WO1994027576A1 - Nasal drug delivery composition containing nicotine - Google Patents
Nasal drug delivery composition containing nicotine Download PDFInfo
- Publication number
- WO1994027576A1 WO1994027576A1 PCT/GB1994/001092 GB9401092W WO9427576A1 WO 1994027576 A1 WO1994027576 A1 WO 1994027576A1 GB 9401092 W GB9401092 W GB 9401092W WO 9427576 A1 WO9427576 A1 WO 9427576A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nicotine
- ion
- exchange
- microspheres
- composition according
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
- A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/553,401 US5935604A (en) | 1993-05-20 | 1994-05-20 | Nasal drug delivery composition containing nicotine |
DE69406440T DE69406440T2 (en) | 1993-05-20 | 1994-05-20 | MEDICINAL COMPOSITION FOR ADMINISTRATION OF NICOTINE BY THE NOSE |
JP7500356A JPH08510467A (en) | 1993-05-20 | 1994-05-20 | Nasal drug delivery composition containing nicotine |
EP94915637A EP0697858B1 (en) | 1993-05-20 | 1994-05-20 | Nasal drug delivery composition containing nicotine |
GB9523372A GB2292316B (en) | 1993-05-20 | 1994-05-20 | Nasal drug delivery composition containing nicotine |
AU67272/94A AU685458B2 (en) | 1993-05-20 | 1994-05-20 | Nasal drug delivery composition containing nicotine |
NO954582A NO306847B1 (en) | 1993-05-20 | 1995-11-14 | Mixture for nasal administration of nicotine |
FI955583A FI955583A (en) | 1993-05-20 | 1995-11-20 | Nasal, nicotine containing pharmaceutical composition distribution |
GR980400063T GR3025890T3 (en) | 1993-05-20 | 1998-01-14 | Nasal drug delivery composition containing nicotine |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939310412A GB9310412D0 (en) | 1993-05-20 | 1993-05-20 | Nasal nicotine system |
GB9310412.3 | 1993-05-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994027576A1 true WO1994027576A1 (en) | 1994-12-08 |
Family
ID=10735826
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1994/001092 WO1994027576A1 (en) | 1993-05-20 | 1994-05-20 | Nasal drug delivery composition containing nicotine |
Country Status (14)
Country | Link |
---|---|
US (1) | US5935604A (en) |
EP (1) | EP0697858B1 (en) |
JP (1) | JPH08510467A (en) |
AT (1) | ATE159425T1 (en) |
AU (1) | AU685458B2 (en) |
CA (1) | CA2163089A1 (en) |
DE (1) | DE69406440T2 (en) |
DK (1) | DK0697858T3 (en) |
ES (1) | ES2111304T3 (en) |
FI (1) | FI955583A (en) |
GB (2) | GB9310412D0 (en) |
GR (1) | GR3025890T3 (en) |
NO (1) | NO306847B1 (en) |
WO (1) | WO1994027576A1 (en) |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996003142A1 (en) * | 1994-07-26 | 1996-02-08 | Danbiosyst Uk Limited | Drug delivery composition for the nasal administration of antiviral agents |
WO1997028801A1 (en) * | 1996-02-09 | 1997-08-14 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
WO1997034605A1 (en) * | 1996-03-21 | 1997-09-25 | Mayo Foundation For Medical Education And Research | Use of nicotine to treat liver disease |
WO1997038726A2 (en) * | 1996-04-17 | 1997-10-23 | Tillotts Pharma Ag | Hydrophobic carbomer complex compositions |
WO1998014216A2 (en) * | 1996-09-30 | 1998-04-09 | Immulogic Pharmaceutical Corporation | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same |
ES2116918A1 (en) * | 1995-07-12 | 1998-07-16 | Ltt Inst Co Ltd | Medicaments for nasal administration |
EP0898961A1 (en) * | 1997-08-27 | 1999-03-03 | Herta-Maria Dr. Sahlender | Pharmaceutical composition to improve the therapy of acute, postoperative or chronic pain |
US5889028A (en) * | 1996-02-09 | 1999-03-30 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
FR2771929A1 (en) * | 1997-12-09 | 1999-06-11 | Biovector Therapeutics | USE IN A PHARMACEUTICAL COMPOSITION FOR NASAL ADMINISTRATION OF HYDROPHILIC PARTICLES FOR THE DELIVERY OF ACTIVE AGENTS TO THE CENTRAL NERVOUS SYSTEM |
