WO1994015632A1 - Vaccine against trichophytosis in animals - Google Patents
Vaccine against trichophytosis in animals Download PDFInfo
- Publication number
- WO1994015632A1 WO1994015632A1 PCT/RU1993/000319 RU9300319W WO9415632A1 WO 1994015632 A1 WO1994015632 A1 WO 1994015632A1 RU 9300319 W RU9300319 W RU 9300319W WO 9415632 A1 WO9415632 A1 WO 9415632A1
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- WO
- WIPO (PCT)
- Prior art keywords
- вес
- animals
- vaccine
- trichophytosis
- days
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract description 16
- 241001465754 Metazoa Species 0.000 title abstract description 4
- 208000002474 Tinea Diseases 0.000 title abstract 3
- 206010067409 Trichophytosis Diseases 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 claims abstract description 4
- 108091007433 antigens Proteins 0.000 claims abstract description 4
- 102000036639 antigens Human genes 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 241001045770 Trichophyton mentagrophytes Species 0.000 abstract 1
- 230000008105 immune reaction Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 244000309466 calf Species 0.000 description 6
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 101150090724 3 gene Proteins 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010048685 Oral infection Diseases 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 101150085091 lat-2 gene Proteins 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 229960005030 other vaccine in atc Drugs 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0002—Fungal antigens, e.g. Trichophyton, Aspergillus, Candida
Definitions
- the invention is not available in biotechnology, particularly in the presence of vascular vaccines.
- Unfortunate There are known to be ill, that they only neglect the illness at the other end of the hospital,
- the purpose of the invention is to operate on a fully-functional basis, from which 30 .7. ⁇ ⁇ - ⁇ ⁇ _ ⁇ pub ⁇ . ⁇ £ >_> ## ⁇ ⁇ ⁇ - ⁇ ⁇ _ ⁇ pub ⁇ . ⁇ £ >_> ## ⁇ ⁇ ⁇ - ⁇ ⁇ _ ⁇ pub ⁇ . ⁇ £ >_> .
- Penetration is due to the absence of penicillin or :: constituent acid, at a rate of 100 ⁇ D for I second;.: 3 gene .-.
- G Ogenet shtayyya musha 1g. ⁇ el ⁇ Communication - ⁇ - ⁇ attribute. 130 Lives a variety of things :; Communion with the Great Sha'zh group
- the vaccine is being produced similarly, in general, I have used it to use it :. Generation of the State:.;:.: As a result of the stabilization of the original product, the result is 15 sugar candies, 5 ⁇ of the parent.
- the bacterium is produced by living in a similar fashion, as it is in I. For its use, it is good to eat the gene.
- the vaccine is highly effective by treating the patient, the vaccine is: the goal is: it removes two
- the vaccine was taken up by a healthy one, which was short of an interval.' 10-14 days in an double dose.
- the use of the vaccine in the invention in the practice of the disease will improve the efficiency of the treatment of the risk of vomiting.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The invention concerns the field of veterinay science, in particular the prevention and treatment of trichophytosis in animals. The proposed trichophytosis vaccine differs from known vaccines in containing in addition an antigen of the strain VGNKI No. 27 of the fungus Trychophyton mentagrophytes in quantities sufficient to provoke an immune reaction in an animal.
Description
ΒΑΙЩИΗΑ ПΡΟΤИΒ ΤΡИΧ05ИΤИИ шшοτныχ PROPERTY FOOD ΤΡIΧ05IΤII
Οбласτь изοбρеτения 5 Изοбρеτенκе οτнοсиτся κ биοτеχнοлοгиκ, в часτнοсτи ваκцинам προτκв τρиχοφиτии жκзοτныχ.BACKGROUND OF THE INVENTION 5 The invention is not available in biotechnology, particularly in the presence of vascular vaccines.
Пρедποсылκπ изοбρеτенияBACKGROUND OF THE INVENTION
Κзвесτнз ваκцина ЛΤЗ-ΙЗΟ н ваκцина ΤΦ-ΙЗΟΚ/ προτив ΙС τρиχοφиτии живοτныχ, πρеимущесτвеннο κρуπнοгο ροгаτοгοWestern vaccine LZZ-ZZN n vaccine ΤΦ-ΙЗΟΚ / prativiv Ι With the traffic of animals
лизаτορ (сϊ/.. πаτенτ Зелиκοбρиϊанπκ 1330240, κл. Α53, 15 1973; Αвτορсκοе свидеτельсτвο СССΡ ."- 955571, κл. ΑбΙΚ 39/00, 1980). Lizata (cϊ / .. Patent of Zelibro 1330240, cl. Α53, 15 1973; Automatic testimony of CCC. "- 955571, cl. ΑбΙΚ 39/00, 1980).
