WO1995007708A3 - Utilisation therapeutique d'un produit genique contre la predisposition au retinoblastome - Google Patents

Utilisation therapeutique d'un produit genique contre la predisposition au retinoblastome Download PDF

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Publication number
WO1995007708A3
WO1995007708A3 PCT/US1994/010357 US9410357W WO9507708A3 WO 1995007708 A3 WO1995007708 A3 WO 1995007708A3 US 9410357 W US9410357 W US 9410357W WO 9507708 A3 WO9507708 A3 WO 9507708A3
Authority
WO
WIPO (PCT)
Prior art keywords
retinoblastoma
cell
gene product
therapeutic use
susceptibility gene
Prior art date
Application number
PCT/US1994/010357
Other languages
English (en)
Other versions
WO1995007708A2 (fr
Inventor
Wen-Hwa Lee
Eva Y-H P Lee
H Michael Shepard
Duane Johnson
David W Goodrich
Nan Ping Wang
Original Assignee
Univ California
Canji Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Canji Inc filed Critical Univ California
Priority to AU78349/94A priority Critical patent/AU7834994A/en
Publication of WO1995007708A2 publication Critical patent/WO1995007708A2/fr
Publication of WO1995007708A3 publication Critical patent/WO1995007708A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4736—Retinoblastoma protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Procédé de prévention ou d'inhibition de la prolifération pathologique d'une cellule, ladite prolifération pathologique de la cellule étant le résultat de l'absence d'une protéine ou d'un polypeptide fonctionnels de rétinoblastome dans la cellule. Ledit procédé consiste à mettre en contact la cellule avec une quantité efficace de protéine ou de polypeptide de rétinoblastome. Ledit procédé est également utile pour prévenir ou traiter le rétinoblastome ou un cancer secondaire du rétinoblastome en administrant à un patient une protéine ou un polypeptide fonctionnels de rétinoblastome.
PCT/US1994/010357 1993-09-13 1994-09-13 Utilisation therapeutique d'un produit genique contre la predisposition au retinoblastome WO1995007708A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU78349/94A AU7834994A (en) 1993-09-13 1994-09-13 Therapeutic use of the retinoblastoma susceptibility gene product

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12110893A 1993-09-13 1993-09-13
US08/121,108 1993-09-13

Publications (2)

Publication Number Publication Date
WO1995007708A2 WO1995007708A2 (fr) 1995-03-23
WO1995007708A3 true WO1995007708A3 (fr) 1995-06-08

Family

ID=22394606

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/010357 WO1995007708A2 (fr) 1993-09-13 1994-09-13 Utilisation therapeutique d'un produit genique contre la predisposition au retinoblastome

Country Status (4)

Country Link
AU (1) AU7834994A (fr)
IL (1) IL110954A (fr)
WO (1) WO1995007708A2 (fr)
ZA (1) ZA947065B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7384735B1 (en) 1986-08-11 2008-06-10 Massachusetts Eye And Ear Infirmary Retinoblastoma nucleic acids
US7223842B1 (en) 1986-08-11 2007-05-29 Massachusetts Eye And Ear Infirmary Detection of proteins whose absence is associated with a neoplasm
WO1997047647A1 (fr) * 1996-06-13 1997-12-18 Consejo Superior De Investigaciones Cientificas Proteines vegetales
NZ333100A (en) 1996-06-13 2000-05-26 Consejo Superior Investigacion Plant retinoblastoma-associated proteins and their use in modulating the cell cycle of a plant
EP0948520B1 (fr) 1996-11-15 2005-01-12 Canji, Inc. Expression specifique tissulaire de la proteine du retinoblastome
CN1259998A (zh) * 1997-02-20 2000-07-12 得克萨斯系统大会评议会 修饰的成视网膜细胞瘤肿瘤抑制蛋白
WO2004094996A2 (fr) * 2001-07-12 2004-11-04 Duke University Systeme et technique de determination d'expression de proteine differentielle, systeme de decouverte de biomarqueur de diagnostic et technique d'utilisation de ce systeme et biomarqueur de proteine et utilisation therapeutique et diagnostique de ceux-ci

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0259031A2 (fr) * 1986-08-11 1988-03-09 MASSACHUSETTS EYE & EAR INFIRMARY ADM humain pour le diganostic du rétinoblastome
WO1989006703A1 (fr) * 1988-01-21 1989-07-27 Massachusetts Eye And Ear Infirmary Diagnostic du retinoblastome
WO1992022640A1 (fr) * 1991-06-10 1992-12-23 Research Development Foundation Cellules de retinoblastome transferees et methode de transfert
EP0529160A1 (fr) * 1990-07-16 1993-03-03 The Regents Of The University Of California Produits de gène contenant des proteines et méthodes de thérapie cellulaire

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0259031A2 (fr) * 1986-08-11 1988-03-09 MASSACHUSETTS EYE & EAR INFIRMARY ADM humain pour le diganostic du rétinoblastome
WO1989006703A1 (fr) * 1988-01-21 1989-07-27 Massachusetts Eye And Ear Infirmary Diagnostic du retinoblastome
EP0529160A1 (fr) * 1990-07-16 1993-03-03 The Regents Of The University Of California Produits de gène contenant des proteines et méthodes de thérapie cellulaire
WO1992022640A1 (fr) * 1991-06-10 1992-12-23 Research Development Foundation Cellules de retinoblastome transferees et methode de transfert

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
K. PITKÄNEN ET AL.: "Expression of the human retinoblastoma gene product in mouse fibroblasts: Effects on cell proliferation and susceptibility to transformation.", EXPERIMENTAL CELL RESEARCH, vol. 207, July 1993 (1993-07-01), NEW YORK NY, USA, pages 99 - 106 *
R. BOOKSTEIN ET AL.: "Molecular genetics of the retinoblastoma suppressor gene.", CRITICAL REVIEWS IN ONCOGENESIS, vol. 2, no. 3, 1991, BOCA RATON FL, USA, pages 211 - 227 *
W. LEE ET AL.: "Human retinoblastoma susceptibility gene: Cloning, identification, and sequence.", SCIENCE, vol. 235, 13 March 1987 (1987-03-13), WASHINGTON DC, USA, pages 1394 - 1399 *
Y. FUNG ET AL.: "The Rb gene suppresses the growth of normal cells.", ONCOGENE, vol. 8, no. 10, October 1993 (1993-10-01), BASINGSTOKE, GB, pages 2659 - 2672 *

Also Published As

Publication number Publication date
WO1995007708A2 (fr) 1995-03-23
ZA947065B (en) 1995-05-03
IL110954A (en) 1999-12-22
IL110954A0 (en) 1994-11-28
AU7834994A (en) 1995-04-03

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