WO1994022412A1 - Preservative-free sterile fluid dispensing system - Google Patents
Preservative-free sterile fluid dispensing system Download PDFInfo
- Publication number
- WO1994022412A1 WO1994022412A1 PCT/US1994/002790 US9402790W WO9422412A1 WO 1994022412 A1 WO1994022412 A1 WO 1994022412A1 US 9402790 W US9402790 W US 9402790W WO 9422412 A1 WO9422412 A1 WO 9422412A1
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- WO
- WIPO (PCT)
- Prior art keywords
- valve
- solution
- container
- self
- support
- Prior art date
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/04—Deformable containers producing the flow, e.g. squeeze bottles
- B05B11/047—Deformable containers producing the flow, e.g. squeeze bottles characterised by the outlet or venting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/0005—Components or details
- B05B11/0037—Containers
- B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
- B05B11/0044—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
- B05B11/00444—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means with provision for filtering or cleaning the air flow drawn into the container
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/0005—Components or details
- B05B11/0062—Outlet valves actuated by the pressure of the fluid to be sprayed
- B05B11/0075—Two outlet valves being placed in a delivery conduit, one downstream the other
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
- B05B11/1042—Components or details
- B05B11/1052—Actuation means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D47/00—Closures with filling and discharging, or with discharging, devices
- B65D47/04—Closures with discharging devices other than pumps
- B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
- B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K15/00—Check valves
- F16K15/02—Check valves with guided rigid valve members
- F16K15/06—Check valves with guided rigid valve members with guided stems
- F16K15/063—Check valves with guided rigid valve members with guided stems the valve being loaded by a spring
- F16K15/066—Check valves with guided rigid valve members with guided stems the valve being loaded by a spring with a plurality of valve members
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K15/00—Check valves
- F16K15/14—Check valves with flexible valve members
- F16K15/144—Check valves with flexible valve members the closure elements being fixed along all or a part of their periphery
- F16K15/147—Check valves with flexible valve members the closure elements being fixed along all or a part of their periphery the closure elements having specially formed slits or being of an elongated easily collapsible form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
- A61J1/145—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using air filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1468—Containers characterised by specific material properties
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/7722—Line condition change responsive valves
- Y10T137/7837—Direct response valves [i.e., check valve type]
- Y10T137/7838—Plural
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/7722—Line condition change responsive valves
- Y10T137/7837—Direct response valves [i.e., check valve type]
- Y10T137/7879—Resilient material valve
- Y10T137/788—Having expansible port
- Y10T137/7882—Having exit lip
Definitions
- the present invention relates to a fluid dispensing system specifically designed to deliver multidose sterile, or homogenized and pasteurized, chemical preservative, antibacterial or antimicrobial additive free (hereinafter known collectively as
- the present invention is directed to a fluid dispensing system with a dual self-sealing valve system with about zero dead space volume to dispense multidose sterile solutions in a dropwise form.
- the dual self-sealing valve system and hydrophobic air filter protects the solutions from contamination after multidose dispensing without the use of preservatives.
- dead space means the space which is formed by the tip compartment surrounding the system outlet on the outside of the container and stops at the closure of the top self-sealing valve.
- dead space volume means the volume of area which lies within this "dead space” which contains and allows remaining fluid to be exposed to the outside environment through the system outlet.
- OTC over-the-counter
- prescription preparations such as ophthalmic pharmaceutical, contact lens solutions, drop-administrated medicines for the ear or nose, and some consumer health care liquid solutions, such as creams, gels and lotions, must be kept sterile to prevent contamination from bacteria or other microbes.
- the conventional means of preventing such contamination is to add a preservative or other antibacterial agent to the solution during packaging.
- preservatives include benzalkonium chloride, methyl parabens, propyl parabens, thimerosal and chlorobutanol.
- antibacterial agents include saline formulations.
- the bottle itself may harbor external bacterial or microbial growth which is carried along with the outflow of fluids.
- the preservatives themselves are often toxic, not just to bacteria or microbes, but also to the cells which are being treated by the bottled solution.
- the preservatives used in most eye drops can disrupt the corneal epithelium, irritate conjunctival tissues and cause allergic reactions. Because of this toxicity level, continued use can cause more long-term problems than the solutions solve.
- squeezable dispensing bottles containing saline formulations in the dispensing liquids may be provided with nozzles including filter membranes which are permeable to the dispensed liquid as well as being permeable to the air which must be aspirated through the nozzle to replace the dispensed liquid and reinflate or re- expand the container.
- the filter membrane must be impermeable to bacteria in order to prevent the aspirated air from carrying bacteria into contact with the stored solution, and contaminating the solution due to repeated dispensing.
