WO1994002204A1 - Microwave treatment apparatus - Google Patents

Microwave treatment apparatus Download PDF

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Publication number
WO1994002204A1
WO1994002204A1 PCT/GB1993/001439 GB9301439W WO9402204A1 WO 1994002204 A1 WO1994002204 A1 WO 1994002204A1 GB 9301439 W GB9301439 W GB 9301439W WO 9402204 A1 WO9402204 A1 WO 9402204A1
Authority
WO
WIPO (PCT)
Prior art keywords
support structure
antenna
assembly
probe
catheter
Prior art date
Application number
PCT/GB1993/001439
Other languages
French (fr)
Inventor
Alan Thompson
Arron Grist
Original Assignee
Microwave Engineering Designs Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microwave Engineering Designs Limited filed Critical Microwave Engineering Designs Limited
Priority to AU45114/93A priority Critical patent/AU4511493A/en
Priority to EP93914910A priority patent/EP0606427A1/en
Publication of WO1994002204A1 publication Critical patent/WO1994002204A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • A61B2018/1861—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves with an instrument inserted into a body lumen or cavity, e.g. a catheter

Definitions

  • This invention relates to microwave treatment apparatus, particularly a catheter and to a reusable applicator assembly for use with a disposable catheter.
  • microwave heating is known for the treatment of both benign and malignant conditions.
  • disorders of the prostate may be treated by means of a microwave applicator contained in or carried upon a transurethral catheter - see for example European patent specifications numbers 0246176, 045 535 and 0462302.
  • transurethral and other small-diameter microwave catheters suffer from a number of disadvantages, amongst which are that they are not re-usable without sterilisation, and that it is difficult to position the microwave applicator at the optimum location for most effective and safest treatment.
  • the latter problem is particularly significant with transurethral microwave catheters; incorrect location of the applicator may result in injury to the lower urethral sphincter which could render the patient incontinent.
  • the present invention in its several aspects has amongst its objects the provision of a microwave applicator in a catheter or a reusable assembly therefor which avoids one or both of these prior-art disadvantages.
  • the invention provides an assembly for insertion in a probe to form a microwave thermal treatment device, comprising a microwave antenna and support structure for locating the antenna within the probe near a distal end thereof, the support structure comprising means for engaging a proximal end of the probe and adjustment means for effecting controlled relative movement between the engaging means and the support structure whereby to adjust the longitudinal position of the antenna within the probe.
  • the invention provides apparatus for microwave thermal treatment comprising a probe, a microwave antenna support structure for locating the antenna within the probe near a distal end thereof, the support structure comprising means engaging the probe at a proximal end thereof and adjustment means for effecting controlled relative movement between the engaging means and the support structure whereby to adjust the longitudinal position of the antenna relative to the probe.
  • this invention provides a reusable microwave applicator assembly for use in thermal treatment and adapted for use with a disposable catheter, the assembly comprising a microwave antenna, support structure for removably locating the antenna in the interior of the catheter near a distal end thereof to be introduced into a patient's body, said support structure comprising a duct which together with the interior of the catheter provides a means of circulating coolant through the catheter externally of the support structure.