EP0739206B1 (en) * | 1993-11-01 | 2001-07-25 | Pharmacia AB | Composition for drug delivery comprising nicotine or a derivative thereof and starch microspheres and method for the manufacturing thereof |
US6391452B1 (en) | 1997-07-18 | 2002-05-21 | Bayer Corporation | Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations |
AT409219B (en) * | 1999-08-13 | 2002-06-25 | Red Bull Gmbh | Use of nicotine for producing pharmaceuticals |
EP1549633A1 (en) * | 2002-05-28 | 2005-07-06 | Cambrex Charles City, Inc. | Nicotine-containing, controlled release composition and method |
EP2086317A2 (en) * | 2006-12-01 | 2009-08-12 | Aradigm Corporation | Nicotine formulations, kits and systems and methods for their use |
US8216604B2 (en) | 2003-01-10 | 2012-07-10 | Archimedes Development Limited | Method of managing or treating pain |
US8256433B2 (en) | 1999-07-16 | 2012-09-04 | Aradigm Corporation | Systems and methods for effecting cessation of tobacco use |
US8859593B2 (en) | 2003-04-29 | 2014-10-14 | Neurim Pharmaceuticals (1991) Ltd. | Composition for improving cognition and memory |
US8955512B2 (en) | 2001-06-05 | 2015-02-17 | Alexza Pharmaceuticals, Inc. | Method of forming an aerosol for inhalation delivery |
US8991387B2 (en) | 2003-05-21 | 2015-03-31 | Alexza Pharmaceuticals, Inc. | Self-contained heating unit and drug-supply unit employing same |
US9119846B2 (en) | 2003-04-29 | 2015-09-01 | Neurim Pharmaceuticals (1991) Ltd. | Method and composition for enhancing cognition in alzheimer's patients |
US9211382B2 (en) | 2001-05-24 | 2015-12-15 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
WO2018113916A1 (en) * | 2016-12-20 | 2018-06-28 | Fertin Pharma A/S | A mucoadhesive oromucosal formulation comprising a nicotine complex |
US10639300B2 (en) | 2016-04-12 | 2020-05-05 | Arturo Solis Herrera | Compositions and methods for treating nasal and paranasal mucosa diseases with nicotinic acetylcholine receptor agonists |
WO2022132018A1 (en) * | 2020-12-16 | 2022-06-23 | Liw Innovation Ab | A new powder composition |
US11642473B2 (en) | 2007-03-09 | 2023-05-09 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
Families Citing this family (53)
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US20070185032A1 (en) * | 1996-12-11 | 2007-08-09 | Praecis Pharmaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
DE69831421T2 (en) * | 1997-12-02 | 2006-06-22 | Archimedes Development Ltd. | COMPOSITIONS FOR NASAL ADMINISTRATION |
US7022683B1 (en) | 1998-05-13 | 2006-04-04 | Carrington Laboratories, Inc. | Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation |
US6358060B2 (en) | 1998-09-03 | 2002-03-19 | Jsr Llc | Two-stage transmucosal medicine delivery system for symptom relief |
US20020098264A1 (en) * | 1998-11-27 | 2002-07-25 | Cherukuri Subraman R. | Medicated chewing gum delivery system for nicotine |
US6344222B1 (en) | 1998-09-03 | 2002-02-05 | Jsr Llc | Medicated chewing gum delivery system for nicotine |
ATE347880T1 (en) * | 1998-10-20 | 2007-01-15 | Univ North Carolina | METHODS FOR MOISTURIZING THE NASAL MUCOSA |
JP2002537355A (en) * | 1999-02-26 | 2002-11-05 | カイロン コーポレイション | Use of bioadhesives and adjuvants for mucosal delivery of antigen |
US20080138294A1 (en) * | 1999-07-16 | 2008-06-12 | Igor Gonda | Systems and methods for effecting cessation of tobacco use |
US20080138399A1 (en) * | 1999-07-16 | 2008-06-12 | Aradigm Corporation | Dual release nicotine formulations, and systems and methods for their use |
US20080138398A1 (en) * | 1999-07-16 | 2008-06-12 | Aradigm Corporation | Dual release nicotine formulations, and systems and methods for their use |
CA2378913C (en) * | 1999-07-16 | 2010-02-23 | Aradigm Corporation | System for effecting smoke cessation |
US6799576B2 (en) * | 1999-07-16 | 2004-10-05 | Aradigm Corporation | System for effecting smoking cessation |
