WO1994016622A1 - Procede et dispositif d'imagerie a des fins diagnostiques - Google Patents

Procede et dispositif d'imagerie a des fins diagnostiques Download PDF

Info

Publication number
WO1994016622A1
WO1994016622A1 PCT/US1994/000702 US9400702W WO9416622A1 WO 1994016622 A1 WO1994016622 A1 WO 1994016622A1 US 9400702 W US9400702 W US 9400702W WO 9416622 A1 WO9416622 A1 WO 9416622A1
Authority
WO
WIPO (PCT)
Prior art keywords
light
lesion
tissue
secondary light
image
Prior art date
Application number
PCT/US1994/000702
Other languages
English (en)
Inventor
Yoram Tsivion
Menashe Shachar
Original Assignee
Computer Aided Medical U.S.A. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Computer Aided Medical U.S.A. Inc. filed Critical Computer Aided Medical U.S.A. Inc.
Priority to AU62309/94A priority Critical patent/AU6230994A/en
Publication of WO1994016622A1 publication Critical patent/WO1994016622A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/444—Evaluating skin marks, e.g. mole, nevi, tumour, scar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/446—Scalp evaluation or scalp disorder diagnosis, e.g. dandruff

Definitions

  • the present invention relates to diagnostic imaging devices, primarily for use by a primary care physician or general practitioner.
  • the present invention provides a relatively consistent and discriminating diagnostic method which utilizes specially selected frequencies of light to highlight factors typically observed in evaluating abnormalities or diseases such as malignancies. These factors include the darkness of the lesion, the regularity of its outline, and the variability or texture of its appearance.
  • Typical unaided visual examination of tissue specimens is of limited effectiveness and reliability because of the limited capability of unaided human vision to perceive the different wavelengths that comprise sensed light such as those wavelengths of light returned from the specimen. For instance, this may result in the mistaken perception of a light as a specific color even though that light includes different radiant energy inputs each having distinct spectral frequencies or wavelengths.
  • a physician may conclude that two distinct tissue types are indistinguishable because they appear to be the same "color" to his eye, while in actuality, the "color" of each tissue is spectrally distinct. This, in turn, may result in an erroneous diagnosis.
  • Kenet et al. U.S. Patent No. 5,016,173, broadly discloses in vivo monitoring of visually accessible body surfaces by stimulating the surface with light and analyzing the images of reflected or emitted light. However, Kenet et al. does not recognize any advantages achieved by specific illumination wavelengths or by imaging specific wavelengths of returned light.
  • the present invention overcomes the drawbacks of these examination techniques by illuminating a specimen suspected of containing a lesion, with primary radiant energy of a desired wavelength or range of wavelengths without causing undue stress to the tissue, selecting the wavelengths or range of wavelengths of secondary radiant energy returned from the specimen at which a particular tissue type can be differentiated from the surrounding tissue environment, and displaying an image derived from one or more of the selected component (s) of secondary light from which the physician can discern the nature of the examined tissue.
  • This information and any output image can be stored for record and comparison purposes or can be transmitted to remote viewing stations, thereby facilitating consultations or specialist reviews.
  • Another object is to provide an imaging diagnostic device by which abnormal tissue can be more readily identified by visual means.
  • a further object of the invention is to provide a resulting diagnostic image of the examined specimen within a short time period.
  • the lesion is capable of being distinguished from normal tissue due to a difference between the lesion and normal tissue as to (i) darkness, (ii) outline, (iii) texture, (iv) other morphological features, or (v) any combination thereof.
  • the suspect tissue is exposed to an ultraviolet primary light, this light being comprised of at least one wavelength component, to yield a secondary light from the tissue. At least one component of the secondary light having a wavelength at least as long as the wavelength of green light is selected, and an image of the lesion derived from the selected secondary light components is displayed.
  • these methods are non-invasive, and the lesion to be detected is a skin or a cervical lesion.
  • the selected components can be digitized before imaging.
  • an apparatus for analyzing tissue illuminated by a primary light comprises (a) a primary light source, (b) a filter for selecting at least one component of the secondary light from the tissue in a band of wavelengths correlated to the type of tissue and type of lesions suspected, and finally (c) a display device for displaying a visual image derived from selected secondary light.
  • An optional image receiving device for producing separate digitized data representing a digitized image of the selected component (s) and means for processing the digital data to produce digitized images of red, green, and blue components of the selected component(s) can be incorporated, and the visual image can be derived from one or more of the red, green, or blue selected components.
  • Figure 1 is a block diagram of an imaging device according to the invention.
  • Figure 2 is a block diagram of another form of imaging device incorporating a filter wheel.
  • Figure 3 is a block diagram of a further form of imaging device incorporating a beam splitter.
  • Abnormal or diseased tissues including, but not limited to, malignant tissues, can be visually distinguished from normal tissues by their preferential absorption, reflection, emittance, and/or fluorescence of radiant energies having particular electromagnetic frequencies or wavelengths.
  • a particular abnormal tissue or lesion may completely, or to a certain extent, absorb, reflect, emit, or fluoresce radiant energy of a specific wavelength while a different type of lesion or normal tissue may do so to a different extent or not at all.
  • healthy skin tissue can be visually differentiated from deviant skin tissue when examined under red light, while healthy cervix tissue is visually distinguishable from unhealthy tissue when observed under green light.
  • the methods and apparatus of the present invention can be used to analyze any tissues.
  • the methods of the present invention are particularly well suited for non- invasive use where a primary light can most easily be directed to the tissue suspected of including a lesion.
  • Suitable tissues include, but are not limited to, skin tissues and cervical tissues, and diagnosable lesions include, but are not limited to, malignant lesions.
  • the present invention can also be used in an invasive procedure to analyze tissues such as cardiac tissue and the like during operations or in invasive or non-invasive biopsies.
  • a tissue or a specimen suspected of including a lesion is exposed, and preferably illuminated, by a source of primary light.
  • the primary light source may be a white light source such as ambient light, incandescent lights, discharge lamps such as an electronic camera flash, or spotlights.
  • the primary light source may be an ultraviolet light source.
