WO1994011005A1 - Inhibiteurs de fixation virale - Google Patents

Inhibiteurs de fixation virale Download PDF

Info

Publication number
WO1994011005A1
WO1994011005A1 PCT/US1992/009745 US9209745W WO9411005A1 WO 1994011005 A1 WO1994011005 A1 WO 1994011005A1 US 9209745 W US9209745 W US 9209745W WO 9411005 A1 WO9411005 A1 WO 9411005A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
compound
group
hydrogen
binds
Prior art date
Application number
PCT/US1992/009745
Other languages
English (en)
Inventor
Nicolai V. Bovin
Nargiz E. Byramova
Alexander B. Tuzikov
Mikhail N. Matrosovich
Larisa V. Mochalova
Alexandra S. Gambaryan
Original Assignee
Scientific Dimensions Usa, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scientific Dimensions Usa, Inc. filed Critical Scientific Dimensions Usa, Inc.
Priority to AU31774/93A priority Critical patent/AU3177493A/en
Priority to PCT/US1992/009745 priority patent/WO1994011005A1/fr
Publication of WO1994011005A1 publication Critical patent/WO1994011005A1/fr
Priority to US08/438,661 priority patent/US5571836A/en
Priority claimed from US08/438,661 external-priority patent/US5571836A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof

Abstract

La fixation virale à des cellules cibles est inhibée par de nouveaux composés d'acide neuraminique de la formule (I) dans laquelle R1 est sélectionnné dans le groupe se composant d'hydrogène et d'acétyle; R2 est sélectionné dans le groupe se composant d'hydrogène et de méthyle; et Y est sélectionné dans le groupe constitué par -H, (a) et (b). Les nouveaux composés fixent les particules du virus et ne sont pratiquement pas segmentés par la neuramidase. L'accouplement de ces nouveaux composés à un polymère inhibe également la fixation virale.
PCT/US1992/009745 1992-11-09 1992-11-09 Inhibiteurs de fixation virale WO1994011005A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU31774/93A AU3177493A (en) 1992-11-09 1992-11-09 Viral attachment inhibitors
PCT/US1992/009745 WO1994011005A1 (fr) 1992-11-09 1992-11-09 Inhibiteurs de fixation virale
US08/438,661 US5571836A (en) 1992-11-09 1995-05-09 Viral attachment inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1992/009745 WO1994011005A1 (fr) 1992-11-09 1992-11-09 Inhibiteurs de fixation virale
US08/438,661 US5571836A (en) 1992-11-09 1995-05-09 Viral attachment inhibitors

Publications (1)

Publication Number Publication Date
WO1994011005A1 true WO1994011005A1 (fr) 1994-05-26

Family

ID=26785163

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/009745 WO1994011005A1 (fr) 1992-11-09 1992-11-09 Inhibiteurs de fixation virale

Country Status (1)

Country Link
WO (1) WO1994011005A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998014215A2 (fr) * 1996-10-02 1998-04-09 Syntesome Gesellschaft Für Med. Biochemie M.B.H. Glyconconjugues comme inhibiteurs d'adherence cellulaire virale
WO1998021243A1 (fr) * 1996-11-14 1998-05-22 Biota Scientific Management Pty. Ltd. Methode et nouveaux composes a utiliser avec ladite methode
US6677164B1 (en) 1995-11-21 2004-01-13 Novartis Ag Multivalent polymers, processes for their preparation, and their use for preparing biologically active compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5109123A (en) * 1988-06-14 1992-04-28 Dana Farber Cancer Institute Alteration of ability of soluble CD4 fragments to bind HIV

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5109123A (en) * 1988-06-14 1992-04-28 Dana Farber Cancer Institute Alteration of ability of soluble CD4 fragments to bind HIV

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
ALITALO et al., "Synthetic Peptides in Biology and Medicine", published 1985, by ELSEVIER SCIENCE PUBLISHERS (AMSTERDAM), pages 191-197. *
ARCH. BIOCHEM. BIOPHYS., Vol. 233(1), 15 August 1984, BEDI et al., "Studies on Turbatrix Aceti Beta-N-Acetylglucosaminidase", pages 251-259. *
BRAUDE et al., "Infectious Diseases and Medical Microbiology", (2nd edition), published 1986, by W.B. SAUNDERS COMPANY (PHILADELPHIA), pages 507-514. *
BRAUDE et al., "Infectious Diseases and Medical Microbiology", (2nd edition), published 1986, by W.B. SAUNDERS COMPANY (PHILADELPHIA), pages 514-520. *
BRAUDE et al., "Infectious Diseases and Medical Microbiology", (2nd edition), published 1986, by W.B. SAUNDERS COMPANY (PHILADELPHIA), pages 60-67. *
CARBOHYDRATE RESEARCH, Vol. 62, issued May 1978, BEDI et al., "A Convenient Synthesis of Para-Nitrophenyl 2-Deoxy-2-(Thioacetamido)-Beta-D-Glucopyranosied, of 2-Acetamide-2-Deoxy-Beta-D-Glucosidase", pages 253-259. *
FIELDS et al., "Fundamental Virology", published 1986, by RAVEN PRESS (NEW YORK), pages 491-512. *
FIELDS et al., "Fundamental Virology", published 1986, by RAVEN PRESS (NEW YORK), pages 68-80. *
J.L. MELNICK, "Infectious Diseases and Medical Microbiology", (2nd edition), published 1986, by W.B. SAUNDERS COMPANY (PHILADELPHIA), pages 68-80. *
M. WINDHOLZ et al., (ed.s), "The Merck Index", (9th edition), published 1976, by MERCK AND COMPANY (RAHWAY, NEW JERSEY), page 842. *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6677164B1 (en) 1995-11-21 2004-01-13 Novartis Ag Multivalent polymers, processes for their preparation, and their use for preparing biologically active compounds
WO1998014215A2 (fr) * 1996-10-02 1998-04-09 Syntesome Gesellschaft Für Med. Biochemie M.B.H. Glyconconjugues comme inhibiteurs d'adherence cellulaire virale
WO1998014215A3 (fr) * 1996-10-02 1998-08-20 Syntesome Ges Fuer Med Biochem Glyconconjugues comme inhibiteurs d'adherence cellulaire virale
WO1998021243A1 (fr) * 1996-11-14 1998-05-22 Biota Scientific Management Pty. Ltd. Methode et nouveaux composes a utiliser avec ladite methode
US6680054B1 (en) 1996-11-14 2004-01-20 Biota Scientific Management Pty Ltd. Macromolecular neuraminidase-binding compounds

Similar Documents

Publication Publication Date Title
US5212075A (en) Compositions and methods for introducing effectors to pathogens and cells
US6172208B1 (en) Oligonucleotides modified with conjugate groups
CN102256989B (zh) 糖基化细菌代谢物的阴离子轭合物
US5760072A (en) Paclitaxel prodrugs, method for preparation as well as their use in selective chemotherapy
EP1928892B1 (fr) Inhibiteurs glycomimetiques de lectine pa-il ou de lectine pa-iil, ou lectines pa-il et pa-iil provenant de pseudomonas
US5466681A (en) Receptor conjugates for targeting penicillin antibiotics to bacteria
Byramova et al. Synthesis of sialic acid pseudopolysaccharides by coupling of spacer-connected Neu5Ac with activated polymer
US5326752A (en) Substituted lactose and lactosamine derivatives as cell adhesion inhibitors
IL77603A (en) Pharmaceutical preparations containing saccharide with antiviral activity and 2-modified hydrocarbylsulfonyl (new ethylsaccharide
Weinhold et al. Design and evaluation of a tightly binding fluorescent ligand for influenza A hemagglutinin
SK113797A3 (en) Bioactive compounds conjugated with glycides
WO2005025513A2 (fr) Derives de guanidinium pour l'amelioration du transfert cellulaire
Sun et al. Syntheses of C‐3‐Modified Sialylglycosides as Selective Inhibitors of Influenza Hemagglutinin and Neuraminidase
EP1575619A1 (fr) Oligosaccharides et conjugues pour le traitement d'infections par bacterie pseudomonale
Tuzikov et al. Conversion of complex sialooligosaccharides into polymeric conjugates and their anti-influenza virus inhibitory potency
US5849709A (en) Saccharopeptides and derivatives thereof
WO2008100553A1 (fr) Ligands multidentates robustes de diagnostics et médicaments antiviraux contre la grippe et des virus associés
AU637975B2 (en) Therapeutic uses of 2',5'-oligoadenylate derivatives
WO1994011005A1 (fr) Inhibiteurs de fixation virale
US5571836A (en) Viral attachment inhibitors
EP0484403A1 (fr) Conjugues porteurs analogues/immunogenes de la lipide a et leur utilisation comme vaccins
Sabesan et al. Structural and functional-group tuning in the design of neuraminidase inhibitors
EP0650492A1 (fr) Reduction de l'inflammation par administration dependante dans le temps d'oligosaccharides glycosides relatifs a des determinants de groupes sanguins
Duquette et al. Puromycin analogs. Ribosomal binding and peptidyl transferase substrate activity of a carbocyclic analog of 8-azapuromycin
EP2350120B1 (fr) Constructions à ligands multiples

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AT AU BB BG BR CA CH CS DE DK ES FI GB HU JP KP KR LK LU MG MN MW NL NO PL RO RU SD SE UA US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL SE BF BJ CF CG CI CM GA GN ML MR SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 08438661

Country of ref document: US

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: CA

122 Ep: pct application non-entry in european phase