  • the support structure may comprise at least one tube forming said duct, and a sleeve wherein the at least one tube and an electrical conductor for the antenna are contained.
  • the antenna may be of helical form, and the said duct may extend at least to the tip of the antenna.
  • a ridged plug for engaging the proximal end of the catheter to form a liquid-tight seal therewith.
  • the adjustment means may comprise a member within which the support structure is longitudinally movable, and means for engaging the member to constrain the support structure against movement, the member being connected or connectable to the catheter or probe.
  • the ridged plug may be carried by the member.
  • the invention also provides microwave thermal treatment equipment comprising an applicator assembly or apparatus as set forth above, a source of microwave frequency electric power and means for operatively connecting said source to the assembly or apparatus.
  • Figure 1 shows a reusable microwave applicator assembly according to the invention
  • Figure 2 is an enlarged and partially disassembled view of the assembly of Figure 1;
  • Figure 3 and 4 are sections through Figure 2 on lines 3"3 and 4-4 respectively;
  • Figure 5 is a side elevation of the assembly of Figure 2
  • Figure 6 is an enlarged view of part of the assembly of Figure 1.
  • the apparatus comprises a probe, specifically a transurethral catheter 10 having a blind distal end 12 (ie having no drainage holes) and a balloon 14, inflatable in a conventional manner via an inflation duct from an inflator connector 16.
  • a microwave applicator comprises a transmitting antenna 17 formed of helically wound copper tape, dimensioned as is known in the art to operate at an allocated medical microwave frequency (eg 434 MHz or 904/915 MHz or other appropriate frequency) .
  • an allocated medical microwave frequency eg 434 MHz or 904/915 MHz or other appropriate frequency
  • the antenna 17 is carried on a support structure 18 consisting of a microwave coaxial conductor 20 and two ptfe tubes 22,24 arranged in a triangular configuration ( Figure 4) and encased within a heat-shrink sleeve 26.
  • the sleeve 26 extends to the antenna 17 as shown in Figure 4; it is shown partially removed in Figure 1 only for reasons of clarity.
  • the outer casing of the conductor 20 is removed and the inner screened lead 28 is connected to the adjacent end of the antenna.
  • the screen lead 30 is sleeved in a piece of ptfe tube 31 and together with the pipes 22,24 are encased in a further short piece of heat shrink sleeve 32 on which the copper tape forming the antenna 17 is wound.
  • the support structure 18 extends back down the catheter to its proximal end 34 and through a tube 36.
  • the bore of the tube 36 is significantly larger than the diameter of the structure 20, so that a flow of coolant (eg deionized water) can also pass through the bore as hereafter described.
  • the tube 36 has a conical ridged plug 38 which can be inserted in the correspondingly-shaped proximal end 3 of the catheter 10 to form a liquid-tight seal.
  • the tube 36 in itself telescopically received in a tubular portion 40 of a manifold 42 within which the heat-shrink sleeve 26 terminates; (the sleeve is again shown foreshortened in Figure 1 for clarity).
  • the microwave conductor 20 is taken out through the manifold 42 to a suitable microwave-frequency connector 44.
  • the connector may alternatively be mounted in the manifold 42.
  • the pipes 22,24 are taken through the tube 40 to a cooling water inlet connection 46.
  • a cooling water outlet connection 48 communicates via a pipe 0 with the interior of the tube 40 and thus with the tube 36, permitting cooling water to flow out of the interior of the catheter to the outlet 48.