  • the ultraviolet light emitted from the primary light source is ultraviolet light in the UV-A region, which is also known as long wave UV, near UV or black light. This region includes light of wavelengths ranging from about 320 nm to about 400 nm.
  • the primary light source generates radiant energy of a sufficient intensity at the particular wavelengths being used to facilitate a high signal-to-noise ratio.
  • the intensity of the radiation should not be so high as to harm a live specimen, such as the skin or other exposed area of a person. Examples of such harmful radiation include, but are not limited, to short wavelength ultra-violet light such as the UV-C region.
  • Secondary light is returned or emanates from the tissue that is exposed to the primary light, by reflection, emission, fluorescence, or any combination thereof.
  • One or more wavelength components of the secondary light returned from the exposed or illuminated specimen are selected, preferentially by passing the secondary light through a selecting device which permits only specific light wavelengths or ranges of wavelengths to pass, and an image of the lesion is derived from the selected secondary light.
  • the selection of the desired component of the secondary light or radiant energy may be accomplished by any known means for the selective transmission of light. These may include filters, including, but not limited to, polarizing light filters, color filters, staining, etc. Special mention is made of a selection means that utilizes a color wheel having filters located about its perimeter or of a prism.
  • the selected secondary light is not limited to a single wavelength in the electromagnetic spectrum. Bands of wavelengths corresponding to a particular region of the electromagnetic spectrum may yield desirable results.
  • the primary light is white light
  • the preferred range of wavelengths of secondary light for the visualization of several skin tissue types corresponds to the red region, i.e. those radiant energies having wavelengths at least as long as that of red light of the visible spectrum or about 610 nm or greater. Therefore, preferred selecting means for use in examination of skin tissue with primary white light would include, for example, a red light passing filter such as Schott Models OG570, RG610, or RG630 filter which pass a band of light of wavelengths greater than about 570 nm, 610 nm or 630 nm respectively.
  • a red narrow pass band filter would additionally minimize those components having wavelengths sufficiently shorter than red light, such as blue and violet components.
  • the primary light is white light
  • the green, yellow and orange regions of the secondary light i.e. those radiant energies having wavelengths at least as long as that of green light or about 520 to about 570 nm, is preferred for the analysis of cervical tissue. Therefore, preferred selecting means for use in examination of cervical tissue with primary white light would include, for example, green light passing filters such as Schott filters GG435, GG495, and green narrow band filters.
  • preferred selecting means for use in examination of tissue and particularly skin tissue with primary ultraviolet or near ultraviolet light include, for example, a green light passing filter as described above, and particularly those such as a Schott OG570 which passes wavelengths greater than about 570 nm.
  • a high pass or a band pass filter that cuts off below or within the green region would additionally minimize those components having wavelengths significantly shorter than green light, such as blue and violet components.
  • a filter when used as a selecting means, it is recognized that the filter may not completely block all of the components having a non-selected wavelength. It is only necessary that a sufficient amount of non-selected components are blocked so that the non- selected components do not interfere with the image.
  • a typical 3 millimeters thick OG570 green filter will allow 46% of the light having a wavelength of 570 nm to pass, 9% of the light having a wavelength of 560 nm to pass, 4x10 ⁇ % of light having a wavelength of 550 nm to pass, and lxl0 "5 % of the light having a wavelength of 360 nm to pass.
  • a rotatable filter wheel can be incorporated.
  • the wheel carries a plurality of filter sectors, each separately and selectively interposable between the specimen and the following light sensor. By rapid rotation of filter wheel, the successive images will represent the exact same specimen area, substantially at the same instant and in the same condition, permitting a comparison of two or more images derived from two different types of secondary light taken through different zones of the filter wheel.
  • the primary light source may be limited to only the desired secondary light wavelength bands and the selecting device can be eliminated or a selecting device, such as for example a prism, may be interposed between the primary light source and the specimen.
  • the method whereby the secondary light components are selected is more desirable to provide higher signal-to-noise values and to inhibit variable effects of ambient light.
  • the different spectral versions correspond to the same geometric area or posture of the subject.
  • the light from the illuminated specimen may pass to a conventional optical beam splitter which divides the image into several beams. Each beam then passes through a respective filter.
  • selection of the specific desired wave band component of the secondary light is preferably made near the point where the radiant energy is imaged or digitized.
  • the secondary light is received by a light sensing or an image capture device to provide an image, which may be of the lesion, from the selected components of the secondary light.
  • the image is in digital form, i.e. a digitized image.
  • the image derived from the selected secondary light component(s) is displayed either directly or indirectly, and is displayed immediately or is stored.
  • the display is derived from secondary light components that are either imaged, imaged and digitized, or digitized and imaged.
  • the selected secondary light will be imaged on a photographic film such as, for example Fuji 400 film.
  • the physician may note the darkness or gray level of the suspected lesion, irregularities of its outline, and/or the texture or variability of its surface, all of which are indicative of possible malignancy or disease.
  • abnormal tissues or lesions exhibit non-uniform surfaces, irregular outlines, or abrupt changes in the image intensity of certain areas relative to other areas.
  • the selected radiant energy is to be digitized, it is converted into digital format by suitable light sensing and digitizing means.
  • a "digitized image” is meant a representation of the specimen in the form of a matrix of pixels (e.g., 1800 pixels wide by 1200 pixels high) , where each pixel is represented by a binary number which includes data as to the position of the pixel in the image and at least one intensity value (e.g., 8 bits to provide 256 gray levels).
  • the necessary functions entail sensing the pattern of different light intensities within a given area at a specific time and converting that pattern into a "digitized image" by assigning for each point of the area (pixel) a digital (preferably binary) value corresponding to the light intensity received from that particular image point at the specified time.
