WO1994011010B1 - Compositions of oak bark extract, related synthetic compositions, and method of using same - Google Patents
Compositions of oak bark extract, related synthetic compositions, and method of using sameInfo
- Publication number
- WO1994011010B1 WO1994011010B1 PCT/US1993/010670 US9310670W WO9411010B1 WO 1994011010 B1 WO1994011010 B1 WO 1994011010B1 US 9310670 W US9310670 W US 9310670W WO 9411010 B1 WO9411010 B1 WO 9411010B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- parts
- ions
- composition
- oak bark
- rubidium
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 17
- 241000219492 Quercus Species 0.000 title claims abstract 9
- 235000016976 Quercus macrolepis Nutrition 0.000 title claims abstract 9
- 229910001419 rubidium ion Inorganic materials 0.000 claims abstract 9
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims abstract 5
- 229910001424 calcium ion Inorganic materials 0.000 claims abstract 5
- 229910001414 potassium ion Inorganic materials 0.000 claims abstract 5
- PTFCDOFLOPIGGS-UHFFFAOYSA-N zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims abstract 5
- 230000001225 therapeutic Effects 0.000 claims abstract 4
- 239000006286 aqueous extract Substances 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 229910003480 inorganic solid Inorganic materials 0.000 claims 4
- 239000000969 carrier Substances 0.000 claims 2
- 230000003902 lesions Effects 0.000 claims 2
- 206010021531 Impetigo Diseases 0.000 claims 1
- 206010049422 Precancerous skin lesion Diseases 0.000 claims 1
- 201000004681 psoriasis Diseases 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 206010040943 Skin ulcer Diseases 0.000 abstract 1
- 230000001154 acute Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 201000000849 skin cancer Diseases 0.000 abstract 1
- 231100000019 skin ulcer Toxicity 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Abstract
Higher concentrations of oak bark ash extract, i.e., greater than 20 % by weight, are useful for the treatment of skin cancers. Lower concentrations of oak bark extract possess additional therapeutic properties not heretofore recognized. For example, preparations containing 40-80 % oak bark extract are useful in the treatment of acute cancerous skin ulcers. In addition, synthetic mixtures containing potassium ions, zinc ions, calcium ions provide many of the same advantageous properties of oak bark extract. The inclusion of rubidium ions and sulfur is also advantageous for some applications.
Claims
1. A composition comprising:
10 to 80 parts potassium ions;
0.00001 to 20 parts zinc ions;
0.01 to 10 parts calcium ions; and
1 to 40 parts rubidium ions by weight of inorganic solids, optionally diluted in a pharmaceutically acceptable carrier, with the proviso that the composition is not identical to an aqueous extract of oak bark ash.
2. A composition according to claim 1, comprising 1 to 30 parts rubidium ions.
3. A composition according to claim 1, wherein the carrier is water.
4. A composition according to claim 1, wherein the carrier is a creme base.
5. A method for treating cancerous and precancerous skin lesions comprising applying to the lesion an effective amount of a therapeutic composition comprising
10 to 80 parts potassium ions;
0.00001 to 20 parts zinc ions;
0.01 to 10 parts calcium ions; and
1 to 40 parts rubidium ions by weight of inorganic solids, optionally diluted in a pharmaceutically acceptable carrier, with the proviso that the composition is not identical to an aqueous extract of oak bark ash. - 19 -
6. A method according to claim 5, wherein the composition comprises 1 to 30 parts rubidium ions.
7. A method for treating psoriasis comprising applying to the lesion an effective amount of a therapeutic composition comprising
10 to 80 parts potassium ions;
0.00001 to 20 parts zinc ions;
0.01 to 10 parts calcium ions; and
1 to 40 parts rubidium ions by weight of inorganic solids, optionally diluted in a pharmaceutically acceptable carrier, with the proviso that the composition is not identical to an aqueous extract of oak bark ash.
8. A method according to claim 7, wherein the composition comprises 1 to 30 parts rubidium ions.
9. A method for treating impetigo comprising topically applying an effective amount of a therapeutic composition comprising
10 to 80 parts potassium ions;
0.00001 to 20 parts zinc ions;
0.01 to 10 parts calcium ions; and
1 to 40 parts rubidium ions by weight of inorganic solids, optionally diluted in a pharmaceutically acceptable carrier, with the proviso that the composition is not identical to an aqueous extract of oak bark ash.