  • the conductor 20 and the tubes 22,24 are potted with epoxy resin within the manifold 42 in a conventional manner, and thus are firmly fixed therein.
  • the end of the tubular portion 40 carries a clamping nut 54 on a threaded portion (not shown) together with a rubber sealing washer between the nut and the end of the tube 40.
  • the washer when axially compressed by the nut 54 expands radially inwardly whereby to grip the tube 36 within it so that the parts 18, 36 and 42 cannot move longitudinally relative to each other.
  • the antenna 17 is thereby fixed longitudinally in the catheter when the clamping nut is tightened.
  • An additional separate blind conduit (not shown) preferably is provided in the catheter 10 to contain a thermocouple or other temperature sensor adjacent the antenna, together with its electrical connection, so that the temperature of the tissue in contact with the catheter during microwave treatment may be monitored.
  • the additional conduit is disposed along the outside of the catheter 10.
  • the re-usable assembly consisting of the antenna 17, support structure 18, tube 36 and manifold etc 40,42 are inserted in the disposable catheter 10, the latter having been sterilised.
  • the catheter is introduced into the patient's urethra until the balloon portion 14 enters his bladder.
  • the balloon is then inflated in the conventional manner to retain the catheter in position.
  • the catheter has been so inserted, the approximate position of the patient's prostate is shown dotted at 56, and that of the lower urethral sphincter sybolically at 58.
  • the position of the antenna relative to these organs is determined by any suitable technique eg ultrasonic imaging, and any necessary adjustment to its position is made by loosening the clamping nut 4 and sliding the manifold 42 and the support structure 18 relative to the tube 36 which is fixed in the proximal end of the catheter 10.
  • the clamping nut is tightened.
  • the necessary water connections 46,48 and the thermocouple connection are completed.
  • the antenna 17 is connected via connector 44 to a source of microwave power (not shown) of appropriate authorised medical frequency suited to the dimensions of the antenna.
  • the catheter may first be introduced into the urethra and the position of the postate and lower sphincter found relative to the end of the catheter by any suitable means eg ultrasound or by a fibre-optic probe introduced into the catheter.
  • the correct length of insertion of the structure 18 and antenna 17 can then be determined, and the telescopic tubes 36,40 adjusted accordingly.
  • a graduated scale may be provided on the tube 36 for this purpose.
  • the antenna is then introduced into the catheter and the plug 38 secured in the proximal end 34 thereof.
  • cooling water is passed along the tubes 22,24 and returns down the interior of the catheter to the outlet 48.
  • the distal ends of the tubes 22,24 may be bent as shown at 60 ( Figures 1 and 6) so as to impart increased turbulence to the water issuing from them, improving heat transfer from the walls of the catheter and thereby from the tissue in contact therewith.
  • the tubes 22,24 extend at least to the end of the antenna, and preferably slightly beyond towards the end of the catheter.
  • the catheter Upon completion of treatment the catheter is withdrawn from the patient and discarded, the applicator assembly being retained for re-use.
  • tubes 22,24 may be replaced by a single tube or by several tubes.
  • two tubes have the advantage of producing a conveniently-shaped structure 18 with the conductor 20, of approximately triangular section, as can be seen from Figure 4.
  • transurethral catheter Although described in the context of a transurethral catheter it will be understood that the invention is applicable also in other catheters or probes for insertion into the body.