US8980290B2 (en) | 2000-08-03 | 2015-03-17 | Antares Pharma Ipl Ag | Transdermal compositions for anticholinergic agents |
US7198801B2 (en) * | 2000-08-03 | 2007-04-03 | Antares Pharma Ipl Ag | Formulations for transdermal or transmucosal application |
AU2001282064B2 (en) * | 2000-08-03 | 2007-02-01 | Antares Pharma Ipl Ag | Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels |
US20070225379A1 (en) * | 2001-08-03 | 2007-09-27 | Carrara Dario Norberto R | Transdermal delivery of systemically active central nervous system drugs |
US6777000B2 (en) * | 2001-02-28 | 2004-08-17 | Carrington Laboratories, Inc. | In-situ gel formation of pectin |
US7494669B2 (en) * | 2001-02-28 | 2009-02-24 | Carrington Laboratories, Inc. | Delivery of physiological agents with in-situ gels comprising anionic polysaccharides |
AU2002258563A1 (en) * | 2001-03-19 | 2002-10-03 | Praecis Pharmaceuticals Incorporated | Pharmaceutical formulations for sustained release |
BR0208382A (en) * | 2001-03-26 | 2004-06-15 | Smithkline Beecham Corp | Nicotine-containing oral dosage form |
US7645442B2 (en) | 2001-05-24 | 2010-01-12 | Alexza Pharmaceuticals, Inc. | Rapid-heating drug delivery article and method of use |
US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
US20040101543A1 (en) * | 2002-03-22 | 2004-05-27 | John Liu | Nicotine-containing oral dosage form |
CA2487712A1 (en) * | 2002-06-28 | 2004-01-08 | Nastech Pharmaceutical Company Inc. | Compositions and methods for modulating physiology of epithelial junctional adhesion molecules for enhanced mucosal delivery of therapeutic compounds |
US20040105818A1 (en) | 2002-11-26 | 2004-06-03 | Alexza Molecular Delivery Corporation | Diuretic aerosols and methods of making and using them |
US7913688B2 (en) | 2002-11-27 | 2011-03-29 | Alexza Pharmaceuticals, Inc. | Inhalation device for producing a drug aerosol |
WO2004056363A2 (en) | 2002-12-20 | 2004-07-08 | Niconovum Ab | A physically and chemically stable nicotine-containing particulate material |
EP1620732A2 (en) * | 2003-04-30 | 2006-02-01 | Nastech Pharmaceutical Company Inc. | Claudins' underexpression as markers of tumor metastasis |
CA2533165A1 (en) * | 2003-07-21 | 2005-01-27 | Bio-Dar Ltd. | Gellan gum based oral controlled release dosage forms- a novel platform technology for gastric retention |
US7387788B1 (en) | 2003-10-10 | 2008-06-17 | Antares Pharma Ipl Ag | Pharmaceutical compositions of nicotine and methods of use thereof |
PT1670433E (en) | 2003-10-10 | 2012-02-08 | Ferring Bv | Transdermal pharmaceutical formulation for minimizing skin residues |
EP1696923B1 (en) * | 2003-12-02 | 2009-08-19 | Fertin Pharma A/S | Nicotine delivery product and method for producing |
US20050129679A1 (en) * | 2003-12-15 | 2005-06-16 | Nastech Pharmaceutical Company Inc. | Method for opening tight junctions |
US7425340B2 (en) * | 2004-05-07 | 2008-09-16 | Antares Pharma Ipl Ag | Permeation enhancing compositions for anticholinergic agents |
US20050265955A1 (en) * | 2004-05-28 | 2005-12-01 | Mallinckrodt Inc. | Sustained release preparations |
US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
WO2006125642A1 (en) | 2005-05-27 | 2006-11-30 | Antares Pharma Ipl Ag | Methods and apparatus for transdermal or transmucosal application of testosterone |
KR100699582B1 (en) | 2005-07-11 | 2007-03-23 | 삼성전기주식회사 | Output buffer circuit |
CA2646942C (en) | 2006-03-16 | 2014-07-29 | Niconovum Ab | Improved snuff composition |
WO2008020318A2 (en) * | 2006-03-30 | 2008-02-21 | Engene, Inc. | Non-viral compositions and methods for transfecting gut cells in vivo |
CA2646667C (en) | 2006-04-21 | 2014-03-11 | Antares Pharma Ipl Ag | Methods of treating hot flashes with formulations for transdermal or transmucosal application |
US8642016B2 (en) | 2006-07-21 | 2014-02-04 | Jsrnti, Llc | Medicinal delivery system, and related methods |