10. A method according to claim 9, wherein the composition comprises 1 to 30 parts rubidium ions.
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ258019A NZ258019A (en) | 1992-11-06 | 1993-11-04 | Medicinal compositions containing potassium, zinc, calcium and rubidium ions having the same properties as oak bark extract |
| DK94900557T DK0668769T3 (en) | 1992-11-06 | 1993-11-04 | Oak barley extract-related synthetic compositions and methods for their use |
| JP51222794A JP3640215B2 (en) | 1992-11-06 | 1993-11-04 | Composition of oak bark extract, related synthetic compositions and methods of using same |
| EP94900557A EP0668769B1 (en) | 1992-11-06 | 1993-11-04 | Synthetic compositions related to oak bark extrakt, and method of using same |
| CA002148795A CA2148795C (en) | 1992-11-06 | 1993-11-04 | Compositions of oak bark extract, related synthetic compositions, and method of using same |
| AT94900557T ATE191850T1 (en) | 1992-11-06 | 1993-11-04 | OAK BARK EXTRACT-RELATED SYNTHETIC PREPARATIONS AND METHODS OF USE |
| DE69328438T DE69328438T2 (en) | 1992-11-06 | 1993-11-04 | OAK Bark EXTRACT-RELATED SYNTHETIC PREPARATIONS AND METHOD FOR USE |
| BR9307401A BR9307401A (en) | 1992-11-06 | 1993-11-04 | Oak bark extract compositions related synthetic compositions and method of using the same |
| AU55500/94A AU700019B2 (en) | 1992-11-06 | 1993-11-04 | Compositions of oak bark extract, related synthetic compositions, and method of using same |
| PL93308770A PL308770A1 (en) | 1992-11-06 | 1993-11-04 | Oak bark extract compositions, similar synthetic composition and method of obtaining them |
| NO951740A NO951740L (en) | 1992-11-06 | 1995-05-04 | Preparations of oak bark extract, related synthetic preparations and methods for using them |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97307192A | 1992-11-06 | 1992-11-06 | |
| US07/973,071 | 1992-11-06 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO1994011010A2 WO1994011010A2 (en) | 1994-05-26 |
| WO1994011010A3 WO1994011010A3 (en) | 1994-09-15 |
| WO1994011010B1 true WO1994011010B1 (en) | 1994-10-27 |
Family
ID=25520460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1993/010670 WO1994011010A2 (en) | 1992-11-06 | 1993-11-04 | Compositions of oak bark extract, related synthetic compositions, and method of using same |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6149947A (en) |
| EP (1) | EP0668769B1 (en) |
| JP (1) | JP3640215B2 (en) |
| AT (1) | ATE191850T1 (en) |
| AU (1) | AU700019B2 (en) |
| BR (1) | BR9307401A (en) |
| CA (1) | CA2148795C (en) |
| CY (1) | CY2231B1 (en) |
| CZ (1) | CZ117395A3 (en) |
| DE (1) | DE69328438T2 (en) |
| DK (1) | DK0668769T3 (en) |
| ES (1) | ES2147780T3 (en) |
| HU (1) | HUT73791A (en) |
| MX (1) | MX9306960A (en) |
| NO (1) | NO951740L (en) |
| NZ (1) | NZ258019A (en) |
| OA (1) | OA10153A (en) |
| PL (1) | PL308770A1 (en) |
| PT (1) | PT668769E (en) |
| WO (1) | WO1994011010A2 (en) |
| ZA (1) | ZA938274B (en) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7014870B1 (en) * | 1992-11-06 | 2006-03-21 | Greystone Medical Group, Inc. | Compositions of oak bark extract related synthetic compositions and method of using same |
| AUPN104895A0 (en) * | 1995-02-10 | 1995-03-09 | Lai, John | Methods of and preparations for the treatment of ailments and disorders |
| US20040037898A1 (en) * | 1997-10-08 | 2004-02-26 | Hon David N.S | Compositions of oak bark extract, related synthetic compositions and method of using same |
