WO1993013808A3 - Improvements in or relating to contrast agents - Google Patents

Improvements in or relating to contrast agents Download PDF

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Publication number
WO1993013808A3
WO1993013808A3 PCT/EP1993/000027 EP9300027W WO9313808A3 WO 1993013808 A3 WO1993013808 A3 WO 1993013808A3 EP 9300027 W EP9300027 W EP 9300027W WO 9313808 A3 WO9313808 A3 WO 9313808A3
Authority
WO
WIPO (PCT)
Prior art keywords
contrast agents
relating
surfactant
microparticulate
carbohydrate
Prior art date
Application number
PCT/EP1993/000027
Other languages
French (fr)
Other versions
WO1993013808A2 (en
Inventor
Jo Klaveness
Paal Rongved
Lars Stubberud
Original Assignee
Holmes Michael John
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10708317&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1993013808(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to AT93902156T priority Critical patent/ATE191646T1/en
Priority to JP5512124A priority patent/JPH07505136A/en
Priority to US08/256,149 priority patent/US5558856A/en
Priority to EP93902156A priority patent/EP0620744B1/en
Priority to DK93902156T priority patent/DK0620744T3/en
Application filed by Holmes Michael John, Nycomed Imaging As filed Critical Holmes Michael John
Priority to DE69328354T priority patent/DE69328354T2/en
Priority to CA002127705A priority patent/CA2127705C/en
Priority to AU33484/93A priority patent/AU676147B2/en
Publication of WO1993013808A2 publication Critical patent/WO1993013808A2/en
Publication of WO1993013808A3 publication Critical patent/WO1993013808A3/en
Priority to NO19942561A priority patent/NO311330B1/en
Priority to HK98100862A priority patent/HK1001994A1/en
Priority to GR20000401587T priority patent/GR3033902T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Organic Insulating Materials (AREA)

Abstract

Contrast agents comprising microbubble-generating carbohydrate microparticles having a surfactant admixed within the microparticulate structure (with the proviso that the surfactant is not a saturated C10-20 fatty acid when the microparticulate carbohydrate is galactose) exhibit useful levels of contrast efficiency and/or stability and may be used in diagnostic applications such as ultrasound and MR imaging.
PCT/EP1993/000027 1992-01-09 1993-01-08 Improvements in or relating to contrast agents WO1993013808A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
AU33484/93A AU676147B2 (en) 1992-01-09 1993-01-08 Improvements in or relating to contrast agents
CA002127705A CA2127705C (en) 1992-01-09 1993-01-08 Improvements in or relating to contrast agents
US08/256,149 US5558856A (en) 1992-01-09 1993-01-08 Microbubble-generating contrast agents for ultrasound and magnetic resonance imaging
EP93902156A EP0620744B1 (en) 1992-01-09 1993-01-08 Improvements in or relating to contrast agents
DK93902156T DK0620744T3 (en) 1992-01-09 1993-01-08 Improvements in or in connection with contrast agents
AT93902156T ATE191646T1 (en) 1992-01-09 1993-01-08 IMPROVEMENTS IN OR RELATING TO CONTRAST AGENTS
DE69328354T DE69328354T2 (en) 1992-01-09 1993-01-08 IMPROVEMENTS IN OR CONTRASTING AGENTS
JP5512124A JPH07505136A (en) 1992-01-09 1993-01-08 Improvements regarding contrast media
NO19942561A NO311330B1 (en) 1992-01-09 1994-07-07 Microparticulate contrast agents with surfactants
HK98100862A HK1001994A1 (en) 1992-01-09 1998-02-05 Improvements in or relating to contrast agents
GR20000401587T GR3033902T3 (en) 1992-01-09 2000-07-05 Improvements in or relating to contrast agents.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9200388.8 1992-01-09
GB929200388A GB9200388D0 (en) 1992-01-09 1992-01-09 Improvements in or relating to contrast agents

Publications (2)

Publication Number Publication Date
WO1993013808A2 WO1993013808A2 (en) 1993-07-22
WO1993013808A3 true WO1993013808A3 (en) 1993-10-14

Family

ID=10708317

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1993/000027 WO1993013808A2 (en) 1992-01-09 1993-01-08 Improvements in or relating to contrast agents

Country Status (16)

Country Link
US (5) US5558856A (en)
EP (2) EP0620744B1 (en)
JP (1) JPH07505136A (en)
AT (1) ATE191646T1 (en)
AU (2) AU676147B2 (en)
CA (1) CA2127705C (en)
DE (1) DE69328354T2 (en)
DK (1) DK0620744T3 (en)
ES (1) ES2144454T3 (en)
GB (1) GB9200388D0 (en)
GR (1) GR3033902T3 (en)
HK (1) HK1001994A1 (en)
NO (1) NO311330B1 (en)
PT (1) PT620744E (en)
SG (1) SG52338A1 (en)
WO (1) WO1993013808A2 (en)

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US5558856A (en) 1996-09-24
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