WO1995017965A1 - Dispositifs a ecoulement de sous-surface et leur utilisation pour effectuer des titrages - Google Patents

Dispositifs a ecoulement de sous-surface et leur utilisation pour effectuer des titrages Download PDF

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Publication number
WO1995017965A1
WO1995017965A1 PCT/US1994/014510 US9414510W WO9517965A1 WO 1995017965 A1 WO1995017965 A1 WO 1995017965A1 US 9414510 W US9414510 W US 9414510W WO 9517965 A1 WO9517965 A1 WO 9517965A1
Authority
WO
WIPO (PCT)
Prior art keywords
layer
drop
capillary track
track
capillary
Prior art date
Application number
PCT/US1994/014510
Other languages
English (en)
Inventor
Marvin Berman
Kevin J. Forney
Jill M. Geist
Jacqueline J. Korn
Thomas J. Langner
Neil W. Loomis
Laura S. Morici
Andrew J. Muetterties
Robert G. Parsons
Jill M. Putman
Paul J. Ropella
Thomas G. Schapira
Neal A. Siegel
Brian K. Wagner
Bob O. Basore
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Priority to AU14379/95A priority Critical patent/AU1437995A/en
Priority to JP7518094A priority patent/JPH09508200A/ja
Priority to EP95905970A priority patent/EP0737104A1/fr
Publication of WO1995017965A1 publication Critical patent/WO1995017965A1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/521—Single-layer analytical elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip

Abstract

L'invention vise à améliorer les performances d'opérations de titrage à l'aide d'un dispositif de titrage jetable qui comprend un matériau poreux (20) mis en communication liquide avec une voie capillaire (18). L'invention se caractérise en ce que la voie capillaire (18) est utilisée conjointement avec le support solide pour diriger les échantillons d'essai et les réactifs de titrage directement vers un site de réaction (22) défini ou dans le matériau poreux (20). Un signal produit au niveau du site de réaction (22) indique le résultat du titrage. L'invention concerne également la réalisation d'un dispositif de titrage (10) jetable comprenant une voie capillaire (18). Plus particulièrement, la voie capillaire est formée par impression d'un matériau (25a) insoluble dans les fluides, sous forme d'une image inversée de la voie capillaire (18) voulue, sur une pellicule (23), puis par recouvrement du matériau imprimé. Selon une variante, la voie capillaire (18) est formée par impression d'un matériau insoluble dans les fluides, sous forme d'image inversée (30) de la voie capillaire (18) voulue, sur un matériau poreux (25b), pris en sandwich entre deux pellicules (23, 26). L'invention concerne en outre un élément de formation de gouttes (50) pouvant comprendre un ou plusieurs réactifs de titrage afin de permettre un meilleur traitement des échantillons, ainsi que l'adjonction de réactifs, des opérations de mélange et d'incubation.
PCT/US1994/014510 1993-12-28 1994-12-16 Dispositifs a ecoulement de sous-surface et leur utilisation pour effectuer des titrages WO1995017965A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU14379/95A AU1437995A (en) 1993-12-28 1994-12-16 Devices having subsurface flow and their use in diagnostic assays
JP7518094A JPH09508200A (ja) 1993-12-28 1994-12-16 表面下流を有する装置及び診断検定におけるその使用
EP95905970A EP0737104A1 (fr) 1993-12-28 1994-12-16 Dispositifs a ecoulement de sous-surface et leur utilisation pour effectuer des titrages

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17465193A 1993-12-28 1993-12-28
US08/174,651 1993-12-28

Publications (1)

Publication Number Publication Date
WO1995017965A1 true WO1995017965A1 (fr) 1995-07-06

Family

ID=22636972

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/014510 WO1995017965A1 (fr) 1993-12-28 1994-12-16 Dispositifs a ecoulement de sous-surface et leur utilisation pour effectuer des titrages

Country Status (5)