- filter membrane materials which are sufficiently hydrophilic to permit permeation of the saline solution often permit retention of the saline solution on the filter so that the retained solution increases the resistance of the filter to passage of the aspirating air.
- the partially obstructed flow of aspirating air not only retards the re-expansion of the squeezed bottle wall, but also impedes repeated squeezing of the bottle when large quantities of the solution must be dispensed.
- portions of the filter are treated to repel the solution and improve air passage, the solution can sometimes leach the treating composition from the filter.
- consumer food products such as milk and dairy products, must be kept refrigerated to reduce the contamination and/or action of bacteria or other microbes.
- Container contamination can also be the result of particulate matter being drawn back into the container with the liquid in the dropper tip that has not been delivered as a drop. Over several drop deliveries, for example, in dusty conditions, a significant accumulation of dust in the container is possible.
- various designs for liquid dispenser for sterile solutions have been reported.
- U.S. Patent No. 4,938,389 describes a dispenser including a filter assembly having a hydrophobic filter and a hydrophilic filter in tandem with the hydrophobic filter located near the dispensing tip.
- U.S. Patent No. 3,760,987 describes a snap assembled dispensing package and cover made up of a container which has a tapered shank on its discharge end and a piercing device, snappably connected to the container, which also serves as a conduit for dispensing the medicament.
- the dispensing package further contains an air filter and a solution filter.
- U.S. Patent No. 4,463,880 describes a medicine drop dispenser with a single hydrophobic and microporous antibacterial filter that provide a barrier to the ingress of bacteria and for permitting the egress of sterile liquid.
- U.S. Patent No. 4,533,068 describes sterile solution delivery and venting devices including a positive acting, normally closed check valve which opens to express solution from the package when squeezing pressure is applied and which automatically closes when the pressure is released.
- a hydrophobic filter is included to sterilize the replacement air which enters the package upon release of the squeezing pressure.
- U.S. Patent No. 2,684,789 describes seal cap and dispensing nozzle for tubes or bottles having a self-closing dispensing valve.
- U.S. Patent No. 3,176,883 describes a fluid dispenser of the squeeze bottle type having an air vent post extending to the side of the dropper tip and directly above the lip of the container.
- an object of the present invention to provide an improved sterile solution delivery and fluid dispensing system of the type set forth. It is a another object of the present invention to provide a multidose fluid dispensing system which can protect the solutions from contamination under prolonged and repeated use without the use of preservatives.
- Another object of the present invention is to provide a multidose fluid dispensing bottle which can be used to dispense medicine solutions, which do not contain preservatives, in substantially uniform drops. It is another object of the present invention to provide a novel fluid dispensing system which incorporates positive acting, normally closed, valve means in combination with a hydrophobic membrane air sterilizing filter means.
- a preservative-free sterile solution dispensing system to eliminate the need of using preservatives in ophthalmic, pharmaceutical, contact lens solutions, consumer health care liquids and consumer food product solutions.
- the fluid dispensing system for dispensing sterile preservative-free solution comprises a container having an outer and an inner surface.
- the container further has a reservoir compartment for storing sterile solution and a tip compartment adapted to dispense the sterile solutions.
- a dual self-sealing valve dispensing assembly is sealed by an adhesive, mechanical compression, ultrasonic sealing, gasket, encapsulation or other commonly known methods, to the inside surface of the tip compartment and comprises a hydrophobic membrane assembly having a membrane housing.
- the membrane housing is constructed of a thermoplastic material, such as polyethylene, polypropylene, polystyrene, ethylene-vinyl acetate or a combination thereof.
- a hydrophobic membrane support is connected to the membrane housing.
- the hydrophobic membrane support has a top surface and a bottom surface.
- the hydrophobic membrane support further has a central fluid channel to allow the solution to pass through.
- the hydrophobic membrane support is also generally constructed of a thermoplastic material such as polyethylene, polypropylene, polystyrene, ethylene-vinyl acetate or a combination thereof.
- a hydrophobic membrane is hermetically sealed to the bottom surface of the hydrophobic membrane support separating the reservoir compartment from the tip compartment.
- the membrane further connects to a central solution flow port which in turn is in communication with the fluid channel in the hydrophobic membrane support to allow the solution to pass through.
- the hydrophobic membrane is constructed of a hydrophobic polymer, such as polyfluoroethylene, including TEFLON ® , polyolefins or a combination thereof.
- a passageway for ingress of air from outside the container through the membrane is provided in the hydrophobic membrane support.