  • the photograph illuminated under normal conditions, can be scanned by a conventional digitizing scanner (such as Scanmaster produced by Microtek Inc.) which provides a digitized image of the photograph, as a matrix array of pixels, each pixel being constituted by digital data defining its position in the matrix array, and additional data representing the filtered light intensity of the individual pixel.
  • a filter wheel or other sequential secondary light output manipulator is used, each filtered output can be supplied to an electronic light sensor connected to respective conventional frame grabbers or image digitizers synchronized to the position of the wheel to provide respective filtered digitized images of the specimen, for subsequent processing.
  • Each of these images may be processed and displayed by an appropriate computerized processor as described above or with another multi-spectral analyzer.
  • Frame grabbers may be used in conjunction with video or high definition video cameras to provide the digitized images.
  • the digitized radiant energy image is converted into a diagnostic image for viewing by utilizing a multi-spectral image-processing algorithm that can normalize the data and separate the data corresponding to pertinent tissue features.
  • a multi-spectral image processing algorithm operates by comparing two different digitized images of the same subject matter, derived by sensing different spectral components of the same object.
  • a digitized image of one color component (such as red) is compared to the digitized image of another color component (such as blue) or to an unfiltered version of the same specimen region.
  • the algorithm derives from the respective pixels at each pixel position, a resultant pixel value.
  • the matrix of such resultant pixel values forms a diagnostic image whereby different tissue types may be visually distinguished.
  • the preferred means to process the digitized data into an output image utilizes a desktop computer running software incorporating multi-spectral image processing algorithms.
  • a preferred means to carry out the digitizing of the selected radiant energy is a digital image sensor or video camera coupled to a digitizer, such as a conventional electronic or video camera.
  • One suitable digitizing image capture device is a Kodak Professional DC 200 Digital Camera having a conventional Nikon camera body and optics incorporating a CCD image sensor and memory, or other electronic camera using an Eastman Kodak KAF-4200 chip such as Photometric Series 200 which interfaces directly with a PC. Such a device provides a digitized image of the specimen, suitable for further processing and display.
  • a digital electronic camera provides a signal for each pixel, which signal includes separate data for the usual three primary color (red, green, blue) components of the light at that pixel position.
  • the digitized pixel signal may have 24 bits devoted to pixel value, with 8 bits for the red component and 8 bits for the green component level and 8 bits for the blue component level.
  • the data processing software may be used to pass only bits representing the desired color component, for example, red or green, thereby restricting the displayed image to only the desired color component. That image is then processed in a light data processor, and is supplied to a display device to provide the examining physician with an image for interpretation.
  • the image capture device may be a video or high definition television camera, in association with a conventional frame grabber circuit to provide the desired digital representation of the restricted-light-band image of the tissue specimen.
  • the resultant image may be displayed by means of a suitable conventional computer peripheral image device, such as a CRT monitor, printer, video screen, etc. Delays in developing and scanning photographs are avoided in a system that provides a substantially immediate display.
  • the preferred means for displaying the digitized output image is a CRT monitor which may be monochrome or polychrome.
  • the digitized image data and the resultant output image may be stored by means of any conventional digital data storage device such as a computer hard disk, a magnetic tape, or an optical disk.
  • the data processor may have conventional image processing means for aiding examination (such as brightening and/or magnification) of selected areas of the input image.
  • PhotoStyler desktop software of U-lead Systems Inc. may be used with a computer, such as a 486 processor based PC with adequate memory.
  • the output of the processor is made visually accessible to the physician by the display device which may be a conventional black and white monitor or a personal computer.
  • a display device of at least 1024x1024 pixels is preferred.
  • a multi-spectral analysis of two or more of these different digitized images will provide more significant displayed images for diagnosis.
  • a separate digitized image matrix may be obtained for each of two different filter bands.
  • the intensity value of each pixel from one image is compared in the data processor 9 with the intensity value of the correspondingly located pixel of the other image, to provide a composite value (e.g. a ratio of intensities) .
  • These composite values may then be displayed by false-color imaging on a color monitor or computer (rather than a monochrome display) to yield color patterns indicative of malignancy or disease distinguishable from similar patterns for healthy tissue.
  • the displayed pixel is given one color (e.g. green) while if the ratio is greater than the fixed value, the displayed pixel is given a distinctive color (e.g. red) .
  • the resulting displayed pattern (like a bit map) may be compared with similar patterns for known malignancies or healthy tissue to provide diagnosis of possible malignancy or disease.
  • a color-restricted digitized image of a specimen may be compared by such multispectral analysis with a concurrent non-color- restricted image of the same tissue specimen, to reduce or eliminate factors which may tend to distort data derived from ambient-illuminated skin or tissue.
  • This permits comparing a selected specimen area with adjoining or background areas, to distinguish them as to malignancy or abnormality.
  • Apparatus for practicing the invention are illustrated in Figures 1-3.
  • the specimen 3 is exposed to the primary light source 1. Secondary light from the specimen 3 passes through the filtering device 5 and to the image capturing device 7.
  • the image from the image capturing device 7 is received by a digital data processor 9 and is displayed by the display device 11 or is recorded by the recording device 13.
  • Figure 2 illustrates the use of a color wheel having a plurality of filter segments 17, each of appropriate light-transmitting characteristics. Secondary light from the specimen 3 passes through the revolving color wheel segments 17. The light data transmitted through each segment of the filter wheel is supplied to respective conventional frame grabbers FG 1-5, which provide respectively filtered digitized images of the specimen 3. Each frame grabber data may be passed to a multi-spectral analyzer for processing and display as described above.
  • Figure 3 illustrates the incorporation of a beam splitter 19 in place of the color wheel. Secondary light from the specimen 3 passes through the beam splitter 19. The light components transmitted by the beam splitter 19 are passed through respective filters 21a-c, and the filtered light is passed to a digitizing data processing and display device as described above.
