WO1995021607A1 - Controlled release hydrogel formulation - Google Patents
Controlled release hydrogel formulation Download PDFInfo
- Publication number
- WO1995021607A1 WO1995021607A1 PCT/US1995/000717 US9500717W WO9521607A1 WO 1995021607 A1 WO1995021607 A1 WO 1995021607A1 US 9500717 W US9500717 W US 9500717W WO 9521607 A1 WO9521607 A1 WO 9521607A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- drug
- hydrogel
- pharmaceutical composition
- ionizable compound
- release
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
Definitions
- the present invention is concerned with a hydrogel based pharmaceutical dosage system that provides sustained release of pharmaceuticals without the need to use special coatings or structures that add to the cost of making a sustained release formulation.
- the in vitro release rates are not zero-order release rates because the initial rate of release of the drug tends to be much higher than the subsequent rate of release of the drug.
- hydrogels have been used to prepare sustained release formulations. These formulations have commonly exhibited an "initial burst effect" which causes a non-linear release rate of a drug. In order to avoid the initial burst effect, hydrogels have been used in combination with mechanical devices and polymeric coatings to control the rate of drug release in order to modify the release rate characteristics and provide a substantially zero-order controlled release formulation.
- the present invention provides a method for modifying the release characteristics of a hydrogel by adding an effective amount of an ionizable compound to the hydrogel and drug formulation.
- the invention comprises a method for the modification of the rate of release of a drug from a hydrogel which is based on the use of an effective amount of a pharmaceutically acceptable ionizable compound that is capable of providing a substantially zero-order release rate of drug from the hydrogel.
- Figure 1 is a graphical representation of the release rates of tablets of diltiazem hydrochloride which are based on unmodified hydrogel, i.e., hydroxypropylmethyl cellulose and modified hydrogel which that has been modified by the addition of certain ionizable compounds that are capable of modifying the rate of release of a drug from a hydrogel.
- Figure 2 is a graphical representation of the release rate of a tablet prepared as described in Example 2.
- the hydrogel that is the basis of the formulation of the present invention is any hydrogel which causes a drug to exhibit a substantially zero-order release rate when the hydrogel is modified by the addition of an effective amount of a non-toxic, pharmaceutically acceptable ionizable compound which is capable of modifying the release rate of the drug from the hydrogel.
- Suitable hydrogels include hydroxypropylmethyl cellulose, sodium alginate, xanthan gum and the like.
- the ionizable compound may be any non-toxic inorganic or organic compound that is compatible with the hydrogel and affects the dissolution rate of a tabletted drug that includes a drug, a hydrogel and said ionizable compound.
- the ionizable compound should have a pH in water of from about 2 to not greater than about 11 and preferably a pH of from 4-8 when one molar equivalent is dissolved in 1 liter of water.
- the ionizable compounds include alkali metal chlorides, magnesium chloride, calcium chloride, organic acids such as citric, succinic, fumaric, malic, maleic, glutaric, lactic and the like, alkali metal sulfates such as sodium sulfate, alkali metal alkyl sulfates wherein the alkyl group is from 1 to 14 carbon atoms, such as sodium methyl sulfate, sodium lauryl sulfate and the like as well as dioctyl sodium sulfosuccinate, dihydrogen sodium phosphate and monohydrogen sodium phosphate. It is to be understood that the ionizable compound may be a single compound or a mixture of two or more materials that provide the desired release characteristics.
- any drug may be used in the practice of the invention which is compatible with the hydrogel and exhibits a substantially zero-order controlled release when tabletted with the hydrogel and an effective amount of the non-toxic, pharmaceutically acceptable ionizable compound.
- drugs that may be utilized are the calcium channel blocking drugs such as diltiazem hydrochloride and verapamil hydrochloride.
- the dosages to be employed are sufficient to maintain a therapeutic level of the drug in a patient.
- the amount of the ionizable compound that is employed will be between 1 and 50% and preferably 5 to 15% by total weight of the hydrogel forming material, the drug and the ionizable compound.
- the drug will generally be from 10 to 90% by total weight of the hydrogel forming material, the drugand the ionizable compound.
