WO1992014470A1 - Treatment of esophageal cancer - Google Patents
Treatment of esophageal cancer Download PDFInfo
- Publication number
- WO1992014470A1 WO1992014470A1 PCT/US1992/001029 US9201029W WO9214470A1 WO 1992014470 A1 WO1992014470 A1 WO 1992014470A1 US 9201029 W US9201029 W US 9201029W WO 9214470 A1 WO9214470 A1 WO 9214470A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hydroxy
- course
- compound
- topotecan
- therapy
- Prior art date
Links
- 0 CCC(C(OC1)=*)C(C=C(C)[C@@]2N=C(C=CC(*)=C3*)C3=CC2C*2)=C1C2=O Chemical compound CCC(C(OC1)=*)C(C=C(C)[C@@]2N=C(C=CC(*)=C3*)C3=CC2C*2)=C1C2=O 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU15406/92A AU664172B2 (en) | 1991-02-21 | 1992-02-07 | Treatment of esophageal cancer |
KR1019930702492A KR930702985A (en) | 1991-02-21 | 1992-02-07 | Treatment of Esophageal Cancer |
JP4507807A JPH06505487A (en) | 1991-02-21 | 1992-02-07 | Pharmaceutical composition for treatment of esophageal cancer |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65893691A | 1991-02-21 | 1991-02-21 | |
US658,936 | 1991-02-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1992014470A1 true WO1992014470A1 (en) | 1992-09-03 |
Family
ID=24643326
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1992/001029 WO1992014470A1 (en) | 1991-02-21 | 1992-02-07 | Treatment of esophageal cancer |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0572563A4 (en) |
JP (1) | JPH06505487A (en) |
KR (1) | KR930702985A (en) |
AU (1) | AU664172B2 (en) |
CA (1) | CA2104449A1 (en) |
MX (1) | MX9200725A (en) |
PT (1) | PT100154A (en) |
WO (1) | WO1992014470A1 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001066144A2 (en) * | 2000-03-08 | 2001-09-13 | Rhode Island Hospital, A Lifespan Partner | Antineoplastic combination comprising an inhibitor of angiogenesis and an inhibitor of dna topoisomerase i enzyme activity |
US6395541B1 (en) | 1996-05-23 | 2002-05-28 | The Rockefeller University | Methods for the identification of compounds capable of inhibiting HIV-1 viral replication employing murine cell lines expressing human topoisomerase I |
US7854933B2 (en) | 2000-03-27 | 2010-12-21 | Thmoas Jefferson University | Compositions and methods for identifying and targeting cancer cells of alimentary canal origin |
WO2011154574A1 (en) * | 2010-06-08 | 2011-12-15 | Consejo Superior De Investigaciones Científicas (Csic) | Camptothecin derivatives as antitumoural agents |
CN102659800A (en) * | 2012-05-11 | 2012-09-12 | 中国药科大学 | Hypoxia-activated antitumor compounds and application thereof |
US8771963B2 (en) | 2005-07-27 | 2014-07-08 | Oncotherapy Science, Inc. | Method of diagnosing esophageal cancer |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
-
1992
- 1992-02-07 KR KR1019930702492A patent/KR930702985A/en not_active Application Discontinuation
- 1992-02-07 EP EP19920908199 patent/EP0572563A4/en not_active Withdrawn
- 1992-02-07 AU AU15406/92A patent/AU664172B2/en not_active Ceased
- 1992-02-07 JP JP4507807A patent/JPH06505487A/en active Pending
- 1992-02-07 CA CA002104449A patent/CA2104449A1/en not_active Abandoned
- 1992-02-07 WO PCT/US1992/001029 patent/WO1992014470A1/en not_active Application Discontinuation
- 1992-02-21 PT PT100154A patent/PT100154A/en not_active Application Discontinuation
- 1992-02-21 MX MX9200725A patent/MX9200725A/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
Non-Patent Citations (1)
Title |
---|
See also references of EP0572563A4 * |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6395541B1 (en) | 1996-05-23 | 2002-05-28 | The Rockefeller University | Methods for the identification of compounds capable of inhibiting HIV-1 viral replication employing murine cell lines expressing human topoisomerase I |
US9429576B2 (en) | 1997-03-12 | 2016-08-30 | Thomas Jefferson University | Compositions and methods for identifying and targeting cancer cells of alimentary canal origin |
US8946168B2 (en) | 1997-03-12 | 2015-02-03 | Thomas Jefferson University | Compositions and methods for identifying and targeting cancer cells of alimentary canal origin |
WO2001066144A2 (en) * | 2000-03-08 | 2001-09-13 | Rhode Island Hospital, A Lifespan Partner | Antineoplastic combination comprising an inhibitor of angiogenesis and an inhibitor of dna topoisomerase i enzyme activity |
WO2001066144A3 (en) * | 2000-03-08 | 2002-03-28 | Rhode Island Hosp Lifespan Ptr | Antineoplastic combination comprising an inhibitor of angiogenesis and an inhibitor of dna topoisomerase i enzyme activity |
US6849599B2 (en) | 2000-03-08 | 2005-02-01 | Rhode Island Hospital | Combination drug therapy |
US7854933B2 (en) | 2000-03-27 | 2010-12-21 | Thmoas Jefferson University | Compositions and methods for identifying and targeting cancer cells of alimentary canal origin |
US8067007B2 (en) | 2000-03-27 | 2011-11-29 | Thomas Jefferson University | Compositions and methods for identifying and targeting cancer cells of alimentary canal origin |
US8771963B2 (en) | 2005-07-27 | 2014-07-08 | Oncotherapy Science, Inc. | Method of diagnosing esophageal cancer |
ES2371171A1 (en) * | 2010-06-08 | 2011-12-28 | Consejo Superior De Investigaciones Científicas (Csic) | Camptothecin derivatives as antitumoural agents |
WO2011154574A1 (en) * | 2010-06-08 | 2011-12-15 | Consejo Superior De Investigaciones Científicas (Csic) | Camptothecin derivatives as antitumoural agents |
CN102659800A (en) * | 2012-05-11 | 2012-09-12 | 中国药科大学 | Hypoxia-activated antitumor compounds and application thereof |
CN102659800B (en) * | 2012-05-11 | 2014-09-03 | 中国药科大学 | Hypoxia-activated antitumor compounds and application thereof |
Also Published As
Publication number | Publication date |
---|---|
CA2104449A1 (en) | 1992-08-22 |
EP0572563A4 (en) | 1993-12-29 |
PT100154A (en) | 1993-05-31 |
EP0572563A1 (en) | 1993-12-08 |
MX9200725A (en) | 1992-09-01 |
JPH06505487A (en) | 1994-06-23 |
KR930702985A (en) | 1993-11-29 |
AU1540692A (en) | 1992-09-15 |
AU664172B2 (en) | 1995-11-09 |
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