WO1993001272A3 - Bioassay method - Google Patents

Bioassay method Download PDF

Info

Publication number
WO1993001272A3
WO1993001272A3 PCT/GB1992/001210 GB9201210W WO9301272A3 WO 1993001272 A3 WO1993001272 A3 WO 1993001272A3 GB 9201210 W GB9201210 W GB 9201210W WO 9301272 A3 WO9301272 A3 WO 9301272A3
Authority
WO
WIPO (PCT)
Prior art keywords
circulation
embryo
reagents
bioassay method
embryonic
Prior art date
Application number
PCT/GB1992/001210
Other languages
French (fr)
Other versions
WO1993001272A2 (en
Inventor
Margaret Kathryn Pratten
Peter Frederick Tho Cumberland
Original Assignee
Univ Leicester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919114638A external-priority patent/GB9114638D0/en
Priority claimed from GB919114955A external-priority patent/GB9114955D0/en
Application filed by Univ Leicester filed Critical Univ Leicester
Priority to JP5502083A priority Critical patent/JPH06509469A/en
Priority to EP92914060A priority patent/EP0594660A1/en
Publication of WO1993001272A2 publication Critical patent/WO1993001272A2/en
Publication of WO1993001272A3 publication Critical patent/WO1993001272A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Abstract

A bioassay method comprises passing test reagents into the circulation of an embryo in such manner that the reagents are not modified by any intermediate metabolism. This can be effected in e.g. rat embryos by microcannulation directly into the vitelline circulation by passing the visceral yolk sac. In chick embryos the test reagent can be administered directly into the extra-embryonic circulation. The embryo is cultured and assessed as to its embryonic development.
PCT/GB1992/001210 1991-07-06 1992-07-03 Bioassay method WO1993001272A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP5502083A JPH06509469A (en) 1991-07-06 1992-07-03 bioassay method
EP92914060A EP0594660A1 (en) 1991-07-06 1992-07-03 Bioassay method

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB919114638A GB9114638D0 (en) 1991-07-06 1991-07-06 Bioassay method
GB9114638.1 1991-07-06
GB9114955.9 1991-07-11
GB919114955A GB9114955D0 (en) 1991-07-11 1991-07-11 Bioassay method

Publications (2)

Publication Number Publication Date
WO1993001272A2 WO1993001272A2 (en) 1993-01-21
WO1993001272A3 true WO1993001272A3 (en) 1993-03-18

Family

ID=26299196

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1992/001210 WO1993001272A2 (en) 1991-07-06 1992-07-03 Bioassay method

Country Status (6)

Country Link
EP (1) EP0594660A1 (en)
JP (1) JPH06509469A (en)
AU (1) AU2230992A (en)
CA (1) CA2112897A1 (en)
IE (1) IE922172A1 (en)
WO (1) WO1993001272A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006716A1 (en) * 1993-08-30 1995-03-09 Northwestern University Rat pluripotent embryonic stem cells and method of obtaining and using same
DE19606207A1 (en) 1996-02-21 1997-08-28 Univ Duesseldorf H Heine Method for determining the phototoxicity and / or photosensitivity of substances or mixtures of substances and their use
JP2006262863A (en) * 2005-03-25 2006-10-05 Gifu Univ Method for evaluating external stimulation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3530336A1 (en) * 1985-08-24 1987-02-26 Wittmann J Dr Process for culturing the poultry embryo

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU461120A1 (en) * 1972-10-30 1975-02-25 Харьковский Научно-Исследовательский Институт Микробиовакцин И Сывороток The method of determining the biological activity of substances

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3530336A1 (en) * 1985-08-24 1987-02-26 Wittmann J Dr Process for culturing the poultry embryo

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIOCHEMICAL SOCIETY TRANSACTIONS vol. 15, no. 5, October 1987, LONDON pages 922 - 923 ERIC P.K. MENSAH-BROWN ET AL. 'THE FATE OF I125-LABELLED PROTEINS AFTER INJECTION INTO 11.5 DAY RAT EMBRYONIC CIRCULATION.' *
DATABASE WPI Section Ch, Week 7603, Derwent Publications Ltd., London, GB; Class B04, AN 76-04952X/03 & SU,A,461 120 (KHARK MICROB VACCIN) 9 July 1975 *

Also Published As

Publication number Publication date
AU2230992A (en) 1993-02-11
WO1993001272A2 (en) 1993-01-21
IE922172A1 (en) 1993-01-13
JPH06509469A (en) 1994-10-27
EP0594660A1 (en) 1994-05-04
CA2112897A1 (en) 1993-01-21

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