  • the apparatus of the present invention can be used under normal light conditions. It includes a primary light source, means for selecting particular wavelengths of light reflected or secondary light from the examined tissue, such as by using light filters that transmit the desired range of light wavelengths; means for obtaining one or more sequential images of the examined tissue, each taken under different light wavelengths, in rapid sequence so that the multiple images are, for the practical purposes of this invention, equivalent as to space and time, such as by a color light filter wheel attachment on an electronic image sensor; means for converting the various light intensities derived from the specimen into a digital form in a specified format, preferably utilizing an electronic image sensor or capture device; means for processing the digital information according to an appropriate image processing algorithm, preferably utilizing a computer with appropriate software; means for storing the processed results in an image memory device, preferably utilizing computer memory; and means for displaying the resulting output image, whereby abnormal diseased or cancerous tissue may be differentiated from healthy tissue by ordinary visual inspection of the display, preferably using a conventional computer peripheral display.
  • a primary light source means
  • Imaging devices include, but are not limited to an image capturing device (camera) for a color-restricted image, an image digitizing device, an image-processing device and a display device, and which enhance the details of tissue under examination by computerized color separation, to provide a diagnostic aid suitable for primary care physicians.
  • an image capturing device for a color-restricted image
  • an image digitizing device for a color-restricted image
  • an image-processing device for a color-restricted image
  • a display device and which enhance the details of tissue under examination by computerized color separation, to provide a diagnostic aid suitable for primary care physicians.
  • the present invention thereby provides an apparatus and methods for the non-invasive screening of body surface tissues to aid in determination of malignancies and other abnormalities, suitable for use by primary care physicians and general practitioners. DESCRIPTION OF ILLUSTRATIVE EXAMPLES Example 1
  • a suspected cheek skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light.
  • the lesion was observed to be a dysplastic pig ented lesion.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be very regular. Visible darkness of the lesion was determined to be dark. Texture of the lesion was determined to be variable.
  • the skin lesion was also analyzed by again exposing, in situ, the suspect tissue to primary white light from the same source. However, secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was determined to be slightly visible in parts.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a Minolta X-700 camera. Image tone was observed as dark- variable.
  • the secondary light returned from the tissue was filtered through a Schott OG570 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. Image tone was observed as dark-regular.
  • a suspected back skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light.
  • the lesion was observed to be dysplastic.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be irregular. Visible darkness of the lesion was determined to be dark. Texture of the lesion was determined to be variable.
  • the skin lesion was also analyzed by exposing, in situ, the suspect tissue to primary white light from the same source. However, secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was not readily visible.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a
  • Minolta X-700 camera Image tone was observed as medium- dark.
  • a suspected neck skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light. A clinical diagnosis of a pigmented lesion was made.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be rather regular. Visible darkness of the lesion was determined to be medium. Texture of the lesion was determined to be variable.
  • the skin lesion was also analyzed by again exposing, in situ, the suspect tissue to primary white light from the same source. However, secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was not visible.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a Minolta X-700 camera. Image tone was observed as light.
  • Example 4 A suspected back skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light. The lesion was observed to be Bowen's disease.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electronic flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be irregular. Visible darkness of the lesion was determined to be light. Texture of the lesion was determined to be even.
  • the skin lesion was also analyzed by again exposing, in situ, the suspect tissue to primary white light from the same source. Secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was not visible.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a Minolta X-700 camera. Image tone was observed as light and peculiarly shaped.
  • the lesion was not a malignant melanoma, and subsequent pathological studies identified the lesion as a crust with formation and fibroblastic proliferation of the upper dermis. The light analyses correctly indicated that tissue excision was unnecessary.
  • a suspected scalp skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light.
  • a clinical diagnosis of seborrheic keratosis was made.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be slightly irregular. Visible darkness of the lesion was determined to be very dark. Texture of the lesion was determined to be variable.
  • the skin lesion was also analyzed by again exposing, in situ, the suspect tissue to primary white light from the same source. Secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was visible in parts.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a
  • Minolta X-700 camera Image tone was observed as dark- variable.
  • the secondary light returned from the tissue was filtered through a Schott OG570 filter. and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. Image tone was observed as very dark.
  • a suspected umbilical region skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light.
  • the lesion was observed to be an umbilical region papillary pigmented nevus.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be very regular. Visible darkness of the lesion was determined to be light. Texture of the lesion was determined to be even.
  • the skin lesion was also analyzed by again exposing, n situ, the suspect tissue to primary white light from the same source. Secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was not visible.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a
  • Minolta X-700 camera The lesion disappeared on the image. The lesion was evaluated as harmless, and subsequent pathological studies identified the lesion as a compound lesion.
  • a suspected cheek skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light.
  • a clinical diagnosis of a pigmented lesion was made.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be regular. Visible darkness of the lesion was determined to be medium. Texture of the lesion was determined to be variable.
  • the skin lesion was also analyzed by again exposing, in situ, the suspect tissue to primary white light from the same source. Secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was not visible.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a
  • Minolta X-700 camera Image tone was observed as medium.
  • a suspected abdominal skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light. A clinical diagnosis of a blue lesion was made.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be regular. Visible darkness of the lesion was determined to be dark in the center and lighter elsewhere.
  • the skin lesion was also analyzed by again exposing, in situ, the suspect tissue to primary white light from the same source. Secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was determined to be visible in the center.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a
  • Minolta X-700 camera Image tone was observed as very dark. Removal was proposed, and subsequent pathological studies identified the lesion as a junctional dysplastic lesion. Results are illustrated in Table 1.
  • a suspected neck skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light. A clinical diagnosis of a suspicious recent growth nevus was made.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be regular. Visible darkness of the lesion was determined to be medium. Texture of the lesion was determined to be light.
  • SPECTRALINE Black Light - Black Light Eastern Corp. - average wavelength 366 nm
  • a suspected back skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light.
  • the lesion was observed to be a dysplastic, pigmented lesion.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be irregular. Visible darkness of the lesion was determined to be dark. Texture of the lesion was determined to be variable.
  • SPECTRALINE Black Light - Black Light Eastern Corp. - average wavelength 366 nm
  • the secondary light returned from the tissue was filtered through a Schott OG570 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. Image tone was observed as medium.
  • Example 11 A suspected thigh skin lesion was evaluated, in situ, by a skill practitioner by unaided visual observation under ambient light. The lesion was observed to be dysplastic.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash/ambient light source.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be regular. Visible darkness of the lesion was determined to be medium. Texture of the lesion was determined to be even.
  • the skin lesion was also analyzed by again exposing, in situ, the suspect tissue to primary white light from the same source. Secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was nearly invisible.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a
  • Minolta X-700 camera Image tone was observed as medium.
  • a suspected elbow skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light.
  • a clinical diagnosis of a changing pigmented lesion was made.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera. Visible darkness of the lesion was determined to be dark. Texture of the lesion was determined to be variable.
  • the skin lesion was also analyzed by again exposing, in situ, the suspect tissue to primary white light from the same source. Secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was not visible.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a Minolta X-700 camera. Outline was observed as irregular.
  • the secondary light returned from the tissue was filtered through a Schott OG570 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. Image tone was observed as very dark.
  • a suspected ear skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light.
  • the lesion was observed to be a non-malignant nevus.
  • the lesion had changed rapidly and was bleeding.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera. Outline of the lesion was determined to be almost regular. Visible darkness of the lesion was determined to be light. Texture of the lesion was determined to be even.
  • the skin lesion was also analyzed by again exposing, in situ, the suspect tissue to primary white light from the same source. Secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was not visible.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a
  • Minolta X-700 camera Image tone was observed as not dark.
  • the lesion was believed to be harmless, papilla or intradermal nevus and subsequent pathological studies identified the lesion as an intradermal lesion. The light analyses correctly indicated that tissue excision was unnecessary.
  • a suspected abdominal skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light.
  • the patient was a multiple lesion case, and the most suspicious specimen was studied.
  • the lesion was observed to be a dysplastic pigmented lesion.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be regular. Visible darkness of the lesion was determined to be dark. Texture of the lesion was determined to be variable.
  • the skin lesion was also analyzed by exposing, in situ, the suspect tissue to primary white light from the same source. Secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was visible.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a Minolta X-700 camera. Image tone was observed as dark/medium.
  • the secondary light returned from the tissue was filtered through a Schott OG570 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. Image tone was observed as dark medium.
  • a suspected back skin lesion was evaluated, in situ, by a dermatologist or a plastic surgeon by unaided visual observation under ambient light.
  • the back lesion was observed to be dysplastic.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be regular.
  • Visible darkness of the lesion was determined to be medium. Texture of the lesion was determined to be even.
  • the skin lesion was also analyzed by again exposing, in situ, the suspect tissue to primary white light from the same source. Secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was barely visible.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a Minolta X-700 camera. Image tone was observed as dark/medium.
  • a suspected abdominal skin lesion was evaluated, in situ, by a skilled practitioner by marked visual observation under ambient light.
  • a clinical diagnosis of a pigmented lesion was made. The lesion had been stable for several years.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash/ambient light source.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be regular.
  • Visible darkness of the lesion was determined to be medium.
  • Texture of the lesion was determined to be variable.
  • SPECTRALINE Black Light - Black Light Eastern Corp. - average wavelength 366 nm
  • a suspected forearm skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light.
  • the lesion was observed to be a keratosis or a malignant melanoma.
  • the patient was stable.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be irregular. Visible darkness of the lesion was determined to be medium. Texture of the lesion was determined to be variable.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a Minolta X-700 camera. Image tone was observed as medium- dark.
  • the lesion was then believed to be non-malignant and loose follow-up was proposed as case management. Subsequent pathological studies identified the lesion as a seborrheic keratosis reticulated lesion. The light analyses correctly indicated that tissue excision was unnecessary.