WO2008067991A2 (en) * | 2006-12-08 | 2008-06-12 | Antares Pharma Ipl Ag | Skin-friendly drug complexes for transdermal administration |
US20080287507A1 (en) * | 2007-05-16 | 2008-11-20 | John Hedenstrom | Nicotine containing toiletry waters |
JP2009209086A (en) * | 2008-03-04 | 2009-09-17 | Masami Moriyama | Mucous membrane administration-type vaccine |
ATE533487T1 (en) | 2008-12-19 | 2011-12-15 | Siegfried Ltd | PRODUCT CONTAINING NICOTINE |
WO2011049960A2 (en) * | 2009-10-21 | 2011-04-28 | Otonomy, Inc. | Compositions and methods for the treatment of sinonasal disorders |
US20110182831A1 (en) * | 2010-01-25 | 2011-07-28 | Aradigm Corporation | Systems and methods used in conjunction with nicotine vaccines for effecting cessation of tobacco use |
US10130120B2 (en) | 2013-03-15 | 2018-11-20 | Altria Client Services Llc | Use of pectin or other anionic polymers in the stabilization and controlled release of nicotine in oral sensorial tobacco products or nicotine containing non-tobacco oral sensorial products |
WO2016130908A1 (en) * | 2015-02-13 | 2016-08-18 | The University Of Toledo | Therapeutic polysaccharide midi-gagr and related materials and methods |
WO2017151651A1 (en) * | 2016-02-29 | 2017-09-08 | Belmont University | Pharmaceutical in situ gelling compositions |
AU2018378648B2 (en) * | 2017-12-08 | 2021-06-03 | Fertin Pharma A/S | Nicotine tablet |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0148749A2 (en) * | 1984-01-09 | 1985-07-17 | Advanced Tobacco Products, Inc. | Nicotine preparation |
WO1993012764A1 (en) * | 1992-01-03 | 1993-07-08 | The Governors Of The University Of Alberta | Composition to help stop smoking |
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US2945783A (en) * | 1957-06-20 | 1960-07-19 | Reheis Company Inc | Aluminum protein antacid and process of making |
US3655866A (en) * | 1970-01-26 | 1972-04-11 | Warner Lambert Co | Sugarless gum containing dicalcium phosphate dihydrate |
CA1139221A (en) * | 1978-10-10 | 1983-01-11 | Vijay B. Surpuriya | Antacid compositions |
CA1208558A (en) * | 1982-10-07 | 1986-07-29 | Kazuo Kigasawa | Soft buccal |
GB2133691B (en) * | 1983-01-21 | 1986-05-21 | Leo Ab | Smoking substitutes for nasal administration |
US4655231A (en) * | 1984-01-09 | 1987-04-07 | Advanced Tobacco Products, Inc. | Snuff and preparation thereof |
JPS6115830A (en) * | 1984-06-28 | 1986-01-23 | ザ プロクタ− アンド ガンブル カンパニ− | Antacid composition and manufacture |
US4971787A (en) * | 1984-08-27 | 1990-11-20 | Warner-Lambert Company | Antacid chewing gum |
US4882152A (en) * | 1985-12-20 | 1989-11-21 | Yang Robert K | Confectionery delivery system for laxatives, vitamins and antacids |
DK179687D0 (en) * | 1987-04-08 | 1987-04-08 | Farma Food As | PREPARATION |
GB8809421D0 (en) * | 1988-04-21 | 1988-05-25 | Fordonal Sa | Antacid compositions with prolonged gastric residence time |
US5525351A (en) * | 1989-11-07 | 1996-06-11 | Dam; Anders | Nicotine containing stimulant unit |
SE8904295D0 (en) * | 1989-12-21 | 1989-12-21 | Pharmacia Ab | SMOKING SUBSTITUTE |
DE4140116A1 (en) * | 1991-12-05 | 1993-06-09 | Bolder Arzneimittel Gmbh | DIMETICON PASTILLES |
EP0713389A4 (en) * | 1993-08-13 | 1997-05-21 | Bayer Ag | Hydrolyzed gelatin as a flavor enhancer in a chewable tablet |
JP3414539B2 (en) * | 1994-05-11 | 2003-06-09 | 有限会社ドット | Composition for nasal absorption |
AU2703795A (en) * | 1994-06-23 | 1996-01-19 | Procter & Gamble Company, The | Treatment of nicotine craving and/or smoking withdrawal symptoms with a transdermal or transmucosal composition containing nicotine and caffeine or xanthine |
-
1993
- 1993-05-20 GB GB939310412A patent/GB9310412D0/en active Pending
-
1994
- 1994-05-20 GB GB9523372A patent/GB2292316B/en not_active Expired - Fee Related
