WO1993018159A3 - Compositions and methods for pace 4 and 4.1 gene and polypeptides in cells - Google Patents

Compositions and methods for pace 4 and 4.1 gene and polypeptides in cells Download PDF

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Publication number
WO1993018159A3
WO1993018159A3 PCT/US1993/002147 US9302147W WO9318159A3 WO 1993018159 A3 WO1993018159 A3 WO 1993018159A3 US 9302147 W US9302147 W US 9302147W WO 9318159 A3 WO9318159 A3 WO 9318159A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
pace
polypeptides
gene
Prior art date
Application number
PCT/US1993/002147
Other languages
French (fr)
Other versions
WO1993018159A2 (en
Inventor
Philip J Barr
Michael C Kiefer
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Priority to EP93907371A priority Critical patent/EP0632833A1/en
Priority to JP5515974A priority patent/JPH07504818A/en
Publication of WO1993018159A2 publication Critical patent/WO1993018159A2/en
Publication of WO1993018159A3 publication Critical patent/WO1993018159A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6454—Dibasic site splicing serine proteases, e.g. kexin (3.4.21.61); furin (3.4.21.75) and other proprotein convertases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Compositions and methods are provided for endopeptidases and their production, and for enhanced efficiencies of processing heterologous precursor polypeptides to mature polypeptides. These compositions and methods utilize recombinant PACE 4 and 4.1, mammalian endopeptidases that are specific for dibasic amino acid sites. Therapeutic compositions and methods employing PACE 4 or 4.1 or their inhibitors are also provided.
PCT/US1993/002147 1992-03-09 1993-03-09 Compositions and methods for pace 4 and 4.1 gene and polypeptides in cells WO1993018159A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP93907371A EP0632833A1 (en) 1992-03-09 1993-03-09 Compositions and methods for pace 4 and 4.1 gene and polypeptides in cells
JP5515974A JPH07504818A (en) 1992-03-09 1993-03-09 Compositions and methods related to intracellular PACE4 and PACE4.1 genes and polypeptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84862992A 1992-03-09 1992-03-09
US07/848,629 1992-03-09

Publications (2)

Publication Number Publication Date
WO1993018159A2 WO1993018159A2 (en) 1993-09-16
WO1993018159A3 true WO1993018159A3 (en) 1993-11-11

Family

ID=25303845

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/002147 WO1993018159A2 (en) 1992-03-09 1993-03-09 Compositions and methods for pace 4 and 4.1 gene and polypeptides in cells

Country Status (5)

Country Link
US (3) US5863756A (en)
EP (1) EP0632833A1 (en)
JP (1) JPH07504818A (en)
CA (1) CA2131549A1 (en)
WO (1) WO1993018159A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840529A (en) * 1995-08-02 1998-11-24 Clinical Research Institute Of Montreal Mammalian pro-hormone convertase
US7081519B1 (en) 1997-04-24 2006-07-25 Zymogenetics, Inc. Antibodies to serine protease polypeptides
US6153420A (en) * 1997-04-24 2000-11-28 Zymogenetics, Inc. Serine protease polypeptides and materials and methods for making them
US6642011B2 (en) * 1998-04-15 2003-11-04 Genencor International, Inc. Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins
US7456007B1 (en) 1998-12-31 2008-11-25 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
US7115410B1 (en) 1999-02-10 2006-10-03 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
JP4653318B2 (en) 1999-02-10 2011-03-16 エラン ファーマシューティカルズ，インコーポレイテッド β-secretase enzyme composition and method
US7514408B1 (en) 1999-12-02 2009-04-07 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
WO2003006680A2 (en) * 2001-07-13 2003-01-23 Thomas Jefferson University Omi and domains thereof that disrupt iap-caspase interaction
JP2007505887A (en) * 2003-09-16 2007-03-15 ファルマシア・コーポレーション PACE4 inhibitor for the treatment of arthritis
US20080050776A1 (en) * 2006-05-26 2008-02-28 Kenneth Neet Stable mutated pro nerve growth factors
US8675068B2 (en) * 2008-04-11 2014-03-18 Nearmap Australia Pty Ltd Systems and methods of capturing large area images in detail including cascaded cameras and/or calibration features

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992009698A1 (en) * 1990-11-26 1992-06-11 Genetics Institute, Inc. Expression of pace in host cells and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2599752B1 (en) 1986-06-10 1989-11-03 Transgene Sa ALPHA1- ANTITRYPSIN VARIANTS USEFUL IN PARTICULAR AS KALLIKREIN INHIBITORS
US5166134A (en) 1986-12-24 1992-11-24 John Lezdey Treatment of allergic rhinitis
US5093316A (en) 1986-12-24 1992-03-03 John Lezdey Treatment of inflammation
US5217951A (en) 1986-12-24 1993-06-08 John Lezdey Treatment of inflammation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992009698A1 (en) * 1990-11-26 1992-06-11 Genetics Institute, Inc. Expression of pace in host cells and methods of use thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CELL vol. 66, no. 1, 12 July 1991, CELL PRESS,CAMBRIDGE, NA,US; pages 1-3 P.J. BARR "Mammalian subtilisins: The long-sought dibasic processing endoproteases" cited in the application see page 1, left column, line 1 - page 3, left column, line 52 *
DNA AND CELL BIOLOGY vol. 10, no. 10, 1991 MARY ANN LIEBERT, INC.,PUBL.,NY,US; pages 757-769 M.C. KIEFER ET AL. "Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15" see page 759, right column, paragraph 2 - page 766, left column, paragraph 2; figures 1-5 *
DNA AND CELL BIOLOGY vol. 10, no. 5, June 1991, MARY ANN LIEBERT, INC., PUBL.,NY,US; pages 319-328 P.J. BARR ET AL. "cDNA and gene structure for a human substilisin-like protease with cleavage specificity for paired basic amino acid residues" see page 321, left column, paragraph 3 - page 326, right column, paragraph 1; figures 1,2 *
PROC. NATL. ACAD SCI. vol. 87, no. 23, December 1990, NATL. ACAD SCI., WASHINGTON,DC,US; pages 9378-9382 R.J. WISE ET AL. "Expression of a human proprotein processing enzyme: Correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site" cited in the application see page 9379, left column, line 35 - page 9381, right column, paragraph 1 *

Also Published As

Publication number Publication date
JPH07504818A (en) 1995-06-01
CA2131549A1 (en) 1993-09-16
EP0632833A1 (en) 1995-01-11
US6277590B1 (en) 2001-08-21
US5863756A (en) 1999-01-26
WO1993018159A2 (en) 1993-09-16
US5989890A (en) 1999-11-23

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