CA2207652A1 - Hemolysis prevention by surfactants and emulsions - Google Patents

Hemolysis prevention by surfactants and emulsions

Info

Publication number
CA2207652A1
CA2207652A1 CA002207652A CA2207652A CA2207652A1 CA 2207652 A1 CA2207652 A1 CA 2207652A1 CA 002207652 A CA002207652 A CA 002207652A CA 2207652 A CA2207652 A CA 2207652A CA 2207652 A1 CA2207652 A1 CA 2207652A1
Authority
CA
Canada
Prior art keywords
emulsions
surfactants
hemolysis prevention
hemolysis
prevention
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002207652A
Other languages
French (fr)
Other versions
CA2207652C (en
Inventor
Timothy Harrison
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9426104.7A external-priority patent/GB9426104D0/en
Application filed by Individual filed Critical Individual
Publication of CA2207652A1 publication Critical patent/CA2207652A1/en
Application granted granted Critical
Publication of CA2207652C publication Critical patent/CA2207652C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/77—Polymers containing oxygen of oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to the use of a non-ionic surface-active agent or an emulsion for the reduction of the hemolytic effects of an amphiphilic compound. There is also provided a method for reducing the hemolytic effects of an amphiphilic compound which comprises formulating said compound with a non-ionic surface-active agent or in the form of an emulsion.
CA002207652A 1994-12-23 1995-12-15 Hemolysis prevention by surfactants and emulsions Expired - Fee Related CA2207652C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9426104.7 1994-12-23
GBGB9426104.7A GB9426104D0 (en) 1994-12-23 1994-12-23 Use of surfactants and emulsions
PCT/GB1995/002936 WO1996019970A1 (en) 1994-12-23 1995-12-15 Hemolysis prevention by surfactants and emulsions

Publications (2)

Publication Number Publication Date
CA2207652A1 true CA2207652A1 (en) 1996-07-04
CA2207652C CA2207652C (en) 2006-07-25

Family

ID=36707910

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002207652A Expired - Fee Related CA2207652C (en) 1994-12-23 1995-12-15 Hemolysis prevention by surfactants and emulsions

Country Status (1)

Country Link
CA (1) CA2207652C (en)

Also Published As

Publication number Publication date
CA2207652C (en) 2006-07-25

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed