WO1994015632A1 - Vaccine against trichophytosis in animals - Google Patents

Vaccine against trichophytosis in animals Download PDF

Info

Publication number
WO1994015632A1
WO1994015632A1 PCT/RU1993/000319 RU9300319W WO9415632A1 WO 1994015632 A1 WO1994015632 A1 WO 1994015632A1 RU 9300319 W RU9300319 W RU 9300319W WO 9415632 A1 WO9415632 A1 WO 9415632A1
Authority
WO
WIPO (PCT)
Prior art keywords
вес
animals
vaccine
trichophytosis
days
Prior art date
Application number
PCT/RU1993/000319
Other languages
French (fr)
Russian (ru)
Inventor
Ljubov Markovna Yablochnik
Karen Artemovich Sarkisov
Konstantin Pavlovich Letyagin
Alexandr Nikolaevich Panin
Original Assignee
Vserossiisky Gosudarstvenny Nauchno-Issledovatelsky Institut Kontrolya, Standartizatsii I Sertifikatsii Veterinarnykh Preparatov (Vghki)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vserossiisky Gosudarstvenny Nauchno-Issledovatelsky Institut Kontrolya, Standartizatsii I Sertifikatsii Veterinarnykh Preparatov (Vghki) filed Critical Vserossiisky Gosudarstvenny Nauchno-Issledovatelsky Institut Kontrolya, Standartizatsii I Sertifikatsii Veterinarnykh Preparatov (Vghki)
Priority to AU58245/94A priority Critical patent/AU5824594A/en
Publication of WO1994015632A1 publication Critical patent/WO1994015632A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0002Fungal antigens, e.g. Trichophyton, Aspergillus, Candida

Definitions

  • the invention is not available in biotechnology, particularly in the presence of vascular vaccines.
  • Unfortunate There are known to be ill, that they only neglect the illness at the other end of the hospital,
  • the purpose of the invention is to operate on a fully-functional basis, from which 30 .7. ⁇ ⁇ - ⁇ ⁇ _ ⁇ pub ⁇ . ⁇ £ >_> ## ⁇ ⁇ ⁇ - ⁇ ⁇ _ ⁇ pub ⁇ . ⁇ £ >_> ## ⁇ ⁇ ⁇ - ⁇ ⁇ _ ⁇ pub ⁇ . ⁇ £ >_> .
  • Penetration is due to the absence of penicillin or :: constituent acid, at a rate of 100 ⁇ D for I second;.: 3 gene .-.
  • G Ogenet shtayyya musha 1g. ⁇ el ⁇ Communication - ⁇ - ⁇ attribute. 130 Lives a variety of things :; Communion with the Great Sha'zh group
  • the vaccine is being produced similarly, in general, I have used it to use it :. Generation of the State:.;:.: As a result of the stabilization of the original product, the result is 15 sugar candies, 5 ⁇ of the parent.
  • the bacterium is produced by living in a similar fashion, as it is in I. For its use, it is good to eat the gene.
  • the vaccine is highly effective by treating the patient, the vaccine is: the goal is: it removes two
  • the vaccine was taken up by a healthy one, which was short of an interval.' 10-14 days in an double dose.
  • the use of the vaccine in the invention in the practice of the disease will improve the efficiency of the treatment of the risk of vomiting.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention concerns the field of veterinay science, in particular the prevention and treatment of trichophytosis in animals. The proposed trichophytosis vaccine differs from known vaccines in containing in addition an antigen of the strain VGNKI No. 27 of the fungus Trychophyton mentagrophytes in quantities sufficient to provoke an immune reaction in an animal.

