WO1993008751A1 - Cryosurgical apparatus - Google Patents

Cryosurgical apparatus Download PDF

Info

Publication number
WO1993008751A1
WO1993008751A1 PCT/GB1992/002028 GB9202028W WO9308751A1 WO 1993008751 A1 WO1993008751 A1 WO 1993008751A1 GB 9202028 W GB9202028 W GB 9202028W WO 9308751 A1 WO9308751 A1 WO 9308751A1
Authority
WO
WIPO (PCT)
Prior art keywords
tip region
probe
probe according
passageway
tube
Prior art date
Application number
PCT/GB1992/002028
Other languages
French (fr)
Inventor
Brian Kevin Roderick Clarke
Original Assignee
Cryogenic Technology Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB919123415A priority Critical patent/GB9123415D0/en
Priority to GB9123415.3 priority
Application filed by Cryogenic Technology Limited filed Critical Cryogenic Technology Limited
Publication of WO1993008751A1 publication Critical patent/WO1993008751A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques

Abstract

A cryosurgical probe has an elongate housing with a tip region (12) at one end, a first passageway (20) extending from an inlet for cryogen to the tip region and a second passageway (24) extending from the tip region to an outlet to exhaust. An insulating jacket (28) is provided, which may be air filled or partially evacuated, to insulate at least part of the external surface of the probe housing remote from the tip region in order to ensure that that part of the surface does not become frozen. Damage to tissue outside the area to be treated is thereby minimised, even in cases where the probe is inserted deeply into the tumour.

Description

Cryosurgical Apparatus

This invention relates to cryosurgical apparatus, and in particular concerns a cryosurgical probe suitable for intra organ penetration.

Cryosurgical probes may be used in the treatment of tumours, for example, using techniques in which a probe tip is inserted to the area of tissue required to be removed and then cooled by the passage therethrough of a cryogen to freeze, and therefore destroy, the tissue surrounding the probe tip. It is desirable to control as carefully as possible a number of parameters, including the speed and extent of the freezing, in order to ensure that tumourouε area is completely destroyed with minimum concomitant damage to surrounding healthy tissue .

The present invention seeks to provide apparatus which may be inserted deeply within an organ whilst mitigating or obviating damage of healthy tissue.

According to one aspect of the invention, there is provided a cryosurgical probe comprising an elongate housing having a tip region at one end thereof, a first passageway extending from an inlet to the tip region and a second passageway extending from the tip region to an outlet and in communication with the first passageway at the tip region, and insulating means for insulating the external surface of the housing in a region remote from the tip region.

According to another aspect of the invention there is provided cryosurgical apparatus comprising an elongate housing having a closed tip region at one end thereof and inlet means and outlet means for a cryogenic fluid on the housing, a first passageway within the housing in communication with the inlet means for deli¬ very of cryogenic fluid along substantially the entire length of the housing to the tip region to cause cooling of the tip region, a second passageway within the hous¬ ing for return of cryogenic fluid from the tip region along substantially the entire length of the housing to the outlet means, and means for insulating the external surface of the housing in a region remote from the tip.

Preferably the first and second passageways are defined by two tubes of generally circular cross- section. One tube may have a smaller diameter than the other and may be located internally thereof. In the preferred embodiment, the smaller diameter tube is concentric with the larger diameter tube. The first passageway in the preferred embodiment is defined by the internal surface of the smaller tube, and the second passageway in the preferred embodiment is annular in cross-section and bounded by the external surface of the smaller tube and the internal surface of the larger tube .

Preferably the insulating means comprises a gas jacket located around the external surface of the larger tube, to form an outer annular chamber. The chamber may be air filled, or may be partially evacuated.

An embodiment of the invention will now be described by means of illustration only with reference to the accompanying drawings in which:-

Fig. 1 is a longitudinal sectional view through an apparatus of the invention; and

Pig. 2 is a transverse sectional view on line A-A of Fig . 1.