  • a suspected nose skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light. The recent lesion was observed to be dysplastic pigmented lesion.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be regular. Visible darkness of the lesion was determined to be light. Variability of the lesion was determined to be even.
  • the skin lesion was also analyzed by again exposing, in situ, the suspect tissue to primary white light from the same source. Secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was not visible.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a Minolta X-700 camera. Image tone was observed as not dark.
  • the lesion was believed to be harmless, and subsequent pathological studies identified the lesion as an intradermal lesion. The light analyses correctly indicated that tissue excision was unnecessary.
  • a suspected neck skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light. The lesion was observed to be an intradermal lesion.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be regular. Visible darkness of the lesion was determined to be light. Texture of the lesion was determined to be even.
  • the skin lesion was also analyzed by again exposing, in situ, the suspect tissue to primary white light from the same source. Secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was not visible.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a Minolta X-700 camera. Image tone was observed as not dark.
  • the lesion was believed to be harmless, and subsequent pathological studies identified the lesion as an intradermal lesion. The light analyses correctly indicated that tissue excision was unnecessary.
  • a suspected neck skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light.
  • the lesion was observed to be a dysplastic papillary pigmented nevus.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be regular. Visible darkness of the lesion was determined to be medium. Texture of the lesion was determined to be variable.
  • the skin lesion was also analyzed by again exposing, in situ, the suspect tissue to primary white light from the same source. Secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was not visible.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a Minolta X-700 camera. Image tone was observed as not dark.
  • a suspected back skin lesion that caused itching was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light.
  • a clinical diagnosis of a malignant melanoma was made.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be regular. Visible darkness of the lesion was determined to be medium. Texture of the lesion was determined to be variable.
  • the skin lesion was also analyzed by again exposing, in situ, the suspect tissue to primary white light from the same source. Secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was not visible.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a Minolta X-700 camera. Image tone was observed as dark variable.
  • a suspected back skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light.
  • the back lesion was observed to be a papillary nevus.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be slightly irregular. Visible darkness of the lesion was determined to be dark in parts. Texture of the lesion was determined to be variable.
  • the skin lesion was also analyzed by again exposing, in situ, the suspect tissue to primary white light from the same source. Secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was not visible.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a Minolta X-700 camera. Image tone was observed as dark. Outline was observed as irregular.
  • a suspected wrist skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light.
  • the lesion was observed to be a blue nevus.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera. Outline of the lesion was determined to be regular. Visible darkness of the lesion was determined to be light. Texture of the lesion was determined to be even.
  • the skin lesion was also analyzed by again exposing, in situ, the suspect tissue to primary white light from the same source. Secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was not visible.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a
  • Minolta X-700 camera Image tone was observed as light.
  • the secondary light returned from the tissue was filtered through a Schott OG570 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. Image tone was observed as dark.
  • the lesion was believed to be harmless and subsequent pathological studies identified the lesion as a blue lesion. The light analyses correctly indicated that tissue excision was unnecessary.
  • a suspected cheek skin lesion was evaluated, in situ, by a skilled practitioner by marked visual observation under a bright light.
  • a clinical diagnosis of a recent lentigo maligna was made.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be slightly irregular. Visible darkness of the lesion was determined to be light. Texture of the lesion was determined to be dark in parts.
  • the skin lesion was also analyzed by again exposing, in situ, the suspect tissue to primary white light from the same source. Secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was visible in parts.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a Minolta X-700 camera. Image tone was observed as medium variable.
  • a suspected neck skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light. This recent lesion was observed to be a papillary nevus.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be regular. Visible darkness of the lesion was determined to be medium. Texture of the lesion was determined to be even.
  • the skin lesion was also analyzed by again exposing, in situ, the suspect tissue to primary white light from the same source. Secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was not visible.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a Minolta X-700 camera. Image tone was observed as medium.
  • the lesion was believed to be harmless and subsequent pathological studies identified the lesion as an intradermal lesion. The light analyses correctly indicated that tissue excision was unnecessary.
  • a suspected back skin lesion was evaluated, in situ, by a skilled practitioner by unaided visual observation under ambient light.
  • the slightly changed lesion was observed to be a papillary pigmented nevus.
  • the same skin lesion was analyzed by exposing, in situ, the tissue suspected of including the lesion to primary white light from an electric flash.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH color film with a Minolta X-700 camera.
  • Outline of the lesion was determined to be very regular. Visible darkness of the lesion was determined to be medium. Texture of the lesion was determined to be even.
  • the skin lesion was also analyzed by again exposing, in situ, the suspect tissue to primary white light from the same source. Secondary light returned from the tissue was filtered through a Schott RG630 filter, and the selected secondary light was imaged on Fuji 400 RH color film with a Minolta X-700 camera. The lesion was visible.
  • the secondary light returned from the tissue was imaged on Fuji 400 RH film with a Minolta X-700 camera. Image tone was observed as very regular.
  • the lesion was believed to be a benign pigmented nevus, and subsequent pathological studies identified the lesion as a seborrheic keratosis. The light analyses correctly indicated that tissue excision was unnecessary.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

