WO1994021295B1 - Methods for inhibiting hiv associated disease using monoclonal antibodies directed against anti-self cytotoxic t-cells - Google Patents
Methods for inhibiting hiv associated disease using monoclonal antibodies directed against anti-self cytotoxic t-cellsInfo
- Publication number
- WO1994021295B1 WO1994021295B1 PCT/US1994/003055 US9403055W WO9421295B1 WO 1994021295 B1 WO1994021295 B1 WO 1994021295B1 US 9403055 W US9403055 W US 9403055W WO 9421295 B1 WO9421295 B1 WO 9421295B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- monoclonal antibodies
- cytotoxic
- directed against
- antibodies directed
- self
- Prior art date
Links
- 229960000070 antineoplastic Monoclonal antibodies Drugs 0.000 title claims abstract 6
- 229960000060 monoclonal antibodies Drugs 0.000 title claims abstract 6
- 102000005614 monoclonal antibodies Human genes 0.000 title claims abstract 6
- 108010045030 monoclonal antibodies Proteins 0.000 title claims abstract 6
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 title claims abstract 5
- 201000010099 disease Diseases 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims abstract 5
- 210000000400 T-Lymphocytes, Cytotoxic Anatomy 0.000 claims abstract 4
- 239000000427 antigen Substances 0.000 claims abstract 4
- 102000038129 antigens Human genes 0.000 claims abstract 4
- 108091007172 antigens Proteins 0.000 claims abstract 4
- 238000001802 infusion Methods 0.000 claims abstract 2
- 230000002101 lytic Effects 0.000 claims 3
- 206010000565 Acquired immunodeficiency syndrome Diseases 0.000 claims 1
- 210000004369 Blood Anatomy 0.000 claims 1
- 102100001475 ITGB2 Human genes 0.000 claims 1
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 201000009910 diseases by infectious agent Diseases 0.000 abstract 1
- 230000001131 transforming Effects 0.000 abstract 1
Abstract
A method for treating and inhibiting disease associated with the human immunodeficiency virus (HIV) is provided. The method includes transforming the human immunodeficiency virus (HIV) infection into a nonserious disease through the infusion of monoclonal antibodies directed against particular antigens on anti-self, anti-CD4 cytotoxic T-lymphocytes.
Claims
1. A method for preventing a host patient with human immunodeficiency virus from acquiring AIDS, comprising the step of: infusing monoclonal antibodies into the patient to inhibit the effect of autoreactive, CD4-specific cytotoxic T-lymphocytes or their lytics from the circulating blood of the host patient, the monoclonal antibodies directed against one or more antigens on the cytotoxic T-lymphocyte or their lytics.
2. The method as described in Claim 1 wherein the antigen on the cytotoxic T-lymphocytes or their lytics is selected from the group consisting of one or more of the following antigens: S6F1, DR, CD8, LFA-1, ICAM and TCR-1.
3. The method as described in Claim 1 wherein the monoclonal antibodies are infused at least once per day.
4. The method as described in Claim 3 wherein the infusion is continued on a day-to-day basis until an acceptable CD4/CD8 ratio is obtained.
5. The method as described in Claim 1 wherein about 0.1 milligrams of monoclonal antibodies are infused for each 1.0 kilogram of body weight of the host patient.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT94912826T ATE267019T1 (en) | 1993-03-19 | 1994-03-21 | METHODS FOR INHIBITION OF HIV-ASSOCIATED DISEASE USING MONOCLONAL ANTIBODIES AGAINST SELF-DIRECTED CYTOTOXIC T CELLS |
| EP94912826A EP0690725B1 (en) | 1993-03-19 | 1994-03-21 | Methods for inhibiting hiv associated disease using monoclonal antibodies directed against anti-self cytotoxic t-cells |
| AU65221/94A AU684074B2 (en) | 1993-03-19 | 1994-03-21 | Methods for inhibiting HIV associated disease using monoclonal antibodies directed against anti-self cytotoxic T-cells |
| DE69433789T DE69433789T2 (en) | 1993-03-19 | 1994-03-21 | METHODS OF INHIBITION OF HIV-ASSAYED DISEASE BY MONOCLONAL ANTIBODY AGAINST SELF-TESTED CYTOTOXIC T CELLS |
| CA002156495A CA2156495C (en) | 1993-03-19 | 1994-03-21 | Methods for inhibiting hiv associated disease using monoclonal antibodies directed against anti-self cytotoxic t-cells |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3340593A | 1993-03-19 | 1993-03-19 | |
