WO1995006764A3 - Oligonucleotides ayant une activite de segmentation de l'arn - Google Patents

Oligonucleotides ayant une activite de segmentation de l'arn Download PDF

Info

Publication number
WO1995006764A3
WO1995006764A3 PCT/IB1994/000288 IB9400288W WO9506764A3 WO 1995006764 A3 WO1995006764 A3 WO 1995006764A3 IB 9400288 W IB9400288 W IB 9400288W WO 9506764 A3 WO9506764 A3 WO 9506764A3
Authority
WO
WIPO (PCT)
Prior art keywords
oligonucleotides
cleavage activity
rna cleavage
rna
activity
Prior art date
Application number
PCT/IB1994/000288
Other languages
English (en)
Other versions
WO1995006764A2 (fr
Inventor
Larry W Mclaughlin
Dong-Jing Fu
Fritz Benseler
Gerd Kotzorek
Janos Ludwig
Original Assignee
Ribonetics Gmbh
Larry W Mclaughlin
Fu Dong Jing
Fritz Benseler
Gerd Kotzorek
Janos Ludwig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribonetics Gmbh, Larry W Mclaughlin, Fu Dong Jing, Fritz Benseler, Gerd Kotzorek, Janos Ludwig filed Critical Ribonetics Gmbh
Priority to AU76231/94A priority Critical patent/AU7623194A/en
Publication of WO1995006764A2 publication Critical patent/WO1995006764A2/fr
Publication of WO1995006764A3 publication Critical patent/WO1995006764A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3183—Diol linkers, e.g. glycols or propanediols
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3527—Other alkyl chain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3535—Nitrogen

Abstract

L'invention se rapporte à de nouveaux oligonucléotides, notamment aux oligonucléotides ayant une activité de segmentation de l'ARN.
PCT/IB1994/000288 1993-09-03 1994-09-05 Oligonucleotides ayant une activite de segmentation de l'arn WO1995006764A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU76231/94A AU7623194A (en) 1993-09-03 1994-09-05 Oligonucleotides with rna cleavage activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11629193A 1993-09-03 1993-09-03
US08/116,291 1993-09-03

Publications (2)

Publication Number Publication Date
WO1995006764A2 WO1995006764A2 (fr) 1995-03-09
WO1995006764A3 true WO1995006764A3 (fr) 1995-10-19

Family

ID=22366298

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1994/000288 WO1995006764A2 (fr) 1993-09-03 1994-09-05 Oligonucleotides ayant une activite de segmentation de l'arn

Country Status (2)

Country Link
AU (1) AU7623194A (fr)
WO (1) WO1995006764A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998193A (en) * 1994-06-24 1999-12-07 Gene Shears Pty., Ltd. Ribozymes with optimized hybridizing arms, stems, and loops, tRNA embedded ribozymes and compositions thereof
US5716824A (en) * 1995-04-20 1998-02-10 Ribozyme Pharmaceuticals, Inc. 2'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes)
AU708995B2 (en) * 1995-06-07 1999-08-19 Gene Shears Pty. Limited Optimized minizymes and miniribozymes and uses thereof
US6127159A (en) * 1997-06-06 2000-10-03 The Board Of Trustees Of The Leland Stanford Junior University Mitofusin genes and their uses
RS50273B (sr) 1998-08-18 2009-07-15 The Regents Of The Univeristy Of California, Antagonisti receptora epidermalnog faktora rasta za lečenje hipersekrecije mukusa u plućima
US6379931B1 (en) * 1999-08-12 2002-04-30 City Of Hope Chimeric DNA/RNA ribozymes containing propanediol
WO2001025274A1 (fr) 1999-10-06 2001-04-12 The Board Of Trustees Of The Leland Stanford Junior University Mitofusines, homologues fzo, et derives fonctionnels de celles-ci
AU785425B2 (en) 2001-03-30 2007-05-17 Genetic Technologies Limited Methods of genomic analysis
CA2470104C (fr) 2001-12-12 2015-01-27 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Procedes d'utilisation d'inhibiteurs de l'adenosine extracellulaire et d'inhibiteurs de recepteur de l'adenosine aux fins d'amelioration de reponse immune et d'inflammation
US7351542B2 (en) 2002-05-20 2008-04-01 The Regents Of The University Of California Methods of modulating tubulin deacetylase activity
EP1723177A2 (fr) 2004-02-24 2006-11-22 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Rab9a, rab11a et leurs modulateurs lies a une maladie infectieuse
US20090087854A1 (en) 2007-09-27 2009-04-02 Perlegen Sciences, Inc. Methods for genetic analysis
AU2005299296A1 (en) 2004-10-27 2006-05-04 Vanderbilt University Mammalian genes involved in infection
US8106013B2 (en) 2006-05-19 2012-01-31 Georgia Tech Research Corporation ABC transporter ligand GATX1
EP2049138A4 (fr) 2006-07-14 2011-11-09 Georgia Tech Res Inst Ligand du canal clc
WO2016187217A2 (fr) 2015-05-18 2016-11-24 The Board Of Trustees Of The Leland Stanford Junior University Méthodes et compositions permettant de traiter des troubles associés au vieillissement
WO2012102793A2 (fr) 2010-12-10 2012-08-02 Zirus, Inc. Gènes de mammifère impliqués dans la toxicité et l'infection
US10265372B2 (en) 2014-08-12 2019-04-23 The Regents Of The University Of California Molecular composition for enhancing and rejuvenating maintenance and repair of mammalian tissues