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Electromagnetism (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)
  • Surgical Instruments (AREA)

Abstract

Apparatus for microwave thermal treatment comprising a probe, a microwave antenna support structure for locating the antenna within the probe near a distal end thereof, the support structure comprising means engaging the probe at a proximal end thereof and adjustment means for effecting controlled relative movement between the engaging means and the support structure whereby to adjust the longitudinal position of the antenna relative to the probe. The support structure further comprises a duct which together with the interior of a disposable catheter forming the probe provides a means of circulating coolant through the catheter externally of the structure.

Description

Microwave Treatment Apparatus
This invention relates to microwave treatment apparatus, particularly a catheter and to a reusable applicator assembly for use with a disposable catheter.
The use of microwave heating is known for the treatment of both benign and malignant conditions. In particular disorders of the prostate may be treated by means of a microwave applicator contained in or carried upon a transurethral catheter - see for example European patent specifications numbers 0246176, 045 535 and 0462302.
However current transurethral and other small-diameter microwave catheters suffer from a number of disadvantages, amongst which are that they are not re-usable without sterilisation, and that it is difficult to position the microwave applicator at the optimum location for most effective and safest treatment. The latter problem is particularly significant with transurethral microwave catheters; incorrect location of the applicator may result in injury to the lower urethral sphincter which could render the patient incontinent.
The present invention in its several aspects has amongst its objects the provision of a microwave applicator in a catheter or a reusable assembly therefor which avoids one or both of these prior-art disadvantages.
In one aspect the invention provides an assembly for insertion in a probe to form a microwave thermal treatment device, comprising a microwave antenna and support structure for locating the antenna within the probe near a distal end thereof, the support structure comprising means for engaging a proximal end of the probe and adjustment means for effecting controlled relative movement between the engaging means and the support structure whereby to adjust the longitudinal position of the antenna within the probe.
In another aspect the invention provides apparatus for microwave thermal treatment comprising a probe, a microwave antenna support structure for locating the antenna within the probe near a distal end thereof, the support structure comprising means engaging the probe at a proximal end thereof and adjustment means for effecting controlled relative movement between the engaging means and the support structure whereby to adjust the longitudinal position of the antenna relative to the probe.
In a third aspect this invention provides a reusable microwave applicator assembly for use in thermal treatment and adapted for use with a disposable catheter, the assembly comprising a microwave antenna, support structure for removably locating the antenna in the interior of the catheter near a distal end thereof to be introduced into a patient's body, said support structure comprising a duct which together with the interior of the catheter provides a means of circulating coolant through the catheter externally of the support structure.
In the last-mentioned aspect there also may be means for adjusting the longitudinal position of the antenna within the catheter.
The support structure may comprise at least one tube forming said duct, and a sleeve wherein the at least one tube and an electrical conductor for the antenna are contained.
The antenna may be of helical form, and the said duct may extend at least to the tip of the antenna.
There may be a ridged plug for engaging the proximal end of the catheter to form a liquid-tight seal therewith.
The adjustment means may comprise a member within which the support structure is longitudinally movable, and means for engaging the member to constrain the support structure against movement, the member being connected or connectable to the catheter or probe.
The ridged plug may be carried by the member.
The invention also provides microwave thermal treatment equipment comprising an applicator assembly or apparatus as set forth above, a source of microwave frequency electric power and means for operatively connecting said source to the assembly or apparatus.
The invention will now be described with reference to the accompanying drawings, wherein;
Figure 1 shows a reusable microwave applicator assembly according to the invention;
Figure 2 is an enlarged and partially disassembled view of the assembly of Figure 1;
Figure 3 and 4 are sections through Figure 2 on lines 3"3 and 4-4 respectively;
Figure 5 is a side elevation of the assembly of Figure 2, and
Figure 6 is an enlarged view of part of the assembly of Figure 1. Referring to Figure 1, the apparatus comprises a probe, specifically a transurethral catheter 10 having a blind distal end 12 (ie having no drainage holes) and a balloon 14, inflatable in a conventional manner via an inflation duct from an inflator connector 16.
A microwave applicator comprises a transmitting antenna 17 formed of helically wound copper tape, dimensioned as is known in the art to operate at an allocated medical microwave frequency (eg 434 MHz or 904/915 MHz or other appropriate frequency) .