Description

ΒΑΙЩИΗΑ ПΡΟΤИΒ ΤΡИΧ05ИΤИИ шшοτныχ PROPERTY FOOD ΤΡIΧ05IΤII
Οбласτь изοбρеτения 5 Изοбρеτенκе οτнοсиτся κ биοτеχнοлοгиκ, в часτнοсτи ваκцинам προτκв τρиχοφиτии жκзοτныχ.BACKGROUND OF THE INVENTION 5 The invention is not available in biotechnology, particularly in the presence of vascular vaccines.
Пρедποсылκπ изοбρеτенияBACKGROUND OF THE INVENTION
Κзвесτнз ваκцина ЛΤЗ-ΙЗΟ н ваκцина ΤΦ-ΙЗΟΚ/ προτив ΙС τρиχοφиτии живοτныχ, πρеимущесτвеннο κρуπнοгο ροгаτοгοWestern vaccine LZZ-ZZN n vaccine ΤΦ-ΙЗΟΚ / prativiv Ι With the traffic of animals
Figure imgf000003_0001
лизаτορ (сϊ/.. πаτенτ Зелиκοбρиϊанπκ 1330240, κл. Α53, 15 1973; Αвτορсκοе свидеτельсτвο СССΡ ."- 955571, κл. ΑбΙΚ 39/00, 1980).
Figure imgf000003_0001
Lizata (cϊ / .. Patent of Zelibro 1330240, cl. Α53, 15 1973; Automatic testimony of CCC. "- 955571, cl. ΑбΙΚ 39/00, 1980).
Ηедοсτаτκο:.: иззесτныχ ваκυπн являеτся το, чτο οни πρэφπлаκτиρуюτ забοлевание τοльκο у οднοгο зπда ικχзοτныχ κρуπнοгο ροгаτοгο сκοτа π τοльκο κ οднοл.у виду зοзбуди- 20 τеля Уг , £οл С θ'<л л .Unfortunate:.: There are known to be ill, that they only neglect the illness at the other end of the hospital,
3 сοοτвеτсτвии с _ЪΟСЬ- УΙ (1902) (см. З.Ы.Леценκο, "Ιабορаτορная дπагнοсτиκа гρибκοвыχ забοлеваниϊ'" , Ιά. , :ма
Figure imgf000003_0002
3 correspondences with _ΟΟS-UΙ (1902) (see Z.Y. Letsenko, "Disease diagnosis of pungent diseases", Ιά.,: Ma
Figure imgf000003_0002
25 τ.κ. сοгласнο κлассπφиκацπκ Гэορга (1957) (сг.. τаϊύ жэ, с.34) вοзбудиτель τρиχοφиτκκ нκвοτныχ и::ееτ οснοзнοе название ^ νгκллιθя иνν-. .25 τ.κ. according to the class of Georgy (1957) (group .. also, p. 34), the causative agent is triplet and :: its basic name is .
Цель.ο изοбρеτения язляеτся ρазρабοτκа вυсοκοлκι.унο- геннοχ ваκπκны προτиз τρиχοφκτπи -ΚΠΕΟΤΗЫΧ вызызаеι.гаκ 30 .7ъ . ν<-τ}_Λлλ.ζ£>_>иνи_. ι 7ъ νζллш_£>_- ил-
Figure imgf000003_0004
_χ ϊУ?1:χ уρ
Figure imgf000003_0003
Figure imgf000003_0005
The purpose of the invention is to operate on a fully-functional basis, from which 30 .7. ν <-τ } _Λлλ.ζ £ >_> иνи_. ι 7ъ νζllsh_ £> _- yl-
Figure imgf000003_0004
_χ ϊУ? 1: χ уρ
Figure imgf000003_0003
Figure imgf000003_0005
Κρаτκοе сοдеμκание πзοбρеτенияFactory Access
Уκазанная цель дοсτигзеτся τеι.., чτο ваκцина дοποл- 35
Figure imgf000003_0006
The stated goal is reached .. that the vaccine is available - 35
Figure imgf000003_0006
0 _< /ο / . - 2 -0 _ < / ο /. - 2 -
Λнτиген из шτамма ιУγ νе ΖΖи.С_θ£___- /?г- 130 Л 300-βΟΟ млн мιшροκοнидиπ/Игntigen from the strain УУγ νе ΖΖи.С_θ £ ___- /? G- 130 L 300- β ΟΟ million m
0 смЗ0 cm3
Αнτπген ΙΪЗ шτамυаΑнτπгΙΪ шЗ Штамυа
Я. млκ шκροκοни-
Figure imgf000004_0001
Саχаροза 10, 0-20 ,0
I. mlk shkροκοni-
Figure imgf000004_0001
Sugar 10, 0-20, 0
10 Зϊелаτин 1 , 5-4 ,010 gel 1, 5-4, 0
Βοда οсτальнοеThe rest of the world
Пοдροбнοе οπисание изοбρеτенияDETAILED DESCRIPTION OF THE INVENTION
15
Figure imgf000004_0002
эшзοοτичесκοгο,выделеннοгο из белο мыши, меτοдου наπ- ρавлеинοгο сτуπенчаτοгο οτбορа πο πρизнаκу сποροοбρазοва- πия наибοлее бысτρο ρасτущиχ κοлοпий с аκτивπυυ κаκοπле-
fifteen
Figure imgf000004_0002
eshosticheskogo isolated from the white mouse, the methods are on the safe side of the mainstream of the market for the most rapid loss of business is faster
20
Figure imgf000004_0003
леκции миκροορганизмοв Βсеροссиысκοгο гοсудаρсτвениοгο научκο-исследοваτельнοгο инсτиτуτа κοыτροля, сτаκдаρτи- зацιш п сπециφиκации веτеρинаρныχ πρеπаρаτοв и пυεеτ ρегπ- сτρациοнный нοмеρ 2
20
Figure imgf000004_0003
lectures of microorganisms of the Russian Federation
25 ΕΙτамм гρиба Л.
Figure imgf000004_0004
ΒГΗШΙ .!327 χаρаκτеρпзуеτся следующиглι πρизπаκами и свοисτзаυп.
25 амτammb L. L.
Figure imgf000004_0004
ΒГΗШΙ. ! 327 are used as follows and are protected.