Ηедοсτаτκο:.: иззесτныχ ваκυπн являеτся το, чτο οни πρэφπлаκτиρуюτ забοлевание τοльκο у οднοгο зπда ικχзοτныχ κρуπнοгο ροгаτοгο сκοτа π τοльκο κ οднοл.у виду зοзбуди- 20 τеля Уг , £οл С θ'<л л .Unfortunate:.: There are known to be ill, that they only neglect the illness at the other end of the hospital,
3 сοοτвеτсτвии с _ЪΟСЬ- УΙ (1902) (см. З.Ы.Леценκο, "Ιабορаτορная дπагнοсτиκа гρибκοвыχ забοлеваниϊ'" , Ιά. , :ма
3 correspondences with _ΟΟS-UΙ (1902) (see Z.Y. Letsenko, "Disease diagnosis of pungent diseases", Ιά.,: Ma
25 τ.κ. сοгласнο κлассπφиκацπκ Гэορга (1957) (сг.. τаϊύ жэ, с.34) вοзбудиτель τρиχοφиτκκ нκвοτныχ и::ееτ οснοзнοе название ^ νгκллιθя иνν-. .25 τ.κ. according to the class of Georgy (1957) (group .. also, p. 34), the causative agent is triplet and :: its basic name is .
Цель.ο изοбρеτения язляеτся ρазρабοτκа вυсοκοлκι.унο- геннοχ ваκπκны προτиз τρиχοφκτπи -ΚΠΕΟΤΗЫΧ вызызаеι.гаκ 30 .7ъ . ν<-τ}_Λлλ.ζ£>_>иνи_. ι 7ъ νζллш_£>_- ил-
_χ ϊУ?1:χ уρ
The purpose of the invention is to operate on a fully-functional basis, from which 30 .7. ν <-τ } _Λлλ.ζ £ >_> иνи_. ι 7ъ νζllsh_ £> _- yl- _χ ϊУ? 1: χ уρ
Κρаτκοе сοдеμκание πзοбρеτенияFactory Access
Уκазанная цель дοсτигзеτся τеι.., чτο ваκцина дοποл- 35
The stated goal is reached .. that the vaccine is available - 35
0 _< /ο / .
- 2 -0 _ < / ο /. - 2 -
Λнτиген из шτамма ιУγ νе ΖΖи.С_θ£___- /?г- 130 Л 300-βΟΟ млн мιшροκοнидиπ/Игntigen from the strain УУγ νе ΖΖи.С_θ £ ___- /? G- 130 L 300- β ΟΟ million m
0 смЗ0 cm3
Αнτπген ΙΪЗ шτамυаΑнτπгΙΪ шЗ Штамυа
10 Зϊелаτин 1 , 5-4 ,010 gel 1, 5-4, 0
Βοда οсτальнοеThe rest of the world
Пοдροбнοе οπисание изοбρеτенияDETAILED DESCRIPTION OF THE INVENTION
15
эшзοοτичесκοгο,выделеннοгο из белο мыши, меτοдου наπ- ρавлеинοгο сτуπенчаτοгο οτбορа πο πρизнаκу сποροοбρазοва- πия наибοлее бысτρο ρасτущиχ κοлοпий с аκτивπυυ κаκοπле-fifteen eshosticheskogo isolated from the white mouse, the methods are on the safe side of the mainstream of the market for the most rapid loss of business is faster
20
леκции миκροορганизмοв Βсеροссиысκοгο гοсудаρсτвениοгο научκο-исследοваτельнοгο инсτиτуτа κοыτροля, сτаκдаρτи- зацιш п сπециφиκации веτеρинаρныχ πρеπаρаτοв и пυεеτ ρегπ- сτρациοнный нοмеρ 220 lectures of microorganisms of the Russian Federation
25 ΕΙτамм гρиба Л.
ΒГΗШΙ .!327 χаρаκτеρпзуеτся следующиглι πρизπаκами и свοисτзаυп.25 амτammb L. L. ΒГΗШΙ. ! 327 are used as follows and are protected.
Ινϊορφοлοгичесκκе πρизнаκп. Ыιщэлий κе οκρашеы, ροвκьχϊ, зеτвисτыϋ, сеπτиροванныϋ, ινοжеτ ρасπадаτься πа φρагменτы, τеρглιыальныэ гиφы не всегда οбρазуюτ сπиρали (οбычыο 3-5Ινϊορφologic statement Yıshcheli κ ο ρ ρ аш аш,,,, ο ο ο ο, аш,, κ аш κ, Ы Ы Ы Ы Ы Ы Ы Ы Ы Ы Ы Ы.
30 завиτκοз), диамеτρ мицелия 2,0-3,0 мκм. ϊ.Ιπκροκοнидшι мπο- гοчпсленные, κρуглые, гρушевпдные , удлинеκπые, блпзκгιе : πалοчκοзιщκοϋ φορме, ρасποлагающиеся на ποвερχнοсτи ιлι- целия гροздьями, чаще οτдельнο, ρазмеρ 1,5-5,2 мκм. ΙΙаι:ρο- κοнидии едπничные. Κοличесτвο πеρегοροдοι: 1-5, чацу 1-2,30 percent), the diameter of the mycelium is 2.0-3.0 μm. Ι.Ιπκροκοдд м мππππππчччччччччччччч,,,,,,,,,,,,,,,,,, угуглыелые,, г г г гушушушевушуш, ненеев, уд, уд, ,нене ,ненели бл бл бл бл бл бл:::::::: :ал :алалалалалалалалалалϋ 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 цел 1,5 1,5 1,5 1,5 1,5 1,5 цел цел цел цел 1,5 цел цел him, it is more common, ΙΙаι: ρο- κοnidii are single. Personally Transmitted: 1-5, Chatsu 1-2,
35 ρазмеρου I0-30x3-8 мκм.35 ρmeasure οου I0-30x3-8 mkm.
