WO1994021249A1 - Arsenic medicaments for the treatment of the chronic asthenia syndrome - Google Patents

Abstract

The object of my invention is to provide a very safe and active drug against the new infectious disease called Chronic Asthenia Syndrome. This illness is characterized by chronic debilitation and anorexia, mild fever, myalgia, momentary paresis, generalized muscle weakness, tendency to sleeping, losing weight and resistance to perform the normal activity. Laboratory findings are represented by high levels of Creatine Phosphokinase (CPK) and Creatinine, Magnesium deficiency, decreased haematocrit and Mean Corpuscular Volume (MCV), hypogammaglobulinaemia, eosinophilia and Monocytosis. The intravenous injection of 0.1 milliliter of Caparsolate or Filaramide per Kilogram of body weight made twice, at a distance of 24 hours, can resolve the symptoms and the aetiology of the infectious disease called Chronic Asthenia Syndrome. The Arsenic, and all his organic and inorganic compounds, works as very good drugs against Chronic Asthenia Syndrome.

Description

Arsenic medicaments for the treatment of the chronic asthenia syndrome.

Technical Field

My invention relates to a group of drugs, organic and inorganic compounds of an element of the fifth group in the periodic table, the Arsenic. 5 In the therapy of a new infectious disease of the animals, the Chronic Asthenia Syndrome (S.A.C. in the translation from Italian) Arsenic is the only useful and resolvent drug to employ.

The Chronic Asthenia Syndrome can affect a 10 great variety of species : domesticated mammals and birds, wild mammals and birds.

This infectious disease is characterized primarily by chronic debilitation and various combinations of other symptoms, including asthenia, 15 anorexia, mild fever, sore throat, myalgia, muscle weakness, tendency to sleeping, loosing weight and resistance to perform the normal activity. Some animals can even die, and others become thin and chronically affected. 20

Background Art

I wish to claim the priority of my earlier patent application for the same invention, the Italian national patent N. TO 93A000179, performed 25 on date 17 March 1993 (17.03-93) in Turin (Italy).

Disclosure of Invention

I began to see and study this new illness, the Chronic Asthenia Syndrome of the animals, just one year ago.

The diagnosis must be made on symptoms and on laboratory results: pathognomonics are high levels in serum of Creatine Phosphokinase (CPK) and

Creatinine. This elevations indicate lesions of the skeletal muscles. Often, particularly after many months of chronic sickness, deficiencies of Magnesium are quite common. In the last, the Magnesium deficiency can lead to hypophosphataemia, because the metabolism of the two electrolytes has many links.

In the Chronic Asthenia Syndrome we can see currently a decreased haematocrit or decreased packed cell volume (PCV), decreased Mean Corpuscolar Volume (MCV), Iron deficiency, decreased platelet count (thrombocytopenia) in the early days of the sudden onset of the illness, together with an increase concentration of Alpha-2-Globulins, due to acute inflammatory disorders.

A quite common acquired immunodeficiency with hypogammaglobulinaemia can be seen in the plasma proteins of the animals affected by Chronic Asthenia Syndrome, after some weeks or months, Eosinophilia and Monocytosis are often presents. The aetiologic agent it's easily revealed by the May-Grunwald-Giemsa method for staining blood smears. Previously fixed in absolute methanol for 2-10 minutes, the blood smear from the sick animal will be stained with the May-Grunwald-Giemsa method and observed in the optical microscope: the aetiologic agent will appear in a red brilliant color beside the Red Blood Cells (RBC).

Until now no one medicinal substance was available to cure this new infectious disease.

My invention relates to a group of drugs, all Arsenic's compounds, in particular the organic compound called 'Caparsolate', that are very active in the therapy of this illness. This drugs are able to restore the state of health in the sicks animals in a very safe, sure and prompt way. With two intravenous injections of 0,1 ml. of Caparsolate per kilogram of body weight of the animal under treatment we can resolve all the symptoms of the Chronic Asthenia Syndrome in few hours or days, depending on how severe the infection is. The two injections must be rigorously intravenous and separated by 24 hours of time. If needed, one more intravenous injection of 0,1 milliliter per kilogram of body weight can be added in the third day of treatment.

Claims

Claims

1. The Arsenic, and all his compounds organics and inorganics, works as very good drugs against the Chronic Asthenia Syndrome (S.A.C. in the Italian translation = Sindro e da Astenia Cronica). Particularly the organic compounds , like Caparsolate for example, containing 10 milligrams of Sodium Caparsolate every 1 milliliter, are very safe and active.

2. The effective treatment against S.A.C. (Chronic Asthenia Syndrome) will be made by two intravenous injections of Caparsolate or other Arsenic's organic compound, like the commercial product 'Filaramide', containing Sodium Tiacetarsamide.

3. The intravenous injection of 0,1 milliliter of

Caparsolate per Kilogram (Kg.) of body weight, made twice, at a distance of 24 hours, can resolve the symptoms and the aetiology of the infectious disease called Chronic Asthenia Syndrome. If it's necessary one more intravenous injection of 0,1 milliliter per

Kilogram can be made in the third day of treatment, particularly in very heavily infected animals.