WO1993006870A1 - Appareil utile pour desinfecter des lentilles de contact - Google Patents

Appareil utile pour desinfecter des lentilles de contact Download PDF

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Publication number
WO1993006870A1
WO1993006870A1 PCT/US1992/007936 US9207936W WO9306870A1 WO 1993006870 A1 WO1993006870 A1 WO 1993006870A1 US 9207936 W US9207936 W US 9207936W WO 9306870 A1 WO9306870 A1 WO 9306870A1
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WO
WIPO (PCT)
Prior art keywords
container
metal component
substrate
chlorine dioxide
lens
Prior art date
Application number
PCT/US1992/007936
Other languages
English (en)
Inventor
John Ennis Ii Neff
Daniel F. Smith
Original Assignee
Allergan, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan, Inc. filed Critical Allergan, Inc.
Publication of WO1993006870A1 publication Critical patent/WO1993006870A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45C—PURSES; LUGGAGE; HAND CARRIED BAGS
    • A45C11/00—Receptacles for purposes not provided for in groups A45C1/00-A45C9/00
    • A45C11/005—Contact lens cases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/10—Halogens or compounds thereof
    • A61L12/102—Chlorine dioxide (ClO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/12—Non-macromolecular oxygen-containing compounds, e.g. hydrogen peroxide or ozone
    • A61L12/124—Hydrogen peroxide; Peroxy compounds
    • A61L12/128—Hydrogen peroxide; Peroxy compounds neutralised with catalysts

Definitions

  • This invention relates to disinfecting lenses, such as contact lenses.
  • the invention relates to apparatus useful to quickly and effectively disinfect lenses while reducing eye irritation caused by disinfecting the lenses.
  • Contact lenses should be periodically disinfected to protect the wearer's eyes f om infection and to improve the wearer's comfort. It is often desirable that contact lens disinfecting be accomplished quickly, e.g., for the convenience of the wearer.
  • conventional fast-acting disinfectants that are used with contact lenses have a high potential to cause eye irritation.
  • the general rule has been that the amount of eye irritation to be expected is directly proportional to the rate of disinfecting.
  • Fast-acting disinfectants such as hydrogen peroxide, cause significant ocular irritation if placed directly in the eye.
  • a thorough rinsing and/or neutralization step is often required to remove substantially all traces of the disinfectant.
  • Gaglia, Jr. U.S. Patent 3,912,451 discloses using a platinum group metal as a hydrogen peroxide decomposition catalyst. This patent discloses that the platinum group metal is supported on a substrate by electrolytic deposition or by coating a substrate with an oxidized platinum group metal component in a liquid carrier and then reducing the oxidized platinum group metal component. Although the platinum group metal component is initially effective to promote the decomposition of hydrogen peroxide, over a relatively short period of time the substrate becomes ineffective. It is believed that the platinum group metal component is lost from the substrate. Since it is important that a contact lens disinfecting system be useful on a repeated basis over a prolonged period to time, this relatively short "effective" life of the Gaglia, Jr. platinum group metal component-containing substrate is a significant drawback to its usefulness.
  • the present apparatus provide for rapid and effective generation of contact lens disinfecting amounts of chlorine dioxide from chlorine dioxide precursors.
  • the present apparatus can be used to disinfect contact lenses using hydrogen peroxide disinfectant which is effectively, rapidly and substantially completely destroyed, thus enabling the disinfected lenses to be comfortably and safely worn.
  • the present apparatus remains useful and effective after repeated uses over a prolonged period of time relative to, for example, certain prior art systems.
  • the present apparatus comprises a container sized to hold a contact lens to be disinfected and a liquid medium containing chlorine dioxide precursor or hydrogen peroxide.
  • a substrate is located within, preferably secured or attached to, the container.
  • a metal component is located, preferably deposited, more preferably deposited from a vaporous medium, on the substrate, and is present in an amount effective to promote the formation of chlorine dioxide from chlorine dioxide precursor in the liquid medium in the container or to promote the decomposition of hydrogen peroxide in the liquid medium in the container.
