WO1992008710A1 - Process for the preparation of difluoromaleic anhydride and intermediate compounds produced thereby - Google Patents
Process for the preparation of difluoromaleic anhydride and intermediate compounds produced thereby Download PDFInfo
- Publication number
- WO1992008710A1 WO1992008710A1 PCT/US1990/006693 US9006693W WO9208710A1 WO 1992008710 A1 WO1992008710 A1 WO 1992008710A1 US 9006693 W US9006693 W US 9006693W WO 9208710 A1 WO9208710 A1 WO 9208710A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dihydrothiophene
- temperature
- sulfur trioxide
- hexafluoro
- reaction
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
- C07C51/305—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with sulfur or sulfur-containing compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/54—Preparation of carboxylic acid anhydrides
Definitions
- the present invention relates to a process for the preparation of difluoromaleic anhydride. More particularly, this invention relates to reacting sulfur trioxide with certain fluorinated precursors to produce difluoromaleic anhydride or intermediates thereof. . BACKGROUND OF THE INVENTION
- U. S. Patent 2,891,968 describes the preparation of difluoromaleic anhydride by the dehydration of difluoromaleic acid, which in turn is obtained by the dehydrofluorination of trifluorosuccinic acid. The present invention represents an improvement over this preparation with respect to ease of synthesis of the difluoromaleic anhydride.
- Khim., vol. 8, pp. 2165-2167 (1972) obtained difluoromaleic acid (which can be converted to the anhydride, see U. S. Patent 2,891,968, supra) in 54% yield by treatment of pentafluorophenol with peroxyacetic acid.
- Difluoromaleic acid was also obtained by analogous reactions of tetrafluoro-p- or tetrafluoro-o- benzoquinone, tetrafluoropyrocatechol and tetrafluoro- muconic acid.
- the preparation of this reference requires the oxidation of a fluorophenol, which is not necessary to the present procedure.
- Difluoromaleic anhydride is useful for the capping of polyimide prepolymers and polymers (U.S. Patent 4,173,700), as a "cure site" monomer in fluoropolymers (D. S. Patents 3,792,022 and 3,761,453) and as a comonomer with phenyl vinyl ether to form an alternating copolyraer (G. Canessa C, Bol. Soc. Chil. Quim., vol. 26, pp. 25-37).
- German Patent 2,649,743 it is used as a component of an antifouling coating. It is used as a chemical intermediate in the preparation of biologically active compounds in ⁇ . S. Patents 3,485,829 and 3,485,827.
- a feature of the present invention is the production of usef l intermediate compounds.
- a process for the production of difluoromaleic anhydride comprising reacting sulfur trioxide with a fluorinated precursor, selected from the group consisting of hexafluoro-2,5-dihydrofuran, hexafluoro-2,5-dihydrothiophene, difluoro-2,5- dihydrothiophene-2,5-dione and tetrafluoro-2,5- dihydrothiophene-2-one.
- a fluorinated precursor selected from the group consisting of hexafluoro-2,5-dihydrofuran, hexafluoro-2,5-dihydrothiophene, difluoro-2,5- dihydrothiophene-2,5-dione and tetrafluoro-2,5- dihydrothiophene-2-one.
- a fluorinated precursor selected from the group consisting of hexafluoro-2,5-dihydrofuran
- Difluoromaleic anhydride is prepared by the reaction of sulfur trioxide (SO 3 ) with a fluorinated precursor selected from the group consisting of hexafluoro-2,5-dihydrofuran, hexafluoro-2,5- dihydrothiophene, difluoro-2,5-dihydrothiophene-2,5- dione and tetrafluoro-2,5-dihydrothiophene-2-one.
- the sulfur trioxide is preferably present as SO 3 alone, or it may be present in solution in sulfuric acid, commonly known as oleum. Usually at least about 3 moles of SO 3 are present for each mole of fluorinated precursor.
- Hexafluoro-2,5-dihydrofuran can be prepared by the method of W. J. Feast, et. al., J. Chem. Soc. C, vol. 1971, pp. 769-772.
- U. S. Patent 3,069,431 reports a method for the synthesis of hexafluoro-2,5- dihydrothiophene. The precursor for the thiophene, hexafluorocyclobutene, is commercially available.
- Both difluoro-2,5-dihydrothiophene-2,5-dione and tetrafluoro-2,5-dihydrothiophene-2-one are made by the reaction of SO 3 with hexafluoro-2,5-dihyrothiophene (Example 3, infra) .
- reaction of the hexafluoro- 2,5-dihydrothiophene with SO 3 under reaction conditions less vigorous than those reported herein that produce difluoromaleic anhydride will produce difluoro-2,5- dihydrothiophene-2,5-dione and/or tetrafluoro-2,5- dihydrothiophene-2-one.