Referring also to Figures 2 to 6 the antenna 17 is carried on a support structure 18 consisting of a microwave coaxial conductor 20 and two ptfe tubes 22,24 arranged in a triangular configuration (Figure 4) and encased within a heat-shrink sleeve 26.
The sleeve 26 extends to the antenna 17 as shown in Figure 4; it is shown partially removed in Figure 1 only for reasons of clarity. At the antenna the outer casing of the conductor 20 is removed and the inner screened lead 28 is connected to the adjacent end of the antenna. The screen lead 30 is sleeved in a piece of ptfe tube 31 and together with the pipes 22,24 are encased in a further short piece of heat shrink sleeve 32 on which the copper tape forming the antenna 17 is wound.
The support structure 18 extends back down the catheter to its proximal end 34 and through a tube 36. The bore of the tube 36 is significantly larger than the diameter of the structure 20, so that a flow of coolant (eg deionized water) can also pass through the bore as hereafter described. The tube 36 has a conical ridged plug 38 which can be inserted in the correspondingly-shaped proximal end 3 of the catheter 10 to form a liquid-tight seal.
The tube 36 in itself telescopically received in a tubular portion 40 of a manifold 42 within which the heat-shrink sleeve 26 terminates; (the sleeve is again shown foreshortened in Figure 1 for clarity). The microwave conductor 20 is taken out through the manifold 42 to a suitable microwave-frequency connector 44. The connector may alternatively be mounted in the manifold 42.
The pipes 22,24 are taken through the tube 40 to a cooling water inlet connection 46. A cooling water outlet connection 48 communicates via a pipe 0 with the interior of the tube 40 and thus with the tube 36, permitting cooling water to flow out of the interior of the catheter to the outlet 48. The conductor 20 and the tubes 22,24 are potted with epoxy resin within the manifold 42 in a conventional manner, and thus are firmly fixed therein.
The end of the tubular portion 40 carries a clamping nut 54 on a threaded portion (not shown) together with a rubber sealing washer between the nut and the end of the tube 40. The washer when axially compressed by the nut 54 expands radially inwardly whereby to grip the tube 36 within it so that the parts 18, 36 and 42 cannot move longitudinally relative to each other.
The antenna 17 is thereby fixed longitudinally in the catheter when the clamping nut is tightened.
An additional separate blind conduit, (not shown) preferably is provided in the catheter 10 to contain a thermocouple or other temperature sensor adjacent the antenna, together with its electrical connection, so that the temperature of the tissue in contact with the catheter during microwave treatment may be monitored.
Preferably the additional conduit is disposed along the outside of the catheter 10.
In use, the re-usable assembly consisting of the antenna 17, support structure 18, tube 36 and manifold etc 40,42 are inserted in the disposable catheter 10, the latter having been sterilised. After insertion of the thermocouple in its conduit the catheter is introduced into the patient's urethra until the balloon portion 14 enters his bladder. The balloon is then inflated in the conventional manner to retain the catheter in position. When the catheter has been so inserted, the approximate position of the patient's prostate is shown dotted at 56, and that of the lower urethral sphincter sybolically at 58.
The position of the antenna relative to these organs is determined by any suitable technique eg ultrasonic imaging, and any necessary adjustment to its position is made by loosening the clamping nut 4 and sliding the manifold 42 and the support structure 18 relative to the tube 36 which is fixed in the proximal end of the catheter 10. When the position of the antenna is correct, the clamping nut is tightened. The necessary water connections 46,48 and the thermocouple connection are completed. The antenna 17 is connected via connector 44 to a source of microwave power (not shown) of appropriate authorised medical frequency suited to the dimensions of the antenna.
Alternatively the catheter may first be introduced into the urethra and the position of the postate and lower sphincter found relative to the end of the catheter by any suitable means eg ultrasound or by a fibre-optic probe introduced into the catheter. The correct length of insertion of the structure 18 and antenna 17 can then be determined, and the telescopic tubes 36,40 adjusted accordingly. A graduated scale may be provided on the tube 36 for this purpose. The antenna is then introduced into the catheter and the plug 38 secured in the proximal end 34 thereof.
During microwave therapy, cooling water is passed along the tubes 22,24 and returns down the interior of the catheter to the outlet 48. If desired the distal ends of the tubes 22,24 may be bent as shown at 60 (Figures 1 and 6) so as to impart increased turbulence to the water issuing from them, improving heat transfer from the walls of the catheter and thereby from the tissue in contact therewith. The tubes 22,24 extend at least to the end of the antenna, and preferably slightly beyond towards the end of the catheter.
Upon completion of treatment the catheter is withdrawn from the patient and discarded, the applicator assembly being retained for re-use.
It will be appreciated that the tubes 22,24 may be replaced by a single tube or by several tubes. However two tubes have the advantage of producing a conveniently-shaped structure 18 with the conductor 20, of approximately triangular section, as can be seen from Figure 4.
Although described in the context of a transurethral catheter it will be understood that the invention is applicable also in other catheters or probes for insertion into the body.

