WO1995016696A3 - Modified oligonucleotides, method for producing them and use as active substances - Google Patents

Modified oligonucleotides, method for producing them and use as active substances Download PDF

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Publication number
WO1995016696A3
WO1995016696A3 PCT/AT1994/000195 AT9400195W WO9516696A3 WO 1995016696 A3 WO1995016696 A3 WO 1995016696A3 AT 9400195 W AT9400195 W AT 9400195W WO 9516696 A3 WO9516696 A3 WO 9516696A3
Authority
WO
WIPO (PCT)
Prior art keywords
oligonucleotides
producing
active substances
modified oligonucleotides
modified
Prior art date
Application number
PCT/AT1994/000195
Other languages
German (de)
French (fr)
Other versions
WO1995016696A2 (en
Inventor
Christian Noe
Helmut Brunar
Original Assignee
Christian Noe
Helmut Brunar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Christian Noe, Helmut Brunar filed Critical Christian Noe
Priority to AU11025/95A priority Critical patent/AU1102595A/en
Publication of WO1995016696A2 publication Critical patent/WO1995016696A2/en
Publication of WO1995016696A3 publication Critical patent/WO1995016696A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The invention pertains to 10 to 50-mer oligonucleotides which, with the attachment of appropriate radicals that carry basic groups, are capable of forming amphoteric ions via intramolecular ammonium salts. Oligonucleotides modified in this way do not lose their ability to pair with their complementary strand. Such oligonucleotides can be expected to show a greater nuclease resistance and better membrane penetrability than natural oligonucleotides. This yields important benefits for antisense therapy.
PCT/AT1994/000195 1993-12-13 1994-12-13 Modified oligonucleotides, method for producing them and use as active substances WO1995016696A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU11025/95A AU1102595A (en) 1993-12-13 1994-12-13 Modified oligonucleotides, method for producing them and use as active substances

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0250593A AT407639B (en) 1993-12-13 1993-12-13 MODIFIED OLIGONUCLEOTIDS, METHOD FOR THE PRODUCTION THEREOF AND USE AS ACTIVE SUBSTANCES FOR THE PRODUCTION OF MEDICINAL PRODUCTS
ATA2505/93 1993-12-13

Publications (2)

Publication Number Publication Date
WO1995016696A2 WO1995016696A2 (en) 1995-06-22
WO1995016696A3 true WO1995016696A3 (en) 1995-07-20

Family

ID=3535494

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AT1994/000195 WO1995016696A2 (en) 1993-12-13 1994-12-13 Modified oligonucleotides, method for producing them and use as active substances

Country Status (3)

Country Link
AT (1) AT407639B (en)
AU (1) AU1102595A (en)
WO (1) WO1995016696A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59610423D1 (en) * 1995-02-10 2003-06-12 Christian Noe PARTICULAR MEDICINE

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991010671A1 (en) * 1990-01-11 1991-07-25 Isis Pharmaceuticals, Inc. Compositions and methods for detecting and modulating rna activity and gene expression
WO1993018052A1 (en) * 1992-03-05 1993-09-16 Isis Pharmaceuticals, Inc. Covalently cross-linked oligonucleotides
WO1994002501A1 (en) * 1992-07-23 1994-02-03 Isis Pharmaceuticals, Inc. Novel 2'-o-alkyl nucleosides and phosphoramidites processes for the preparation and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5418290A (en) * 1989-03-31 1990-11-05 University Patents Inc. Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991010671A1 (en) * 1990-01-11 1991-07-25 Isis Pharmaceuticals, Inc. Compositions and methods for detecting and modulating rna activity and gene expression
WO1993018052A1 (en) * 1992-03-05 1993-09-16 Isis Pharmaceuticals, Inc. Covalently cross-linked oligonucleotides
WO1994002501A1 (en) * 1992-07-23 1994-02-03 Isis Pharmaceuticals, Inc. Novel 2'-o-alkyl nucleosides and phosphoramidites processes for the preparation and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MANOHARAN M. ET AL: "NOVEL FUNCTIONALIZATION OF THE SINGLE SUGAR MOIETY OF NUCLEIC ACIDS FOR MULTIPLE LABELING IN THE MINOR GROOVE", TETRAHEDRON LETTERS, vol. 32, no. 49, pages 7171 - 7174 *

Also Published As

Publication number Publication date
ATA250593A (en) 2000-09-15
AU1102595A (en) 1995-07-03
WO1995016696A2 (en) 1995-06-22
AT407639B (en) 2001-05-25

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