Β κульτуρаχ 20-30 днезιюгο вοзρасτа мοгуτ πаблюдаτься χла- щидοсπορы οκρуглοй φορι.ъ" с двуκοнτуρнοπ οбοлοчκοιϊ, зсегда
- 3 -From 20-30 days of age, you can observe the sweeteners of the environment , with two-sided, always - 3 -
единичные, 3,0-5,0 гκ; в диагеτρе. Αρτροсπορы зοзниκаюτ н οτдельныχ учасτκаχ ιαιυелия, τοнκοсτенные, πο £ορι е наπο-single, 3.0-5.0 gk; in the diagram. Occupants are aware of the private parts of the city, the walls are private, for example,
5 гинаιэτ οвальные ιιлп πалзчκοзκдные гиκροκοнπдπн 3,0-9,0 гκ Κульτуρальные сзοйсτза. Ηа суелο-агаρе ρасτеτ в видз πлοс κοπ белοπ, баρχаτнсτοπ κοлοнππ с незначиτэльны;.; вοззыше- ниег з цеκτρе, ρасτуцπй κρаπ ροзныπ, ρевеρс κρаснοзаτο- κορичневый, диагеτρ κοлοнκи 50-9С г... (15-20 дневная κуль-5 gynoetalnaya vylp lazyzkozdnye gikrupokonpdpn 3.0-9.0 gk Cultural complications. In the case of bustle-agar, it grows in the video area of the territory of Belarus, the profitability of the community is insignificant;.; Reduced loss of life, loss of health, loss of health, loss of health 50–9C g ... (15-20 days old
Ю τуρа).Yu τуρа).
Ηа агаρе Сабуρο ρасτеτ в виде πлοсκοπ, белοй, баρχа- τπсτοй с κρегοзыг οττенκο:.; κοлοниπ с небοлыπκι. вοзвышэни- ег в ценτρе, ρасτущий κρай ροзныГ;, ρевеρс бледнο .κелτыπ, инοгда бοлее τеυныГ: Ε ценτρе, ρазгеρ κοлοниπ 50-90 гOn the Sabareu agrast, it grows in the form of a flat, white, velvet with a quick release:.; well-known. increased in the center, growing at the expense of the gry;; a reversal of the pale. kelty, sometimes more than the average: the center, the rate of 50-90
1 (15-20 дневная κульτуρа).1 (15-20 days old culture).
Ηа сρеде Геннебеρга ρасτеτ з зπде белοн, баρχаτπсτοπ, ρадиальκο-сκладчаτοГ: κοлοнππ, ρасτущий κρай πауτπнисτыπ, ρезеρс κραснοзаτэ-φиοлэτοвыГ, дπагеτρ κοлοнπи 50-СС гг (15-20 дневная κульτуρа). 0 Сποροοбρазοванπе. Ιлаκсπгальныπ уροзень сποροοбρазο- ванπя на суслο-агаρ-з 198,4-259,2 глн/сгЗ.In the midst of Gennebug, it will run out of front of Belon, baruchatstst, radial fold: the kolonpπ, the growing krpund, the result is a payload, 0 ποροοbρazovanpe. The reduction in output from the wort-agar-z is 198.4-259.2 hl / sZ.
Зиρуленτные сзοπсτза. Пρπ знуτρнгышечнοι.: ззедении κульτуρа шτа:..гз 7ι.
Г° 27 у гορсκиχ свинοκ, κροлπκοз, οзеυ, κοз, τеляτ сπусτя 2-3 недели на 5 гесτз инъэκυκл ραззπваеτся сπзππгннιзсκπГ. лοκализοззнны.Г ποвэρχποсτныГ: οча-κοκ д" а,еτροг 2,0-2,5 сг, κοτορгл сагο- προπзвοльнο иззлечπзаеτся в τечение 15-20 днеГ. Μπκο- лοгичесκπ Εыделиτь зοзбудπτзχь ?:э удаэτся. Пρπ нанесениπ κульτуρг шτаπгз
нπзοτньг на сκаρπгι-- 0 циροзанную κοιχу в дοзу 0,25...лιι/сг 3 гнκροκοκπдπκ на ι.есτэ аππлиκаπиπ ρаззπзаэτся з τечениэ 10-20 днэπ τππичπгπ гρи- χοϊπτийньιГ; οчаг. Зыдэлзнны πз πаτοлοгπчесκοгο ι.аτэρκала шτа; πό сзοи. сзοйсτза: сοοτзэτсτзуеτ πсχοднοιу.SURPRISE RESPONSE. Ρ ыш з ыш ыш ыш .: .: .:. At 27 ° C, in pigs, κ свин π,,,,, зе зе υ κ,, еля, calves down after 2-3 weeks for 5 gestational injections инъ з з з ва ва...... They are localized: a good result, but 2.0-2.5 s, but a saga - will be neglected for 15–20 days. nothing to skarpig-- 0 cited to a dose of 0.25 ... liι / cg of 3 sockets in the country, the appendix is open for 10-20 days; source Ideal for the mercantile state; πό communication. Occupation: It is inactive.
Αнτигенные сзοГιсτза. ηа зведзниε κульτуρы шτагга з 5 ορганизге. τсляτ, οзэπ, προлиκοз οбρазуэτся сπецιгνлчесκπе агглюτπнины з τиτρаχ 1:40-1 :Ι2СЗ.
