WO1995015001A3 - Enhanced resolution maldi tof-ms sample surface - Google Patents

Enhanced resolution maldi tof-ms sample surface Download PDF

Info

Publication number
WO1995015001A3
WO1995015001A3 PCT/US1994/012963 US9412963W WO9515001A3 WO 1995015001 A3 WO1995015001 A3 WO 1995015001A3 US 9412963 W US9412963 W US 9412963W WO 9515001 A3 WO9515001 A3 WO 9515001A3
Authority
WO
WIPO (PCT)
Prior art keywords
matrix
solid
thin layer
substrate
sample surface
Prior art date
Application number
PCT/US1994/012963
Other languages
French (fr)
Other versions
WO1995015001A2 (en
Inventor
Joseph A Jarrell
Michael J Tomany
Craig A Dorschel
Original Assignee
Waters Corp
Joseph A Jarrell
Michael J Tomany
Craig A Dorschel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Waters Corp, Joseph A Jarrell, Michael J Tomany, Craig A Dorschel filed Critical Waters Corp
Priority to EP95902508A priority Critical patent/EP0764264A2/en
Priority to CA002205040A priority patent/CA2205040C/en
Publication of WO1995015001A2 publication Critical patent/WO1995015001A2/en
Publication of WO1995015001A3 publication Critical patent/WO1995015001A3/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0409—Sample holders or containers
    • H01J49/0418—Sample holders or containers for laser desorption, e.g. matrix-assisted laser desorption/ionisation [MALDI] plates or surface enhanced laser desorption/ionisation [SELDI] plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

A thin layer for sample analysis by matrix-assisted laser desorption mass spectrometry, comprising a matrix material in a supported dispersion wherein the support is a solid or is formed from a solid. The invention is also directed to a method of making a thin layer for sample analysis by matrix-assisted laser desorption mass spectrometry, the layer comprising a matrix-solid composition disposed upon a substrate, comprising the step of depositing a solution containing matrix, solid and solvent upon a spinning substrate at a deposition rate sufficient to allow evaporation of the solvent, thereby interspersing the matrix and support on the substrate in a thin layer. Enhanced mass resolution is described.
PCT/US1994/012963 1993-11-12 1994-11-09 Enhanced resolution maldi tof-ms sample surface WO1995015001A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP95902508A EP0764264A2 (en) 1993-11-12 1994-11-09 Enhanced resolution maldi tof-ms sample surface
CA002205040A CA2205040C (en) 1993-11-12 1994-11-09 Enhanced resolution maldi tof-ms sample surface

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15149093A 1993-11-12 1993-11-12
US08/151,490 1993-11-12

Publications (2)

Publication Number Publication Date
WO1995015001A2 WO1995015001A2 (en) 1995-06-01
WO1995015001A3 true WO1995015001A3 (en) 1995-09-21

Family

ID=22538995

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/012963 WO1995015001A2 (en) 1993-11-12 1994-11-09 Enhanced resolution maldi tof-ms sample surface

Country Status (3)

Country Link
EP (1) EP0764264A2 (en)
CA (1) CA2205040C (en)
WO (1) WO1995015001A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19608963C2 (en) * 1995-03-28 2001-03-22 Bruker Daltonik Gmbh Process for ionizing heavy molecules at atmospheric pressure
DE19617011C2 (en) * 1996-04-27 2000-11-02 Bruker Daltonik Gmbh Matrix component mixture for matrix-assisted laser desorption and ionization and method for preparing a matrix component mixture
DE19618032C2 (en) * 1996-05-04 2000-04-13 Bruker Daltonik Gmbh Prepared Maldi sample carriers that can be stored
US6723564B2 (en) * 1998-05-07 2004-04-20 Sequenom, Inc. IR MALDI mass spectrometry of nucleic acids using liquid matrices
EP1166329A4 (en) * 1999-03-09 2005-03-23 Scripps Research Inst Improved desorption/ionization of analytes from porous light-absorbing semiconductor
US6436640B1 (en) 1999-03-18 2002-08-20 Exiqon A/S Use of LNA in mass spectrometry
JP2005516114A (en) * 2002-01-25 2005-06-02 サイファージェン バイオシステムズ， インコーポレイテッド Monomers and polymers having energy absorbing moieties useful for analyte desorption / ionization
JP2007502980A (en) * 2003-08-21 2007-02-15 アプレラ コーポレイション Reduction of matrix interference for MALDI mass spectrometry
CA2582338A1 (en) * 2004-09-29 2006-04-13 Bio-Rad Laboratories, Inc. Host-guest enery-absorbing complex
US20060261267A1 (en) * 2005-05-20 2006-11-23 Agency For Science, Technology And Research Composite MALDI matrix material and methods of using it and kits thereof in MALDI
KR101231157B1 (en) 2011-07-07 2013-02-08 한국과학기술연구원 Direct analysis of biomolecules from the blood spot on paper using matrix assisted laser desorption ionization-mass spectrometry

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0333912A2 (en) * 1988-03-22 1989-09-27 Bruker Franzen Analytik GmbH Method for the evaporation of a sample
WO1991002961A1 (en) * 1989-08-23 1991-03-07 Finnigan Mat Ltd. Method of preparing a sample for analysis
WO1991003068A1 (en) * 1989-08-23 1991-03-07 Finnigan Mat Ltd. Method of preparing a sample for analysis
GB2236185A (en) * 1989-08-22 1991-03-27 Finnigan Mat Gmbh Laser desorbtion of analyte bound on a surface
GB2257295A (en) * 1991-06-21 1993-01-06 Finnigan Mat Ltd Sample holder for use in a mass spectrometer.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0333912A2 (en) * 1988-03-22 1989-09-27 Bruker Franzen Analytik GmbH Method for the evaporation of a sample
GB2236185A (en) * 1989-08-22 1991-03-27 Finnigan Mat Gmbh Laser desorbtion of analyte bound on a surface
WO1991002961A1 (en) * 1989-08-23 1991-03-07 Finnigan Mat Ltd. Method of preparing a sample for analysis
WO1991003068A1 (en) * 1989-08-23 1991-03-07 Finnigan Mat Ltd. Method of preparing a sample for analysis
GB2257295A (en) * 1991-06-21 1993-01-06 Finnigan Mat Ltd Sample holder for use in a mass spectrometer.

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CURRIE: "analysis of oligo-deoxy-nucleotides by negative-ion maldi-ms", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, vol. 4, no. 12, pages 955 - 963 *
KARAS ET AL.: "maldi mass spectrometry, fundamentals and applications", AIP CONFERENCE PROCEEDINGS, no. 288, KNOXVILLE USA, pages 447 - 458 *
S.J.DOKTYCZ: "matrix-sample interactions in uv-desorption of proteins", RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 5, pages 145 - 148 *

Also Published As

Publication number Publication date
EP0764264A2 (en) 1997-03-26
WO1995015001A2 (en) 1995-06-01
CA2205040C (en) 2006-10-17
CA2205040A1 (en) 1995-06-01

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