| US08/033,405 | 1993-03-19 | ||
| US16575193A | 1993-12-13 | 1993-12-13 | |
| US08/165,751 | 1993-12-13 | ||
| CA002425086A CA2425086A1 (en) | 1993-03-19 | 2003-04-10 | Method of increasing the delayed-type hypersensitivity response by infusing lfa-1 specific antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1994021295A1 WO1994021295A1 (en) | 1994-09-29 |
| WO1994021295B1 true WO1994021295B1 (en) | 1994-10-27 |
Family
ID=34084057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1994/003055 WO1994021295A1 (en) | 1993-03-19 | 1994-03-21 | Methods for inhibiting hiv associated disease using monoclonal antibodies directed against anti-self cytotoxic t-cells |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5424066A (en) |
| EP (2) | EP1438970B1 (en) |
| AT (2) | ATE408418T1 (en) |
| AU (1) | AU684074B2 (en) |
| CA (2) | CA2156495C (en) |
| DE (2) | DE69433789T2 (en) |
| DK (1) | DK1438970T3 (en) |
| ES (2) | ES2219647T3 (en) |
| HK (1) | HK1067958A1 (en) |
| PT (2) | PT690725E (en) |
| WO (1) | WO1994021295A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5651970A (en) * | 1993-03-19 | 1997-07-29 | Allen; Allen D. | Method for inhibiting disease associated with the human immunodeficiency virus through the use of monoclonal antibodies directed against anti-self cytotoxic T-lymphocytes or their lytics |
| US6534057B2 (en) | 1993-03-19 | 2003-03-18 | Allen D. Allen | Method increasing the delayed-type hypersensitivity response by infusing LFA-1-specific antibodies |
| WO1995028176A1 (en) * | 1994-04-15 | 1995-10-26 | Allen Allen D | Method of treating hiv infection using antibodies against cytotoxic t-cells and thymic humoral factor |
| CN1102631C (en) * | 1995-04-14 | 2003-03-05 | 株式会社东京化学研究所 | Phosphor with afterglow characteristic |
| EP0831907A4 (en) * | 1995-06-06 | 2005-05-04 | D Allen Allen | Method for treating molluscum contagiosum resulting from hiv infection |
| WO1996040215A1 (en) * | 1995-06-07 | 1996-12-19 | Connective Therapeutics, Inc. | Treating immune deficiency diseases using t cell receptor peptides |
| EP2301567A1 (en) * | 1997-02-28 | 2011-03-30 | Enzo Therapeutics, Inc. | Selective immune down regulation (SIDR) for transplantation |
| US20030170258A1 (en) * | 2001-05-09 | 2003-09-11 | Enzo Therapeutics, Inc. | Novel processes implementing selective immune down regulation (SIDR) |
| US6919077B2 (en) * | 2002-09-27 | 2005-07-19 | Aids Research, Llc | LFA-1 alpha subunit antibodies and methods of use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5002869A (en) * | 1987-11-02 | 1991-03-26 | Dana-Farber Cancer Institute | Monoclonal antibody specific to a novel epitope of the LFA-1 antigen of human T lymphocytes |
-
1994
- 1994-03-21 CA CA002156495A patent/CA2156495C/en not_active Expired - Lifetime
- 1994-03-21 WO PCT/US1994/003055 patent/WO1994021295A1/en active IP Right Grant
- 1994-03-21 DK DK04101437T patent/DK1438970T3/en active
- 1994-03-21 AU AU65221/94A patent/AU684074B2/en not_active Ceased
- 1994-03-21 DE DE69433789T patent/DE69433789T2/en not_active Expired - Lifetime
- 1994-03-21 EP EP04101437A patent/EP1438970B1/en not_active Expired - Lifetime
- 1994-03-21 EP EP94912826A patent/EP0690725B1/en not_active Expired - Lifetime
- 1994-03-21 ES ES94912826T patent/ES2219647T3/en not_active Expired - Lifetime
- 1994-03-21 DE DE69435142T patent/DE69435142D1/en not_active Expired - Lifetime
- 1994-03-21 PT PT94912826T patent/PT690725E/en unknown
- 1994-03-21 PT PT04101437T patent/PT1438970E/en unknown
- 1994-03-21 AT AT04101437T patent/ATE408418T1/en active
- 1994-03-21 AT AT94912826T patent/ATE267019T1/en not_active IP Right Cessation
- 1994-03-21 ES ES04101437T patent/ES2314341T3/en not_active Expired - Lifetime
- 1994-09-07 US US08/302,113 patent/US5424066A/en not_active Expired - Lifetime
-
2003
- 2003-04-10 CA CA002425086A patent/CA2425086A1/en not_active Abandoned
-
2005
- 2005-01-08 HK HK05100178A patent/HK1067958A1/en not_active IP Right Cessation
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