  • the metal component preferably has a longer effective useful life relative to a substantially identical metal component located on a substantially identical substrate by electrolytic decomposition or by coating the substantially identical substrate with an oxidized metal component in a liquid carrier and then reducing the oxidized metal component.
  • the apparatus includes a container, a substrate and a metal component.
  • the container has an inner surface and is sized to hold a contact lens to be disinfected and a liquid medium containing at least one chlorine dioxide precursor or hydrogen peroxide.
  • the substrate is located within, preferably secured or attached to, the container, and more preferably secured or attached to the inner surface of the container.
  • the substrate can be adhesively secured to the inner surface of the container, such as by using one or more conventional adhesives.
  • the substrate preferably covers at least about 50% of the inner sidewall surface of the container, thus providing for every effective contacting between the metal component and the chlorine dioxide precursor/hydrogen peroxide in the liquid medium.
  • the metal component is located on, preferably deposited on, the substrate.
  • the metal component is present in an amount effective to promote the formation of chlorine dioxide, preferably a contact lens disinfecting amount of chlorine dioxide, from the chlorine dioxide precursor in the container or to promote the decomposition of hydrogen peroxide in the container.
  • the present apparatus may be constructed from any suitable material of construction or combination of materials of construction. Such material or materials of construction should have no substantial adverse effect on the functioning of the present apparatus, on the liquid medium or on the lens being disinfected.
  • One or more polymeric materials are particularly useful in constructing one or more components of the present apparatus.
  • Any metal component capable of promoting the formation of chlorine dioxide from a chlorine dioxide precursor in a liquid medium, in particular in an aqueous liquid medium, preferably at a pH in the range of about 6 to about 10 or possibly higher, or of promoting the decomposition of hydrogen peroxide in a liquid medium may be employed in the present invention.
  • the preferred metal components include the transition metals and mixtures thereof, in particular selected from the metals of the following groups of the Periodic Table of Elements: Group III metals, Group IV metals, Group V metals, Group VI metals, Group VII metals, Group VIII metals and mixtures thereof.
  • platinum group metal components and mixtures thereof preferably platinum components, palladium components, ruthenium components and mixtures thereof, and especially palladium components and mixtures thereof, are particularly useful.
  • the platinum group metals include platinum, palladium, iridium, ruthenium, rhodium and osmium.
  • the metal component or components may be present in the metallic form and/or in a combined form as part of an organic or inorganic compound or complex.
  • the amount of metal component or components needed is to be viewed in terms of what quantity is needed to promote the generation of a particular amount of chlorine dioxide or to promote the decomposition of a particular amount of hydrogen peroxide in a given time and in light of the amount of chlorine dioxide precursor or hydrogen peroxide present in the liquid medium in the container.
  • the metal component is often present in a minor amount relative to the amount of the substrate employed. Because of the high cost and good performance of the platinum group metals, one or more of such metals are preferably employed in amounts of about 1% by weight or less, more preferably about 0.5% by weight or less and still more preferably about 0.1% by weight or less, based on the weight of the substrate.
  • the metal component or components are located, preferably deposited, on a substrate which is located in, preferably secured or attached to, the container, more preferably to the inner surface of the container.
  • the substrate may be chosen so as to provide surface area on which the metal component or components can be placed.
  • any suitable substrate material may be employed, and preferably is substantially inert at the conditions employed in the present invention.
  • substrate materials include polymeric materials (plastics), metals, aluminas, silicas, clays, ceramics and the like.
  • the substrate may have any suitable shape or configuration.
  • the substrate is in the form of a film, for example, a film of polymeric material, having a first surface facing the inner surface of the container and a substantially opposing second surface.
  • the metal component is preferably deposited onto the second surface of the substrate film, that is the surface of the film that is directly exposed to the liquid medium in the container.
  • any of a number of conventional techniques can be employed to incorporate, preferably deposit, the metal component or components in and/or on the substrate.
  • vapor deposition techniques have been found to be particularly useful.
  • Techniques involving vapor deposition of the metal component or components that is techniques which involve depositing the metal component or components on the substrate from a vaporous medium, include, for example, sputtering techniques, electron beam vapor deposition techniques and the like, many of which are conventionally used to deposit metal and the like components on films.
  • Such vapor deposition techniques have been found to provide metal component/substrate combinations which have longer effective useful lives relative to a substantially identical metal component located on a substantially identical substrate by electrolytic deposition or by coating the substantially identical substrate with an oxidized metal component in a liquid carrier and then reducing the oxidized metal component, such as disclosed in Gaglia U.S. Patent 3,912,451.
  • the present apparatus is applicable to disinfecting all types of contact lenses.
  • Such lenses may be made of any material or combination of materials and may have any suitable configuration.
  • the present system can be used to disinfect lenses made from hydrogels ("soft" lenses), lenses made from polymethyl methacrylate (PMMA) , the so called “hard” lenses and other non-hydrogel gas permeable lenses.
  • Present day examples or non-hydrogel gas permeable lens materials are organosiloxane-methacrylate polymers (Polycoi-P lenses), fluorocarbon polymers (Advent lenses), cellulose acetate butyrate (CAB) materials and silicone elastomers of various compositions.
  • chlorine dioxide-containing liquid media provided in the present apparatus contain sufficient chlorine dioxide to disinfect a given device in a given period of time.
  • such liquid media contain at least about 0.1 ppm, more preferably about 0.2 ppm, and still more preferably at least about 0.5 ppm, by weight of chlorine dioxide.
  • Such amounts of chlorine dioxide, when present in solution in an aqueous liquid medium are effective to disinfect a contact lens in about 1 to about 2 hours or less. Higher amounts of chlorine dioxide disinfect in a shorter period of time.
  • the chlorine dioxide precursors referred to herein are compounds or components capable of generating,, releasing or being converted to, chlorine dioxide when exposed to one or more of the present metal components in a liquid medium.
  • Chlorites include metal chlorite salts, particularly alkali metal chlorites.
  • a specific example of a chlorite salt which is useful as a chlorine dioxide precursor is sodium chlorite.
  • stabilized chlorine dioxide means, for example, one or more chlorine dioxide-containing complexes disclosed in U.S. patents 4,696,811 and 4,689,215, each of which is hereby incorporated in its entirety by reference herein.
  • preferred stabilized chlorine dioxide complexes are carbonate and bicarbonate complexes. The exact chemical composition of many stabilized chlorine dioxide products is not completely understood. The manufacture or production of certain chlorine dioxide precursors is described in McNicholas U.S. Patent 3,278,447, which is hereby incorporated in its entirety by reference herein.
  • An especially useful stabilized chlorine dioxide is a product sold by Bio-Cide International, Inc. under the trademark Purogene
  • the chlorine dioxide precursor includes a functionality selected from carbonate, borate, sulfate, phosphate, and mixtures thereof. Without intending to limit the scope of the present invention to any particular theory of operation, the inclusion of such groups in the chlorine dioxide precursor may correspond or be analogous to the effect of certain buffer components, as is discussed hereinafter. But the invention is fully operable without reference to a specific buffer.
  • the chlorine dioxide precursor is preferably present in the liquid medium at a predetermined concentration so as to provide a disinfecting amount, for example, a contact lens disinfecting amount, of chlorine dioxide in the presence of the metal component.
  • the liquid medium has sufficient chlorine dioxide precursor so as to have a potential of producing chlorine dioxide in a concentration of at least about 0.1 ppm by weight.
  • hydrogen peroxide-containing liquid media provided in the present apparatus contain sufficient hydrogen peroxide to disinfect a given device in a given period of time.
  • such liquid media contain about 0.2% or about 0.5% to about 6% of hydrogen peroxide (w/v).
  • compositions in particular such aqueous hydrogen peroxide solutions, are known to be effective disinfectant compositions for contact lenses, and are effective at killing bacteria and fungi which may be found on contact lenses.
  • the amount of hydrogen peroxide used in the liquid medium is well in excess ' of that required to effectively disinfect a contact lens. Substantial excess hydrogen peroxide is used so that the lens disinfection can be completed in a reasonable period of time.
  • the liquid medium and the components included therein are used selected to have no substantial detrimental effect on the device, e.g., contact lens, being disinfected and to allow and even facilitate the disinfection.
  • the liquid medium and included components preferably have no substantial detrimental effect on the metal component or components being employed.
  • the liquid medium is preferably aqueous- based.
  • a particularly useful aqueous liquid medium is that derived from saline, e.g., a conventional saline solution.
  • the aqueous liquid medium containing chlorine dioxide precursor and the aqueous liquid medium containing chlorine dioxide have a pH in the range of about 6 to about 10, more preferably about 6.5 to about 8, and still more preferably about 7.5.
  • the liquid aqueous medium including hydrogen peroxide have a pH in the range of about 3 to about 9, more preferably about 6 to about 8. Such more preferred and still more preferred pH ranges are substantially consistent with the normal physiological pH for humans.
  • the disinfected contact lens may be placed directly in the eye or may need only be saline rinsed before being placed in the eye. This is in contrast to other systems which require elaborate neutralization procedures before the lens is suitable for placement in the eye.
  • the aqueous liquid medium containing may, and preferably does, include at least one buffer component.
  • any suitable buffer component may be employed, it is preferred to select such component so as not to substantially detrimentally affect the disinfectant, that is the chlorine dioxide or hydrogen peroxide, as the case may be. It is preferred that the buffer component be inorganic.
  • buffer components actually increase or facilitate the rate and/or amount of chlorine dioxide formed from the precursor.
  • these buffer components are those which include phosphate functionalities, borate functionalities, carbonate functionalities and mixtures thereof. Particularly increased rates of chlorine dioxide formation are achieved when the buffer component includes phosphate functionalities, borate functionalities and mixtures thereof.
  • Alkali metal and alkaline earth metal buffer components are advantageously used in the present invention.
  • the presently useful liquid media have an osmolality (a measure of tonicity) of at least about 200 mOsmol/kg, preferably in the range of about 200 to about 350 or about 400 mOsmol/kg.
  • the osmolality or tonicity of the liquid medium substantially corresponds to the tonicity of the fluids of the eye, in particular the human eye.
  • Any suitable ophthalmically acceptable tonicity component or components may be employed, provided that such component or components are compatible with the other ingredients of the liquid medium and do not have deleterious or toxic properties which could harm the eye.
  • useful tonicity components include sodium chloride, potassium chloride, mannitol, dextrose, glycerin, propylene glycol and mixtures thereof.
  • the tonicity component is selected from inorganic salts and mixtures thereof. The amount of ophthalmically acceptable tonicity component utilized can vary widely.
  • the tonicity component is preferably present in the liquid medium in an amount in the range of about 0.5 to about 0.9 weight/volume percent of the formulation.
  • Typical of ophthalmically acceptable inorganic salt tonicity components are alkali metal chlorides and alkaline earth metal chlorides, such as sodium chloride, potassium chloride, calcium chloride and magnesium chloride.
  • One or more additional components can be included in the presently useful liquid media. Such additional component or components are chosen to impart or provide at least one beneficial or desired property to the liquid media. Such additional components may be selected from components which are conventionally used in one or more contact lens care compositions.
  • additional components include cleaning agents, wetting agents, nutrient agents, sequestering agents, viscosity builders, contact lens conditioning agents, antioxidants, and the like. These additional components may each be included in the liquid media in an amount effective to impart or provide the beneficial or desired property to the liquid medium. For example, such additional components may be included in the presently useful liquid media in amounts similar to the amounts of such components used in other, e.g., conventional, contact lens care products.
  • useful wetting agents include polyvinyl alcohol, polyoxamers, polyvinylpyrrollidone, hydroxypropyl methyl cellulose and mixtures thereof.
  • useful sequestering agents include disodium ethylene diamine tetraace ate, alkali metal hexametaphosphate, citric acid, sodium citrate and mixtures thereof.
  • useful viscosity builders include hydroxyethyl cellulose, hydroxymethyl cellulose, poly inyl pyrrolidone, polyvinyl alcohol and mixtures thereof.
  • antioxidants examples include sodium metabisulfite, sodium thiosulfate, N-acetylcysteine, butylated hydroxyanisole, butylated hydroxytoluene and mixtures thereof.
  • the chlorine dioxide-containing liquid medium or the hydrogen peroxide-containing liquid medium in the present apparatus is preferably used to disinfect a device, in particular a contact lens.
  • the device to be disinfected is contacted with the chlorine dioxide-containing liquid medium or the hydrogen peroxide-containing liquid medium at conditions effective to disinfect the device.
  • the disinfecting contacting preferably occurs at a temperature to maintain the liquid medium substantially liquid.
  • the contacting temperature be in the range of about 0 C to about 100°C and more preferably in the range of about 10°C to about 60°C.
  • Contacting at or about ambient temperature is very convenient and useful.
  • the contacting preferably occurs at or about atmospheric pressure.
  • This contacting preferably occurs for a time to substantially completely disinfect the substrate being treated.
  • contacting times can be in the range of about 0.1 hours to about 12 hours or more.
  • the contact lens may be cleaned of one or more types of debris using enzymatic action.
  • One or more types of debris may be present on a single contact lens.
  • the enzyme or enzymes used are capable of removing at least one type of debris from a contact lens.
  • the amount of such enzyme or enzymes used is preferably effective to remove substantially all of at least one type of debris from a debris laden contact lens in a reasonable time, preferably within about 12 hours, for example, in the range of about 1 minute to about 12 hours, and more preferably within about 2 hours, for example, about 1 minute to about 2 hours.
  • the active enzyme-containing liquid medium preferably contains sufficient enzyme to provide between about 0.0001 to about 5 Anson units of activity, more preferably between about 0.001 or about 0.01 to about 0.1 or about 1 Anson unit, per single lens treatment. Higher or lower amounts may be used.
  • the enzyme employed may be selected from enzymes which are conventionally employed in the enzymatic cleaning of contact lenses.
  • many of the enzymes disclosed in Huth et al Reissue U.S. Patent 32,672 and Karageozian et al U.S. ' Patent 3,910,296 are useful in the present invention. Each of these patents is incorporated in its entirety by reference herein.
  • the useful enzymes are those selected from proteolytic enzymes. Upases and mixtures thereof.
  • the enzyme may be one or more carbohydrate-active or carbolytic enzymes. Specific examples of useful enzymes include proteases, amylases, lipases and mixtures thereof.
  • Preferred proteolytic enzymes are those which are substantially free of sulfhydryl groups or disulfide bonds.
  • Metallo-proteases those enzymes which contain a divalent metal ion such as calcium, magnesium or zinc bound to the protein, may also be used.
  • a more preferred group of proteolytic enzymes are the serine proteases, particularly those derived from Bacillus and Streptomyces bacteria and Asperigillus molds. Within this grouping, the still more preferred enzymes are the derived alkaline proteases generically called subtilisin enzymes.
  • subtilisin enzymes Reference is made to Deayl, L., Moser, P.W. and Wildi. B.S., "Proteases of the Genus Bacillus. II Alkaline Proteases", Biotechnology and Bioengineering, Vol. XII, pp 213-249 (1970) and Keay, L.
  • subtilisin A subtilisin A grouping are enzymes derived from such species are B_ ; _ subtilis, B. licheniformis and B. pumilis. Organisms in this sub-class produce little or no neutral protease or amylase.
  • subtilisin B sub ⁇ class is made up of enzymes from such organisms a B. subtilis, B. subtilis var. amylosacchariticus, B.
  • One or more enzymes from the subtilisin A sub-class are particularly useful.
  • enzymes are, for example, pancreatin, trypsin, collaginase, keratinase, carboxylase, aminopeptidase, elastase, and aspergillo- peptidase A and B, pronase E (from S. griseus) and dispase (from Bacillus polymyxa).
  • An effective amount of enzyme is to be used in the practice of this invention. Such amount will be that amount which effects removal in a reasonable time (for example overnight) of substantially all of at least one type of debris from a lens deposited due to normal wear.
  • This standard ' is stated with reference to contact lens wearers with a history of normal pattern of lens debris accretion, not the very small group who may at one time or another have a significantly increased rate of debris accretion such that cleaning is recommended every day, or every two or three days.
  • the amount of enzyme required to make an effective lens cleaner will depend on several factors, including the inherent activity of the enzyme.
  • Enzyme activity is pH dependent so for any given enzyme, there is a particular pH range in which that enzyme will function best. The determination of such range can readily be done by known techniques.
  • the enzymatic cleaning of the lens can conveniently be conducted simultaneously with the disinfection in the present apparatus.
  • chlorine dioxide has a substantial detrimental effect, for example, an inactivating effect, on the cleaning enzymes. Therefore, if chlorine dioxide is the disinfectant, it is preferred to enzymatically clean the lens before or after the lens is disinfected.
  • the cleaning enzyme is included in a delayed release tablet which is placed in the present container at substantially the same time the lens to be disinfected is so placed.
  • the delayed release tablet is structured so that the enzyme is released into the liquid medium only after the lens is disinfected and the chlorine dioxide in the liquid medium is substantially dissipated.
  • the delayed release tablet preferably includes an effective amount of a reducing component which acts to chemically reduce the chlorine dioxide present in the liquid medium.
  • the cleaned lens should be rinsed, e.g., in saline, to remove enzyme residue before being placed in the eye.
  • Fig. 1 is a top front view, in perspective, of one embodiment of the present apparatus.
  • Fig. 2 is a front elevation view, partly in cross- section, of the embodiment shown in Fig. 1.
  • Fig. 3 is a cross-sectional view taken generally along line 3-3 of Fig. 2.
  • a lens disinfection apparatus shown generally at 10, includes a lens container 12, a cover 14, lens basket 16, and a palladium-containing film 18.
  • Lens container 12 is made of a transparent, thermoplastic polymeric material, such as polymethylmethacrylate, and is made, e.g., molded, using conventional techniques as a single unit.
  • Lens container 12 includes a bottom wall 19 and a sidewall 20.
  • the top 24 of sidewall 20 includes a threaded outer surface 26.
  • the cross-section of lens container 12 parallel to bottom wall 18 is generally circular.
  • Lens container 12 defines an interior space 28 in which is placed a buffered stabilized chlorine dioxide- containing aqueous liquid medium.
  • Within interior space 28 and secured to the inner surface 30 of sidewall 20 is palladium-containing film 18.
  • Palladium-containing film 18 is derived by depositing palladium in the vapor state onto a polymeric film, such as a film of polyethylene terephthalate, using a sputtering process or an electron beam vapor deposition process. Using such vapor deposition techniques has been found to prolong the effective useful life of palladium-containing film 18, and thus of apparatus 10, for example, relative to certain other techniques previously used to deposit metals or substrates.
  • Palladium-containing film 18 is about 1.5 mils (0.0015 inch) thick and includes a 400-
  • Palladium-containing film 18 is sized to cover about 60-70% of the inner surface 30 of sidewall 20, and is located so that the bottom end 31 of the palladium- containing film approaches or is in proximity to the bottom end wall 19 of lens container 12.
  • palladium-containing film 18 is secured to the inner surface 30 of sidewall 20 using an adhesive layer 32.
  • Any suitable adhesive can be used in adhesive layer 32 provided that it functions to secure palladium-containing film 18 to sidewall 20 and has no substantial detrimental effect on the functioning of apparatus 10 or on the lenses being disinfected in apparatus 10.
  • useful adhesives include, but are not limited to, acrylic adhesives approved for medical applications, other adhesives approved for medical applications, and the like.
  • Palladium-containing film 18 can be formed, for example, by cutting, from bulk polymeric film material on which palladium is deposited. This bulk material is then cut into strips of appropriate size. A single such strip is secured to sidewall 20 to form palladium- containing film 18.
  • the palladium-containing film 18 in apparatus 10 is substantially right circular cylindrical in configuration and is positioned to be completely submerged in the buffered stabilized chlorine dioxide- containing aqueous liquid medium during contact lens disinfecting.
  • Cover 14 includes a top wall 36 and a downwardly depending sidewall 38.
  • Cover 14 is made of a non- transparent, thermoplastic polymeric material, such as acrylonitrile/butadiene/styrene polymer alloy.
  • Top wall 36 is generally circular and the cross-section of sidewall 38 parallel to top wall 36 is generally circular.
  • Sidewall 38 includes a threaded inner surface 40 the threads of which matingly engage the threads of threaded outer surface 26 to secure cover 14 to lens container 12.
  • Cover 14 also includes a central, circular attachment element 44 which extends downwardly into lens container 12 when cover 14 is secured to lens container 12. Attachment element 44 is secured to lens basket 16. In this manner, lens basket 16 is secured to cover 14.
  • a foamed polymeric sealing element 46 is fitted on the underside of cover 14 around attachment element 44 and acts to provide a substantially liquid tight seal when cover 14 is secured to lens container 12.
  • Lens basket 16 is made of a non-transparent, thermoplastic polymeric material, such as acrylonitrile/butadiene/styrene polymer alloy. Like lens container 12 and cover 14, lens basket 16 can be made, e.g., molded, using conventional techniques. Extending downwardly from attachment element 44 is basket body 50 which includes left lens mount 52 and right lens mount 54. Basket body 50 includes a series of through holes (not shown) which allow liquid to freely pass through the basket body.
  • a left basket cover 56 and a right basket cover 58 are both hingedly secured to basket body 50 and are structured to be “snapped" closed around left lens mount 52 and right lens mount 54, respectively, as desired, to form a left lens compartment 60 and a right lens compartment 62, respectively.
  • the basket covers 56 and 58 are made separately from the other components of the lens basket 16.
  • Each of the basket covers 56 and 58 include a series of through holes which allow liquid to flow freely through. However, these through holes are sized so that the contact lenses in lens compartments 60 and 62 cannot be removed when the lens covers 56 and 58 are closed.
  • Left basket cover 56 may be marked with a "L” to indicate that it is to be used with the left contact lens.
  • the right basket cover 58 may be marked with a "R" to indicate that it is to be used with the right contact lens.
  • Lens disinfection apparatus 10 may be used as follows. With cover 14 removed from lens container 12, the contact lenses to be disinfected are placed on the appropriate left and right lens mounts 52 and 54, respectively and the left and right basket covers 56 and 58 are snapped closed. A quantity, e.g., about 10 ml, of a conventional saline solution buffered with borate buffer to maintain a pH of about 7.5 and containing about 100 ppm by weight of stabilized chlorine dioxide, in particular the product sold by Biocide International, Inc., under
  • the cover 14 is removed from the lens container 12 and the disinfected lenses are removed from the lens compartments, optionally rinsed in saline solution .and are available to be placed in the wearer's eyes for safe and comfortable wear.
  • lens disinfection apparatus 10 may be used as follows. With cover 14 removed from lens container 12, the contact lenses to be disinfected are placed on the appropriate left and right lens mounts 52 and 54, respectively and the left and right basket covers 56 and 58 are snapped closed.
  • the cover 14 is removed from the lens container 12 and the disinfected contact lens can then be removed from the lens compartments 60 and 62, optionally rinsed with saline solution, and placed directly into the wearer's eyes for safe and comfortable wear.
  • the lens disinfecting apparatus 10 is very effective using either chlorine dioxide or hydrogen peroxide as the active disinfectant.
  • the palladium- containing film is very effective after repeated uses in promoting the generation of contact lens disinfecting amounts of chlorine dioxide from chlorine dioxide precursors, such as stabilized chlorine dioxide. Also, such palladium-containing film is effective to destroy substantially all of the residual hydrogen peroxide after the hydrogen peroxide acts to disinfect the contact lenses. Using vapor deposition techniques to deposit the palladium onto the film results in a longer effective useful life for the apparatus 10.

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Abstract

Un appareil pour désinfecter une lentille de contact comporte un récipient présentant une surface intérieure et étant dimensionné pour contenir une lentille de contact à désinfecter ainsi qu'un milieu liquide renfermant un précurseur de dioxyde de chlore ou du peroxyde d'hydrogène; un substrat situé dans le récipient; et un constituant métallique déposé sur le substrat à partir d'un milieu de vapeur. Ce constituant métallique est présent en quantité efficace pour favoriser la formation de dioxyde de chlore à partir du précurseur de dioxyde de chlore contenu dans le récipient ou bien pour favoriser la décomposition du peroxyde d'hydrogène contenu dans ce dernier.
PCT/US1992/007936 1991-10-03 1992-09-22 Appareil utile pour desinfecter des lentilles de contact WO1993006870A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77061391A 1991-10-03 1991-10-03
US770,613 1991-10-03

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WO1993006870A1 true WO1993006870A1 (fr) 1993-04-15

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996024385A1 (fr) * 1995-02-09 1996-08-15 Unilever Plc Articles, compositions et procedes de nettoyage de surfaces a l'aide de catalyseurs deposes sur celles-ci
EP0786258A1 (fr) * 1996-01-17 1997-07-30 Wolfgang G.K. Dr. Müller-Lierheim Procédé et système de traitement de lentilles de contact
WO1997048423A1 (fr) * 1996-06-17 1997-12-24 Mdle Medical Device Laboratories Europe Gmbh Dispositif de dissolution catalytique de peroxyde d'hydrogene
WO2000016815A1 (fr) * 1998-09-21 2000-03-30 Mdle Medical Device Laboratories Europe Gmbh Dispositif pour l'entretien de lentilles de contact

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0421737A1 (fr) * 1989-10-02 1991-04-10 Allergan, Inc. Méthode pour la génération de dioxide de chlore et compositions désinfectantes
EP0436466A2 (fr) * 1989-12-28 1991-07-10 Ciba-Geigy Ag Contrôle amélioré d'une réaction catalytique et dispositif pour sa mise en oeuvre
US5077258A (en) * 1990-06-15 1991-12-31 Flex Products, Inc. Vapor deposited metal catalytic film, process for making the same and liquid container with the film

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0421737A1 (fr) * 1989-10-02 1991-04-10 Allergan, Inc. Méthode pour la génération de dioxide de chlore et compositions désinfectantes
EP0436466A2 (fr) * 1989-12-28 1991-07-10 Ciba-Geigy Ag Contrôle amélioré d'une réaction catalytique et dispositif pour sa mise en oeuvre
US5077258A (en) * 1990-06-15 1991-12-31 Flex Products, Inc. Vapor deposited metal catalytic film, process for making the same and liquid container with the film

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996024385A1 (fr) * 1995-02-09 1996-08-15 Unilever Plc Articles, compositions et procedes de nettoyage de surfaces a l'aide de catalyseurs deposes sur celles-ci
AU687301B2 (en) * 1995-02-09 1998-02-19 University Of Manchester, The Articles, compositions and process for cleaning surfaces by use of a catalyst at the surface
EP0786258A1 (fr) * 1996-01-17 1997-07-30 Wolfgang G.K. Dr. Müller-Lierheim Procédé et système de traitement de lentilles de contact
WO1997048423A1 (fr) * 1996-06-17 1997-12-24 Mdle Medical Device Laboratories Europe Gmbh Dispositif de dissolution catalytique de peroxyde d'hydrogene
US6228333B1 (en) 1996-06-17 2001-05-08 Mdle Medical Device Laboratories Europe Gmbh Device for catalytically dissolving hydrogen peroxide
WO2000016815A1 (fr) * 1998-09-21 2000-03-30 Mdle Medical Device Laboratories Europe Gmbh Dispositif pour l'entretien de lentilles de contact

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