| US20050033251A1 (en) * | 1998-12-08 | 2005-02-10 | Quick-Med Technologies, Inc. | Controlled release of biologically active substances from select substrates |
| US20040170703A1 (en) * | 2001-11-29 | 2004-09-02 | Greystone Medical Group, Inc. | Reduction of reactive oxygen species in chronic wound management |
| MXPA04005219A (en) * | 2001-11-29 | 2005-06-20 | Greystone Medical Group Inc | Treatment of wounds and compositions employed. |
| US6667026B1 (en) | 2002-03-15 | 2003-12-23 | Pocono Falls, Inc. | Allergic contact dermatitis treatment and composition therefor |
| WO2003099218A2 (en) * | 2002-05-24 | 2003-12-04 | Greystone Medical Group, Inc. | Anti-cancer formulation |
| JP2006511585A (en) * | 2002-12-23 | 2006-04-06 | グレイストーン メディカル グループ、インコーポレイテッド | Reduction of reactive oxygen species in chronic wound management |
| WO2005000328A1 (en) * | 2003-06-24 | 2005-01-06 | Zanti Gianfranco | Compositions based on plant ash for the treatment of skin diseases |
| US20060105017A1 (en) * | 2004-06-22 | 2006-05-18 | Greystone Medical Group, Inc. | Methods for treatment of wounds using time release compositions |
| US7687650B2 (en) | 2006-02-03 | 2010-03-30 | Jr Chem, Llc | Chemical compositions and methods of making them |
| EP1993569B1 (en) | 2006-02-03 | 2014-07-23 | OMP, Inc. | Anti-aging treatment using copper and zinc compositions |
| US7897800B2 (en) | 2006-02-03 | 2011-03-01 | Jr Chem, Llc | Chemical compositions and methods of making them |
| US7867522B2 (en) | 2006-09-28 | 2011-01-11 | Jr Chem, Llc | Method of wound/burn healing using copper-zinc compositions |
| CA2700990C (en) * | 2007-03-15 | 2014-08-12 | Om Kataria | Uterine stimulant sticks |
| EP2211868B1 (en) | 2007-10-15 | 2017-08-02 | 7 Oaks Pharmaceutical Corporation | Silicate containing compositions for the treatment of melanoma |
| US8273791B2 (en) | 2008-01-04 | 2012-09-25 | Jr Chem, Llc | Compositions, kits and regimens for the treatment of skin, especially décolletage |
| US20160184354A1 (en) | 2009-01-23 | 2016-06-30 | Jr Chem, Llc | Rosacea treatments and kits for performing them |
| US20110200655A1 (en) * | 2010-02-16 | 2011-08-18 | Michael Darryl Black | Systems and methods that kill infectious agents (bacteria) without the use of a systemic anti-biotic |
| US8952057B2 (en) | 2011-01-11 | 2015-02-10 | Jr Chem, Llc | Compositions for anorectal use and methods for treating anorectal disorders |
| US8828449B2 (en) | 2012-01-26 | 2014-09-09 | Libby Robinson | Wound dressing composition and method of use |
| US9351995B1 (en) | 2011-04-29 | 2016-05-31 | Red Oax Holdings, LLC | Compositions and methods of enhancing wound healing |
| WO2013012968A1 (en) | 2011-07-20 | 2013-01-24 | 3M Innovative Properties Company | Dressing with ion-carrying composition |
| US20140194803A1 (en) * | 2011-07-28 | 2014-07-10 | Regents Of The University Of Minnestoa | Wound-healing compositions and method of use |
| WO2013025579A2 (en) | 2011-08-17 | 2013-02-21 | 3M Innovative Properties Company | Monomer-grafted fibers and uses thereof |
| GB201402672D0 (en) | 2014-02-14 | 2014-04-02 | Medical Res Council | Materials and methods relating to stabilised polymeric silicate compositions |
| WO2016123539A1 (en) | 2015-01-29 | 2016-08-04 | Wardell Mark R | Wound healing compositions involving medicinal honey, mineral ions, and methylglyoxal, and methods of use |
| HRP20240085T1 (en) * | 2019-03-04 | 2024-03-29 | Aurealis Therapeutics AG | Chloride-inducible prokaryotic expression system |
| IT201900018047A1 (en) * | 2019-10-07 | 2021-04-07 | Nello Vallicella | PROCEDURE FOR THE PREPARATION OF A LIQUID TOPICAL COMPOSITION. |