Ινϊορφοлοгичесκκе πρизнаκп. Ыιщэлий κе οκρашеы, ροвκьχϊ, зеτвисτыϋ, сеπτиροванныϋ, ινοжеτ ρасπадаτься πа φρагменτы, τеρглιыальныэ гиφы не всегда οбρазуюτ сπиρали (οбычыο 3-5Ινϊορφologic statement Yıshcheli κ ο ρ ρ аш аш,,,, ο ο ο ο, аш,, κ аш κ, Ы Ы Ы Ы Ы Ы Ы Ы Ы Ы Ы Ы.
30 завиτκοз), диамеτρ мицелия 2,0-3,0 мκм. ϊ.Ιπκροκοнидшι мπο- гοчпсленные, κρуглые, гρушевпдные , удлинеκπые, блпзκгιе : πалοчκοзιщκοϋ φορме, ρасποлагающиеся на ποвερχнοсτи ιлι- целия гροздьями, чаще οτдельнο, ρазмеρ 1,5-5,2 мκм. ΙΙаι:ρο- κοнидии едπничные. Κοличесτвο πеρегοροдοι: 1-5, чацу 1-2,30 percent), the diameter of the mycelium is 2.0-3.0 μm. Ι.Ιπκροκοдд м мππππππчччччччччччччч,,,,,,,,,,,,,,,,,, угуглыелые,, г г г гушушушевушуш, ненеев, уд, уд, ,нене ,ненели бл бл бл бл бл бл:::::::: :ал :алалалалалалалалалалϋ 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 1,5 цел 1,5 1,5 1,5 1,5 1,5 1,5 цел цел цел цел 1,5 цел цел him, it is more common, ΙΙаι: ρο- κοnidii are single. Personally Transmitted: 1-5, Chatsu 1-2,
35 ρазмеρου I0-30x3-8 мκм.35 ρmeasure οου I0-30x3-8 mkm.
Β κульτуρаχ 20-30 днезιюгο вοзρасτа мοгуτ πаблюдаτься χла- щидοсπορы οκρуглοй φορι.ъ" с двуκοнτуρнοπ οбοлοчκοιϊ, зсегда - 3 -From 20-30 days of age, you can observe the sweeteners of the environment , with two-sided, always - 3 -
единичные, 3,0-5,0 гκ; в диагеτρе. Αρτροсπορы зοзниκаюτ н οτдельныχ учасτκаχ ιαιυелия, τοнκοсτенные, πο £ορι е наπο-single, 3.0-5.0 gk; in the diagram. Occupants are aware of the private parts of the city, the walls are private, for example,
5 гинаιэτ οвальные ιιлп πалзчκοзκдные гиκροκοнπдπн 3,0-9,0 гκ Κульτуρальные сзοйсτза. Ηа суелο-агаρе ρасτеτ в видз πлοс κοπ белοπ, баρχаτнсτοπ κοлοнππ с незначиτэльны;.; вοззыше- ниег з цеκτρе, ρасτуцπй κρаπ ροзныπ, ρевеρс κρаснοзаτο- κορичневый, диагеτρ κοлοнκи 50-9С г... (15-20 дневная κуль-5 gynoetalnaya vylp lazyzkozdnye gikrupokonpdpn 3.0-9.0 gk Cultural complications. In the case of bustle-agar, it grows in the video area of the territory of Belarus, the profitability of the community is insignificant;.; Reduced loss of life, loss of health, loss of health, loss of health 50–9C g ... (15-20 days old
Ю τуρа).Yu τуρа).
Ηа агаρе Сабуρο ρасτеτ в виде πлοсκοπ, белοй, баρχа- τπсτοй с κρегοзыг οττенκο:.; κοлοниπ с небοлыπκι. вοзвышэни- ег в ценτρе, ρасτущий κρай ροзныГ;, ρевеρс бледнο .κелτыπ, инοгда бοлее τеυныГ: Ε ценτρе, ρазгеρ κοлοниπ 50-90 гOn the Sabareu agrast, it grows in the form of a flat, white, velvet with a quick release:.; well-known. increased in the center, growing at the expense of the gry;; a reversal of the pale. kelty, sometimes more than the average: the center, the rate of 50-90
1 (15-20 дневная κульτуρа).1 (15-20 days old culture).
Ηа сρеде Геннебеρга ρасτеτ з зπде белοн, баρχаτπсτοπ, ρадиальκο-сκладчаτοГ: κοлοнππ, ρасτущий κρай πауτπнисτыπ, ρезеρс κραснοзаτэ-φиοлэτοвыГ, дπагеτρ κοлοнπи 50-СС гг (15-20 дневная κульτуρа). 0 Сποροοбρазοванπе. Ιлаκсπгальныπ уροзень сποροοбρазο- ванπя на суслο-агаρ-з 198,4-259,2 глн/сгЗ.In the midst of Gennebug, it will run out of front of Belon, baruchatstst, radial fold: the kolonpπ, the growing krpund, the result is a payload, 0 ποροοbρazovanpe. The reduction in output from the wort-agar-z is 198.4-259.2 hl / sZ.
Зиρуленτные сзοπсτза. Пρπ знуτρнгышечнοι.: ззедении κульτуρа шτа:..гз 7ι.
Figure imgf000005_0001
Г° 27 у гορсκиχ свинοκ, κροлπκοз, οзеυ, κοз, τеляτ сπусτя 2-3 недели на 5 гесτз инъэκυκл ραззπваеτся сπзππгннιзсκπГ. лοκализοззнны.Г ποвэρχποсτныГ: οча-κοκ д" а,еτροг 2,0-2,5 сг, κοτορгл сагο- προπзвοльнο иззлечπзаеτся в τечение 15-20 днеГ. Μπκο- лοгичесκπ Εыделиτь зοзбудπτзχь ?:э удаэτся. Пρπ нанесениπ κульτуρг шτаπгз
Figure imgf000005_0002
нπзοτньг на сκаρπгι-- 0 циροзанную κοιχу в дοзу 0,25...лιι/сг 3 гнκροκοκπдπκ на ι.есτэ аππлиκаπиπ ρаззπзаэτся з τечениэ 10-20 днэπ τππичπгπ гρи- χοϊπτийньιГ; οчаг. Зыдэлзнны πз πаτοлοгπчесκοгο ι.аτэρκала шτа; πό сзοи. сзοйсτза: сοοτзэτсτзуеτ πсχοднοιу.
SURPRISE RESPONSE. Ρ ыш з ыш ыш ыш .: .: .:.
Figure imgf000005_0001
At 27 ° C, in pigs, κ свин π,,,,, зе зе υ κ,, еля, calves down after 2-3 weeks for 5 gestational injections инъ з з з ва ва...... They are localized: a good result, but 2.0-2.5 s, but a saga - will be neglected for 15–20 days.
Figure imgf000005_0002
nothing to skarpig-- 0 cited to a dose of 0.25 ... liι / cg of 3 sockets in the country, the appendix is open for 10-20 days; source Ideal for the mercantile state; πό communication. Occupation: It is inactive.
Αнτигенные сзοГιсτза. ηа зведзниε κульτуρы шτагга з 5 ορганизге. τсляτ, οзэπ, προлиκοз οбρазуэτся сπецιгνлчесκπе агглюτπнины з τиτρаχ 1:40-1 :Ι2СЗ. - 4 -Antigeneration. ηa zvezdnizε cultivars of step 5 of the city. Therefore, there is no need to forget about agglutination in the air from 1: 40-1: Ι2ЗЗ. - 4 -
Иыыунοгенные свοнсτза. Пρи дзуκρаτнο:.; внуτρиιышечнο:.; взедении τеляτаι.:, κροлиκа:.: ваκцины, нзгοτοзлзннοГ; из дан- с нοгο _лτаы;,:а в дοзе, сοдеρ.κащей 10-20 ит-ι шιзын ыиκροκοπи-Lasting Interest. In case of zukrat:.; internally:.; retraction of the tel.:., circle:.: vaccines, vaccine; from the data from _ltaia ;,: and in the dose, which is 10-20 it-ι shyzyn yykροκοπ-
-дин, у жизοτныχ φορыиρуеτся наπρя:κеннын и:.;:,униτеτ κ ποс- ледующеι.у заρаженπю
Figure imgf000006_0001
προдοлжиτелы-ιοсτью не ι.:е- нее δ леτ (сροκ наблюдения).
-din, living things happen: Kenny and:.;:, it’s worse for the next
Figure imgf000006_0001
Well, there is no v.: it is more than δ leth (observation period).
Шτаыл Ιх..
Figure imgf000006_0002
ЗГШИ Iй 27 οτличаеτся οτ 10 эπизοοτичесκин слабοГ: виρуленτнοсτью, οτсуτсτвиеы заρа:κе- нπя πρπ κοнτаκτе ь;е;κду жизοτныыπ, высοκο:: аκτивнοсτью на- κοπлеπия ыиκροκοнπдий и иыыунοгеннοсτью πρπ знуτρи:..яшеч- нοϊ; введении κивοτныы.
Shtayl Ιh ..
Figure imgf000006_0002
ZGSHI I th 27 οτlichaeτsya οτ 10 eπizοοτichesκin slabοG: viρulenτnοsτyu, οτsuτsτviey zaρa: κe- nπya πρπ κοnτaκτe b; e; κdu zhizοτnyyπ, vysοκο :: aκτivnοsτyu HA κοπleπiya yiκροκοnπdy and iyyunοgennοsτyu πρπ znuτρi: .. yashech- nοϊ; introduction of livestock.
15 Пρиыеρы ποлученπя ваκцины πο изοбρеτению. ПΡΙΙΙЖ? I.15 Other Vaccines Received from the Invention ПЖЖ? I.
20 агаρе (ρΗ 6,2-6,0) πρи τеι.шеρаτуρе 2б-28οС в τечение 12-20 дней.20 agarе (ρΗ 6,2-6,0) πρ and τеι.more than 2b-28οС for 12-20 days.
Зыρащенную гρибницу κаздοГ; κульτуρы з услοзияχ асеπ- τиκπ сниыаюτ с ποзеρχнοсτπ πиτаτельнοй сρеды сπециальны- .:и сκρзбκаιлπ π ποыещаюτ в сτеρильные банκи. Гρибную ыассуA swollen stump is located in the back; Cultures under conditions of accep- ticism reduce the benefits of a healthy environment: special: and they are stored in stylish banks. Flexible yassu
25 κаздοгο шτаыыа гοιοгёнизиρуюτ з ыπκсеρан или κοллοиднοπ ι/ельн;ιце, а заτе:-.; с πο:.;οщью сτеρильнοπ зοды ποлученныГ: гοыοгенаτ _ νгνи( <_νе>-.'<лγνъ 130 Л ρесусπензиρуюτ дο κοнценτρаππи ыπκροκοнндии 300 :ллн/с:,;3, на гοыοгенаτ τ.
Figure imgf000006_0004
ЗГΗΚП"'' 27 - 600 ЫЛΗ/СУ.З. Ρесус-
25 Each of the United States is goryuniziruyut zypkseran or kolloidnopi v / eln; vce, and then: - .; with πο:.; in general, the stylish rooms have been upgraded: Г ο ο ο ((((<<<<<<<(<_ е (- - <. γ. 130 130 130 ус).
Figure imgf000006_0004
ЗГΗΚП "'' 27 - 600 YLΗ / SU.Z. Jesus Christ-
30 πензиροзанне προзοдяτ з πρнсуτсτзππ πенициллина ил:: сτρеπτοϊν.иπина нз ρасчеτа 100 ΕД на I с;.:3 гοι.-.οгенаτа. Гο:..οгенаτ шτаыыа гρиба 1г. νел νи-^-αт. 130 Л οбъедπняюτ Б ρазнο:; οбъеие с гοыοгенаτοм шаϊ'ж гρπба30 Penetration is due to the absence of penicillin or :: constituent acid, at a rate of 100 Ε D for I second;.: 3 gene .-. G:: Ogenet shtayyya musha 1g. νel νи - ^ - αт. 130 Lives a variety of things :; Communion with the Great Sha'zh group
Figure imgf000006_0005
елаτннι:. Зсε τщаτзльнο πеρеыешизаюτ, ρазлπааюτ з сτеρн- льные α.лаκοны н лиοφπльнο зысушизаюτ. 5 -
Figure imgf000006_0005
previous :. It can be easily removed, and it can be expanded with a solid α. It is not limited to dry. 5 -
ПΡПΙлΞΡ 2.ПΡПΙлΞΡ 2.
Βаκцину ποлучаюτ аналοгичнο , ιаκ οππсанο з πρκιлеρе I Для ее πρигοτοвления исποльзугэτ гο:. οгенаτ шτа:.;:.:οв гρπбοз
Figure imgf000007_0001
κачесτве сτабκлκзаτορа вοдныκ ρасτвορ , сοдзρ.κащπχ 15 саχаροзы κ , 5 γ.едаτина.
The vaccine is being produced similarly, in general, I have used it to use it :. Generation of the State:.;:.:
Figure imgf000007_0001
As a result of the stabilization of the original product, the result is 15 sugar candies, 5 γ of the parent.
ПΡΙΙΙ.ΕΡ 3.PΡΙΙΙ.ΕΡ 3.
Баκцину προτκз τρκχοφκτκи живοτныχ πρигοτавливаюτ аналοгκчнο, κаκ οπκсанο в πρκыеρе I. Для ее ποлученχя исποльзуιэτ гοыοгенаτ ι_ιτаιл;.:а гρκбл 7г . ν -ъναι < *лл ж 5 130 Л с κοнценτρацπεκ ι..κκροκοнχдκκ 600 ;,:лн/сι.;3 κ гοыοге-The bacterium is produced by living in a similar fashion, as it is in I. For its use, it is good to eat the gene. ν -ъναι <* lll 5,130 L with an incentive ι..κκροκοnхдкк 600;,: ln / s.; 3
Figure imgf000007_0002
желаτмна.
Figure imgf000007_0002
desirable.
20 Гοτοвая ваκцκна πρедсτазляеτ сοбο": οднοροдную πορис- τую суχу-э ыассу в вκде τаблеτκκ сеροгο цвеτа. Βаκцκна сοχρаняеτ свοи биοлοгичесκκе свοκсτва πρи услοзиπ χρане- ния в заκρыτыχ суχκχ, τеыныχ ποιлещенπяχ πρκ τеыπеρаτуρе 2-Ι0°С. Сροκ гοднοсτκ 12 месяцев. Κ ваκцине πρилагагоτся20 Gοτοvaya vaκtsκna πρedsτazlyaeτ sοbο ": οdnοροdnuyu πορis- τuyu suχu-e yassu in vκde τableτκκ seροgο tsveτa Βaκtsκna sοχρanyaeτ svοi biοlοgichesκκe svοκsτva πρi uslοziπ χρane- Niya in zaκρyτyχ suχκχ, τeynyχ ποιleschenπyaχ πρκ τeyπeρaτuρe 2-Ι0 ° C Sροκ gοdnοsτκ 12 months... Κ vaccine is being tested
2 φлаκοны сο сτеρильныы ρазбавκτеле;..2 vials of solid diluent; ..
ПИΪΜΕΡ 4.PI 4.
Пρχгοτοзленные сеρκκ ваκиκны προτκз τρκχοφχτиκ живο- τныχ πο πρκыеρа:.: 1, 2, 3 πеρед πρκχенение:' ρасτвορяιэτ в 30 ρазбевиτеле из ρасчеτа I дοза в I сыЗ. Пοлучаιэτ сеρии ьаκцинь:, сοдзρжащκе в πρκзивοчнοκ дοзе следующуго κοнцен- τρаπκю анτκгенοз в ылн/сι.ιЗ (τаблκца I).The resulting selections are va- rious due to live traffic::: 1, 2, 3 before transfer: 'I dispose of it 30 times. This is the case for the series: which is available on an actual basis after the following evaluation of the general antigenesis in the textbook (Table I).
ΤΑΕЛΙЩΑ IΤΑΕLΙSCHΑ I
ЗδЗδ
Κаи.ленοзание анτκгена Заκцκна πο Βаκцина πο Заκцина πο πρπыеρ I πρπмеρу 2 πρπκеρу 3Filing the antigen Zaktsna ο ци ци ци ци За За За За За За За κ κ κ κ κ κ κ κ κ κο За κ ο κ ο ο κ ο ο ο ο ο κ ο
7г . νζлмлιθτ ш 'τη, 130 Л 5 7, 5 ΙС - 6 -7g νζlml θ τ w 'τη, 130 L 5 7, 5 ΙС - 6 -
Пροдοлжение τаблицы I
Figure imgf000008_0001
Table I
Figure imgf000008_0001
ΪГ» 27 ЗПΙΚИ 10 7,5 5ΪГ »27 ЗПΙΚИ 10 7.5 5
Βаκцину πο πρимеρам 1, 2, 3 исποльзуюτ для κшуниза- ции τеляτ, ввοдя внуτρиκышечнο дзуκρаτнο с инτеρзалοι»: 10-Actually, for examples 1, 2, 3, they are used for communalization of calves by introducing internal muscle from the interer ”: 10-
Ю 14 дней в дοзе I смЗ.10 days in the dose of I cm3.
3 κачесτзе κοнτροля исπыτывагаτ аналοгичнο πρигοτοв- денные ваκпины κз шτаι а Зκ,. νе лиβ&_м,ун 130 Л и 1ч,.
Figure imgf000008_0002
ΒГΗΚИ ГС 27 с κοнценτρацией миκοκοπиндии анτигена Ε πρививοчнοй дοзе 7, 5 млн/смЗ.
3 In the short run, you will experience a similar production of vases from the factory. νе лиβ & _м, un 130 L and 1 h.
Figure imgf000008_0002
ΒGΗΚI G C 27 with a concentration of mycopindia antigen Ε a natural dose of 7.5 mln / cm3.
15 Чеρез 35 дней ποсле вτοροй им лунизации τеляτ заρажагаτ вπρуленτныυи κульτуρашι шτашοв 7г_, ν-&/ζΛ ес,≤* . ?!'- 15315 After 35 days after the second lunarization, they incarcerate virulent and cultured states 7g_, ν- & / ζΛ ес , ≤ *. ?! '- 153
Figure imgf000008_0003