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007065A1 (fr) * 1990-10-12 1992-04-30 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Ribozymes modifies
WO1993015187A1 (fr) * 1992-01-31 1993-08-05 Massachusetts Institute Of Technology Nucleoenzymes
WO1994013688A1 (fr) * 1992-12-08 1994-06-23 Gene Shears Pty. Limited Ribozymes avec bras d'adn et minizymes
WO1994013793A1 (fr) * 1992-12-04 1994-06-23 Apollon, Inc. Composes et methodes de traitement des leucemies
WO1994013789A2 (fr) * 1992-12-04 1994-06-23 Ribonetics Gmbh Oligonucleotides presentant une activite de clivage de l'arn

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007065A1 (fr) * 1990-10-12 1992-04-30 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Ribozymes modifies
WO1993015187A1 (fr) * 1992-01-31 1993-08-05 Massachusetts Institute Of Technology Nucleoenzymes
WO1994013793A1 (fr) * 1992-12-04 1994-06-23 Apollon, Inc. Composes et methodes de traitement des leucemies
WO1994013789A2 (fr) * 1992-12-04 1994-06-23 Ribonetics Gmbh Oligonucleotides presentant une activite de clivage de l'arn
WO1994013688A1 (fr) * 1992-12-08 1994-06-23 Gene Shears Pty. Limited Ribozymes avec bras d'adn et minizymes

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
D. B. OLSEN ET AL.: "Study of a hammerhead ribozyme containing 2'-modified adenosine residues", BIOCHEMISTRY, vol. 30, pages 9735 - 41 *
D. M. WILLIAMS ET AL.: "Function of specific 2'-hydroxyl groups of guanosines in a hammerhead ribozyme probed by 2'-modifications", P.N.A.S., vol. 89, pages 918 - 21 *
F. BENSELER ET AL.: "Hammerhead-like molecules containing non-nucleoside linkers are active RNA catalysts", J. AM. CHEM. SOC., vol. 115, pages 8483 - 4 *
M. Y.-X. MA ET AL.: "Design and Synthesis of RNA miniduplexes via a synthetic linker approach", BIOCHEMISTRY, vol. 32, pages 1751 - 58 *
O. HEIDENREICH, F. ECKSTEIN: "Hammerhead ribozyme-mediated cleavage of the long terminal repeat RNA of human immunodeficiency virus type I", J. BIOL. CHEM., vol. 267, pages 1904 - 9 *
W. A. PIEKEN ET AL.: "Kinetic characterization of ribonuclease-resistant 2'-modified hammerhead-ribozymes", SCIENCE, vol. 253, pages 314 - 7 *

Also Published As

Publication number Publication date
AU7623194A (en) 1995-03-22
WO1995006764A2 (fr) 1995-03-09

Similar Documents

Publication Publication Date Title
EP0629633A3 (en) Dinucleotide analogues, intermediates therefor and oligonucleotides derived therefrom.
EP0623171A4 (fr) Molecules d'arn enzymatiques.
WO1995006764A3 (fr) Oligonucleotides ayant une activite de segmentation de l'arn
EP0679716A4 (fr) Signature genique.
ZA964136B (en) Catalytic DNA.
ZA965019B (en) Isothermal PCR.
AU6298694A (en) Insecticidal substituted-2,4-diaminoquinazolines
WO1999057325A3 (fr) Melanges d'enzymes
EP0663305A3 (fr) Bandage pneumatique pouvant rouler à plat.
ZA961291B (en) Naphthyl compounds, intermediates, compositions, and methods.
AU6720798A (en) 2-arylcyclopentan-1,3-diones
ZA987057B (en) 2-benzoylcyclohexane-1,3-diones.
ZA987056B (en) 2-benzoylcyclohexane-1,3-diones.
CY2333B1 (en) 10-Aminoaliphatyl-dibenz (b,f) oxepins with antineur odegenarative activity.
ZA98387B (en) Novel microorganisms.
ZA9610278B (en) Pyridylcarbamates, processes and intermediates for their preparation, and their use.
ZA961082B (en) DNA sequence.
AU5974194A (en) Oligonucleotides with rna cleavage activity
AU1981295A (en) Novel protein-kinase, nucleic acid sequences encoding the same and methods related thereto
ZA988B (en) 3-aminocarbonyl-/3-aminothiocarbonyl-substituted 2-benzoylcyclohexane-1,3-diones.
EP0622464A3 (fr) Procédé de dosage d'acide nucléique.
EP0607897A3 (en) Hydraulically-damped, active engine support.
ZA986B (en) Substituted 2-benzoylcyclohexane-1,3-diones.
EP0657679A3 (fr) Dispositif d'accouplement, en particulier un connecteur rapide multiple.
EP1118659A4 (fr) Systemes d'expression servant a l'expression d'acides nucleiques fonctionnels

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AM AT AU BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU JP KE KG KP KR KZ LK LR LT LU LV MD MG MN MW NL NO NZ PL PT RO RU SD SE SI SK TJ TT UA US UZ VN

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): KE MW SD AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AM AT AU BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU JP KE KG KP KR KZ LK LR LT LU LV MD MG MN MW NL NO NZ PL PT RO RU SD SE SI SK TJ TT UA US UZ VN

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): KE MW SD AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA