WO1994006568A1 - Nebuliseur - Google Patents

Nebuliseur Download PDF

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Publication number
WO1994006568A1
WO1994006568A1 PCT/US1993/007988 US9307988W WO9406568A1 WO 1994006568 A1 WO1994006568 A1 WO 1994006568A1 US 9307988 W US9307988 W US 9307988W WO 9406568 A1 WO9406568 A1 WO 9406568A1
Authority
WO
WIPO (PCT)
Prior art keywords
nebulizer
crystal
recited
projection
positive displacement
Prior art date
Application number
PCT/US1993/007988
Other languages
English (en)
Inventor
Bernard J. Greenspan
Owen R. Moss
Keith E. Schleiffer
Original Assignee
Battelle Memorial Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Battelle Memorial Institute filed Critical Battelle Memorial Institute
Publication of WO1994006568A1 publication Critical patent/WO1994006568A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
    • B05B5/025—Discharge apparatus, e.g. electrostatic spray guns
    • B05B5/053—Arrangements for supplying power, e.g. charging power
    • B05B5/0531—Power generators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
    • B05B5/16—Arrangements for supplying liquids or other fluent material

Definitions

  • the present invention relates to devices for atomizing liquids and, more particularly, to devices for producing finely divided aerosols having uniformly sized droplets.
  • Finely divided aerosols have generally been produced by nebulizers employing compressed air to atomize fluids. These devices operate by allowing compressed air to escape from a small orifice at the end of a tube at high velocity.
  • the low pressure created in the exit region as a result of the Bernoulli effect causes the fluid to be atomized to be drawn out of a second tube as a thin filament which is broken up into droplets of various small sizes, thereby forming a spray, as it is accelerated in the airstream.
  • This spray is then directed around an impaction surface on which the large droplets are preferentially deposited, and whereby some uniformity is provided with respect to droplet size.
  • Difficulties include the use of environmentally harmful propellants that may affect the earth's atmospheric ozone layer. Other difficulties include formation of large droplets and streams that cause liquid to impact tissue membranes of the mouth and throat rather than form a mist that is airborne into the furthest reaches of the lung.
  • the present invention comprises a portable hand-held nebulizer capable of generating aerosols characterized by uniformly sized droplets of very small dimensions by elec- trical atomization.
  • a piezoelectric crystal is constructed and arranged for being mechanically deformed in accordance with pressure applied to a trigger mechanism.
  • the crystal is adapted for generating high voltages in response to such deformations.
  • the crystal is electrically coupled to a capillary tube and a grid element which is spaced apart from the tip of the tube.
  • the capillary tube is connected to a reservoir of fluid to be atomized so as to allow the fluid to be supplied up to the tip of the tube.
  • the pre ⁇ ferred embodiment of the present invention also includes a control circuit which regulates the output of this piezo ⁇ electric crystal in order to cut off the output below and above prescribed voltage limits. Since a piezoelectric crystal will provide a voltage signal both when stressed and when stress is relieved, the voltage limits are selec- ted to permit only one, either stress induced or stress relief, induced voltage signal to be applied to the fluid to be atomized.
  • the deformation of the piezoelectric crystal produces a high voltage which is transmitted to and applied across the capillary tube and grid element.
  • the electric field existing between the tip of the tube and the grid encourages the discharge of fluid from the tube.
  • This fluid is broken into a very large number of similarly sized droplets Joy the effects of the electric charges carried by the fluid and a "fan spray" aerosol is thereby formed.
  • This process of electrical atomization furnishes an aerosol consisting of large numbers of very fine particles having a high degree of uniformity.
  • Such aerosols are highly useful in pneumonically administering medications and in many other applications.
  • the nebulizer is capable of delivering precise doses of fluid. Very often the total amount of fluid must be small; for example, as small as 5 microliters. To ensure control of the total amount of delivered fluid, a mechan ⁇ ical positive displacement fluid delivery means is combined with the piezoelectric atomizer.
  • FIG. 1 is a diagrammatic view illustrating the overall system of the present invention.
  • the present invention comprises a nebulizer device (5) including a piezoelectric ceramic crystal (10) of a conventional type such as a lead titanate-zirconate crystal.
  • An impact element (20) is positioned for engaging the surface (12) of the crystal (10) so that force (F) exerted on the element (20) can bend and deform the crystal (10) .
  • the rate of impact and defor ⁇ mation of the crystal may be slow as a squeeze, to fast as a hammer blow.
  • the electrical contacts 24 and 26 are attached to opposite faces on the longitudinal ends of the crystal (10) for picking up electrical potentials generated across the crystal (10) by the deformation previously referred to.