- the dual self-sealing valve dispensing assembly further comprises a valve assembly, which in turn, comprises a valve housing support with a top and a bottom surface.
- the bottom surface of the valve housing support further connects to the top surface of the hydrophobic membrane support; a first self-sealing valve is hermetically sealed to the bottom surface of the housing support; a second self-sealing valve is hermetically sealed to the top surface of the valve housing support and in series with the first self-sealing valve wherein an outlet of the first valve opens to an inlet of the second valve to allow the solution to pass through; and a system outlet from which solution from an outlet of the second valve passes through.
- Figure 1 is a perspective cross-sectional view of one embodiment of the present invention showing a preservative-free sterile fluid dispensing system with two duckbill values in series;
- Figure 2 is a perspective cross-sectional view of another embodiment of the present invention showing the preservative-free sterile fluid dispensing system with one duckbill valve in series with an umbrella valve.
- Figure 3 is a perspective cross-sectional view of yet another embodiment of the present invention showing the preservative-free sterile fluid dispensing system with two umbrella valves in series.
- the preservative-free fluid dispensing system 10 is provided with a container 12 having an outer surface 14 and an inner surface 16.
- the container 12 is provided with means to temporarily reduce its volume, typically by providing that at least part of the container is elastically deformable. Thus, pressure on a deformable portion of the container will force the fluid contained therein out of the container when it is appropriately oriented.
- the container 12 can be a standard dispensing bottles with removable tip, e.g., low density polypropylene such as those made by Wheaton Plastics, Melville, N.J.
- the container 12 further has a reservoir compartment 18 for storing sterile solution 20 and a tip compartment 22 adapted to dispense the sterile solution 20.
- a dual self-sealing valve dispensing assembly 24 is sealed to the inside surface 16 of the container 12.
- the dual self-sealing valve dispensing assembly 24 has a membrane housing 26 to which hydrophobic membrane support 27 with a top surface 28 and a bottom surface 30 is attached.
- the hydrophobic membrane support 27 further has a central fluid channel 32 for the solution 20 to pass through.
- the hydrophobic membrane support 27 also has a passageway 40 (comprising an inflow 3, side port 9 and channel 11 discussed below) for ingress of air from outside the container 12 through the membrane 34.
- the hydrophobic membrane 34 has pore openings from 0.01 to 1 micron, and preferably about 0.2 to 0.24 micron, in flat sheet configuration.
- hydrophobic membranes are readily available commercially and can be fabricated from any suitable hydrophobic polymer, such as tetrafluoroethylene, polyolefins, including polyethylene and polypropylene or a mixture thereof.
- the hydrophobic membrane is a laminated tetrafluoroethylene (e.g. TEFLON ® , a trademark of E.I. du Pont de Nemours Co.) membrane obtained from W.L. Gore, Inc. and has a pore size of about 0.2 to about 0.24 microns and preferably about 0.22 microns.
- the hydrophobic membrane is used to separate the reservoir compartment 18 from the tip compartment 22, it has a surface area of about 0.1 to about 0.2 cm 2 and preferably about 0.13 cm 2 .
- the dual self-sealing valve dispensing assembly 24 further has a valve assembly 42 comprising a valve housing 44 with a top surface 46 and a bottom surface 48 and sealed by gasket to the top surface 28 of the hydrophobic membrane support 27.
- a first self-sealing valve 56 is hermetically sealed to the bottom surface 48 of the valve support 44.
- a second self-sealing valve 58 is similarly hermetically sealed to the top surface 46 of the valve housing support 44 and in series with the first self-sealing valve 56 wherein the outlet 60 of the first valve opens to an inlet 62 of the second valve to allow solution to pass through. Solution 20, after passing through the outlet 64 of the second self-sealing valve 58, then dispenses to the outside of the container 12 via system outlet
- the first and second self-sealing valves used are generally of the duckbill type and are normally closed during storage.
- the self-sealing valves used in the preferred embodiment are of the duckbill type, model X6079 and can be obtained from Vernay Laboratories, Inc. While a duckbill valve is described and disclosed in the drawings herein, it should be appreciated that any suitable one-way self-sealing valve may be utilized in the present invention.
- the outlet 64 from the second self-sealing valve opens to a system outlet 66 from which the solution 20 is dispensed.
- elements 26 membrane housing
- hydrophobic membrane support 27 valve housing support 44
- second self-sealing valve 56 in the form of O-rings
- gasket 69 in the form of O-rings
- bottle 12 After assembly, during a dispensing cycle, bottle 12 is squeezed in an inverted position with sterile solution 20 flowing from the reservoir compartment, through the central solution flow port 38, channel 32 in the center of hydrophobic membrane support 27, through the first self-sealing valve 56 and outlet 60 of same, through inlet 62 and outlet 64 of second self-sealing valve 58 and finally out through system outlet 66 of container 12.
