WO1994027594A3 - Complexes stables de cuivre(i) et leur utilisation comme substances therapeutiques actives - Google Patents

Complexes stables de cuivre(i) et leur utilisation comme substances therapeutiques actives Download PDF

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Publication number
WO1994027594A3
WO1994027594A3 PCT/US1994/006247 US9406247W WO9427594A3 WO 1994027594 A3 WO1994027594 A3 WO 1994027594A3 US 9406247 W US9406247 W US 9406247W WO 9427594 A3 WO9427594 A3 WO 9427594A3
Authority
WO
WIPO (PCT)
Prior art keywords
copper
agents
complexes
stable
stable copper
Prior art date
Application number
PCT/US1994/006247
Other languages
English (en)
Other versions
WO1994027594A2 (fr
Inventor
Alexander J Pallenberg
Andrew Branca
Thomas M Marschner
Leonard M Patt
Original Assignee
Procyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procyte Corp filed Critical Procyte Corp
Priority to AU70517/94A priority Critical patent/AU7051794A/en
Priority to JP7501073A priority patent/JPH08511006A/ja
Priority to EP94919342A priority patent/EP0701439A1/fr
Priority to ZA949336A priority patent/ZA949336B/xx
Publication of WO1994027594A2 publication Critical patent/WO1994027594A2/fr
Publication of WO1994027594A3 publication Critical patent/WO1994027594A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des composés stables de cuivre(I) et des procédés affins. Les composés stables de cuivre(I) comprennent un ion de cuivre(I) associé à un ligand polydenté qui favorise l'état d'oxydation +1 du cuivre. Les procédés décrits comprennent l'utilisation des composés stables de cuivre(I) comme agents de guérison de blessures, agents antioxydants, agents anti-inflammatoires, modulateurs de lipides, modulateurs de la transduction de signaux, comme agents stimulant la pousse des cheveux et comme agents antiviraux. Des exemples de composés stables de cuivre(I) comprennent la néocupréine de cuivre(I) et l'acide disulfonique de bathocuproïne de cuivre(I).
PCT/US1994/006247 1993-06-02 1994-06-02 Complexes stables de cuivre(i) et leur utilisation comme substances therapeutiques actives WO1994027594A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU70517/94A AU7051794A (en) 1993-06-02 1994-06-02 Stable copper(1) complexes and methods related thereto
JP7501073A JPH08511006A (ja) 1993-06-02 1994-06-02 安定な銅（▲ｉ▼）錯体及びそれに関する方法
EP94919342A EP0701439A1 (fr) 1993-06-02 1994-06-02 Complexes stables de cuivre(i) et leur utilisation comme substances therapeutiques actives
ZA949336A ZA949336B (en) 1994-06-02 1994-11-24 Stable copper (I) complexes and methods related thereto.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7144093A 1993-06-02 1993-06-02
US08/071,440 1993-06-02

Publications (2)

Publication Number Publication Date
WO1994027594A2 WO1994027594A2 (fr) 1994-12-08
WO1994027594A3 true WO1994027594A3 (fr) 1995-04-27

Family

ID=22101339

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/006247 WO1994027594A2 (fr) 1993-06-02 1994-06-02 Complexes stables de cuivre(i) et leur utilisation comme substances therapeutiques actives

Country Status (8)