Country Link
EP (1) EP0737104A1 (fr)
JP (1) JPH09508200A (fr)
AU (1) AU1437995A (fr)
CA (1) CA2178330A1 (fr)
WO (1) WO1995017965A1 (fr)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2107388A1 (es) * 1995-11-07 1997-11-16 Univ Granada Desarrollo de un kit rapido para el diagnostico de la trichinellosis.
WO1998028441A1 (fr) * 1996-12-23 1998-07-02 bioMérieux Vitek, Inc. Materiau a matrice d'air utilise dans des reactions chimiques
ES2119674A1 (es) * 1996-02-01 1998-10-01 Univ Granada Desarrollo de un kit rapido para el diagnostico de la hidatidosis.
WO2000042430A1 (fr) * 1999-01-15 2000-07-20 Medtox Scientific, Inc. Bande de test a ecoulement lateral
WO2001024931A1 (fr) * 1999-10-05 2001-04-12 Roche Diagnostic Gmbh Dispositif capillaire de separation de composants non desires d'un echantillon liquide et procede relatif
EP1327474A1 (fr) * 2000-09-22 2003-07-16 Kawamura Institute Of Chemical Research Tres petit dispositif chimique et procede de reglage du debit de celui-ci
WO2005080978A1 (fr) * 2004-02-25 2005-09-01 Roche Diagnostics Gmbh Element d'essai a tube capillaire pour le transport d'un echantillon liquide
EP1895308A1 (fr) * 2006-09-01 2008-03-05 Agilent Technologies, Inc. Couplage fluidique à base de gouttelettes
WO2009126252A1 (fr) * 2008-04-09 2009-10-15 Corning Incorporated Micro-article et son procédé de fabrication
WO2010007613A1 (fr) * 2008-06-29 2010-01-21 Realbio Technologies Ltd. Dispositif de transfert de liquide particulièrement utile comme dispositif de capture dans un processus de dosage biologique
US8337775B2 (en) 2002-02-26 2012-12-25 Siemens Healthcare Diagnostics, Inc. Apparatus for precise transfer and manipulation of fluids by centrifugal and or capillary forces
US9726581B2 (en) 2011-12-22 2017-08-08 Realbio Technologies Ltd. Sequential lateral flow capillary device for analyte determination
US10335783B2 (en) 2005-01-31 2019-07-02 Realbio Technologies, Ltd. Multistep reaction lateral flow capillary device
CN111595836A (zh) * 2020-04-16 2020-08-28 四川轻化工大学 手持式气液相界面化学发光检测笔、装置、系统及其检测方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE358274T1 (de) * 2001-12-12 2007-04-15 Proteome Systems Intellectual Diagnostisches testverfahren

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010456A1 (fr) * 1978-10-25 1980-04-30 EASTMAN KODAK COMPANY (a New Jersey corporation) Dispositif de transport d'un liquide
US4933092A (en) * 1989-04-07 1990-06-12 Abbott Laboratories Methods and devices for the separation of plasma or serum from whole blood
EP0398739A2 (fr) * 1989-05-18 1990-11-22 Quidel Corporation Tube applicateur avec un filtre
WO1992007655A1 (fr) * 1990-10-30 1992-05-14 Hypoguard (Uk) Limited Dispositif de recueil et de presentation
WO1992008972A1 (fr) * 1990-11-16 1992-05-29 Abbott Laboratories Dispositif de reaction d'agglutination ameliore dote de chambres geometriquement modifiees
WO1993020939A1 (fr) * 1992-04-10 1993-10-28 Biotrack, Inc. Cartouche d'analyse et systeme de detection de produits d'analyse
WO1994009366A1 (fr) * 1992-10-08 1994-04-28 Abbott Laboratories Dispositifs de titrage a ecoulement de sous-surface

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010456A1 (fr) * 1978-10-25 1980-04-30 EASTMAN KODAK COMPANY (a New Jersey corporation) Dispositif de transport d'un liquide
US4933092A (en) * 1989-04-07 1990-06-12 Abbott Laboratories Methods and devices for the separation of plasma or serum from whole blood
EP0398739A2 (fr) * 1989-05-18 1990-11-22 Quidel Corporation Tube applicateur avec un filtre
WO1992007655A1 (fr) * 1990-10-30 1992-05-14 Hypoguard (Uk) Limited Dispositif de recueil et de presentation
WO1992008972A1 (fr) * 1990-11-16 1992-05-29 Abbott Laboratories Dispositif de reaction d'agglutination ameliore dote de chambres geometriquement modifiees
WO1993020939A1 (fr) * 1992-04-10 1993-10-28 Biotrack, Inc. Cartouche d'analyse et systeme de detection de produits d'analyse
WO1994009366A1 (fr) * 1992-10-08 1994-04-28 Abbott Laboratories Dispositifs de titrage a ecoulement de sous-surface