- the system outlet 66 is of a dimension of only about 0.050 to about 0.127 cm.
- a dead space of about 5.36 ⁇ l is calculated when a cap 70 with bayonet extension 72 is in position of closing off the system outlet 66.
- a dead space of 6.4 ⁇ l is calculated for the system without the cap 70 in place over the system outlet 66.
- the cap 70 Protection of the external surface 14 of the container tip compartment 22 is achieved by means of the cap 70 with bayonet extension 72 which hermetically seals the outlet of the fluid dispensing system upon closure.
- the cap further is provided with antislip knurls 74 which are threaded together by means of threads 76.
- the cap 70 can be rendered bactericidal and bacteriostatic by further impregnating the plastic material with an antibacterial agent such as salts of common heavy metal oxides, including oxides of silver, gold or copper.
- FIG 2 shows another embodiment of the preservative-free fluid dispensing system 10 having a dual self-sealing valve dispensing assembly 24 with the second self-sealing duckbill valve 58 (as shown in Figure 1), replaced with an umbrella valve 58A, such as are known in the art.
- umbrella valve 58A is comprised of a circumferential seal head portion 80 attached to a stem portion 82 which slidably is positioned in a bore 84 through a top wall 86 of the container.
- a biasing member 88 in the form of an elastomeric spring and a lock step holds umbrella valve 58A in the position shown in Figure 2.
- container 12 is squeezed in an inverted position with sterile fluid 20, flowing through central solution flowport 38, through outlet 60 of first self-sealing valve 56, through inlet 62A of umbrella valve 58A and finally through an opening 66A formed by the upward movement of the head portion of the umbrella valve.
- biasing member 88 would force umbrella valve 58A back to a covering relation over the bore 84.
- the unique design of the umbrella valve 58A allows the sterile fluid 20 to pass through a center shaft with the stem of the umbrella at its center position.
- the umbrella valve 58A is positioned close to the top of the tip compartment 22.
- the preservative-free fluid dispensing system has dead space volume close to zero. This is because the pressure of the container 12 during compression provides for a spontaneous expulsion of fluid 20, while release of the pressure during decompression causes a spontaneous closure of the 360° opening of the circumferential seal head position 80 of the umbrella valve 58A.
- the umbrella valve 58A only opens as the fluid 20 is allowed to flow out during the pressurized phase of fluid expulsion. At closure, all fluid 20 is isolated from the outside, thereby preventing possible contamination of the sterile fluid 20 under the circumferential seal head position 80 of the umbrella valve 58A and in the container.
- Pressure equilibrium during the decompression stage is similar to before, obtained by the inflow of room air 3 through side port 9 of housing 26 and channel 11 of hydrophobic membrane support 27.
- the air is then filtered and rendered sterile by hydrophobic membrane 34 against circumferential seal 80 on membrane housing body 26.
- Figure 3 shows yet another embodiment of the preservative-free fluid dispensing system 10 having a dual self-sealing valve dispensing assembly 24 with both the first and second self-sealing valve being that of an umbrella type.
- two umbrella valves 56A and 58A are used to dispense sterile preservative- free eye care fluids from the container 12.
- the dispensing cycle of the dual umbrella- valve dispensing system is essentially similar to that of the first and second embodiments described above.
- a 5% aqueous solution of food grade blue dye was prepared from a stock concentrate.
- Fifteen double duckbill self-sealing valve dispensing assemblies in their normally closed position were connected in parallel on a tubing set testing fixture. The entire tubing set was primed with the dye solution and the dual double duckbill self- sealing valve assemblies connected to each of the parallel tubing arms.
- a calibrated pressure gauge connected to the tubing assembly was used to monitor the hydraulic pressure continuously for 24 hours. After 24 hours exposure to a pressure of 20 mm Hg, no retrograde migration of dye was detected past the first or second duckbill valve by direct observation and by calorimetric determination.
- Example 2 Double Duckbill Back Flow Air Pressure Integrity Tests Fifteen double duckbill self-sealing valve dispensing assemblies were inserted into the outlet of standard Wheaton squeeze bottles containing 15 ml of water. To each unit, a "T" tubing assembly containing a pre-calibrated pressure gauge and a compressed air source was connected to the dispensing tip outlets. The self-sealing double duckbill valve assemblies were subjected to an air pressure of 160 mm Hg for 90 seconds and isolated from the air pressure source by cross clamping the tubing. With the squeeze bottle inverted, no air bubbles were detected entering the water contained within the bottle while the pressure gauge reading remained constant.