Claims

Claims
1. An assembly for insertion in a probe to form a microwave thermal treatment device, comprising a microwave antenna and support structure for locating the antenna within the probe near a distal end thereof, the support structure comprising means for engaging a proximal end of the probe and adjustment means for effecting controlled relative movement between the engaging means and the support structure whereby to adjust the longitudinal position of the antenna within the probe.
2. Apparatus for microwave thermal treatment comprising a probe, a microwave antenna support structure for locating the antenna within the probe near a distal end thereof, the support structure comprising means engaging the probe at a proximal end thereof and adjustment means for effecting controlled relative movement between the engaging means and the support structure whereby to adjust the longitudinal position of the antenna relative to the probe.
_ . A reusable microwave applicator assembly for use in thermal treatment and adapted for use with a disposable catheter, the assembly comprising a microwave antenna, support structure for removably locating the antenna in the interior of the catheter near a distal end thereof to be introduced into a patient's body, said support structure comprising a duct which together with the interior of the catheter provides a means of circulating coolant through the catheter externally of the support structure.
4. An assembly as claimed in Claim 3t wherein the support structure comprises at least one tube forming said duct, and a sleeve wherein the at least one tube and an electrical conductor for the antenna are contained.
5. An assembly as claimed in Claim 3 or Claim 4, wherein the antenna is of helical form.
6. An assembly as claimed in any of Claims 3 to 5. wherein the said duct extends at least to the tip of the antenna.
7. An assembly as claimed in any of Claims 3 to 6 comprising a ridged plug for engaging the proximal end of the catheter to form a liquid-tight seal therewith.
8. An assembly as claimed in any of Claims 3 to 7 comprising means for adjusting the longitudinal position of the antenna within the catheter.
9. An assembly or apparatus as claimed in Claim 1, 2 or 8, wherein the adjustment means comprises a member within which the support structure is longitudinally movable, and means for locking the support structure relative to said member.
10. An assembly as claimed in Claims 7 and 9t wherein the member within which the support structure is longitudinally movable is a sleeve which comprises the said ridged plug.
11. An assembly or apparatus as claimed in any of Claims 1, 2, 8, or 10, comprising means for indicating the relative positions of the engaging means and the support structure.
12. An apparatus or assembly substantially as herein described with reference to and as shown in the accompanying drawings.
13. Microwave thermal treatment equipment comprising apparatus or an assembly as claimed in any preceding claim, a source of microwave frequency electric power and means for operatively connecting said source to the apparatus or assembly.
PCT/GB1993/001439 1992-07-15 1993-07-09 Microwave treatment apparatus WO1994002204A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU45114/93A AU4511493A (en) 1992-07-15 1993-07-09 Microwave treatment apparatus
EP93914910A EP0606427A1 (en) 1992-07-15 1993-07-09 Microwave treatment apparatus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929215042A GB9215042D0 (en) 1992-07-15 1992-07-15 Microwave treatment apparatus
GB9215042.4 1992-07-15

Publications (1)

Publication Number Publication Date
WO1994002204A1 true WO1994002204A1 (en) 1994-02-03

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1993/001439 WO1994002204A1 (en) 1992-07-15 1993-07-09 Microwave treatment apparatus

Country Status (4)

Country Link
EP (1) EP0606427A1 (en)
AU (1) AU4511493A (en)
GB (1) GB9215042D0 (en)
WO (1) WO1994002204A1 (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5628770A (en) * 1995-06-06 1997-05-13 Urologix, Inc. Devices for transurethral thermal therapy
US5788692A (en) * 1995-06-30 1998-08-04 Fidus Medical Technology Corporation Mapping ablation catheter
US5800486A (en) * 1996-06-17 1998-09-01 Urologix, Inc. Device for transurethral thermal therapy with cooling balloon
US5938692A (en) * 1996-03-26 1999-08-17 Urologix, Inc. Voltage controlled variable tuning antenna
US6122551A (en) * 1998-12-11 2000-09-19 Urologix, Inc. Method of controlling thermal therapy
US6245062B1 (en) 1998-10-23 2001-06-12 Afx, Inc. Directional reflector shield assembly for a microwave ablation instrument
US6272384B1 (en) 1999-05-27 2001-08-07 Urologix, Inc. Microwave therapy apparatus
US6673068B1 (en) 2000-04-12 2004-01-06 Afx, Inc. Electrode arrangement for use in a medical instrument
US6802840B2 (en) 2000-12-29 2004-10-12 Afx, Inc. Medical instrument positioning tool and method
US8224455B2 (en) 2002-02-15 2012-07-17 Boston Scientific Corporation Drug delivery
US10076384B2 (en) 2013-03-08 2018-09-18 Symple Surgical, Inc. Balloon catheter apparatus with microwave emitter