- 4 -Antigeneration. ηa zvezdnizε cultivars of step 5 of the city. Therefore, there is no need to forget about agglutination in the air from 1: 40-1: Ι2ЗЗ. - 4 -
Иыыунοгенные свοнсτза. Пρи дзуκρаτнο:.; внуτρиιышечнο:.; взедении τеляτаι.:, κροлиκа:.: ваκцины, нзгοτοзлзннοГ; из дан- с нοгο _лτаы;,:а в дοзе, сοдеρ.κащей 10-20 ит-ι шιзын ыиκροκοπи-Lasting Interest. In case of zukrat:.; internally:.; retraction of the tel.:., circle:.: vaccines, vaccine; from the data from _ltaia ;,: and in the dose, which is 10-20 it-ι shyzyn yykροκοπ-
-дин, у жизοτныχ φορыиρуеτся наπρя:κеннын и:.;:,униτеτ κ ποс- ледующеι.у заρаженπю
προдοлжиτелы-ιοсτью не ι.:е- нее δ леτ (сροκ наблюдения).-din, living things happen: Kenny and:.;:, it’s worse for the next Well, there is no v.: it is more than δ leth (observation period).
Шτаыл Ιх..
ЗГШИ Iй 27 οτличаеτся οτ 10 эπизοοτичесκин слабοГ: виρуленτнοсτью, οτсуτсτвиеы заρа:κе- нπя πρπ κοнτаκτе ь;е;κду жизοτныыπ, высοκο:: аκτивнοсτью на- κοπлеπия ыиκροκοнπдий и иыыунοгеннοсτью πρπ знуτρи:..яшеч- нοϊ; введении κивοτныы.Shtayl Ιh .. ZGSHI I th 27 οτlichaeτsya οτ 10 eπizοοτichesκin slabοG: viρulenτnοsτyu, οτsuτsτviey zaρa: κe- nπya πρπ κοnτaκτe b; e; κdu zhizοτnyyπ, vysοκο :: aκτivnοsτyu HA κοπleπiya yiκροκοnπdy and iyyunοgennοsτyu πρπ znuτρi: .. yashech- nοϊ; introduction of livestock.
15 Пρиыеρы ποлученπя ваκцины πο изοбρеτению. ПΡΙΙΙЖ? I.15 Other Vaccines Received from the Invention ПЖЖ? I.
20 агаρе (ρΗ 6,2-6,0) πρи τеι.шеρаτуρе 2б-28οС в τечение 12-20 дней.20 agarе (ρΗ 6,2-6,0) πρ and τеι.more than 2b-28οС for 12-20 days.
Зыρащенную гρибницу κаздοГ; κульτуρы з услοзияχ асеπ- τиκπ сниыаюτ с ποзеρχнοсτπ πиτаτельнοй сρеды сπециальны- .:и сκρзбκаιлπ π ποыещаюτ в сτеρильные банκи. Гρибную ыассуA swollen stump is located in the back; Cultures under conditions of accep- ticism reduce the benefits of a healthy environment: special: and they are stored in stylish banks. Flexible yassu
25 κаздοгο шτаыыа гοιοгёнизиρуюτ з ыπκсеρан или κοллοиднοπ ι/ельн;ιце, а заτе:-.; с πο:.;οщью сτеρильнοπ зοды ποлученныГ: гοыοгенаτ _ νгνи( <_νе>-.'<лγνъ 130 Л ρесусπензиρуюτ дο κοнценτρаππи ыπκροκοнндии 300 :ллн/с:,;3, на гοыοгенаτ τ.
ЗГΗΚП"'' 27 - 600 ЫЛΗ/СУ.З. Ρесус-25 Each of the United States is goryuniziruyut zypkseran or kolloidnopi v / eln; vce, and then: - .; with πο:.; in general, the stylish rooms have been upgraded: Г ο ο ο ((((<<<<<<<(<_ е (- - <. γ. 130 130 130 ус). ЗГΗΚП "'' 27 - 600 YLΗ / SU.Z. Jesus Christ-
30 πензиροзанне προзοдяτ з πρнсуτсτзππ πенициллина ил:: сτρеπτοϊν.иπина нз ρасчеτа 100 ΕД на I с;.:3 гοι.-.οгенаτа. Гο:..οгенаτ шτаыыа гρиба 1г. νел νи-^-αт. 130 Л οбъедπняюτ Б ρазнο:; οбъеие с гοыοгенаτοм шаϊ'ж гρπба30 Penetration is due to the absence of penicillin or :: constituent acid, at a rate of 100 Ε D for I second;.: 3 gene .-. G:: Ogenet shtayyya musha 1g. νel νи - ^ - αт. 130 Lives a variety of things :; Communion with the Great Sha'zh group
елаτннι:. Зсε τщаτзльнο πеρеыешизаюτ, ρазлπааюτ з сτеρн- льные α.лаκοны н лиοφπльнο зысушизаюτ.
5 - previous :. It can be easily removed, and it can be expanded with a solid α. It is not limited to dry. 5 -
ПΡПΙлΞΡ 2.ПΡПΙлΞΡ 2.
Βаκцину ποлучаюτ аналοгичнο , ιаκ οππсанο з πρκιлеρе I Для ее πρигοτοвления исποльзугэτ гο:. οгенаτ шτа:.;:.:οв гρπбοз
κачесτве сτабκлκзаτορа вοдныκ ρасτвορ , сοдзρ.κащπχ 15 саχаροзы κ , 5 γ.едаτина.The vaccine is being produced similarly, in general, I have used it to use it :. Generation of the State:.;:.: As a result of the stabilization of the original product, the result is 15 sugar candies, 5 γ of the parent.
.υ.υ
ПΡΙΙΙ.ΕΡ 3.PΡΙΙΙ.ΕΡ 3.
Баκцину προτκз τρκχοφκτκи живοτныχ πρигοτавливаюτ аналοгκчнο, κаκ οπκсанο в πρκыеρе I. Для ее ποлученχя исποльзуιэτ гοыοгенаτ ι_ιτаιл;.:а гρκбл 7г . ν -ъναι < *лл ж 5 130 Л с κοнценτρацπεκ ι..κκροκοнχдκκ 600 ;,:лн/сι.;3 κ гοыοге-The bacterium is produced by living in a similar fashion, as it is in I. For its use, it is good to eat the gene. ν -ъναι <* lll 5,130 L with an incentive ι..κκροκοnхдкк 600;,: ln / s.; 3
20 Гοτοвая ваκцκна πρедсτазляеτ сοбο": οднοροдную πορис- τую суχу-э ыассу в вκде τаблеτκκ сеροгο цвеτа. Βаκцκна сοχρаняеτ свοи биοлοгичесκκе свοκсτва πρи услοзиπ χρане- ния в заκρыτыχ суχκχ, τеыныχ ποιлещенπяχ πρκ τеыπеρаτуρе 2-Ι0°С. Сροκ гοднοсτκ 12 месяцев. Κ ваκцине πρилагагоτся20 Gοτοvaya vaκtsκna πρedsτazlyaeτ sοbο ": οdnοροdnuyu πορis- τuyu suχu-e yassu in vκde τableτκκ seροgο tsveτa Βaκtsκna sοχρanyaeτ svοi biοlοgichesκκe svοκsτva πρi uslοziπ χρane- Niya in zaκρyτyχ suχκχ, τeynyχ ποιleschenπyaχ πρκ τeyπeρaτuρe 2-Ι0 ° C Sροκ gοdnοsτκ 12 months... Κ vaccine is being tested
2 φлаκοны сο сτеρильныы ρазбавκτеле;..2 vials of solid diluent; ..
ПИΪΜΕΡ 4.PI 4.
Пρχгοτοзленные сеρκκ ваκиκны προτκз τρκχοφχτиκ живο- τныχ πο πρκыеρа:.: 1, 2, 3 πеρед πρκχенение:' ρасτвορяιэτ в 30 ρазбевиτеле из ρасчеτа I дοза в I сыЗ. Пοлучаιэτ сеρии ьаκцинь:, сοдзρжащκе в πρκзивοчнοκ дοзе следующуго κοнцен- τρаπκю анτκгенοз в ылн/сι.ιЗ (τаблκца I).The resulting selections are va- rious due to live traffic::: 1, 2, 3 before transfer: 'I dispose of it 30 times. This is the case for the series: which is available on an actual basis after the following evaluation of the general antigenesis in the textbook (Table I).
ΤΑΕЛΙЩΑ IΤΑΕLΙSCHΑ I
ЗδЗδ
Κаи.ленοзание анτκгена Заκцκна πο Βаκцина πο Заκцина πο πρπыеρ I πρπмеρу 2 πρπκеρу 3Filing the antigen Zaktsna ο ци ци ци ци За За За За За За За κ κ κ κ κ κ κ κ κ κο За κ ο κ ο ο κ ο ο ο ο ο κ ο
7г . νζлмлιθτ ш 'τη, 130 Л 5 7, 5 ΙС
- 6 -7g νζlml θ τ w 'τη, 130 L 5 7, 5 ΙС - 6 -
ΪГ» 27 ЗПΙΚИ 10 7,5 5ΪГ »27 ЗПΙΚИ 10 7.5 5
Βаκцину πο πρимеρам 1, 2, 3 исποльзуюτ для κшуниза- ции τеляτ, ввοдя внуτρиκышечнο дзуκρаτнο с инτеρзалοι»: 10-Actually, for examples 1, 2, 3, they are used for communalization of calves by introducing internal muscle from the interer ”: 10-
Ю 14 дней в дοзе I смЗ.10 days in the dose of I cm3.
3 κачесτзе κοнτροля исπыτывагаτ аналοгичнο πρигοτοв- денные ваκпины κз шτаι а Зκ,. νе лиβ&_м,ун 130 Л и 1ч,.
ΒГΗΚИ ГС 27 с κοнценτρацией миκοκοπиндии анτигена Ε πρививοчнοй дοзе 7, 5 млн/смЗ.3 In the short run, you will experience a similar production of vases from the factory. νе лиβ & _м, un 130 L and 1 h. ΒGΗΚI G C 27 with a concentration of mycopindia antigen Ε a natural dose of 7.5 mln / cm3.
15 Чеρез 35 дней ποсле вτοροй им лунизации τеляτ заρажагаτ вπρуленτныυи κульτуρашι шτашοв 7г_, ν-&/ζΛ ес,≤* . ?!'- 15315 After 35 days after the second lunarization, they incarcerate virulent and cultured states 7g_, ν- & / ζΛ ес , ≤ *. ?! '- 153
0 заρажаюτ эτими же κульτуρаι.ιи ο κοнτροльныχ (неимунизиρο- ванныχ) τеляτ. 0 they infect the same culture. And they are in contact with (non-immunizing baths) calves.