| WO2024196897A1 (en) * | 2023-03-22 | 2024-09-26 | Courtland Imel | Novel methods for increasing healing speed of human and animal wounds |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US55911A (en) * | 1866-06-26 | Improved medical compound | ||
| US202246A (en) * | 1878-04-09 | Improvement in medical compounds | ||
| US37901A (en) * | 1863-03-17 | Improved liniment | ||
| US256847A (en) * | 1882-04-25 | Salve | ||
| DE819127C (en) * | 1949-09-28 | 1951-10-29 | Heinz Dr Bauer | Process for the preparation of a therapeutic bath against skin eczema |
| DE812341C (en) * | 1950-03-07 | 1951-08-27 | Penicillin Ges Dauelsberg & Co | Process for the preparation of a skin treatment agent |
| DE833840C (en) * | 1950-06-01 | 1952-03-13 | Dr Heinz Bauer | Process for the preparation of an ointment against skin eczema |
| US3928584A (en) * | 1969-06-30 | 1975-12-23 | Us Health Education & Welfare | Extracts from active tree saps for treating P388 mouse leukemia |
| US4059695A (en) * | 1974-02-14 | 1977-11-22 | Kanari Hirosaki | Method for manufacturing a tonic composition for man and other animals |
| JPS60164467A (en) * | 1984-02-07 | 1985-08-27 | Rooman Kogyo:Kk | Drink |
| DE3584837D1 (en) * | 1985-10-08 | 1992-01-16 | Psori Med Ag | SALT MIXTURE FOR THE TREATMENT OF PSORIASIS AND OTHER SKIN DISEASES. |
| US4847083A (en) * | 1986-04-02 | 1989-07-11 | Dermasciences, Inc. | Two-step procedure for indolent wound healing and aqueous medium and topical ointment used in connection therewith |
| BE1000950A3 (en) * | 1987-10-05 | 1989-05-23 | Claude Patricia | Cosmetic and pain-relieving compsns. - contg. Dead Sea salt and green clay |
| AT393221B (en) * | 1988-02-03 | 1991-09-10 | Leopold Pharma Gmbh | AGENT WITH DESTROYING EFFECT ON MALIGNE TUMORS, METHOD FOR THE PRODUCTION THEREOF AND PREPARATION FOR USE IN THE THERAPY OF CANCER DISEASES |
| US5080900A (en) * | 1990-04-17 | 1992-01-14 | Stanley R Thomas | Treatment of skin ulcers with an aqueous extract of oak bark ash |
-
1993
- 1993-11-04 PL PL93308770A patent/PL308770A1/en unknown
- 1993-11-04 NZ NZ258019A patent/NZ258019A/en not_active IP Right Cessation
- 1993-11-04 DE DE69328438T patent/DE69328438T2/en not_active Expired - Lifetime
- 1993-11-04 AT AT94900557T patent/ATE191850T1/en not_active IP Right Cessation
- 1993-11-04 JP JP51222794A patent/JP3640215B2/en not_active Expired - Fee Related
- 1993-11-04 DK DK94900557T patent/DK0668769T3/en active
- 1993-11-04 WO PCT/US1993/010670 patent/WO1994011010A2/en active IP Right Grant
- 1993-11-04 AU AU55500/94A patent/AU700019B2/en not_active Ceased
- 1993-11-04 HU HU9501323A patent/HUT73791A/en active IP Right Revival
- 1993-11-04 PT PT94900557T patent/PT668769E/en unknown
- 1993-11-04 CA CA002148795A patent/CA2148795C/en not_active Expired - Fee Related
- 1993-11-04 CZ CZ951173A patent/CZ117395A3/en unknown
- 1993-11-04 BR BR9307401A patent/BR9307401A/en not_active Application Discontinuation
- 1993-11-04 ES ES94900557T patent/ES2147780T3/en not_active Expired - Lifetime
- 1993-11-04 EP EP94900557A patent/EP0668769B1/en not_active Expired - Lifetime
- 1993-11-05 ZA ZA938274A patent/ZA938274B/en unknown
- 1993-11-08 MX MX9306960A patent/MX9306960A/en not_active IP Right Cessation
-
1995
- 1995-05-04 NO NO951740A patent/NO951740L/en unknown
- 1995-05-05 OA OA60657A patent/OA10153A/en unknown
-
1997
- 1997-10-08 US US08/947,055 patent/US6149947A/en not_active Expired - Fee Related
-
2001
- 2001-08-31 CY CY0100022A patent/CY2231B1/en unknown
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