- Example 3 Hydrophobic Membrane Air Venting Tests Fifteen Wheaton bottles containing 15 ml of water were each equipped with double duckbill self-sealing valve dispensing assemblies and integrity tested for leaks. The valve assemblies were provided with a freshly mounted hydrophobic membrane disc measuring 8 mm in diameter and hermetically sealed to a holder on two separate, but concentric sealing surfaces. The hydrophobic disc contained a functional surface area of 0.13 cm 2 and 0.2 micron pore size. The hydrophobic membrane discs had not been exposed to water before the tests. During the tests, the squeeze bottles were inverted and hand squeezed until 5 drops to 3-4 ml of water were expelled through the double duckbill valves and tip assembly.
- Example 3 The same conditions as in Example 3 except that the hydrophobic membrane discs in all fifteen double duckbill valve assemblies were immersed in water at room temperature for 24 hours. The ability of the hydrophobic membrane discs to filter air entering the bottle was similar to the results obtained with the hydrophobic membrane never exposed to water.
- Example 6 Sterility Test After the sterile fluid dispensing system 10 with a hydrophobic membrane air filter 34 and dual self-sealing valve dispensing assembly 24 in the preferred embodiments of the present invention was tested with Pseudomonas diminuta to a population of 10 million per milliliter (HIMA challenge), the bacterial retentivity of the membranes and the double self-sealing valving system met a sterility grade barrier.
- HIMA challenge Pseudomonas diminuta to a population of 10 million per milliliter
- HIMA challenge Pseudomonas diminuta to a population of 10 million per milliliter
- the bacterial retentivity of the membranes and the double self-sealing valving system met a sterility grade barrier.
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- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Food Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Closures For Containers (AREA)
- Packages (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19940913906 EP0691838A1 (en) | 1993-03-30 | 1994-03-15 | Preservative-free sterile fluid dispensing system |
AU65883/94A AU6588394A (en) | 1993-03-30 | 1994-03-15 | Preservative-free sterile fluid dispensing system |
KR1019950704259A KR960701624A (en) | 1993-03-30 | 1994-03-15 | Preservative-FREE STERILE FLUID DISPENSING SYSTEM |
JP52210194A JPH08510395A (en) | 1993-03-30 | 1994-03-15 | System for dispensing sterile fluids without preservatives |
FI954636A FI954636A (en) | 1993-03-30 | 1995-09-29 | Dispensing system for dispensing sterile solutions free of preservatives |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/039,655 | 1993-03-30 | ||
US08/039,655 US5373972A (en) | 1991-11-15 | 1993-03-30 | Preservative-free sterile fluid dispensing system |
Publications (1)
Publication Number | Publication Date |
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WO1994022412A1 true WO1994022412A1 (en) | 1994-10-13 |
Family
ID=21906641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1994/002790 WO1994022412A1 (en) | 1993-03-30 | 1994-03-15 | Preservative-free sterile fluid dispensing system |
Country Status (13)
Country | Link |
---|---|
US (1) | US5373972A (en) |
EP (1) | EP0691838A1 (en) |
JP (1) | JPH08510395A (en) |
KR (1) | KR960701624A (en) |
CN (1) | CN1124919A (en) |
AU (1) | AU6588394A (en) |
CA (1) | CA2159600A1 (en) |
FI (1) | FI954636A (en) |
HU (1) | HUT72994A (en) |
IL (1) | IL109028A (en) |
NO (1) | NO941099L (en) |
WO (1) | WO1994022412A1 (en) |
ZA (1) | ZA941882B (en) |
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Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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NL1010749C2 (en) * | 1998-12-07 | 2000-06-08 | V O F Pharmasept | Holder for dosed and substantially germ-free dispensing of a liquid. |