  • the conductive leads (28 and 30) transmit the voltage from the contacts (24 and 26) to the control circuit (32) .
  • the impact element (20) is connected by a mechanical linkage to a trigger mechanism (18) which may be conven ⁇ iently depressed by hand-gripping pressure exerted by a user of the device (5) .
  • the force applied by the user to the trigger mechanism (18) is multiplied by the mechanical linkage and brought to bear on the crystal (10) by the impact element (20) .
  • the linkage suitably comprises a rigid lever arm with fulcrum 16 positioned more closely to element 20 than to trigger 18 (i.e., with arm 17 being substantially shorter than arm 19) .
  • the mechanical linkage may comprise a rack and pinion system with the impact element (20) being driven by a cam from the pinion.
  • the control circuit (32) is operative for regulating the voltage generated by the piezoelectric crystal (10) so that the electrical potential applied between the capillary tube (40) and grid (42) over the electrically conductive leads (46 and 48) is maintained within the range of 60-15 kV.
  • the voltage is preferably not applied between the tube (40) and grid (42) when it is less than about 6 kV, since this may detrimentally affect the uniformity of the aerosol (52) .
  • the control circuit (32) also provides a capacitive or storing function for storing and releasing electrical charge in a well known manner so that the voltage supplied to tube 40 and grid 42 may be sustained beyond the actual period of depression of the trigger mechanism (18) .
  • the leads (46 and 48) transmit the electrical potential from the control circuit (32) to the tube (40) and grid (42) .
  • the electrical potential may be positive or negative and may be applied to either the tube (40) or the grid (42) . It is preferred that the electrical potential be a positive potential and it is further pre ⁇ ferred that the positive potential is applied to the tube (40) (and/or the fluid within the tube (40)).
  • the reservoir (50) contains a fluid (and more partic ⁇ ularly a liquid) capable of being dispersed by electrical atomization techniques, such as water or ethyl alcohol, and is hydraulically connected to the capillary tube (40) so that the fluid from the reservoir (50) can flow up to the tip (44) of the tube (40) .
  • the inside diameter of the capillary tube (40) is preferably in the range of 100 to 500 microns, with its outside dimensions being as thin as possible consistent with maintaining sufficient strength and rigidity.
  • the capillary tube (40) preferably comprises a stainless steel tube such as a No. 25 hypodermic needle, although the tube (40) may be constructed of glass or of a plastic such as tetrafluoroethylene.
  • the electrically conductive element may be an electrically conductive coating on the tip of the tube, or it may be an electrically conductive material inserted through the tube.
  • the fluid level in reservoir (50) should be high enough to allow the fluid to reach the tip of tube 40 by fluid flow or capillary action.
  • Grid (42) is preferably spaced apart from about a minimum of 1.5 cm to about 2.5 cm from the tip (44) of the capillary tube (40) . Greater spacing may be used with no maximum limit up to having no grid (42) at all.
  • the user presses the trigger mechanism (18) which results in the crystal (10) being deformed as force is applied to the crystal (10) by impact element 20.
  • the piezoelectric crystal (10) generates a voltage which may ordinarily range upward to 20 kV and may be sustained in the range of 6 to 15 kV for a period of several seconds.
  • the exact levels of voltage generated are a function of the force applied to the trigger, and the characteristics of the mechanical linkage (16) , impact element (20) , and the piezoelectric crystal (10) itself. These components may be adjusted to assist in achieving the desired raw voltage output to the control circuit (32) .
  • the control circuit desirably regulates the output of the crystal (10) so as to limit it within the range of 6 to 15 kV, and "lengthen” the period of time during which voltage is provided.
  • the voltage provided by the control circuit (32) is applied between the capillary tube (40) and the grid (42) .
  • the resultant elec- trie field existing between a projection formed by the tip (44) of the tube (40), and this grid (42), causes the generation of a fan spray aerosol composed of substantially monodispersed droplets capable of exhibiting higher order Tyndall spectra. Aerosol (52) having droplets with sizes in the range of 0.2 to 5 microns can be readily produced with droplet concentration levels approaching 10 8 particles per cubic centimeter.
  • the ability of the device (5) to produce a satisfac ⁇ tory aerosol (52) can, however, be dependent on the type of fluid which is desired to be dispersed. Fluids having either very low (e.g., benzene) or very high (e.g., inorganic acids, salts) conductivities are difficult to disperse by electrical atomization. Furthermore, other characteristics of fluids such as their dielectric con- stants, dipole moments, and surface tensions may affect their ability to be electrically atomized. Consequently, when medications which are dissolved in solution are desired to be dispersed, appropriate vehicles should be chosen for solvating such medications for allowing efficient atomizations.
  • very low e.g., benzene