The drawings show a cryosurgical probe having an elongate housing 10 comprising a tip region 12. and a main body portion 14. An inlet 18 is provided at one end 16 of the main body portion 14. The latter is formed substantially along the length thereof by three concentric tubes 20, 24, 28, the respective diameters of the tubes 20, 24, 28 providing an annular passageway 34 defined by the tube 24 around the tube 20, and an annular passageway 30 defined by the tube 28 around the tube 24. The tubes 20, 24 extend beyond the tube 28 at the end of the housing remote from the inlet 18 to def¬ ine the tip region 12, with the tube 24 having a closed end extending beyond the end of the tube 20 to define a space 22 at the end of the tip region 12. The tube 20 is open at the end within the tip region 12 and thereby presents a bore 32 extending from the inlet 18 and communicating with the space 22, the latter also being in communication with the annular passageway 34.

The body 10 of the probe may conveniently be made of stainless steel, whilst the tip region 12 which must have optimum thermal conductivity may be formed from gold plated brass.

In use, the probe tip is inserted into the centre of the tumour or other tissue area required to be removed. A liquid cryogen such as helium or nitrogen is supplied to the inlet 18 and passes along the bore 32 to flood the space 22, and therefore freeze the tip region 12. In causing this cooling effect, cryogen is vapour- ised. The resulting gas passes along the passageway 34 and is exhausted via the outlet 26.

The annular passageway 30 may be filled or parti¬ ally filled with air to provide insulation. When air is present in the annular passageway 30, some liquefaction occurs during circulation of the cryogen, resulting in a partial vacuum.

The insulating effect of the passageway 30 ensures that the outer surface of the body portion 14 of the probe does not become frozen. Therefore damage to tissue outside the area to be treated is minimised, even in cases where the probe is inserted deeply into the tumour .

The proportion of the probe housing 10 which is covered by the outer insulating tube 28 may be chosen according to specific requirements in any particular case .

It will be appreciated that various modifications may be made without departing from the scope of the invention. The construction and arrangement of the cryogen inlet and outlet, and the arrangement of the delivery and return tubes may be different from that described and shown.

Whilst endeavouring in the foregoing Specification to draw attention to those features of the invention believed to be of particular importance it should be understood that the Applicant claims protection in respect of any patentable feature or combination of features hereinbefore referred to and/or shown in the drawings whether or not particular emphasis has been placed thereon.

Claims

Claims : -
1. A cryosurgical probe comprising an elongate housing having a tip region at one end thereof, a first passageway extending from an inlet to the tip region and a second passageway extending from the tip region to an outlet and in communication with the first passageway at the tip region, and insulating means for insulating the external surface of the housing in a region remote from the tip region.
2. A probe according to Claim 1 wherein the first and second passageways are defined by two tubes of generally circular crosεsection.
3. A probe according to Claim 2 wherein the first tube has a smaller diameter than the second and is located concentrically internally thereof.
4. A probe according to any of the preceding Claims wherein the insulating means comprises a gas jacket.
5. A probe according to Claim 4 when dependent on
Claim 3 wherein the gas jacket is located around the external surface of the larger tube, to form an outer annular chamber.
6. A probe according to Claim 4 or Claim 5 wherein the jacket contains air.
7. A probe according to any of Claims 4 to 6 wherein the jacket is partially evacuated.
8. A probe substantially as hereinbefore described with reference to the accompanying drawings.
9. Any novel subject matter or combination including novel subject matter disclosed, whether or not within the scope of or relating to the same invention as any of the preceding Claims.
PCT/GB1992/002028 1991-11-05 1992-11-03 Cryosurgical apparatus WO1993008751A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB919123415A GB9123415D0 (en) 1991-11-05 1991-11-05 Cryosurgical apparatus
GB9123415.3 1991-11-05

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19920922620 EP0611294A1 (en) 1991-11-05 1992-11-03 Cryosurgical apparatus
JP50826392A JPH07503624A (en) 1991-11-05 1992-11-03

Publications (1)