- the hydrogel will be the difference of the total weight of the formulation less the combined weight of the drug and the ionizable compound.
- hydroxypropylmethyl cellulose and sodium chloride are employed to prepare a tablet formulation of diltiazem, it has been found that a blend of 26.09g of diltiazem hydrochloride; 6.5g of sodium chloride; 3g of sodium lauryl sulfate and 30g of hydroxypropylmethyl cellulose may be employed to provide a substantially zero-order release tablet.
- the amount of the hydrogel and the ionizable compound that are used may be determined by preparing a series of tablets using varying amounts of hydrogel and ionizable compound in combination with the selected drug.
- the release characteristics may be determined separately using simulated gastric fluid (pH 1.2- without enzymes) ;simulated intestinal fluid (pH 7.5-without enzymes) and a pH 6.2 buffer solution.
- the "paddle method" from USP XXII which is incorporated by reference, may be used to determine the release characteristics of a given formulation and by the addition of or subtraction of increasing amounts of the ionizable compound to a particular tablet formulation, the release curve for a particular drug may be shifted to a zero-order release product.
- compositions of the invention will contain an effective amount of the drug and an amount of the hydrogel and ionizable compound that may be made into tablets which will have a substantially zero-order release of the selected drug.
- the tabletted product may contain an inert solid diluent such as lactose, dextrose, maltose, fructose, corn starch, rice starch and the like.
- Other conventional additives such as binding agents such as polyvinylpyrrolidoine, starch, gelatin, microcrystalline cellulose and the like may be added to the tablet formulation.
- coloring agents such as stearic acid, palmitic acid, magnesium stearate, and the like may be added to the tabletting composition in amounts which are determined to produce the desired effect. Tablets may be made using conventional tabletting machines and appropriately sized dies.
- Blend A A blend of diltiazem hydrochloride dispersed in hydroxypropylmethyl cellulose (HPMC) (100,000cps as measured in a 2wt% solution in water) was prepared by first separately passing the ingredients through a #40 US Standard mesh sieve and thereafter blending the mixture in a V-blender for 5 minutes.
- HPMC hydroxypropylmethyl cellulose
- HPMC Metal stearate 27.0wt% Lactose,Anhydrous 35.1wt% Magnesium stearate 1.0wt%
- the powder was blended and compressed into capsule shaped tablets (0.70" x 0.29") with the compression set at twotons.
- An in vitro dissolution test was carried out separately using 900ml of an enzyme free simulated gastricfluid (pH 1.2); 900ml of an enzyme free simulatedintestinal fluid (pH 7.5) and a buffer solution (pH 6.2) substantially as described in USP XXII.
- the USPXXII method that was used was apparatus No. 2.
- the dissolution curve was prepared by determining at preset intervals the amount of dissolved diltiazem.
- Fig. 1 The results are shown on Fig. 1 as curve A.
- tablets were prepared which contained 10% by weight of sodium chloride (B); 10% by weight of Na HPO (C) : 10% by weight of sodium lauryl sulfate (D) in place of 10% by weight of the anhydrous lactose that was employed in Blend A.
- the dissolution characteristics were determined according to the procedure set forth above and the characteristics are curves B, C and D of Fig. 1, respectively.
- the presence of the ionizable compound has the effect of flattening the release curve by preventing the initial burst of the active drug which results when a tablet, made from unmodified HPMC, is employed with diltiazem hydrochloride.
- Example 2 The ingredients were blended and compressed into 0.28" round tablets using the procedure described in Example 1. The tablets were tested according to the procedure of Example 1 and the dissolution curve is set forth in Fig. 2. The results show that the tablets produced according to Example 2 have a substantially zero-order release rate.