US6488427B1 (en) | 2000-02-29 | 2002-12-03 | Diane C. Breidenbach | Cosmetic applicator |
US20040234321A1 (en) | 2001-04-25 | 2004-11-25 | Breidenbach Diane C. | Dual cosmetic container |
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US7378058B2 (en) * | 2002-01-30 | 2008-05-27 | Ventana Medical Systems, Inc. | Method and apparatus for modifying pressure within a fluid dispenser |
DE10231749B4 (en) * | 2002-07-13 | 2004-07-29 | Aero Pump GmbH, Zerstäuberpumpen | Suction-pressure pump for dispensing a liquid from a container |
JP2006027654A (en) * | 2004-07-15 | 2006-02-02 | Katsutoshi Masuda | Fluid discharge pump |
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WO2007127847A2 (en) * | 2006-04-27 | 2007-11-08 | Hunter Delivery Systems, Inc. | Sheath for one way valve |
EP1870008A1 (en) * | 2006-06-22 | 2007-12-26 | The Procter and Gamble Company | A package for dosing and dispensing liquids |
US9162016B2 (en) * | 2006-09-22 | 2015-10-20 | Medela Holding Ag | Breastpump with irregular milk expression sequences |
US8070716B2 (en) * | 2007-04-11 | 2011-12-06 | Medela Holding Ag | Method and apparatus for minimum negative pressure control, particularly for a breastpump with breastshield pressure control system |
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JP2007330800A (en) * | 2007-07-20 | 2007-12-27 | Nipro Corp | Infusion speed adjusting device of chemical syringe |
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FR2934572A1 (en) | 2008-07-31 | 2010-02-05 | Thea Lab | BOTTLE FOR FLASK OF LIQUID CONDITIONING TO DISPENSE DROP GOUTTE. |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992012065A1 (en) * | 1991-01-09 | 1992-07-23 | Ryder International Corporation | Solution delivery nozzle and system with antimicrobial features |
WO1993010015A1 (en) * | 1991-11-15 | 1993-05-27 | Bystrom Steven R | Preservative free sterile fluid dispensing system |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2594318A (en) * | 1947-03-19 | 1952-04-29 | Jesse D Langdon | Valved coupling |
US2761833A (en) * | 1951-12-26 | 1956-09-04 | Samuel I Ward | Liquid treating apparatus |
US2783091A (en) * | 1955-06-10 | 1957-02-26 | Stratafoam Corp | Foam-dispensing package |
US3034731A (en) * | 1959-03-04 | 1962-05-15 | R E Chapin Mfg Works Inc | Back flow preventing valve assembly |
US3176883A (en) * | 1963-04-15 | 1965-04-06 | Jr George B Davis | Fluid dispenser |
US3365240A (en) * | 1967-05-04 | 1968-01-23 | Gordon Mack | Valve control for discharge of finely divided material from vacuum to atmosphere |
US3572375A (en) * | 1967-06-02 | 1971-03-23 | David Rosenberg | Twin valve t-connector |
ES419697A1 (en) * | 1972-10-18 | 1976-03-16 | Ivanov Mantchev | Valvular liquid dispensing closure |
DE2405687A1 (en) * | 1974-02-06 | 1975-08-07 | Jakob Westermeier | Automatic opener for container outlet - outlet enclosing piston of lever activated by pressure on container |
AR207395A1 (en) * | 1976-01-16 | 1976-09-30 | Ferrante J | IMPROVEMENTS IN DOSING CONTAINERS OF POWDERED GRANULATED PRODUCTS ETC |
FR2364168A1 (en) * | 1976-09-10 | 1978-04-07 | Workum Donald | Atomiser for window cleaning fluid - has tube immersed in liq. within squeezable container with ball valve allowing air intake |
US4139469A (en) * | 1977-01-21 | 1979-02-13 | Altex Scientific, Inc. | Fluid control mechanism |
FR2419873A1 (en) * | 1978-03-16 | 1979-10-12 | Normos Norbert | Discharge nozzle for flexible tube - has double skin and inlet holes leading to central discharge tube |
GB2021429B (en) * | 1978-04-14 | 1982-08-11 | Roussel Lab Ltd | Dispensers for sterile liquids |
GB2048827A (en) * | 1979-05-04 | 1980-12-17 | Chappell A | Metering device |
US4349134A (en) * | 1980-09-09 | 1982-09-14 | Ahk Alkohol Handelskontor Gmbh | Valved, resilient-walled container for safely dispensing flammable liquids |