- 1994-05-20 EP EP94915637A patent/EP0697858B1/en not_active Expired - Lifetime
- 1994-05-20 AU AU67272/94A patent/AU685458B2/en not_active Ceased
- 1994-05-20 JP JP7500356A patent/JPH08510467A/en active Pending
- 1994-05-20 CA CA002163089A patent/CA2163089A1/en not_active Abandoned
- 1994-05-20 ES ES94915637T patent/ES2111304T3/en not_active Expired - Lifetime
- 1994-05-20 DK DK94915637.6T patent/DK0697858T3/en active
- 1994-05-20 US US08/553,401 patent/US5935604A/en not_active Expired - Fee Related
- 1994-05-20 AT AT94915637T patent/ATE159425T1/en not_active IP Right Cessation
- 1994-05-20 WO PCT/GB1994/001092 patent/WO1994027576A1/en active IP Right Grant
- 1994-05-20 DE DE69406440T patent/DE69406440T2/en not_active Expired - Fee Related
-
1995
- 1995-11-14 NO NO954582A patent/NO306847B1/en unknown
- 1995-11-20 FI FI955583A patent/FI955583A/en not_active Application Discontinuation
-
1998
- 1998-01-14 GR GR980400063T patent/GR3025890T3/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0148749A2 (en) * | 1984-01-09 | 1985-07-17 | Advanced Tobacco Products, Inc. | Nicotine preparation |
WO1993012764A1 (en) * | 1992-01-03 | 1993-07-08 | The Governors Of The University Of Alberta | Composition to help stop smoking |
Cited By (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0739206B1 (en) * | 1993-11-01 | 2001-07-25 | Pharmacia AB | Composition for drug delivery comprising nicotine or a derivative thereof and starch microspheres and method for the manufacturing thereof |
GB2305606A (en) * | 1994-07-26 | 1997-04-16 | Danbiosyst Uk | Drug delivery composition for the nasal administration of antiviral agents |
GB2305606B (en) * | 1994-07-26 | 1998-08-05 | Danbiosyst Uk | Drug delivery composition for the nasal administration of ICAM-1 |
WO1996003142A1 (en) * | 1994-07-26 | 1996-02-08 | Danbiosyst Uk Limited | Drug delivery composition for the nasal administration of antiviral agents |
ES2116918A1 (en) * | 1995-07-12 | 1998-07-16 | Ltt Inst Co Ltd | Medicaments for nasal administration |
US5889028A (en) * | 1996-02-09 | 1999-03-30 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
WO1997028801A1 (en) * | 1996-02-09 | 1997-08-14 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
US5846983A (en) * | 1996-02-09 | 1998-12-08 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
US6166044A (en) * | 1996-02-09 | 2000-12-26 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
WO1997034605A1 (en) * | 1996-03-21 | 1997-09-25 | Mayo Foundation For Medical Education And Research | Use of nicotine to treat liver disease |
WO1997038726A2 (en) * | 1996-04-17 | 1997-10-23 | Tillotts Pharma Ag | Hydrophobic carbomer complex compositions |
WO1997038726A3 (en) * | 1996-04-17 | 1997-12-31 | Tillotts Pharma Ag | Hydrophobic carbomer complex compositions |
JP2001501933A (en) * | 1996-09-30 | 2001-02-13 | イミュロジック ファーマシューティカル コーポレイション | Hapten-carrier conjugates for use in treating drug abuse and methods for preparing the same |
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Also Published As
Publication number | Publication date |
---|---|
DK0697858T3 (en) | 1998-05-04 |
NO306847B1 (en) | 2000-01-03 |
EP0697858B1 (en) | 1997-10-22 |
GB9523372D0 (en) | 1996-01-17 |
GR3025890T3 (en) | 1998-04-30 |
JPH08510467A (en) | 1996-11-05 |
NO954582D0 (en) | 1995-11-14 |
DE69406440T2 (en) | 1998-04-02 |
AU685458B2 (en) | 1998-01-22 |
GB9310412D0 (en) | 1993-07-07 |
FI955583A0 (en) | 1995-11-20 |
CA2163089A1 (en) | 1994-12-08 |
AU6727294A (en) | 1994-12-20 |
GB2292316A (en) | 1996-02-21 |
GB2292316B (en) | 1997-03-26 |
DE69406440D1 (en) | 1997-11-27 |
EP0697858A1 (en) | 1996-02-28 |
ES2111304T3 (en) | 1998-03-01 |
FI955583A (en) | 1996-01-19 |
NO954582L (en) | 1995-11-14 |
US5935604A (en) | 1999-08-10 |
ATE159425T1 (en) | 1997-11-15 |
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