- Verapamil HC1 40.00wt.% HPMC 22.22wt.%
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002182587A CA2182587A1 (en) | 1994-02-14 | 1995-01-18 | Controlled release hydrogel formulation |
EP95908570A EP0744942B1 (en) | 1994-02-14 | 1995-01-18 | Controlled release hydrogel formulation |
DE69527509T DE69527509T2 (en) | 1994-02-14 | 1995-01-18 | HYDROGEL FORMULATION WITH CONTROLLED RELEASE |
AU16836/95A AU680112B2 (en) | 1994-02-14 | 1995-01-18 | Controlled release hydrogel formulation |
JP7521221A JPH10500658A (en) | 1994-02-14 | 1995-01-18 | Hydrogel formulations with controlled release |
AT95908570T ATE220896T1 (en) | 1994-02-14 | 1995-01-18 | CONTROLLED RELEASE HYDROGEL FORMULATION |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/195,377 | 1994-02-14 | ||
US08/195,377 US5419917A (en) | 1994-02-14 | 1994-02-14 | Controlled release hydrogel formulation |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1995021607A1 true WO1995021607A1 (en) | 1995-08-17 |
Family
ID=22721188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1995/000717 WO1995021607A1 (en) | 1994-02-14 | 1995-01-18 | Controlled release hydrogel formulation |
Country Status (10)
Country | Link |
---|---|
US (1) | US5419917A (en) |
EP (1) | EP0744942B1 (en) |
JP (1) | JPH10500658A (en) |
AT (1) | ATE220896T1 (en) |
AU (1) | AU680112B2 (en) |
CA (1) | CA2182587A1 (en) |
DE (1) | DE69527509T2 (en) |
NZ (1) | NZ279648A (en) |
TW (1) | TW340045B (en) |
WO (1) | WO1995021607A1 (en) |
Cited By (2)
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WO1999030714A1 (en) * | 1997-12-17 | 1999-06-24 | Nikken Chemicals Co., Ltd. | Sustained-release theophylline preparation and process for producing the same |
WO2008154339A2 (en) * | 2007-06-08 | 2008-12-18 | Addrenex Pharmaceuticals, Inc. | Extended release formulation and method of treating adrenergic dysregulation |
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-
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- 1995-01-18 AT AT95908570T patent/ATE220896T1/en active
- 1995-01-18 EP EP95908570A patent/EP0744942B1/en not_active Revoked
- 1995-01-18 JP JP7521221A patent/JPH10500658A/en active Pending
- 1995-01-18 WO PCT/US1995/000717 patent/WO1995021607A1/en not_active Application Discontinuation
- 1995-01-18 CA CA002182587A patent/CA2182587A1/en not_active Abandoned
- 1995-01-18 AU AU16836/95A patent/AU680112B2/en not_active Ceased
- 1995-01-18 DE DE69527509T patent/DE69527509T2/en not_active Expired - Fee Related
- 1995-01-18 NZ NZ279648A patent/NZ279648A/en unknown
- 1995-02-07 TW TW084100943A patent/TW340045B/en active
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999030714A1 (en) * | 1997-12-17 | 1999-06-24 | Nikken Chemicals Co., Ltd. | Sustained-release theophylline preparation and process for producing the same |
WO2008154339A2 (en) * | 2007-06-08 | 2008-12-18 | Addrenex Pharmaceuticals, Inc. | Extended release formulation and method of treating adrenergic dysregulation |
WO2008154339A3 (en) * | 2007-06-08 | 2009-07-30 | Addrenex Pharmaceuticals Inc | Extended release formulation and method of treating adrenergic dysregulation |
US7884122B2 (en) | 2007-06-08 | 2011-02-08 | Shionogi Pharma, Inc. | Extended release formulation and method of treating adrenergic dysregulation |
Also Published As
Publication number | Publication date |
---|---|
US5419917A (en) | 1995-05-30 |
ATE220896T1 (en) | 2002-08-15 |
AU680112B2 (en) | 1997-07-17 |
DE69527509T2 (en) | 2003-02-27 |
EP0744942A4 (en) | 1997-11-12 |
DE69527509D1 (en) | 2002-08-29 |
AU1683695A (en) | 1995-08-29 |
EP0744942B1 (en) | 2002-07-24 |
JPH10500658A (en) | 1998-01-20 |
NZ279648A (en) | 1997-06-24 |
CA2182587A1 (en) | 1995-08-17 |
EP0744942A1 (en) | 1996-12-04 |
TW340045B (en) | 1998-09-11 |
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