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2107388A1 (es) * 1995-11-07 1997-11-16 Univ Granada Desarrollo de un kit rapido para el diagnostico de la trichinellosis.
ES2119674A1 (es) * 1996-02-01 1998-10-01 Univ Granada Desarrollo de un kit rapido para el diagnostico de la hidatidosis.
WO1998028441A1 (fr) * 1996-12-23 1998-07-02 bioMérieux Vitek, Inc. Materiau a matrice d'air utilise dans des reactions chimiques
WO2000042430A1 (fr) * 1999-01-15 2000-07-20 Medtox Scientific, Inc. Bande de test a ecoulement lateral
US6566051B1 (en) 1999-01-15 2003-05-20 Medtox Scientific, Inc. Lateral flow test strip
WO2001024931A1 (fr) * 1999-10-05 2001-04-12 Roche Diagnostic Gmbh Dispositif capillaire de separation de composants non desires d'un echantillon liquide et procede relatif
EP1327474A1 (fr) * 2000-09-22 2003-07-16 Kawamura Institute Of Chemical Research Tres petit dispositif chimique et procede de reglage du debit de celui-ci
EP1327474A4 (fr) * 2000-09-22 2004-12-29 Kawamura Inst Chem Res Tres petit dispositif chimique et procede de reglage du debit de celui-ci
US7238325B2 (en) 2000-09-22 2007-07-03 Kawamura Institute Of Chemical Research Very small chemical device and flow rate adjusting method therefor
US8337775B2 (en) 2002-02-26 2012-12-25 Siemens Healthcare Diagnostics, Inc. Apparatus for precise transfer and manipulation of fluids by centrifugal and or capillary forces
WO2005080978A1 (fr) * 2004-02-25 2005-09-01 Roche Diagnostics Gmbh Element d'essai a tube capillaire pour le transport d'un echantillon liquide
US7901622B2 (en) 2004-02-25 2011-03-08 Roche Diagnostics Operations, Inc. Test element with a capillary for transport of a liquid sample
US10335783B2 (en) 2005-01-31 2019-07-02 Realbio Technologies, Ltd. Multistep reaction lateral flow capillary device
EP1895308A1 (fr) * 2006-09-01 2008-03-05 Agilent Technologies, Inc. Couplage fluidique à base de gouttelettes
WO2009126252A1 (fr) * 2008-04-09 2009-10-15 Corning Incorporated Micro-article et son procédé de fabrication
WO2010007613A1 (fr) * 2008-06-29 2010-01-21 Realbio Technologies Ltd. Dispositif de transfert de liquide particulièrement utile comme dispositif de capture dans un processus de dosage biologique
US9952211B2 (en) 2008-06-29 2018-04-24 Realbio Technologies Ltd. Liquid-transfer device particularly useful as a capturing device in a biological assay process
US11280785B2 (en) 2008-06-29 2022-03-22 Realbio Technologies Ltd. Liquid-transfer device particularly useful as a capturing device in a biological assay process
US9726581B2 (en) 2011-12-22 2017-08-08 Realbio Technologies Ltd. Sequential lateral flow capillary device for analyte determination
US10598572B2 (en) 2011-12-22 2020-03-24 Realbio Technologies, Ltd. Sequential lateral capillary flow device for analyte determination
CN111595836A (zh) * 2020-04-16 2020-08-28 四川轻化工大学 手持式气液相界面化学发光检测笔、装置、系统及其检测方法
CN111595836B (zh) * 2020-04-16 2022-09-30 四川轻化工大学 手持式气液相界面化学发光检测笔、装置、系统及其检测方法

Also Published As

Publication number Publication date
EP0737104A1 (fr) 1996-10-16
AU1437995A (en) 1995-07-17
CA2178330A1 (fr) 1995-07-06
JPH09508200A (ja) 1997-08-19

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