Country Link
EP (1) EP0701439A1 (fr)
JP (1) JPH08511006A (fr)
AU (1) AU7051794A (fr)
CA (1) CA2163640A1 (fr)
OA (1) OA10198A (fr)
TW (1) TW239077B (fr)
WO (1) WO1994027594A2 (fr)
ZA (1) ZA943857B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562854B2 (en) 1994-12-14 2003-05-13 Axys Pharmaceuticals, Inc. Compositions comprising a substituted benzimidazole useful for treating immunomediated inflammatory disorders
WO1996039144A1 (fr) * 1995-06-06 1996-12-12 Procyte Corporation Complexes cuivreux stables utilises comme substances a activite therapeutique
US5637311A (en) * 1995-06-29 1997-06-10 Procyte Corporation Zinc(II) complexes and methods related thereto
US7045531B1 (en) 1997-03-11 2006-05-16 The General Hospital Corporation Composition comprising a metal chelator and a method of treating amyloidosis by administering the metal chelator
US6150379A (en) * 1997-11-26 2000-11-21 Axys Pharmaceuticals, Inc. Compounds and compositions as anticoagulants
US6638711B1 (en) 1999-04-29 2003-10-28 The General Hospital Corporation Methods for identifying an agent that inhibits oxygen-dependent hydrogen peroxide formation activity but does not inhibit superoxide-dependent hydrogen peroxide formation
WO2005115379A2 (fr) * 2004-05-24 2005-12-08 New York University Methode de traitement ou de prevention d'effets pathologiques d'augmentations aigues de l'hyperglycemie et/ou d'augmentations aigues de flux d'acides gras libres
CA2613297C (fr) * 2005-06-20 2016-12-06 Dynamiclear Pty Ltd. Composition pour traiter les lesions cutanees
CA2933788C (fr) * 2008-09-03 2017-11-28 Nbc Meshtec, Inc. Agent antiviral
US10098857B2 (en) 2008-10-10 2018-10-16 The Board Of Trustees Of The Leland Stanford Junior University Topical and transdermal delivery of HIF-1 modulators to prevent and treat chronic wounds
TWI580787B (zh) * 2012-12-28 2017-05-01 簡宏堅 重組蛋白質、含有該重組蛋白質之醫藥組成物及該重組蛋白質之製備方法
WO2019055490A1 (fr) 2017-09-14 2019-03-21 The Board Of Trustees Of The Leland Stanford Junior University Conditionnement de tissu irradié pour rétention de greffe de graisse

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6259213A (ja) * 1985-09-10 1987-03-14 Eisai Co Ltd ス−パ−オキサイド除去剤
US4760051A (en) * 1985-01-24 1988-07-26 Pickart Loren R Use of GHL-Cu as a wound-healing and anti-inflammatory agent

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760051A (en) * 1985-01-24 1988-07-26 Pickart Loren R Use of GHL-Cu as a wound-healing and anti-inflammatory agent
JPS6259213A (ja) * 1985-09-10 1987-03-14 Eisai Co Ltd ス−パ−オキサイド除去剤

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BIJLOO, G. J. ET AL: "Copper complexes of 1,10-phenanthroline and related compounds as superoxide dismutase mimetics", J. INORG. BIOCHEM., 1990, VOL. 40, PAGE(S) 237-44 *
BROWN DH ET AL: "Antiinflammatory effects of some copper complexes.", J MED CHEM (UNITED STATES), JUL 1980, VOL. 23, NO. 7, PAGE(S) 729-34, *
DATABASE WPI Week 8716, Derwent World Patents Index; AN 87-112954 *
DAVIS P.: "Penicillamine metal chelates and their possible importance in rheumatoid arthritis - A brief review", CLIN. INVEST. MED. (ENGLAND), 1984, VOL. 7, NO. 1, PAGE(S) 41-44, *
GAISSER, H. D. ET AL: "Determination of pKa values of 2,2'-bipyridyl analogs and stability constants of their copper(I) and copper(II) complexes;relationship to antimycoplasmal activity.", EUR. J. MED. CHEM.--CHIM. THER., 1986, VOL. 21, PAGES 285-9 *
SORENSON J.R.J. ET AL: "Antiulcer activities of D-penicillamine copper complexes", AGENTS ACTIONS (SWITZERLAND), 1982, VOL. 12, NO. 3, PAGE(S) 408-411, *

Also Published As

Publication number Publication date
OA10198A (en) 1996-12-18
ZA943857B (en) 1995-02-01
TW239077B (fr) 1995-01-21
EP0701439A1 (fr) 1996-03-20
WO1994027594A2 (fr) 1994-12-08
JPH08511006A (ja) 1996-11-19
AU7051794A (en) 1994-12-20
CA2163640A1 (fr) 1994-12-08

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