides and uses thereof |
CA2492211A1 (en) * | 2002-07-22 | 2004-01-29 | Genzyme Corporation | Poly(potassium and sodium styrene sulfonate), its manufacture and its uses |
US7682631B2 (en) * | 2003-10-01 | 2010-03-23 | Clemson University | Adhesin-specific nanoparticles and process for using same |
WO2005055944A2 (en) * | 2003-12-05 | 2005-06-23 | Cincinnati Children's Hospital Medical Center | Oligosaccharide compositions and use thereof in the treatment of infection |
US20060078534A1 (en) * | 2004-10-13 | 2006-04-13 | Dominique Charmot | Toxin binding compositions |
EP1802349A1 (en) * | 2004-10-13 | 2007-07-04 | Ilypsa, Inc. | Pharmaceutical compositions comprising a toxin-binding oligosaccharide and a polymeric particle |
WO2006122835A1 (en) * | 2005-05-18 | 2006-11-23 | Da Volterra | Colonic delivery of adsorbents |
US7915235B2 (en) * | 2006-03-20 | 2011-03-29 | Brian Dieckgraefe | High affinity ligands bind to clostridium difficile toxin A |
WO2007114683A1 (en) * | 2006-03-30 | 2007-10-11 | N.V. Nutricia | Milk oligosaccharides for stimulating the immune system |
US8048413B2 (en) * | 2006-05-17 | 2011-11-01 | Helene Huguet | Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules |
US20080041643A1 (en) * | 2006-08-17 | 2008-02-21 | Khalife Tony N | Wind-power vehicle aka WPV |
JP5766947B2 (en) | 2007-09-07 | 2015-08-19 | チルドレンズ ホスピタル メディカル センター | Use of secreted Lewis and sialylated antigen levels in clinical samples as predictors of disease risk |
EP3248605A1 (en) | 2009-07-06 | 2017-11-29 | Children's Hospital Medical Center | Inhibiting inflammation with milk oligosaccharides |
WO2014130789A1 (en) | 2013-02-21 | 2014-08-28 | Children's Hospital Medical Center | Use of glycans and glycosyltransferases for diagnosing/monitoring inflammatory bowel disease |
WO2016176484A1 (en) | 2015-04-28 | 2016-11-03 | Children's Hospital Medical Center | Use of oligosaccharide compositions to enhance weight gain |
CN108977497A (en) * | 2018-06-12 | 2018-12-11 | 深圳市领治医学科技有限公司 | A method of acquisition and depositary's trace fecal sample |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1544908A (en) * | 1975-07-08 | 1979-04-25 | Chembiomed Ltd | Artificial oligosaccharide antigenic determinants |
DE2857790C2 (en) * | 1977-04-14 | 1983-12-22 | Chembiomed Ltd., Edmonton, Alberta | Process for the preparation of O-protected 2-azido-2-deoxy-glycosyl halides, some such compounds as such and their use |
US4362720A (en) * | 1977-04-14 | 1982-12-07 | Chembiomed Ltd. | Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-deoxyglycosides from glycals |
US4713240A (en) * | 1985-04-04 | 1987-12-15 | Research Corporation | Vaccines based on insoluble supports |
US4863852A (en) * | 1985-07-03 | 1989-09-05 | Virginia Tech Intellectual Properties, Inc. | Method of detecting, isolating and purifying clostridium difficile toxin A and its receptors |
US5079353A (en) * | 1987-12-02 | 1992-01-07 | Chembiomed, Ltd. | Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation |
US5098826A (en) * | 1990-03-09 | 1992-03-24 | Virginia Tech Intellectual Properties, Inc. | Detection, isolation and purification of Clostridium difficile toxin A with toxin receptors |
US5266315A (en) * | 1990-05-07 | 1993-11-30 | Kabushiki Kaisha Miyarisan Seibutsu Igaku Kenkyusho | Composite for Clostridium difficile diarrhea and pseudomembranous colitis |
EP1018342A3 (en) * | 1991-10-18 | 2001-04-11 | SYNSORB Biotech Inc. | Diagnosis and treatment of bacterial dysentery |
-
1994
- 1994-02-14 US US08/195,009 patent/US5484773A/en not_active Expired - Lifetime
-
1995
- 1995-01-24 IL IL11242895A patent/IL112428A/en active IP Right Grant
- 1995-01-26 ZA ZA95630A patent/ZA95630B/en unknown
- 1995-02-09 AU AU15727/95A patent/AU698275B2/en not_active Ceased
- 1995-02-09 WO PCT/CA1995/000060 patent/WO1995021628A1/en active IP Right Grant
- 1995-02-09 JP JP52086995A patent/JP4122052B2/en not_active Expired - Fee Related
- 1995-02-09 CA CA002181359A patent/CA2181359C/en not_active Expired - Fee Related
- 1995-02-09 AT AT95907526T patent/ATE267614T1/en not_active IP Right Cessation
- 1995-02-09 NZ NZ279180A patent/NZ279180A/en unknown
- 1995-02-09 DE DE69533084T patent/DE69533084T2/en not_active Expired - Fee Related
- 1995-02-09 EP EP95907526A patent/EP0744959B1/en not_active Expired - Lifetime
- 1995-02-09 CN CN95191615A patent/CN1131070C/en not_active Expired - Fee Related
- 1995-05-25 US US08/450,572 patent/US5635606A/en not_active Expired - Fee Related
-
1996
- 1996-08-13 KR KR19967004399A patent/KR970701064A/en unknown
- 1996-08-13 MX MX9603403A patent/MX197129B/en unknown
- 1996-08-13 NO NO963378A patent/NO963378D0/en not_active Application Discontinuation
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