La présente invention concerne le domaine des dispositifs d'imagerie à des fins diagnostiques pour les premiers soins et la médecine générale. L'appareil et le procédé de la présente invention produisent une image à des fins diagnostiques. Ledit procédé consiste à exposer l'échantillon de tissus vivants in situ à une lumière primaire, à choisir des longueurs d'onde particulières de la lumière secondaire renvoyée par les tissus examinés et à obtenir une ou plusieurs images séquentielles des tissus examinés. L'image est affichée si bien que l'utilisateur peut distinguer les tissus anormaux des tissus sains en inspectant attentivement l'image affichée.
PCT/US1994/000702 1993-01-19 1994-01-19 Procede et dispositif d'imagerie a des fins diagnostiques WO1994016622A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU62309/94A AU6230994A (en) 1993-01-19 1994-01-19 Diagnostic imaging method and device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US489493A 1993-01-19 1993-01-19
US004,894 1993-01-19

Publications (1)

Publication Number Publication Date
WO1994016622A1 true WO1994016622A1 (fr) 1994-08-04

Family

ID=21713053

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/000702 WO1994016622A1 (fr) 1993-01-19 1994-01-19 Procede et dispositif d'imagerie a des fins diagnostiques

Country Status (4)

Country Link
AU (1) AU6230994A (fr)
IL (1) IL108350A0 (fr)
WO (1) WO1994016622A1 (fr)
ZA (1) ZA94343B (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0783867A1 (fr) * 1995-12-21 1997-07-16 Unilever Plc Dispositif destiné à l'identification d'acné, des comedons et des bactéries sur la peau humaine
WO1998022023A1 (fr) * 1996-11-19 1998-05-28 Optiscan Ltd. Procede de mesure de l'histologie cutanee
WO1998024360A1 (fr) * 1996-12-04 1998-06-11 Harvey Lui Systeme de fluoroscopie pour diagnostic dermatologique
US6110106A (en) * 1998-06-24 2000-08-29 Biomax Technologies, Inc. Endoscopes and methods relating to direct viewing of a target tissue
US6201989B1 (en) 1997-03-13 2001-03-13 Biomax Technologies Inc. Methods and apparatus for detecting the rejection of transplanted tissue
JP2001521772A (ja) * 1997-10-30 2001-11-13 ハイパーメッド・イメジング・インコーポレーテッド マルチスペクトル／ハイパースペクトルの医療用計器
US7054674B2 (en) 1996-11-19 2006-05-30 Astron Clinica Limited Method of and apparatus for investigating tissue histology
US8175688B2 (en) 1997-10-30 2012-05-08 Hypermed Imaging, Inc. Multispectral/hyperspectral medical instrument
FR2984721A1 (fr) * 2011-12-26 2013-06-28 Chanel Parfums Beaute Procede et dispositif de detection et de quantification de signes cutanes sur une zone de peau
US20220303508A1 (en) * 2019-11-08 2022-09-22 Korea Electrotechnology Research Institute Multi-band optical filtering method and apparatus

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4170987A (en) * 1977-11-28 1979-10-16 California Institute Of Technology Medical diagnosis system and method with multispectral imaging
US5016173A (en) * 1989-04-13 1991-05-14 Vanguard Imaging Ltd. Apparatus and method for monitoring visually accessible surfaces of the body

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4170987A (en) * 1977-11-28 1979-10-16 California Institute Of Technology Medical diagnosis system and method with multispectral imaging
US5016173A (en) * 1989-04-13 1991-05-14 Vanguard Imaging Ltd. Apparatus and method for monitoring visually accessible surfaces of the body