Ρезульτаτы эκсπеρиι. енτальнοгο заρажения τеляτ πρед- Сτавлень: в τаблице 2. 5 ΤΑΕЖΙЦΑ 2The results of the experiment. oral infection calves Delivery: in table 2. 5 ΤΑΕ 5ΙЦΑ 2
].*." Κ-вο Биοπροπеρаτ Ишу- Κοлκчеτсτвο забοлезшиχ гρ. жизοτныχ исποльзуемый низиρ. жизοτныχ πρи эκсπеρи- Ε гρуπ- для имιуниза- τеляτ .ен альнο _з_^а ен_::_ πе цκи τеляτ (гοл.) τз_ та_ τс_ ΤЗ - ΤЗ-]. *. "Κ-vο Biοπροπeρaτ Ishu- Κοlκcheτsτvο zabοlezshiχ gρ. Zhizοτnyχ isποlzuemy niziρ. Zhizοτnyχ πρi eκsπeρi- Ε gρuπ- for imιuniza- τelyaτ .en alnο _z_ and en ^ _ :: _ πe tsκi τelyaτ (gοl.) Τz _ that _ τс _ Τ З - ΤЗ-
153251 724 118 20 0153 251 724 118 20 0
3 7 Заκцина πο πρиϊлеρу 3 7 0 С 0 0 υ3 7 Zaktsina πο πρиϊлеρу 3 7 0 С 0 0 υ
4 10 Заκцина из шτаιлма 10 0 4 2 0 .ννν сοζиνη4 10 Standard vaccine 10 0 4 2 0 .ννν сοζиνη
ΙЗΟЛΙЗΟЛ
10 5 Заκцина из шτаϊν.ιла 9 δ 0 I 2 <-»10 5 Zaczin from the staff of v. Vla 9 δ 0 I 2 <- »
Α.Α.
ЗГΗЮΪ I? 27 б б ΚοнτροльЗГΗЮΪ I? 27 b b
(неимь.унизи- 1 ροванные) - 2(neim.unizi- 1 ροvannye) - 2
Пз τаблππы виднο, чτο 1,2 и 3 сеρии ваκπины у ;;:.:;ιуни- зиροванныχ τеляτ зыρабаτываюτ наπρяженныκ (Ι00 ) иммуни- τеτ προτив τρиχοφиτии πρπ эκсπеρиϊν.-енτальκοκ заρа.κениκ. ИммFrom the table it is visible that 1.2 and 3 series of vapin y ;;:.:; Imm
20 низацπя τеляτ ϊν_οнοваκцинаι_:и не вызыыаеτ дοсτаτοчнο сτοйκο- гο иυι.униτеτа πρи ποследу.οщеϊ/. заρаженχκ геτеροлοгκчныыи κульτуρами зοзбудиτелей τρиχοφиτиπ. Τеляτа ρанее не κι.α.у- низκροванные κ не бοлезшне τρκχοφχτκеχ зορπρии:»;чивы κ эκс- πеρи:.:енτальнο:су заρаяенπю зиρуленτныκи κульτуρа;,:и зοзбуди-20 nizatsya calves ϊν_onovacinia_: and does not cause a sufficiently long-term and viva.uniteta for the next. /. contagious heterogeneous cultures of pathogens are toxic. I didn’t have κι.α.- lower ones ı not worse then:;; live ı EXCEPT:.: Ntal: su за zirulent ow;
25 τелеχ τρиχοφиτиχ.25 telephones.
ПΡИΙЖΡ 5.FUN 5.
Τρеιля ΟΚЫΤΗЫΙ..И сеρия:.:ι ваκцκκь: аκалοгичκο πρπ:,:еρу 4 и;.;;.:унκзиρу:οτ 14 κοз с ποследущκ;.. иχ заρаженχе;; виρуленτ- 30 Τь. г л*-υΟю < я.уν_. - 153 κ 1 251. Κοнτροльныχ жχзοτныχ (2
Τ е ля ΟΚ ΤΗ ΤΗ ΤΗ Ι Ι Ι ... And the series:.:: Vakt ва: akalogogich πρπ:,: ery 4 and;. ;;.:: Κ:: ο 14 с с с с с с с .. .. .. .. .. .. .. .. .. .. .. .. ..; virulent- 30 b. g l * -υΟю < Я.уν_. - 153 κ 1 251. Economic Railways (2
Зсе ваκπиниροзанные жκзοτные не забοлелχ τρκχοφχτχеχ, у κοнτροльныχ были οτыечены все πρκзнаκи забοлезания с 35 выделенκеι из πορаженныχ οчагοв уκазанныχ шτаκιгоз зκρулен- τκыχ κульτуρ.
- ε -All the vascularized infections did not get sick, all the signs of the disease were removed from the terminal with 35 selected cases from the excluded cases. - ε -
ΠΡΚ .ΕΡ 6.ΠΡΚ .ΕΡ 6.