- reaction of hexafluoro-2,5-dihydrothiophene with SO 3 to produce difluoromaleic anhydride reaction of either difluoro-2,5-dihydrothiophene-2,5-dione or tetrafluoro- 2,5-dihydrothiophene-2-one with SO 3 under conditions described herein will yield difluoromaleic anhydride.
- Compounds containing trivalent boron may optionally be added as catalysts to accelerate the formation of difluoromaleic anhydride. They are especially useful at relatively low reaction temperatures.
- Active catalysts include, but are not limited to trimethyl borate, boron
- the amount of boron catalyst used is preferably about 0.5 to about 5 weight percent of the SO 3 present.
- reaction to produce difluoromaleic anhydride is run at 25-200°C, preferably 50-100°C. Reaction times
- reaction 25 typically vary from about 0.5-24 hr., the longer times being needed at lower temperatures. Reactions may be run at atmospheric pressure, but to achieve higher reaction temperatures, the reaction can be run under pressure,' typically up to about 20 atm.
- starting materials and products may be present, but it is preferred to conduct the reaction in the absence of solvent. Water should be excluded to a reasonable extent, thus starting materials should be dry and moist air should be excluded from the reaction. Reaction vessels should be inert to the starting materials and products. Glass and alloys such as stainless steel and Hastelloy®, a trademark of Stoody
- Deloro Stellite, Inc. are suitable for reaction vessels.
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3500581A JPH06501675A (en) | 1990-11-15 | 1990-11-15 | Method for producing difluoromaleic anhydride and intermediate compound for producing the same |
EP90917387A EP0557272B1 (en) | 1990-11-15 | 1990-11-15 | Process for the preparation of difluoromaleic anhydride and intermediate compounds produced thereby |
DE69017720T DE69017720T2 (en) | 1990-11-15 | 1990-11-15 | METHOD FOR PRODUCING DIFLUORMALIC ACID ANHYDRIDE AND INTERMEDIATE PRODUCTS PRODUCED THEREOF. |
PCT/US1990/006693 WO1992008710A1 (en) | 1990-11-15 | 1990-11-15 | Process for the preparation of difluoromaleic anhydride and intermediate compounds produced thereby |
CA002095641A CA2095641A1 (en) | 1990-11-15 | 1990-11-15 | Process or the preparation of difluoromaleic anhydride and intermediate compounds produced thereby |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1990/006693 WO1992008710A1 (en) | 1990-11-15 | 1990-11-15 | Process for the preparation of difluoromaleic anhydride and intermediate compounds produced thereby |
CA002095641A CA2095641A1 (en) | 1990-11-15 | 1990-11-15 | Process or the preparation of difluoromaleic anhydride and intermediate compounds produced thereby |
Publications (1)
Publication Number | Publication Date |
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WO1992008710A1 true WO1992008710A1 (en) | 1992-05-29 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/US1990/006693 WO1992008710A1 (en) | 1990-11-15 | 1990-11-15 | Process for the preparation of difluoromaleic anhydride and intermediate compounds produced thereby |
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WO (1) | WO1992008710A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4446646A1 (en) * | 1994-12-19 | 1996-06-20 | Teledrive Telematik Im Verkehr | Motor vehicle unit for system for collecting tolls automatically |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1282893A (en) * | 1961-02-27 | 1962-01-27 | Inst Chemii Ogolnej | Process for obtaining nicotinic and isonicotinic acids from pyridine bases as well as from chinoline and its derivatives |
DE1290551B (en) * | 1965-06-22 | 1969-03-13 | Hoechst Ag | Process for the preparation of 3, 4-dichlorothiacyclopentene-2, 5-dione |
US4067887A (en) * | 1976-08-12 | 1978-01-10 | Vadim Dmitrievich Simonov | Method of preparing dichloromaleic anhydride |
-
1990
- 1990-11-15 WO PCT/US1990/006693 patent/WO1992008710A1/en active IP Right Grant
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1282893A (en) * | 1961-02-27 | 1962-01-27 | Inst Chemii Ogolnej | Process for obtaining nicotinic and isonicotinic acids from pyridine bases as well as from chinoline and its derivatives |
DE1290551B (en) * | 1965-06-22 | 1969-03-13 | Hoechst Ag | Process for the preparation of 3, 4-dichlorothiacyclopentene-2, 5-dione |
US4067887A (en) * | 1976-08-12 | 1978-01-10 | Vadim Dmitrievich Simonov | Method of preparing dichloromaleic anhydride |
Non-Patent Citations (1)
Title |
---|
Journal of the Chemical Society (C), 1971, W.J. Feast et al.: "Fluorination of Perchloro-2,5-dihydrofuran", pages 769-772 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4446646A1 (en) * | 1994-12-19 | 1996-06-20 | Teledrive Telematik Im Verkehr | Motor vehicle unit for system for collecting tolls automatically |
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