WO1994025604A3 - Steroid 21-hydroxylase fragments and assays using the same - Google Patents
Steroid 21-hydroxylase fragments and assays using the same Download PDFInfo
- Publication number
- WO1994025604A3 WO1994025604A3 PCT/GB1994/000855 GB9400855W WO9425604A3 WO 1994025604 A3 WO1994025604 A3 WO 1994025604A3 GB 9400855 W GB9400855 W GB 9400855W WO 9425604 A3 WO9425604 A3 WO 9425604A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- steroid
- hydroxylase
- polypeptides
- assays
- fragments
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
- C12N9/0087—Steroid 21-monooxygenase (1.14.99.10)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Polypeptides comprising an amino acid sequence of steroid 21-hydroxylase containing an epitopic region for adrenal autoantibody are useful in assay for adrenal autoantibodies or the therapy of adrenal autoimmune disease. The polypeptides may be synthetic or expressed by novel transformants transfected with DNA encoding the polypeptides.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU66610/94A AU6661094A (en) | 1993-04-24 | 1994-04-22 | Steroid 21-hydroxylase fragments and assays using the same |
JP6523997A JPH09500008A (en) | 1993-04-24 | 1994-04-22 | Steroid 21-hydroxylase fragment and assay method using the same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939308544A GB9308544D0 (en) | 1993-04-24 | 1993-04-24 | Assay |
GB9308544.7 | 1993-04-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1994025604A2 WO1994025604A2 (en) | 1994-11-10 |
WO1994025604A3 true WO1994025604A3 (en) | 1996-05-02 |
Family
ID=10734450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1994/000855 WO1994025604A2 (en) | 1993-04-24 | 1994-04-22 | Steroid 21-hydroxylase fragments and assays using the same |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPH09500008A (en) |
AU (1) | AU6661094A (en) |
GB (1) | GB9308544D0 (en) |
WO (1) | WO1994025604A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5723343A (en) * | 1995-08-28 | 1998-03-03 | University Of Florida | Autoantibodies in patients with acquired hypoparathyroidism and assay method therefor |
GB9725105D0 (en) | 1997-11-28 | 1998-01-28 | Rsr Ltd | Diagnosis of autoimmune adrenal disease |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988009932A1 (en) * | 1987-06-03 | 1988-12-15 | Amrad Corporation Limited | NUCLEAR ANTIGEN La |
WO1989009222A1 (en) * | 1988-03-23 | 1989-10-05 | The Johns Hopkins University | Cloned human topoisomerase i |
DE3929822A1 (en) * | 1989-09-07 | 1991-03-14 | Max Planck Gesellschaft | DNA vector including multiple cloning site - for cloning, specific mutagenesis, sequencing and optimised expression of inserted genes, and construction of gene banks |
GB2256046A (en) * | 1992-07-31 | 1992-11-25 | R S R Limited | Assay for adrenal autoantibodies useful in the diagnosis of addison's disease |
WO1993005151A1 (en) * | 1991-09-12 | 1993-03-18 | The Johns Hopkins University | Cloned human cenp-c antigen |
-
1993
- 1993-04-24 GB GB939308544A patent/GB9308544D0/en active Pending
-
1994
- 1994-04-22 AU AU66610/94A patent/AU6661094A/en not_active Abandoned
- 1994-04-22 JP JP6523997A patent/JPH09500008A/en active Pending
- 1994-04-22 WO PCT/GB1994/000855 patent/WO1994025604A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988009932A1 (en) * | 1987-06-03 | 1988-12-15 | Amrad Corporation Limited | NUCLEAR ANTIGEN La |
WO1989009222A1 (en) * | 1988-03-23 | 1989-10-05 | The Johns Hopkins University | Cloned human topoisomerase i |
DE3929822A1 (en) * | 1989-09-07 | 1991-03-14 | Max Planck Gesellschaft | DNA vector including multiple cloning site - for cloning, specific mutagenesis, sequencing and optimised expression of inserted genes, and construction of gene banks |
WO1993005151A1 (en) * | 1991-09-12 | 1993-03-18 | The Johns Hopkins University | Cloned human cenp-c antigen |
GB2256046A (en) * | 1992-07-31 | 1992-11-25 | R S R Limited | Assay for adrenal autoantibodies useful in the diagnosis of addison's disease |
Non-Patent Citations (3)
Title |
---|
J. BEDNAREK ET AL: "Steroid 21-hydroxylase is a major autoantigen involved in adult onset autoimmune Addison's disease", FEBS LETTERS., vol. 309, no. 1, August 1992 (1992-08-01), AMSTERDAM NL, pages 51 - 55 * |
N. WEDLOCK ET AL: "Autoimmune Addison's disease. Analysis of autoantibody binding sites on human steroid 21-hydroxylase", FEBS LETTERS, vol. 332, no. 1,2, October 1993 (1993-10-01), pages 123 - 126 * |
P. WHITE ET AL: "Structure of human steroid 21-hydroxylase", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 83, July 1986 (1986-07-01), WASHINGTON US, pages 5111 - 5115 * |
Also Published As
Publication number | Publication date |
---|---|
GB9308544D0 (en) | 1993-06-09 |
JPH09500008A (en) | 1997-01-07 |
WO1994025604A2 (en) | 1994-11-10 |
AU6661094A (en) | 1994-11-21 |
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