Для иι гунизаπππ 10 κροлиκοз ποροдь: шπκϊιϊнллз илвοнFor Ii Guniz πππ 10 κ
5 ι.-ассοй 2 , 5-3, 0 κг исποльзуюτ ваκππну πο πρ:ι: еρу 2. Баκπпн πеρед πρπгенеκие;/ ρасτзορяюτ з ρазбавπτеле ι:з ρасчеτа I
5 v.-assy 2, 5-3, 0 kg use the option πο: ι: ery: 2. Most importantly π г г ас ас / / /;
Пοлучаюτ следующую κοнценτρаππ:ο аκτигеκοз з I πρπви- зοчнοй дοзе : Я. νчτгηл_. && <-.γ _. 130 Л 7, 5 :ллн гиκροκοнидThe following accent is received: а Actighez I with a physical dose: Ya. Vchtgηl_. &&<-. γ _. 130 L 7, 5: LLH
Ю
ΒГΗΚΙΙ ?* 27 7, 5 ι:лκ. ιлπκροκο κидии . Заκциκу звοдяτ κροлζκам Εκуτρи:.:ышечнο дзуκρаτнο в дο-
лπκοв исποльзуιэτ ваκππну из шτаπла 7 . \щш£ ~су_νρ \£^г1ь_-YU ΒГΗΚΙΙ? * 27 7, 5 ι: лκ. ілπκροκο кидии. Zakutsu is well-known for his acquaintances:.: Muscular in the home Most of the time, it’s possible from station 7. \ uh £ ~ su_νρ \ £ ^ r 1__-
15 :* 135 , сοдеρжаπу.ο в I πρививοчнοГι дοзе 20
πиκροκο- κπдий в I с: :3, κοτορую πρπглеκяюτ внуτρπιгышечнο в οбласτь ягοдичнын глышπ. Чеρез 30 дκеπ κροлиκοз заρа .аюτ наκοжнο зπρуленτныιли κульτуρами шτаιлιлοз Τъ. т^ ^ οψ и^Ιг^ - 251 и 1ъ, 25 0 дκей учπτыва
ο исποльзοванπе заκцины сποсοбсτзуеτ οбρазοзанию надежнοгο иπуниτеτа у всеχ иιлιунизиροзанныχ κροлиκοз, в το вρеι:я κаκ исποльзοзание иззесτнοй ваκцнκы Μенτазаκ не даеτ наде жнοгο эφφеκτа - 2 κροлнκа из 10 забοлели τριπсοφиτπеГ: , а ?; 5 οчагοв πορа;κенπя выделены κульτуρп вπρуленτнπχ шτаπлοз.15: * 135, content on the first day at 20 Practically in I since:: 3, they take a look at the inside of the muscle in the area of the mute. After 30 days, it’s easy to get ready for work. t ^ ^ οψ and ^ Ιг ^ - 251 and 1b, 25 0 ο isποlzοvanπe zaκtsiny sποsοbsτzueτ οbρazοzaniyu nadezhnοgο iπuniτeτa in vseχ iιlιuniziροzannyχ κροliκοz in το vρeι I κaκ isποlzοzanie izzesτnοy vaκtsnκy Μenτazaκ not daeτ Nadia zhnοgο eφφeκτa - 2 κροlnκa 10 zabοleli τριπsοφiτπeG: and;? 5 foci of success; the culture is highlighted in the incarnation.
ПΡИ÷.ΞΡ 7.ПΡИ ÷ .ΞΡ 7.
20 τеляτ ιπлгунизπρуюτ заρπанτаππ ваκцπны πο πρинегу I и 3 с κοκπеκτρаπиеπ аκτπгεнοз в πρπзнзοчнοг дззз πο ~:н- 0 геρу 4, Κа.κдο" гρуππе τеляτ (10 гοлοь) заκπнну πρи::еняюτ БΗ-.' οϊнΗπечκο дзуκюаτнο в οοъеге I сιлЗ с ннτзοзалοг 10-14 днеГ:. Чеρез 4 и 9 гесяπез ποслэ вτορο" нπ.'Лунπзаπππ οбе гρуππы τэляτ заρа.κаюτ зиρуленτныги Зг ν_ ιли.<ϊ ι,γл у- 153 и 7г.
251. 5 3 ρезульτаτе ни οдπκ τзленοκ не забοлел. Τаκπг οбρлзοг заκππна πο изοбρеτению сοχρаняеτ сτοГκπГ γ ;униτеτ чеρез 4 π 9 ; есяπез ποслε- зεюзϊлβния.
<__>20 τelyaτ ιπlgunizπρuyuτ zaρπanτaππ vaκtsπny πο πρinegu I and 3 κοκπeκτρaπieπ aκτπgεnοz in πρπznzοchnοg dzzz πο ~: n 0 geρu 4 Κa.κdο "gρuππe τelyaτ (10 gοlο) zaκπnnu πρi enyayuτ BΗ- :: '. The last year in the first day, I had to wait 10-14 days: After 4 and 9 days after that , the second time, the group would be ignored. 251. 5 3 As a result, no red tape did not become ill. Downloading this product is protected by the inadvertent loss of γ; it disappears after 4 π 9; one more time after the fact. <__>
Βаκцина высοκοэφφеκτивна προτив τρиχοφиτии κившτнκχ, Βаκцину с προφилаκτичесκοГ: цель:ο πρиιленяюτ двуκρаτнο сThe vaccine is highly effective by treating the patient, the vaccine is: the goal is: it removes two
5 ιшτеρвалοι.1 10-14 дней в следующиχ дοзаχ: τеляτаы οτ 14 днеГ: дο 4 лесяцез I смЗ, сτаρше 5* г/есяцев 2 сι.:3 и мелκουу ροгаτοму сκοτу (οвцы, κοзы) οτ 3 дο 6 ыесяцев - 0,5 смЗ, сτаρше б ыесяцев - ΙсмЗ. Κροлиκам мас сοй 2,5-3,0 κг ввοдяτ 0,3-0,5 сι/3 с προφилаκτичесκοй це-5 months. 1 10-14 days in the following doses: calves from 14 days: up to 4 months I cm3, older than 5 * months 2 s.: 3 and small prices (October, 6 days old) , 5 cm3, older than the second - цев cm3. For masters with a weight of 2.5-3.0 kg, 0.3-0.5 si / 3 is introduced with a regular dose
10 лыο. С лечебнοй целью ваκцину взοдяτ бοльныιл жизοτныл дз κρаτнο с инτеρвалοι.' 10-14 дней в удвοеннοй дοзиροвκе.10 ly. 'With a curative purpose, the vaccine was taken up by a healthy one, which was short of an interval.' 10-14 days in an double dose.
Κсποльзοвание ваκцины πο изοбρеτεнию в веτеρинаρнοπ πρаκτиκе ποзвοлиτ ποвысиτь эφφеκτивнοсτь меροπρияτий πο бορьбе с τρиχοφиτией живοτныχ.The use of the vaccine in the invention in the practice of the disease will improve the efficiency of the treatment of the risk of vomiting.
15fifteen
2020
2525
30thirty
35
35
Claims
- 10 - - 10 -
ΦΟΡΙ.ΙУЛΑ ΙΪЗΟΕΡΞΤΞΙШΦΟΡΙ.ΙУЛΑ ΙΪЗΟΕΡΞΤΞΙШ
Заκцина προτив τρиχοφπτии κκзοτнυχ, сοдеρκащая ан τπгεπ πз шτа:.::а
130 Л саχаροзу, κелаτин и вοду, ο τ л и ч а ю ц а я с я τег чτο οна дοποлнκτельнο сοдеρжиτ анτиген из шτашла 1г.
ΒГΗΚП "- 27 πρπ следующеϊν: сοοτнθ' шенπи κοιшοненτοз (вес/οб %): анτπген из шτамιла 7г.
130 ЛZaktsina on the other hand, which includes the state law:. :: a 130 Sugar, kelatin and water, so that you can get additional antigen from the 1st stage. ΒГΗΚП "- 27 πρπ as followsϊν: ο ο τ ен ен π π κ κ ((вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес::::::: 130 L
300-600 ылн. шκροκοнидии/ сιлЗ анτиген из шτаιлιла Τг.
ЗГШИ ?г 27300-600 School / Anthony Antigene from the United Kingdom. ZGSHI? g 27
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU58245/94A AU5824594A (en) | 1992-12-30 | 1993-12-27 | Vaccine against trichophytosis in animals |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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RU92015462/13 | 1992-12-30 | ||
RU92015462A RU2018321C1 (en) | 1992-12-30 | 1992-12-30 | Vaccine against trychophytosis of animals |
Publications (1)
Publication Number | Publication Date |
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WO1994015632A1 true WO1994015632A1 (en) | 1994-07-21 |
Family
ID=20134793
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/RU1993/000319 WO1994015632A1 (en) | 1992-12-30 | 1993-12-27 | Vaccine against trichophytosis in animals |
Country Status (3)
Country | Link |
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AU (1) | AU5824594A (en) |
RU (1) | RU2018321C1 (en) |
WO (1) | WO1994015632A1 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2025222A (en) * | 1978-06-07 | 1980-01-23 | Inst Experimentalnoi Veterinar | Vaccine for treatment of trichophytosis caused by trichophyton mentagrophytes |
SU955571A1 (en) * | 1980-03-28 | 1984-11-07 | Всесоюзный Ордена Ленина Институт Экспериментальной Ветеринарии | Vaccine tf-130 (k) against trichophytosis of cattle and method for treatment and prophylaxis of trichophytosis of cattle |
-
1992
- 1992-12-30 RU RU92015462A patent/RU2018321C1/en not_active IP Right Cessation
-
1993
- 1993-12-27 WO PCT/RU1993/000319 patent/WO1994015632A1/en active Application Filing
- 1993-12-27 AU AU58245/94A patent/AU5824594A/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2025222A (en) * | 1978-06-07 | 1980-01-23 | Inst Experimentalnoi Veterinar | Vaccine for treatment of trichophytosis caused by trichophyton mentagrophytes |
US4368191A (en) * | 1978-06-07 | 1983-01-11 | Sarkisov Arutjun K | Vaccine and method prophylaxis and treatment of trichophytosis caused by pathogenic organism trichophyton mentagrophtyes and method for preparing same |
SU955571A1 (en) * | 1980-03-28 | 1984-11-07 | Всесоюзный Ордена Ленина Институт Экспериментальной Ветеринарии | Vaccine tf-130 (k) against trichophytosis of cattle and method for treatment and prophylaxis of trichophytosis of cattle |
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RU2018321C1 (en) | 1994-08-30 |
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