FR2494603A1 (en) * | 1980-11-26 | 1982-05-28 | Normos Norbert | Manually-operated fluid-sprayer - has chamber with elastic wall and rigid tube from nozzle to discharge passage |
US4533068A (en) * | 1981-08-17 | 1985-08-06 | Health Care Concepts, Inc. | Sterile solution delivery and venting devices |
US4432496A (en) * | 1981-12-08 | 1984-02-21 | Toyo Seikan Kaisha, Ltd. | Foam liquid dispensing device |
US4513891A (en) * | 1982-04-15 | 1985-04-30 | Sterling Drug Inc. | Spray dispensing container and valve therefor |
US4475274A (en) * | 1982-07-07 | 1984-10-09 | Hunt-Wesson Foods, Inc. | Method of making and installing a pouring fitment |
DK148704C (en) * | 1983-01-04 | 1986-04-01 | Coloplast As | RETURN VALVE FOR A BAG FOR COLLECTION OF LIQUID BODY SECRETS |
DE3305898A1 (en) * | 1983-02-19 | 1984-08-23 | Günter 7535 Königsbach-Stein Hirsch | Fluid dispenser |
FR2543920A1 (en) * | 1983-04-11 | 1984-10-12 | Dore Pierre | Stopper device for a bottle or deformable bottle with a self-sealing valve cap |
US4728006A (en) * | 1984-04-27 | 1988-03-01 | The Procter & Gamble Company | Flexible container including self-sealing dispensing valve to provide automatic shut-off and leak resistant inverted storage |
US4676407A (en) * | 1985-03-20 | 1987-06-30 | Risdon Corporation | Mounting cap with extended sleeve |
NL8600111A (en) * | 1986-01-20 | 1987-08-17 | Bernardus Johannes Josephus Au | STOP FOR A CONTAINER, LIKE A BOTTLE AND A PUMP CONTAINABLE FOR SUCTION RESP. PRESSING GASEOUS MEDIUM FROM RESP. IN THE HOLDER. |
FR2597551B1 (en) * | 1986-04-16 | 1993-11-12 | Alpha Systemes | DISPOSABLE DISPENSING PUMP FOR LIQUID OR PASTY PRODUCTS |
EP0280669A1 (en) * | 1987-02-24 | 1988-08-31 | Erik Bottger | A device for discharging cream or paste-like material from a container |
US4785978A (en) * | 1987-03-02 | 1988-11-22 | Japan Crown Cork Co., Ltd. | Container closure provided with automatic opening-closing mechanism |
US4842165A (en) * | 1987-08-28 | 1989-06-27 | The Procter & Gamble Company | Resilient squeeze bottle package for dispensing viscous products without belching |
US4905819A (en) * | 1988-08-24 | 1990-03-06 | Alcon Laboratories, Inc. | System for storage and caring for contact lenses |
US5025957A (en) * | 1988-10-07 | 1991-06-25 | Ryder International Corp. | Liquid dispenser nozzle assembly |
US5183184A (en) * | 1988-10-07 | 1993-02-02 | Ryder International Corporation | Liquid dispenser nozzle assembly |
US4938389A (en) * | 1988-11-03 | 1990-07-03 | Eye Research Institute Of Retina Foundation | Filter bottle |
US4978036A (en) * | 1988-11-15 | 1990-12-18 | Koller Enterprises, Inc. | Dispensing valve |
US4875603A (en) * | 1989-01-26 | 1989-10-24 | Primary Delivery Systems, Inc. | Metered dispensing cap for tubes |
GB9011455D0 (en) * | 1989-06-01 | 1990-07-11 | Pall Corp | Contamination-resistant dispensing and metering device |
GB2234965A (en) * | 1989-08-08 | 1991-02-20 | Kenneth Simon Aylett Moore | Container closure |
US4953588A (en) * | 1989-08-16 | 1990-09-04 | Mueller Co. | Dual check valve |
ES2057844T3 (en) * | 1990-02-16 | 1994-10-16 | Sterisol Ab | DISTRIBUTION VALVE OF A FLUID. |
DE4008442A1 (en) * | 1990-03-16 | 1991-09-19 | Detlef Dr Schierstedt | Self-sealing sealed dispensing system for cosmetics or foodstuff - comprises elastic element e.g. spring and sealing element e.g. cone, reducing risk of microbial attack |
FR2660877B1 (en) * | 1990-04-13 | 1992-07-31 | Oreal | DISPENSING ASSEMBLY OF AT LEAST ONE LIQUID OR CREAM PRODUCT. |
CA2043521A1 (en) * | 1990-05-31 | 1991-12-01 | Vlado I. Matkovich | Contamination-resistant dispensing and metering device |
US5074440A (en) * | 1990-07-16 | 1991-12-24 | Alcon Laboratories, Inc. | Container for dispensing preservative-free preparations |
DE4027539A1 (en) * | 1990-08-31 | 1992-03-05 | Kautex Werke Gmbh | Squeeze bottle with inner bag |
CA2025105A1 (en) * | 1990-09-11 | 1992-03-12 | Garth T. Webb | Device for storing and dispensing sterile liquids |
JPH075135B2 (en) * | 1990-10-12 | 1995-01-25 | 株式会社フローレックス | Adhesive container |
FR2671538A1 (en) * | 1991-01-11 | 1992-07-17 | Saint Laurent Parfums Yves | Device for dispensing and metering products |
US5238153A (en) * | 1991-02-19 | 1993-08-24 | Pilkington Visioncare Inc. | Dispenser for dispersing sterile solutions |
DE4119634A1 (en) * | 1991-06-14 | 1992-12-17 | Gerd Hermann | VALVE FOR A CRUSH TANK |
GB9122319D0 (en) * | 1991-10-19 | 1991-12-04 | Coda Plastics Ltd | Fluid dispensing closure |
-
1993
- 1993-03-30 US US08/039,655 patent/US5373972A/en not_active Expired - Fee Related
-
1994
- 1994-03-15 CA CA 2159600 patent/CA2159600A1/en not_active Abandoned
- 1994-03-15 WO PCT/US1994/002790 patent/WO1994022412A1/en not_active Application Discontinuation
- 1994-03-15 CN CN94192299A patent/CN1124919A/en active Pending
- 1994-03-15 AU AU65883/94A patent/AU6588394A/en not_active Abandoned
- 1994-03-15 HU HU9502857A patent/HUT72994A/en unknown
- 1994-03-15 JP JP52210194A patent/JPH08510395A/en active Pending
- 1994-03-15 KR KR1019950704259A patent/KR960701624A/en not_active Application Discontinuation
- 1994-03-15 EP EP19940913906 patent/EP0691838A1/en not_active Ceased
- 1994-03-17 IL IL10902894A patent/IL109028A/en not_active IP Right Cessation
- 1994-03-17 ZA ZA941882A patent/ZA941882B/en unknown
- 1994-03-25 NO NO941099A patent/NO941099L/en unknown
-
1995
- 1995-09-29 FI FI954636A patent/FI954636A/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992012065A1 (en) * | 1991-01-09 | 1992-07-23 | Ryder International Corporation | Solution delivery nozzle and system with antimicrobial features |
WO1993010015A1 (en) * | 1991-11-15 | 1993-05-27 | Bystrom Steven R | Preservative free sterile fluid dispensing system |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1622813A2 (en) * | 2003-03-31 | 2006-02-08 | Nick J. Manesis | Multi-dose liquid dispensing assembly |
EP1622813A4 (en) * | 2003-03-31 | 2009-12-30 | Nick J Manesis | Multi-dose liquid dispensing assembly |
FR2862052A1 (en) * | 2003-11-10 | 2005-05-13 | Rexam Pharma | Liquid container and dispenser with micro-filtering membranes has liquid absorbing membrane extending along lengthwise axis of flask neck |
WO2005046541A3 (en) * | 2003-11-10 | 2005-07-07 | Rexam Pharma | Assembly for packaging and dispensing a liquid, comprising membrane microfilters |
US9228222B2 (en) | 2012-12-05 | 2016-01-05 | Bracco Imaging S.P.A. | Validation techniques for fluid delivery systems |
US9228221B2 (en) | 2012-12-05 | 2016-01-05 | Bracco Imaging S.P.A. | Validation techniques for fluid delivery systems |
US9228220B2 (en) | 2012-12-05 | 2016-01-05 | Bracco Imaging S.P.A. | Validation techniques for fluid delivery systems |
US9260741B2 (en) | 2012-12-05 | 2016-02-16 | Bracco Imaging S.P.A. | Validation techniques for fluid delivery systems |
WO2019121025A1 (en) * | 2017-12-21 | 2019-06-27 | Shl Medical Ag | Spray nozzle chip and a medicament delivery device comprising the same |
US11254488B2 (en) | 2017-12-21 | 2022-02-22 | Shl Medical Ag | Spray nozzle chip and a medicament delivery device comprising the same |
WO2019222032A1 (en) * | 2018-05-12 | 2019-11-21 | Exploramed Nc7, Inc. | Leash valve apparatus |
Also Published As
Publication number | Publication date |
---|---|
US5373972A (en) | 1994-12-20 |
JPH08510395A (en) | 1996-11-05 |
NO941099D0 (en) | 1994-03-25 |
AU6588394A (en) | 1994-10-24 |
EP0691838A1 (en) | 1996-01-17 |
FI954636A (en) | 1995-11-29 |
IL109028A (en) | 1997-09-30 |
CN1124919A (en) | 1996-06-19 |
HU9502857D0 (en) | 1995-11-28 |
FI954636A0 (en) | 1995-09-29 |
IL109028A0 (en) | 1994-06-24 |
ZA941882B (en) | 1994-10-14 |
NO941099L (en) | 1994-10-03 |
CA2159600A1 (en) | 1994-10-13 |
HUT72994A (en) | 1996-06-28 |
KR960701624A (en) | 1996-03-28 |
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