  • very high conductivities are difficult to disperse by electrical atomization.
  • other characteristics of fluids such as their dielectric con- stants, dipole moments, and surface tensions may affect their ability to be electrically atomized. Consequently, when medications which are dissolved in solution are desired to be dis
  • the nature of the aerosol (52) produced by the device (5) is a complex function of the applied voltage, the size and structure of the capillary tube (40) , the spacing between the tube (40) and the grid (42) , the hydrostatic pressure of liquid at the tip (44) of the tube (40) , and the characteristics of the liquid as previously discussed. These factors may be adjusted either individually or in combination to achieve the aerosol particle size and volume desired.
  • the control circuit (32) is suitably used to ensure that voltage applied between the tube and grid is of consistent level and duration for aerosol generation, thereby resulting in measured dosages of medical products atomized by the device (5) .
  • the total amount of fluid dispensed must be pre ⁇ cisely controlled.
  • Another practical consideration is that many fluids are volatile, having a high vapor pressure, and can evaporate even through a small diameter capillary.
  • user manipulation is relied upon as an external energy source, while the control circuit (32) controls the amount of electric energy delivered to the fluid to be atomized, and a mechanical positive displacement fluid control means (60) controls the amount of fluid dispensed and atomized.
  • control circuit (32) described herein is exemplary and not intended to be limited to the features described.
  • FIG. 2 it shows a typical voltage output from deformation of a piezoelectric crystal in terms of electrical potential versus time.
  • Two voltage signals (201 and 202) having opposite polarity are produced.
  • a first voltage signal having a first polarity is observed, and when the crystal is allowed to relax back to its original shape, a second voltage signal having a second polarity opposite to the first polarity is observed.
  • FIG. 2 shows the positive polarity voltage signal (201) ahead of the negative polarity voltage signal (202) , but it is known that the negative polarity voltage signal (202) may be first.
  • the voltage signals (201 and 202) may be applied to create a spray of aerosol (52) .
  • One way is to select either the positive voltage signal (201) or the negative voltage signal (202) , preferably the positive voltage signal (201) , and charge the tube (40) .
  • Selection may be by means of a switch that is closed while the piezoelectric crystal (10) is sending the positive voltage signal (201) , and is open while the piezoelectric crystal (10) is sending the negative voltage signal (202) .
  • Selection may also be made using a diode that permits only one or the other, preferably the positive voltage signal (201) , to pass to the tube (40) .
  • one of the voltage signals in FIG. 2 is converted so that both signals have the same polarity and may be added, thereby utilizing all of the electrical energy of the piezoelectric crystal deformation and relaxation to create a spray.
  • FIG. 3 a control circuit is shown that utilizes the voltage output of FIG. 2.
  • the positive voltage signal (201) from the piezoelectric crystal (10) passes through diode 301 and charges capacitor 302.
  • the negative voltage signal (202) passes through diode 304 and charges capacitor 306.
  • the total potential between leads 46 and 48 is the sum of the charges in capacitors 302 and 306.
  • a preferred mechanical positive displace ⁇ ment fluid control means (60) may be a valve and, most preferably, a check valve of the type disclosed in U.S. Pat. No. 5,129,426 assigned to Vernay Laboratories, Inc., Yellow Springs, Ohio, and is hereby incorporated by reference. The Vernay valve is preferably deployed as an in-line check valve.
  • the Jade Systems valve may be deployed as an on-off valve, or as an insertion valve.
  • an internal or external magnet may be displaced to move an internal ball to open and close the Jade Systems valve.
  • a capillary tube end that is placed within the Jade Systems valve is connected to means for displacing the capillary tube end toward and away from an internal sealing ball to alternately introduce and inter ⁇ rupt fluid flow to the capillary tip (44) .
  • the reservoir (50) In combination with a check valve, the reservoir (50) would be a syringe pump.
  • the syringe pump has a plunger within a cylinder and a means for controlling the plunger stroke.
  • Means for controlling plunger stroke include but are not limited to ratchet and collet. The purpose of controlling the plunger stroke is to deliver a precise amount of fluid with each crystal deformation.
  • the plunger stroke may be controlled by any means, including but not limited to ratchets and collets.
  • Miniature pumps include but are not limited to micro- machines, and peristaltic pumps.
  • capillary tube may be employed in the same nebulizer device so as to increase the volume of the aerosol produced as compared with a single- tube nebulizer device.
  • the hollow capillary tube may, under suitable conditions, be replaced by another type of projection such as a short solid needle constructed and arranged so as to allow the liquid to be atomized as otherwise supplied to its tip.

Landscapes

  • Electrostatic Spraying Apparatus (AREA)

Abstract

La présente invention se rapporte à un nébuliseur portatif pouvant produire un aérosol finement divisé à gouttelettes de grosseur uniforme. Le nébuliseur comprend une source de fluide telle qu'un tube capillaire (40) relié à un réservoir de fluide (50) auquel une tension élevée est appliquée afin de générer l'aérosol par atomisation électrique. Le nébuliseur comprend en outre un cristal piézoélectrique (10) et un mécanisme (20) permettant de déformer le cristal de façon à générer la tension requise. Le dispositif comprend également un moyen (60) de régulation de fluide volumétrique et mécanique permettant de réguler la quantité de fluide pulvérisée. L'utilisation de l'atomisation électrique pour produire l'aérosol et la génération piézoélectrique de la tension requise pour l'atomisation permet d'obtenir un nébuliseur compact, adapté à une commande manuelle, mais qui peut toutefois produire des quantités mesurées d'aérosols finement divisés, qui sont sensiblement mono-dispersés.
PCT/US1993/007988 1992-09-22 1993-08-25 Nebuliseur WO1994006568A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94996592A 1992-09-22 1992-09-22
US07/949,965 1992-09-22

Publications (1)

Publication Number Publication Date
WO1994006568A1 true WO1994006568A1 (fr) 1994-03-31

Family

ID=25489756

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/007988 WO1994006568A1 (fr) 1992-09-22 1993-08-25 Nebuliseur

Country Status (1)

Country Link
WO (1) WO1994006568A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5927547A (en) * 1996-05-31 1999-07-27 Packard Instrument Company System for dispensing microvolume quantities of liquids
WO2014177824A1 (fr) * 2013-04-29 2014-11-06 Amb Engineering Limited Appareil et procédé d'atomisation de fluide conducteur

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2128900A (en) * 1982-10-29 1984-05-10 Theoktiste Christofidis Ionising spray
JPS6488158A (en) * 1987-09-30 1989-04-03 Toshiba Corp Reagent dispenser for automatic chemical analyzer
US5115971A (en) * 1988-09-23 1992-05-26 Battelle Memorial Institute Nebulizer device

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2128900A (en) * 1982-10-29 1984-05-10 Theoktiste Christofidis Ionising spray
JPS6488158A (en) * 1987-09-30 1989-04-03 Toshiba Corp Reagent dispenser for automatic chemical analyzer
US5115971A (en) * 1988-09-23 1992-05-26 Battelle Memorial Institute Nebulizer device

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 13, no. 316 (P - 900) 18 July 1989 (1989-07-18) *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5927547A (en) * 1996-05-31 1999-07-27 Packard Instrument Company System for dispensing microvolume quantities of liquids
US6112605A (en) * 1996-05-31 2000-09-05 Packard Instrument Company Method for dispensing and determining a microvolume of sample liquid
WO2014177824A1 (fr) * 2013-04-29 2014-11-06 Amb Engineering Limited Appareil et procédé d'atomisation de fluide conducteur
GB2527474A (en) * 2013-04-29 2015-12-23 Amb Engineering Ltd Apparatus and a method for atomising a conducting liquid

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