WO1994024150A3 - Pepstatin derivatives for treatment, prevention and detection of infections - Google Patents

Pepstatin derivatives for treatment, prevention and detection of infections Download PDF

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Publication number
WO1994024150A3
WO1994024150A3 PCT/US1994/004566 US9404566W WO9424150A3 WO 1994024150 A3 WO1994024150 A3 WO 1994024150A3 US 9404566 W US9404566 W US 9404566W WO 9424150 A3 WO9424150 A3 WO 9424150A3
Authority
WO
WIPO (PCT)
Prior art keywords
sta
val
ala
asp
absent
Prior art date
Application number
PCT/US1994/004566
Other languages
French (fr)
Other versions
WO1994024150A2 (en
Inventor
Joel Bolonick
A Stevens Delk
Original Assignee
Nzym Inc
Joel Bolonick
A Stevens Delk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nzym Inc, Joel Bolonick, A Stevens Delk filed Critical Nzym Inc
Priority to AU66686/94A priority Critical patent/AU6668694A/en
Publication of WO1994024150A2 publication Critical patent/WO1994024150A2/en
Publication of WO1994024150A3 publication Critical patent/WO1994024150A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The subject invention provides novel proteinase inhibitors that find use in both the isolation of proteins and the treatment and prevention of animal and plant diseases, particularly diseases stemming from fungal infections. Novel proteinase inhibitors of the subject invention are the polypeptides according to the formula (I): A-B-G-C-Sta-Ala-Sta-E-F, wherein A is absent or an amino acid blocking group; C is either absent or peptide consisting of 1-3 amino acids; B is an amino acid, E is either absent or selected from the group consisting of glycine and β-alanine; F is either absent or a 1-5 amino acid peptides composed of amino acids that are either positively charged, negatively charged, or have hydroxyl groups on side chains; and G is an amino acid. Preferred embodiments of the compounds of formula (I) are: (II) Iva-Val-Val-Sta-Ala-Sta-Bal-D-Asp-D-Asp; (III) Iva-Val-Val-Sta-Ala-Sta-D-Ser-D-Ser; (IV) D-Asp-Bal-Val-Val-Val-Sta-Ala-Sta-Bal-D-Asp; and (V) Iva-Dab-Val-Sta-Ala-Sta. Also described are methods for assaying for the presence of fungal proteinases. The invention also provides kits for the performing assays for fungal proteinases.
PCT/US1994/004566 1993-04-21 1994-04-21 Pepstatin derivatives for treatment, prevention and detection of infections WO1994024150A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU66686/94A AU6668694A (en) 1993-04-21 1994-04-21 Pepstatin derivatives for treatment, prevention and detection of infections

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5091693A 1993-04-21 1993-04-21
US050,916 1993-04-21

Publications (2)

Publication Number Publication Date
WO1994024150A2 WO1994024150A2 (en) 1994-10-27
WO1994024150A3 true WO1994024150A3 (en) 1994-10-27

Family

ID=21968288

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/004566 WO1994024150A2 (en) 1993-04-21 1994-04-21 Pepstatin derivatives for treatment, prevention and detection of infections

Country Status (2)

Country Link
AU (1) AU6668694A (en)
WO (1) WO1994024150A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4104996A (en) * 1994-10-20 1996-05-15 Nzym, Inc. Pepstatin-derivatives for the treatment and detection of fungal infections
US5833946A (en) * 1995-06-06 1998-11-10 Bayer Corporation Dissemination of fungal infections: animal model and method of prophylaxis
EP2113510A1 (en) 2008-04-30 2009-11-04 Freie Universität Berlin Pepstatin A derivatives

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4185096A (en) * 1977-08-04 1980-01-22 Agence Nationale De Valorisation De La Recherche (Anvar) Novel derivatives of pepstatin, their preparation and compositions containing them
EP0165151A1 (en) * 1984-05-25 1985-12-18 Sanofi Peptide derivatives as renin inhibitors, process for their preparation and their therapeutical application

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4185096A (en) * 1977-08-04 1980-01-22 Agence Nationale De Valorisation De La Recherche (Anvar) Novel derivatives of pepstatin, their preparation and compositions containing them
EP0165151A1 (en) * 1984-05-25 1985-12-18 Sanofi Peptide derivatives as renin inhibitors, process for their preparation and their therapeutical application

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HUDDY, S.P.J. ET AL.: "Synthesis of novel semi-synthetic tight binding inhibitors of pepsin", BIOCHEM. SOC. TRANS., vol. 17, no. 6, 1989, pages 1124 - 1125 *

Also Published As

Publication number Publication date
AU6668694A (en) 1994-11-08
WO1994024150A2 (en) 1994-10-27

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