Citations (5)

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Publication number Priority date Publication date Assignee Title
EP0248758A1 (en) * 1986-05-12 1987-12-09 Biodan Medical Systems Ltd Applicator for insertion into a body opening for medical purposes
US4795434A (en) * 1987-09-10 1989-01-03 C. R. Bard, Inc. Apparatus for positioning a sensor in vivo
EP0368161A2 (en) * 1988-11-07 1990-05-16 OMRON Corporation Electrode structure for high frequency hyperthermia device
EP0372100A1 (en) * 1986-10-29 1990-06-13 Microthermia Technology, Inc. Apparatus and a method for destroying cells in tumors and the like
WO1992010932A1 (en) * 1990-12-17 1992-07-09 Microwave Medical Systems, Inc. Therapeutic probe for radiating microwave and nuclear radiation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0248758A1 (en) * 1986-05-12 1987-12-09 Biodan Medical Systems Ltd Applicator for insertion into a body opening for medical purposes
EP0372100A1 (en) * 1986-10-29 1990-06-13 Microthermia Technology, Inc. Apparatus and a method for destroying cells in tumors and the like
US4795434A (en) * 1987-09-10 1989-01-03 C. R. Bard, Inc. Apparatus for positioning a sensor in vivo
EP0368161A2 (en) * 1988-11-07 1990-05-16 OMRON Corporation Electrode structure for high frequency hyperthermia device
WO1992010932A1 (en) * 1990-12-17 1992-07-09 Microwave Medical Systems, Inc. Therapeutic probe for radiating microwave and nuclear radiation

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5628770A (en) * 1995-06-06 1997-05-13 Urologix, Inc. Devices for transurethral thermal therapy
US5788692A (en) * 1995-06-30 1998-08-04 Fidus Medical Technology Corporation Mapping ablation catheter
US5938692A (en) * 1996-03-26 1999-08-17 Urologix, Inc. Voltage controlled variable tuning antenna
US6032078A (en) * 1996-03-26 2000-02-29 Urologix, Inc. Voltage controlled variable tuning antenna
US5800486A (en) * 1996-06-17 1998-09-01 Urologix, Inc. Device for transurethral thermal therapy with cooling balloon
US6364876B1 (en) 1998-10-23 2002-04-02 Afx, Inc. Vacuum-assisted securing apparatus for a microwave ablation instrument
US6245062B1 (en) 1998-10-23 2001-06-12 Afx, Inc. Directional reflector shield assembly for a microwave ablation instrument
US6383182B1 (en) 1998-10-23 2002-05-07 Afx Inc. Directional microwave ablation instrument with off-set energy delivery portion
US6122551A (en) * 1998-12-11 2000-09-19 Urologix, Inc. Method of controlling thermal therapy
US6490488B1 (en) 1998-12-11 2002-12-03 Urologix, Inc. Method of controlling thermal therapy
US6272384B1 (en) 1999-05-27 2001-08-07 Urologix, Inc. Microwave therapy apparatus
US6673068B1 (en) 2000-04-12 2004-01-06 Afx, Inc. Electrode arrangement for use in a medical instrument
US6802840B2 (en) 2000-12-29 2004-10-12 Afx, Inc. Medical instrument positioning tool and method
US8224455B2 (en) 2002-02-15 2012-07-17 Boston Scientific Corporation Drug delivery
US8374702B2 (en) 2002-02-15 2013-02-12 Medifocus, Inc. Drug delivery
US10076384B2 (en) 2013-03-08 2018-09-18 Symple Surgical, Inc. Balloon catheter apparatus with microwave emitter

Also Published As

Publication number Publication date
GB9215042D0 (en) 1992-08-26
EP0606427A1 (en) 1994-07-20
AU4511493A (en) 1994-02-14

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