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760407A (en) * 1995-12-21 1998-06-02 Elizabeth Arden Co., Division Of Conopco, Inc. Device for the identification of acne, microcomedones, and bacteria on human skin
EP0783867A1 (fr) * 1995-12-21 1997-07-16 Unilever Plc Dispositif destiné à l'identification d'acné, des comedons et des bactéries sur la peau humaine
US6324417B1 (en) 1996-11-19 2001-11-27 Optiscan Limited Method for measurement of skin histology
WO1998022023A1 (fr) * 1996-11-19 1998-05-28 Optiscan Ltd. Procede de mesure de l'histologie cutanee
US7647085B2 (en) 1996-11-19 2010-01-12 Astron Clinica Limted Method of and apparatus for investigating tissue histology
US7054674B2 (en) 1996-11-19 2006-05-30 Astron Clinica Limited Method of and apparatus for investigating tissue histology
US6021344A (en) * 1996-12-04 2000-02-01 Derma Technologies, Inc. Fluorescence scope system for dermatologic diagnosis
WO1998024360A1 (fr) * 1996-12-04 1998-06-11 Harvey Lui Systeme de fluoroscopie pour diagnostic dermatologique
US6201989B1 (en) 1997-03-13 2001-03-13 Biomax Technologies Inc. Methods and apparatus for detecting the rejection of transplanted tissue
JP2001521772A (ja) * 1997-10-30 2001-11-13 ハイパーメッド・イメジング・インコーポレーテッド マルチスペクトル／ハイパースペクトルの医療用計器
US8175688B2 (en) 1997-10-30 2012-05-08 Hypermed Imaging, Inc. Multispectral/hyperspectral medical instrument
US9084533B2 (en) 1997-10-30 2015-07-21 Hypermed Imaging, Inc. Multispectral/hyperspectral medical instrument
US6110106A (en) * 1998-06-24 2000-08-29 Biomax Technologies, Inc. Endoscopes and methods relating to direct viewing of a target tissue
FR2984721A1 (fr) * 2011-12-26 2013-06-28 Chanel Parfums Beaute Procede et dispositif de detection et de quantification de signes cutanes sur une zone de peau
WO2013098512A1 (fr) 2011-12-26 2013-07-04 Chanel Parfums Beaute Procédé et dispositif de détection et de quantification de signes cutanés sur une zone de peau
US20220303508A1 (en) * 2019-11-08 2022-09-22 Korea Electrotechnology Research Institute Multi-band optical filtering method and apparatus
US11902675B2 (en) * 2019-11-08 2024-02-13 Korea Electrotechnology Research Institute Multi-band optical filtering method and apparatus

Also Published As

Publication number Publication date
AU6230994A (en) 1994-08-15
IL108350A0 (en) 1994-04-12
ZA94343B (en) 1994-08-26

Similar Documents

Publication Publication Date Title
US11699102B2 (en) System and method for multiclass classification of images using a programmable light source
CN112005312B (zh) 伤口成像和分析
US6902935B2 (en) Methods of monitoring effects of chemical agents on a sample
US8472682B2 (en) Medical image processing
Pogue et al. Analysis of acetic acid-induced whitening of high-grade squamous intraepithelial lesions
US20100092064A1 (en) Methods for tissue classification in cervical imagery
US20120061590A1 (en) Selective excitation light fluorescence imaging methods and apparatus
JP2000139846A (ja) 患者の皮膚組織への創傷の程度の診断用デ―タを発生するための方法および装置
JP2003513735A (ja) 皮膚状態を検査し、記録し、解析するシステムおよび方法
JP2005137756A (ja) 健康度測定システムおよびプログラム
CA2258124A1 (fr) Systeme et procede d'analyse diagnostique dermique
JP2015500722A (ja) 皮膚ゾーンにおける皮膚症状を検出して数量化する方法および装置
Yang et al. Development of an integrated multimodal optical imaging system with real-time image analysis for the evaluation of oral premalignant lesions
US12052526B2 (en) Imaging system having structural data enhancement for non-visible spectra
WO1994016622A1 (fr) Procede et dispositif d'imagerie a des fins diagnostiques
US20200390383A1 (en) Complex analysis system of spectrophotometry and ultrasound images and data for automatic early-stage diagnosing of malignant skin tumors
WO2021210676A1 (fr) Dispositif de traitement d'image médicale, système d'endoscope, procédé de fonctionnement pour appareil de traitement d'image médicale et programme pour dispositif de traitement d'image médicale
Peller et al. Hyperspectral Imaging Based on Compressive Sensing: Determining Cancer Margins in Human Pancreatic Tissue ex Vivo, a Pilot Study
Husemann et al. Computerised diagnosis of skin cancer using neural networks
WO2022065301A1 (fr) Dispositif d'image médicale et son procédé de fonctionnement
Finkšt et al. Autofluorescence bronchoscopy image processing in the selected colour spaces
Van Raad et al. Emerging Technologies, Signal Processing and Statistical Methods for Screening of Cervical Cancer In Vivo: Are They Good Candidates for Cervical Screening?
Xu Dartmouth Digital Common s
Mekonnen Color Medical Image Edge Detection based on Higher Dimensional Fourier Transforms Applied in Diabetic Retinopathy Studies
Kulas et al. Numerical analysis of endoscopic autofluorescence imaging for cancerous tissue detection

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AT AU BB BG BR BY CA CH CN CZ DE DK ES FI GB HU JP KP KR KZ LK LU LV MG MN MW NL NO NZ PL PT RO RU SD SE SK UA US UZ VN

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)

Free format text: BY,PT

121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref country code: US

Ref document number: 1995 500870

Date of ref document: 19951012

Kind code of ref document: A

Format of ref document f/p: F

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA