WO1994002508A3 - Polypeptide antigens of mycobacterium bovis - Google Patents

Polypeptide antigens of mycobacterium bovis Download PDF

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Publication number
WO1994002508A3
WO1994002508A3 PCT/GB1993/001527 GB9301527W WO9402508A3 WO 1994002508 A3 WO1994002508 A3 WO 1994002508A3 GB 9301527 W GB9301527 W GB 9301527W WO 9402508 A3 WO9402508 A3 WO 9402508A3
Authority
WO
WIPO (PCT)
Prior art keywords
thr
ala
val
gln
gly
Prior art date
Application number
PCT/GB1993/001527
Other languages
French (fr)
Other versions
WO1994002508A2 (en
Inventor
Robert Vincent Fishleigh
Barry Robson
Paul John Greaney
Original Assignee
Proteus Molecular Design
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929215514A external-priority patent/GB9215514D0/en
Application filed by Proteus Molecular Design filed Critical Proteus Molecular Design
Priority to AU45800/93A priority Critical patent/AU4580093A/en
Publication of WO1994002508A2 publication Critical patent/WO1994002508A2/en
Publication of WO1994002508A3 publication Critical patent/WO1994002508A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Abstract

The invention provides a synthetic polypeptide having at least one antigenic property of the MPB-70 protein of at least one strain of Mycobacterium bovis, said polypeptide of Formula (I) comprising an amino acid sequence selected from Formulae Seq. ID Nos 1-14: Seq. ID No 1: X-Glu-Tyr-Ala-Ala-Ala-Asn-Pro-Thr-Gly-Pro-Ala-Ser-Val-Gln-Gly-Y; Seq. ID No 2: X-Met-Ser-Gln-Asp-Pro-Val-Ala-Val-Ala-Ala-Ser-Asn-Asn-Pro-Y; Seq. ID No 3: X-Pro-Glu-Leu-Thr-Thr-Leu-Thr-Ala-Ala-Leu-Ser-Gly-Gln-Leu-Asn-Pro-Gln-Y; Seq. ID No 4: X-Val-Val-Ala-Gly-Gln-Thr-Ser-Pro-Ala-Asn-Val-Y; Seq. ID No 5: X-Pro-Gln-Val-Asn-Leu-Val-Asp-Thr-Leu-Asn-Ser-Gly-Gln-Tyr-Ser-Val-Y; Seq. ID No 6: X-Phe-Ala-Pro-Thr-Asn-Ala-Ala-Phe-Ser-Y; Seq. ID No 7: X-Pro-Ala-Ser-Thr-Leu-Asp-Glu-Leu-Thr-Asn-Y; Seq. ID No 8: X-Gly-Thr-Arg-Thr-Gln-Leu-Gln-Gly-Ala-Ser-Val-Thr-Y; Seq. ID No 9: X-Gly-Thr-Arg-Gln-Thr-Leu-Gln-Gly-Ala-Ser-Val-Thr-Y; Seq. ID No 10: X-Pro-Ala-Asn-Val-Val-Gly-Thr-Arg-Thr-Gln-Leu-Gln-Gly-Y; Seq. ID No 11: X-Pro-Ala-Asn-Val-Val-Gly-Thr-Arg-Gln-Thr-Leu-Gln-Gly-Y; Seq. ID No 12: X-Thr-Gly-Gln-Gly-Asn-Ser-Leu-Lys-Val-Gly-Asn-Ala-Asp-Y; Seq. ID No 13: X-Ala-Thr-Val-Tyr-Met-Ile-Asp-Ser-Val-Leu-Met-Pro-Pro-Ala-Y; and Seq. ID No 14: X-Pro-Gln-Val-Asn-Leu-Val-Asp-Thr-Leu-Asn-His-Gly-Gln-Tyr-Ser-Y; wherein X and Y may each independently be absent or independently be one or more amino acid residues, with the proviso that when present they do not provide or form part of an epitope of the MPB-70 protein of at least one strain of Mycobacterium bovis which is contiguous with the sequence to which X and Y are attached, X or Y optionally being terminated by a functionalised coupling moiety. The synthetic polypeptides according to the invention may be used to elicit the production of antibodies to the MPB-70 protein.
PCT/GB1993/001527 1992-07-22 1993-07-21 Polypeptide antigens of mycobacterium bovis WO1994002508A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU45800/93A AU4580093A (en) 1992-07-22 1993-07-21 Polypeptide antigens of mycobacterium bovis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB929215514A GB9215514D0 (en) 1992-07-22 1992-07-22 Synthetic polypeptides
GB9215514.2 1992-07-22
GB939311273A GB9311273D0 (en) 1992-07-22 1993-06-01 Synthetic polypeptides
GB9311273.8 1993-06-01

Publications (2)

Publication Number Publication Date
WO1994002508A2 WO1994002508A2 (en) 1994-02-03
WO1994002508A3 true WO1994002508A3 (en) 1994-06-09

Family

ID=26301295

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1993/001527 WO1994002508A2 (en) 1992-07-22 1993-07-21 Polypeptide antigens of mycobacterium bovis

Country Status (5)

Country Link
AU (1) AU4580093A (en)
IL (1) IL106436A0 (en)
MX (1) MX9304388A (en)
WO (1) WO1994002508A2 (en)
ZW (1) ZW9093A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR950702839A (en) * 1992-08-27 1995-08-23 스티븐 딕 Retro, Inverso-, and Retro-Inverso Synthetic Peptide Analogues (RETRO-, INVERSO-, AND RETRO-INVERSO SYNTHETIC PEPTIDE ANALOGUES)
US6752993B1 (en) 1993-11-23 2004-06-22 The Regents Of The University Of California Abundant extracellular product vaccines and methods for their production and use
ATE407945T1 (en) 1993-11-23 2008-09-15 Univ California ABUNDANT EXTRACELLULAR PRODUCTS AND METHODS FOR THEIR PRODUCTION AND THEIR USE
US7300660B2 (en) 1993-11-23 2007-11-27 The Regents Of The University Of California Abundant extracellular products and methods for their production and use
US6013660A (en) * 1996-10-02 2000-01-11 The Regents Of The University Of California Externally targeted prophylactic and chemotherapeutic method and agents
CN102183649A (en) * 2011-01-31 2011-09-14 中国农业大学 Bovine tuberculosis antigen specific gamma-interferon enzyme-linked immuno sorbent assay (ELISA) kit

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006974A2 (en) * 1988-02-01 1989-08-10 Praxis Biologics, Inc. T-cell epitope as carriers molecule for conjugate vaccines
WO1989009261A1 (en) * 1988-03-31 1989-10-05 Commonwealth Scientific And Industrial Research Or Diagnosis of mycobacterium bovis infection
WO1990009395A1 (en) * 1989-02-17 1990-08-23 Coselco Mimotopes Pty. Ltd. Method for the use and synthesis of peptides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006974A2 (en) * 1988-02-01 1989-08-10 Praxis Biologics, Inc. T-cell epitope as carriers molecule for conjugate vaccines
WO1989009261A1 (en) * 1988-03-31 1989-10-05 Commonwealth Scientific And Industrial Research Or Diagnosis of mycobacterium bovis infection
WO1990009395A1 (en) * 1989-02-17 1990-08-23 Coselco Mimotopes Pty. Ltd. Method for the use and synthesis of peptides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A.J.RADFORD ET AL: "Epitope mapping of the M.bovis secretory protein MPB70 using overlapping peptide analysis", J.GEN.MICROBIOL., vol. 136, 1990, pages 265 - 272, XP001206929 *
B.WEINSTEIN: "CHEMISTRY AND BIOCHEMISTRY OF AMINO ACIDS, PEPTIDES AND PROTEINS;VOL.7", 1983, MARCEL DEKKER INC., NEW YORK *
BILLMAN-JACOBE ET AL: "Mapping of the T and B cell epitopes of the M.bovis protein MPB70", IMMUNOL.CELL.BIOL., vol. 68, 1990, pages 359 - 365 *

Also Published As

Publication number Publication date
ZW9093A1 (en) 1994-04-20
MX9304388A (en) 1994-03-31
WO1994002508A2 (en) 1994-02-03
AU4580093A (en) 1994-02-14
IL106436A0 (en) 1993-11-15

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