0 заρажаюτ эτими же κульτуρаι.ιи ο κοнτροльныχ (неимунизиρο- ванныχ) τеляτ.
Figure imgf000008_0003
0 they infect the same culture. And they are in contact with (non-immunizing baths) calves.
Ρезульτаτы эκсπеρиι. енτальнοгο заρажения τеляτ πρед- Сτавлень: в τаблице 2. 5 ΤΑΕЖΙЦΑ 2The results of the experiment. oral infection calves Delivery: in table 2. 5 ΤΑΕ 5ΙЦΑ 2
].*." Κ-вο Биοπροπеρаτ Ишу- Κοлκчеτсτвο забοлезшиχ гρ. жизοτныχ исποльзуемый низиρ. жизοτныχ πρи эκсπеρи- Ε гρуπ- для имιуниза- τеляτ .ен альнο _з_^а ен_::_ πе цκи τеляτ (гοл.) τз_ та_ τс_ ΤЗ - ΤЗ-]. *. "Κ-vο Biοπροπeρaτ Ishu- Κοlκcheτsτvο zabοlezshiχ gρ. Zhizοτnyχ isποlzuemy niziρ. Zhizοτnyχ πρi eκsπeρi- Ε gρuπ- for imιuniza- τelyaτ .en alnο _z_ and en ^ _ :: _ πe tsκi τelyaτ (gοl.) Τz _ that _ τс _ Τ З - ΤЗ-
153251 724 118 20 0153 251 724 118 20 0
С 0 0 υ
Figure imgf000008_0004
0 С 0 с 5 Пροдοлжение τаблицы 2
C 0 0 υ
Figure imgf000008_0004
0 s 0 s 5 Table 2
3 7 Заκцина πο πρиϊлеρу 3 7 0 С 0 0 υ3 7 Zaktsina πο πρиϊлеρу 3 7 0 С 0 0 υ
4 10 Заκцина из шτаιлма 10 0 4 2 0 .ννν сοζиνη4 10 Standard vaccine 10 0 4 2 0 .ννν сοζиνη
ΙЗΟЛΙЗΟЛ
10 5 Заκцина из шτаϊν.ιла 9 δ 0 I 2 <-»10 5 Zaczin from the staff of v. Vla 9 δ 0 I 2 <- »
Α.Α.
ЗГΗЮΪ I? 27 б б ΚοнτροльЗГΗЮΪ I? 27 b b
(неимь.унизи- 1 ροванные) - 2(neim.unizi- 1 ροvannye) - 2
Пз τаблππы виднο, чτο 1,2 и 3 сеρии ваκπины у ;;:.:;ιуни- зиροванныχ τеляτ зыρабаτываюτ наπρяженныκ (Ι00 ) иммуни- τеτ προτив τρиχοφиτии πρπ эκсπеρиϊν.-енτальκοκ заρа.κениκ. ИммFrom the table it is visible that 1.2 and 3 series of vapin y ;;:.:; Imm
20 низацπя τеляτ ϊν_οнοваκцинаι_:и не вызыыаеτ дοсτаτοчнο сτοйκο- гο иυι.униτеτа πρи ποследу.οщеϊ/. заρаженχκ геτеροлοгκчныыи κульτуρами зοзбудиτелей τρиχοφиτиπ. Τеляτа ρанее не κι.α.у- низκροванные κ не бοлезшне τρκχοφχτκеχ зορπρии:»;чивы κ эκс- πеρи:.:енτальнο:су заρаяенπю зиρуленτныκи κульτуρа;,:и зοзбуди-20 nizatsya calves ϊν_onovacinia_: and does not cause a sufficiently long-term and viva.uniteta for the next. /. contagious heterogeneous cultures of pathogens are toxic. I didn’t have κι.α.- lower ones ı not worse then:;; live ı EXCEPT:.: Ntal: su за zirulent ow;
25 τелеχ τρиχοφиτиχ.25 telephones.
ПΡИΙЖΡ 5.FUN 5.
Τρеιля ΟΚЫΤΗЫΙ..И сеρия:.:ι ваκцκκь: аκалοгичκο πρπ:,:еρу 4 и;.;;.:унκзиρу:οτ 14 κοз с ποследущκ;.. иχ заρаженχе;; виρуленτ- 30 Τь. г л*-υΟю < я.уν_. - 153 κ 1 251. Κοнτροльныχ жχзοτныχ (2
Figure imgf000009_0001
Τ е ля ΟΚ ΤΗ ΤΗ ΤΗ Ι Ι Ι ... And the series:.:: Vakt ва: akalogogich πρπ:,: ery 4 and;. ;;.:: Κ:: ο 14 с с с с с с с .. .. .. .. .. .. .. .. .. .. .. .. ..; virulent- 30 b. g l * -υΟю < Я.уν_. - 153 κ 1 251. Economic Railways (2
Figure imgf000009_0001
Зсе ваκπиниροзанные жκзοτные не забοлелχ τρκχοφχτχеχ, у κοнτροльныχ были οτыечены все πρκзнаκи забοлезания с 35 выделенκеι из πορаженныχ οчагοв уκазанныχ шτаκιгоз зκρулен- τκыχ κульτуρ. - ε -All the vascularized infections did not get sick, all the signs of the disease were removed from the terminal with 35 selected cases from the excluded cases. - ε -
ΠΡΚ .ΕΡ 6.ΠΡΚ .ΕΡ 6.
Для иι гунизаπππ 10 κροлиκοз ποροдь: шπκϊιϊнллз илвοнFor Ii Guniz πππ 10 κ
5 ι.-ассοй 2 , 5-3, 0 κг исποльзуюτ ваκππну πο πρ:ι: еρу 2. Баκπпн πеρед πρπгенеκие;/ ρасτзορяюτ з ρазбавπτеле ι:з ρасчеτа I
Figure imgf000010_0001
5 v.-assy 2, 5-3, 0 kg use the option πο: ι: ery: 2. Most importantly π г г ас ас / / /;
Figure imgf000010_0001
Пοлучаюτ следующую κοнценτρаππ:ο аκτигеκοз з I πρπви- зοчнοй дοзе : Я. νчτгηл_. && <-.γ _. 130 Л 7, 5 :ллн гиκροκοнидThe following accent is received: а Actighez I with a physical dose: Ya. Vchtgηl_. &&<-. γ _. 130 L 7, 5: LLH
Ю
Figure imgf000010_0002
ΒГΗΚΙΙ ?* 27 7, 5 ι:лκ. ιлπκροκο κидии . Заκциκу звοдяτ κροлζκам Εκуτρи:.:ышечнο дзуκρаτнο в дο-
Figure imgf000010_0003
лπκοв исποльзуιэτ ваκππну из шτаπла 7 . \щш£ ~су_νρ \£^г1ь_-
YU
Figure imgf000010_0002
ΒГΗΚΙΙ? * 27 7, 5 ι: лκ. ілπκροκο кидии. Zakutsu is well-known for his acquaintances:.: Muscular in the home
Figure imgf000010_0003
Most of the time, it’s possible from station 7. \ uh £ ~ su_νρ \ £ ^ r 1__-
15 :* 135 , сοдеρжаπу.ο в I πρививοчнοГι дοзе 20
Figure imgf000010_0004
πиκροκο- κπдий в I с: :3, κοτορую πρπглеκяюτ внуτρπιгышечнο в οбласτь ягοдичнын глышπ. Чеρез 30 дκеπ κροлиκοз заρа .аюτ наκοжнο зπρуленτныιли κульτуρами шτаιлιлοз Τъ. т^ ^ οψ и^Ιг^ - 251 и 1ъ, 25 0 дκей учπτыва
Figure imgf000010_0005
ο исποльзοванπе заκцины сποсοбсτзуеτ οбρазοзанию надежнοгο иπуниτеτа у всеχ иιлιунизиροзанныχ κροлиκοз, в το вρеι:я κаκ исποльзοзание иззесτнοй ваκцнκы Μенτазаκ не даеτ наде жнοгο эφφеκτа - 2 κροлнκа из 10 забοлели τριπсοφиτπеГ: , а ?; 5 οчагοв πορа;κенπя выделены κульτуρп вπρуленτнπχ шτаπлοз.
15: * 135, content on the first day at 20
Figure imgf000010_0004
Practically in I since:: 3, they take a look at the inside of the muscle in the area of the mute. After 30 days, it’s easy to get ready for work. t ^ ^ οψ and ^ Ιг ^ - 251 and 1b, 25 0
Figure imgf000010_0005
ο isποlzοvanπe zaκtsiny sποsοbsτzueτ οbρazοzaniyu nadezhnοgο iπuniτeτa in vseχ iιlιuniziροzannyχ κροliκοz in το vρeι I κaκ isποlzοzanie izzesτnοy vaκtsnκy Μenτazaκ not daeτ Nadia zhnοgο eφφeκτa - 2 κροlnκa 10 zabοleli τριπsοφiτπeG: and;? 5 foci of success; the culture is highlighted in the incarnation.
ПΡИ÷.ΞΡ 7.ПΡИ ÷ .ΞΡ 7.
20 τеляτ ιπлгунизπρуюτ заρπанτаππ ваκцπны πο πρинегу I и 3 с κοκπеκτρаπиеπ аκτπгεнοз в πρπзнзοчнοг дззз πο ~:н- 0 геρу 4, Κа.κдο" гρуππе τеляτ (10 гοлοь) заκπнну πρи::еняюτ БΗ-.' οϊнΗπечκο дзуκюаτнο в οοъеге I сιлЗ с ннτзοзалοг 10-14 днеГ:. Чеρез 4 и 9 гесяπез ποслэ вτορο" нπ.'Лунπзаπππ οбе гρуππы τэляτ заρа.κаюτ зиρуленτныги Зг ν_ ιли.<ϊ ι,γл у- 153 и 7г.
Figure imgf000010_0006
251. 5 3 ρезульτаτе ни οдπκ τзленοκ не забοлел. Τаκπг οбρлзοг заκππна πο изοбρеτению сοχρаняеτ сτοГκπГ γ ;униτеτ чеρез 4 π 9 ; есяπез ποслε- зεюзϊлβния. <__>
20 τelyaτ ιπlgunizπρuyuτ zaρπanτaππ vaκtsπny πο πρinegu I and 3 κοκπeκτρaπieπ aκτπgεnοz in πρπznzοchnοg dzzz πο ~: n 0 geρu 4 Κa.κdο "gρuππe τelyaτ (10 gοlο) zaκπnnu πρi enyayuτ BΗ- :: '. The last year in the first day, I had to wait 10-14 days: After 4 and 9 days after that , the second time, the group would be ignored.
Figure imgf000010_0006
251. 5 3 As a result, no red tape did not become ill. Downloading this product is protected by the inadvertent loss of γ; it disappears after 4 π 9; one more time after the fact. <__>
Βаκцина высοκοэφφеκτивна προτив τρиχοφиτии κившτнκχ, Βаκцину с προφилаκτичесκοГ: цель:ο πρиιленяюτ двуκρаτнο сThe vaccine is highly effective by treating the patient, the vaccine is: the goal is: it removes two
5 ιшτеρвалοι.1 10-14 дней в следующиχ дοзаχ: τеляτаы οτ 14 днеГ: дο 4 лесяцез I смЗ, сτаρше 5* г/есяцев 2 сι.:3 и мелκουу ροгаτοму сκοτу (οвцы, κοзы) οτ 3 дο 6 ыесяцев - 0,5 смЗ, сτаρше б ыесяцев - ΙсмЗ. Κροлиκам мас сοй 2,5-3,0 κг ввοдяτ 0,3-0,5 сι/3 с προφилаκτичесκοй це-5 months. 1 10-14 days in the following doses: calves from 14 days: up to 4 months I cm3, older than 5 * months 2 s.: 3 and small prices (October, 6 days old) , 5 cm3, older than the second - цев cm3. For masters with a weight of 2.5-3.0 kg, 0.3-0.5 si / 3 is introduced with a regular dose
10 лыο. С лечебнοй целью ваκцину взοдяτ бοльныιл жизοτныл дз κρаτнο с инτеρвалοι.' 10-14 дней в удвοеннοй дοзиροвκе.10 ly. 'With a curative purpose, the vaccine was taken up by a healthy one, which was short of an interval.' 10-14 days in an double dose.
Κсποльзοвание ваκцины πο изοбρеτεнию в веτеρинаρнοπ πρаκτиκе ποзвοлиτ ποвысиτь эφφеκτивнοсτь меροπρияτий πο бορьбе с τρиχοφиτией живοτныχ.The use of the vaccine in the invention in the practice of the disease will improve the efficiency of the treatment of the risk of vomiting.
15fifteen
2020
2525
30thirty
35 35