Publication Number Publication Date
WO1993008751A1 true WO1993008751A1 (en) 1993-05-13

Family

ID=10704054

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1992/002028 WO1993008751A1 (en) 1991-11-05 1992-11-03 Cryosurgical apparatus

Country Status (4)

Country Link
EP (1) EP0611294A1 (en)
JP (1) JPH07503624A (en)
GB (1) GB9123415D0 (en)
WO (1) WO1993008751A1 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0917447A1 (en) * 1996-06-24 1999-05-26 Allegheny-Singer Research Institute Method and apparatus for cryosurgery
WO1999065410A1 (en) * 1998-06-19 1999-12-23 Endocare, Inc. Sheath, cryoprobe, and methods for use
US6306129B1 (en) 1997-09-22 2001-10-23 Femrx, Inc. Cryosurgical system and method
WO2002002026A1 (en) * 2000-07-05 2002-01-10 Mor - Research Applications Ltd. Cryoprobe and method of treating scars
EP1592357A2 (en) * 2003-01-15 2005-11-09 Cryodynamics, LLC. Cryotherapy probe and system
US7410484B2 (en) 2003-01-15 2008-08-12 Cryodynamics, Llc Cryotherapy probe
US8382698B2 (en) 2004-04-16 2013-02-26 Nuvue Therapeutics, Inc. Systems and methods for improving image-guided tissue ablation
CN104427949A (en) * 2012-04-27 2015-03-18 Dgs计算机株式会社 Cylindrical probe outer casing for cryosurgery device, and treatment unit

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1103079A (en) * 1966-02-17 1968-02-14 Internat Res And Dev Company L Improvements in and relating to surgical probes
DE2251626A1 (en) * 1972-10-20 1974-04-25 Linde Ag cryosurgical probe

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1103079A (en) * 1966-02-17 1968-02-14 Internat Res And Dev Company L Improvements in and relating to surgical probes
DE2251626A1 (en) * 1972-10-20 1974-04-25 Linde Ag cryosurgical probe

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0917447A1 (en) * 1996-06-24 1999-05-26 Allegheny-Singer Research Institute Method and apparatus for cryosurgery
EP0917447A4 (en) * 1996-06-24 2001-08-01 Allegheny Singer Res Inst Method and apparatus for cryosurgery
US6306129B1 (en) 1997-09-22 2001-10-23 Femrx, Inc. Cryosurgical system and method
WO1999065410A1 (en) * 1998-06-19 1999-12-23 Endocare, Inc. Sheath, cryoprobe, and methods for use
WO2002002026A1 (en) * 2000-07-05 2002-01-10 Mor - Research Applications Ltd. Cryoprobe and method of treating scars
US6503246B1 (en) 2000-07-05 2003-01-07 Mor Research Applications Ltd. Cryoprobe and method of treating scars
EP1592357A2 (en) * 2003-01-15 2005-11-09 Cryodynamics, LLC. Cryotherapy probe and system
EP1592357A4 (en) * 2003-01-15 2007-10-31 Cryodynamics Llc Cryotherapy probe and system
US7410484B2 (en) 2003-01-15 2008-08-12 Cryodynamics, Llc Cryotherapy probe
US9408656B2 (en) 2003-01-15 2016-08-09 Adagio Medical, Inc. Cryotherapy probe
US8382698B2 (en) 2004-04-16 2013-02-26 Nuvue Therapeutics, Inc. Systems and methods for improving image-guided tissue ablation
CN104427949A (en) * 2012-04-27 2015-03-18 Dgs计算机株式会社 Cylindrical probe outer casing for cryosurgery device, and treatment unit
EP2842505A4 (en) * 2012-04-27 2015-12-16 Dgs Comp Co Ltd Cylindrical probe outer casing for cryosurgery device, and treatment unit

Also Published As

Publication number Publication date
JPH07503624A (en) 1995-04-20
EP0611294A1 (en) 1994-08-24
GB9123415D0 (en) 1991-12-18

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