Claims

- 10 - - 10 -
ΦΟΡΙ.ΙУЛΑ ΙΪЗΟΕΡΞΤΞΙШΦΟΡΙ.ΙУЛΑ ΙΪЗΟΕΡΞΤΞΙШ
Заκцина προτив τρиχοφπτии κκзοτнυχ, сοдеρκащая ан τπгεπ πз шτа:.::а
Figure imgf000012_0001
130 Л саχаροзу, κелаτин и вοду, ο τ л и ч а ю ц а я с я τег чτο οна дοποлнκτельнο сοдеρжиτ анτиген из шτашла 1г.
Figure imgf000012_0002
ΒГΗΚП "- 27 πρπ следующеϊν: сοοτнθ' шенπи κοιшοненτοз (вес/οб %): анτπген из шτамιла 7г.
Figure imgf000012_0003
130 Л
Zaktsina on the other hand, which includes the state law:. :: a
Figure imgf000012_0001
130 Sugar, kelatin and water, so that you can get additional antigen from the 1st stage.
Figure imgf000012_0002
ΒГΗΚП "- 27 πρπ as followsϊν: ο ο τ ен ен π π κ κ ((вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес вес:::::::
Figure imgf000012_0003
130 L
300-600 ылн. шκροκοнидии/ сιлЗ анτиген из шτаιлιла Τг.
Figure imgf000012_0004
ЗГШИ ?г 27
300-600 School / Anthony Antigene from the United Kingdom.
Figure imgf000012_0004
ZGSHI? g 27
300-600 млн. миκροκοнидий/
Figure imgf000012_0005
саχаροза 10,0-20,0 желаτин 1,5-4,0 вοда οсτальнοе
300-600 million micronidium /
Figure imgf000012_0005
sugar 10.0-20.0 gelatin 1.5-4.0 other water
PCT/RU1993/000319 1992-12-30 1993-12-27 Vaccine against trichophytosis in animals WO1994015632A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU58245/94A AU5824594A (en) 1992-12-30 1993-12-27 Vaccine against trichophytosis in animals

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU92015462/13 1992-12-30
RU92015462A RU2018321C1 (en) 1992-12-30 1992-12-30 Vaccine against trychophytosis of animals

Publications (1)

Publication Number Publication Date
WO1994015632A1 true WO1994015632A1 (en) 1994-07-21

Family

ID=20134793

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU1993/000319 WO1994015632A1 (en) 1992-12-30 1993-12-27 Vaccine against trichophytosis in animals

Country Status (3)

Country Link
AU (1) AU5824594A (en)
RU (1) RU2018321C1 (en)
WO (1) WO1994015632A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2025222A (en) * 1978-06-07 1980-01-23 Inst Experimentalnoi Veterinar Vaccine for treatment of trichophytosis caused by trichophyton mentagrophytes
SU955571A1 (en) * 1980-03-28 1984-11-07 Всесоюзный Ордена Ленина Институт Экспериментальной Ветеринарии Vaccine tf-130 (k) against trichophytosis of cattle and method for treatment and prophylaxis of trichophytosis of cattle

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2025222A (en) * 1978-06-07 1980-01-23 Inst Experimentalnoi Veterinar Vaccine for treatment of trichophytosis caused by trichophyton mentagrophytes
US4368191A (en) * 1978-06-07 1983-01-11 Sarkisov Arutjun K Vaccine and method prophylaxis and treatment of trichophytosis caused by pathogenic organism trichophyton mentagrophtyes and method for preparing same
SU955571A1 (en) * 1980-03-28 1984-11-07 Всесоюзный Ордена Ленина Институт Экспериментальной Ветеринарии Vaccine tf-130 (k) against trichophytosis of cattle and method for treatment and prophylaxis of trichophytosis of cattle

Also Published As

Publication number Publication date
AU5824594A (en) 1994-08-15
RU2018321C1 (en) 1994-08-30

Similar Documents

Publication Publication Date Title
Black et al. Microbiology: principles and explorations
Burnet et al. Natural history of infectious disease
Summers Felix dHerelle and the origins of molecular biology
Taylor et al. Campylobacter fetus infection in human subjects: association with raw milk
Park et al. Pathogenic Microörganisms: A Practical Manual for Students, Physicians and Health Officers
Kirkwood Time of our lives: The science of human aging
Drews The roots of microbiology and the influence of Ferdinand Cohn on microbiology of the 19th century
Maraz et al. An overview on impact and application of microorganisms on human health, medicine and environment
Robbins Louis Pasteur and the hidden world of microbes
BG98070A (en) RECOGNITION AND USE OF FORMALIN ORIGINAL ORGANISMS OF E. SOLI, EXPRESSING ANTIGEN OF THE COLLANE-EROTIC FACTOR, FOR VACCINATION AGAINST RARE INFECTIONS / DIARIES CAUSED BY E.COLI ENTEROTOXIC BACTERIA
Allison Personal recollections of Sir Almroth Wright and Sir Alexander Fleming
Lagerkvist Pioneers of microbiology and the Nobel Prize
Woodhead Bacteria and their Products
WO1994015632A1 (en) Vaccine against trichophytosis in animals
Aneja A textbook of Basic and Applied Microbiology
Holmes Louis Pasteur
Buchanan Veterinary bacteriology
Buonasera et al. Sex-Biased Differences in Infant Mortality and Life Expectancy at Síi Túupentak, an Ancestral Ohlone Village in Central California (ca. 540–145 cal. BP)
Fildes Frederick William Twort, 1877-1950
Vasiliadi History and Basics of Microbiology and Epidemiology
Daëron Before the Immune System
Zeldovich The Living Medicine: The remarkable history of a life-saving cure and how it will rescue us when antibiotics fail
Bowater The Microbiologists
Thomas Bacteriology: a text book on fundamentals
Daëron Endless Immunity: Rethinking the Immune System

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU BG CA CZ FI LV NO PL SK US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA