WO1992008710A1 - Process for the preparation of difluoromaleic anhydride and intermediate compounds produced thereby - Google Patents

Process for the preparation of difluoromaleic anhydride and intermediate compounds produced thereby Download PDF

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Publication number
WO1992008710A1
WO1992008710A1 PCT/US1990/006693 US9006693W WO9208710A1 WO 1992008710 A1 WO1992008710 A1 WO 1992008710A1 US 9006693 W US9006693 W US 9006693W WO 9208710 A1 WO9208710 A1 WO 9208710A1
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dihydrothiophene
temperature
sulfur trioxide
hexafluoro
reaction
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PCT/US1990/006693
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French (fr)
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Carl George Krespan
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E.I. Du Pont De Nemours And Company
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Priority to JP3500581A priority Critical patent/JPH06501675A/en
Priority to EP90917387A priority patent/EP0557272B1/en
Priority to DE69017720T priority patent/DE69017720T2/en
Priority to PCT/US1990/006693 priority patent/WO1992008710A1/en
Priority to CA002095641A priority patent/CA2095641A1/en
Priority claimed from CA002095641A external-priority patent/CA2095641A1/en
Publication of WO1992008710A1 publication Critical patent/WO1992008710A1/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30Hetero atoms other than halogen
    • C07D333/32Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/305Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with sulfur or sulfur-containing compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/54Preparation of carboxylic acid anhydrides

Definitions

  • the present invention relates to a process for the preparation of difluoromaleic anhydride. More particularly, this invention relates to reacting sulfur trioxide with certain fluorinated precursors to produce difluoromaleic anhydride or intermediates thereof. . BACKGROUND OF THE INVENTION
  • U. S. Patent 2,891,968 describes the preparation of difluoromaleic anhydride by the dehydration of difluoromaleic acid, which in turn is obtained by the dehydrofluorination of trifluorosuccinic acid. The present invention represents an improvement over this preparation with respect to ease of synthesis of the difluoromaleic anhydride.
  • Khim., vol. 8, pp. 2165-2167 (1972) obtained difluoromaleic acid (which can be converted to the anhydride, see U. S. Patent 2,891,968, supra) in 54% yield by treatment of pentafluorophenol with peroxyacetic acid.
  • Difluoromaleic acid was also obtained by analogous reactions of tetrafluoro-p- or tetrafluoro-o- benzoquinone, tetrafluoropyrocatechol and tetrafluoro- muconic acid.
  • the preparation of this reference requires the oxidation of a fluorophenol, which is not necessary to the present procedure.
  • Difluoromaleic anhydride is useful for the capping of polyimide prepolymers and polymers (U.S. Patent 4,173,700), as a "cure site" monomer in fluoropolymers (D. S. Patents 3,792,022 and 3,761,453) and as a comonomer with phenyl vinyl ether to form an alternating copolyraer (G. Canessa C, Bol. Soc. Chil. Quim., vol. 26, pp. 25-37).
  • German Patent 2,649,743 it is used as a component of an antifouling coating. It is used as a chemical intermediate in the preparation of biologically active compounds in ⁇ . S. Patents 3,485,829 and 3,485,827.
  • a feature of the present invention is the production of usef l intermediate compounds.
  • a process for the production of difluoromaleic anhydride comprising reacting sulfur trioxide with a fluorinated precursor, selected from the group consisting of hexafluoro-2,5-dihydrofuran, hexafluoro-2,5-dihydrothiophene, difluoro-2,5- dihydrothiophene-2,5-dione and tetrafluoro-2,5- dihydrothiophene-2-one.
  • a fluorinated precursor selected from the group consisting of hexafluoro-2,5-dihydrofuran, hexafluoro-2,5-dihydrothiophene, difluoro-2,5- dihydrothiophene-2,5-dione and tetrafluoro-2,5- dihydrothiophene-2-one.
  • a fluorinated precursor selected from the group consisting of hexafluoro-2,5-dihydrofuran
  • Difluoromaleic anhydride is prepared by the reaction of sulfur trioxide (SO 3 ) with a fluorinated precursor selected from the group consisting of hexafluoro-2,5-dihydrofuran, hexafluoro-2,5- dihydrothiophene, difluoro-2,5-dihydrothiophene-2,5- dione and tetrafluoro-2,5-dihydrothiophene-2-one.
  • the sulfur trioxide is preferably present as SO 3 alone, or it may be present in solution in sulfuric acid, commonly known as oleum. Usually at least about 3 moles of SO 3 are present for each mole of fluorinated precursor.
  • Hexafluoro-2,5-dihydrofuran can be prepared by the method of W. J. Feast, et. al., J. Chem. Soc. C, vol. 1971, pp. 769-772.
  • U. S. Patent 3,069,431 reports a method for the synthesis of hexafluoro-2,5- dihydrothiophene. The precursor for the thiophene, hexafluorocyclobutene, is commercially available.
  • Both difluoro-2,5-dihydrothiophene-2,5-dione and tetrafluoro-2,5-dihydrothiophene-2-one are made by the reaction of SO 3 with hexafluoro-2,5-dihyrothiophene (Example 3, infra) .
  • reaction of the hexafluoro- 2,5-dihydrothiophene with SO 3 under reaction conditions less vigorous than those reported herein that produce difluoromaleic anhydride will produce difluoro-2,5- dihydrothiophene-2,5-dione and/or tetrafluoro-2,5- dihydrothiophene-2-one.
  • reaction of hexafluoro-2,5-dihydrothiophene with SO 3 to produce difluoromaleic anhydride reaction of either difluoro-2,5-dihydrothiophene-2,5-dione or tetrafluoro- 2,5-dihydrothiophene-2-one with SO 3 under conditions described herein will yield difluoromaleic anhydride.
  • Compounds containing trivalent boron may optionally be added as catalysts to accelerate the formation of difluoromaleic anhydride. They are especially useful at relatively low reaction temperatures.
  • Active catalysts include, but are not limited to trimethyl borate, boron
  • the amount of boron catalyst used is preferably about 0.5 to about 5 weight percent of the SO 3 present.
  • reaction to produce difluoromaleic anhydride is run at 25-200°C, preferably 50-100°C. Reaction times
  • reaction 25 typically vary from about 0.5-24 hr., the longer times being needed at lower temperatures. Reactions may be run at atmospheric pressure, but to achieve higher reaction temperatures, the reaction can be run under pressure,' typically up to about 20 atm.
  • starting materials and products may be present, but it is preferred to conduct the reaction in the absence of solvent. Water should be excluded to a reasonable extent, thus starting materials should be dry and moist air should be excluded from the reaction. Reaction vessels should be inert to the starting materials and products. Glass and alloys such as stainless steel and Hastelloy®, a trademark of Stoody
  • Deloro Stellite, Inc. are suitable for reaction vessels.

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A process for producing difluoromaleic anhydride by reacting sulfur trioxide with a fluorinated precursor selected from the group consisting of hexafluoro-2,5-dihydrofuran, hexafluoro-2,5-dihydrothiophene, difluoro-2,5-dihydrothiophene-2,5-dione and tetrafluoro-2,5-dihydrothiophene-2-one. Also disclosed are the compounds difluoro-2,5-dihydrothiophene-2,5-dione and tetrafluoro-2,5-dihydrothiophene-2-one.

Description

TITLE PROCESS FOR THE PREPARATION OF DIFLUOROMALEIC ANHYDRIDE AND INTERMEDIATE COMPOUNDS PRODUCED THEREBY
FIELD OF INVENTION The present invention relates to a process for the preparation of difluoromaleic anhydride. More particularly, this invention relates to reacting sulfur trioxide with certain fluorinated precursors to produce difluoromaleic anhydride or intermediates thereof. . BACKGROUND OF THE INVENTION U. S. Patent 2,891,968 describes the preparation of difluoromaleic anhydride by the dehydration of difluoromaleic acid, which in turn is obtained by the dehydrofluorination of trifluorosuccinic acid. The present invention represents an improvement over this preparation with respect to ease of synthesis of the difluoromaleic anhydride. L. S. Kobrina, et. al., Zh. Org. Khim., vol. 8, pp. 2165-2167 (1972) obtained difluoromaleic acid (which can be converted to the anhydride, see U. S. Patent 2,891,968, supra) in 54% yield by treatment of pentafluorophenol with peroxyacetic acid. Difluoromaleic acid was also obtained by analogous reactions of tetrafluoro-p- or tetrafluoro-o- benzoquinone, tetrafluoropyrocatechol and tetrafluoro- muconic acid. However, the preparation of this reference requires the oxidation of a fluorophenol, which is not necessary to the present procedure.
C. G. Krespan and and D. A. Dixon, J. Org. Chem., vol. 51, pp. 4460-4466 (1986) describe the reaction of SO3 with perfluoro-2-butene. In this reaction only one of the terminal carbons reacted to form a carbonyl group, yielding the compound CF3CF=CFCθ22F in relatively low yields even though high reaction temperatures and long reaction times were used. A small amount (0.05%) of trimethyl borate was present as a stabilizer in the SO3 used. The use of boron compounds as catalysts is discussed in this paper. However, neither difluoromaleic anhydride nor difluoromaleic acid are produced in the reviewed reactions.
Difluoromaleic anhydride is useful for the capping of polyimide prepolymers and polymers (U.S. Patent 4,173,700), as a "cure site" monomer in fluoropolymers (D. S. Patents 3,792,022 and 3,761,453) and as a comonomer with phenyl vinyl ether to form an alternating copolyraer (G. Canessa C, Bol. Soc. Chil. Quim., vol. 26, pp. 25-37). In German Patent 2,649,743 it is used as a component of an antifouling coating. It is used as a chemical intermediate in the preparation of biologically active compounds in ϋ. S. Patents 3,485,829 and 3,485,827.
It is an object of the present invention to provide a one step process for the production of difluoromaleic anhydride from commonly available starting materials. A feature of the present invention is the production of usef l intermediate compounds. It is an advantage of the present invention to provide catalysts for the reaction to facilitate commercial scale production of difluoromaleic anhydride. These and other objects, features and advantages of the present invention will become apparent upon having reference to the following description of the invention. SUMMARY OF THE INVENTION
A process for the production of difluoromaleic anhydride is provided, comprising reacting sulfur trioxide with a fluorinated precursor, selected from the group consisting of hexafluoro-2,5-dihydrofuran, hexafluoro-2,5-dihydrothiophene, difluoro-2,5- dihydrothiophene-2,5-dione and tetrafluoro-2,5- dihydrothiophene-2-one. Usually at least about 3 moles of sulfur trioxide is used for each mole of fluorinated precursor used. The reaction may optionally be catalyzed by trivalent boron compounds. Also provided are the compounds difluoro-2,5-dihydrothiophene-2, 5- dione and tetrafluoro-2,5-dihydrothiophene-2-one which are useful as intermediates in the production of difluoromaleic anhydride. DETAILS OF THE INVENTION
Difluoromaleic anhydride is prepared by the reaction of sulfur trioxide (SO3) with a fluorinated precursor selected from the group consisting of hexafluoro-2,5-dihydrofuran, hexafluoro-2,5- dihydrothiophene, difluoro-2,5-dihydrothiophene-2,5- dione and tetrafluoro-2,5-dihydrothiophene-2-one. The sulfur trioxide is preferably present as SO3 alone, or it may be present in solution in sulfuric acid, commonly known as oleum. Usually at least about 3 moles of SO3 are present for each mole of fluorinated precursor. Although no upper limit on the molar ratio of SO3 to fluorinated precursor is known, molar ratios of SO3 to fluorinated precursor of about 3 to about 10 are preferred. Hexafluoro-2,5-dihydrofuran can be prepared by the method of W. J. Feast, et. al., J. Chem. Soc. C, vol. 1971, pp. 769-772. U. S. Patent 3,069,431 reports a method for the synthesis of hexafluoro-2,5- dihydrothiophene. The precursor for the thiophene, hexafluorocyclobutene, is commercially available.
Both difluoro-2,5-dihydrothiophene-2,5-dione and tetrafluoro-2,5-dihydrothiophene-2-one are made by the reaction of SO3 with hexafluoro-2,5-dihyrothiophene (Example 3, infra) . Thus reaction of the hexafluoro- 2,5-dihydrothiophene with SO3 under reaction conditions less vigorous than those reported herein that produce difluoromaleic anhydride will produce difluoro-2,5- dihydrothiophene-2,5-dione and/or tetrafluoro-2,5- dihydrothiophene-2-one. Less vigorous conditions 5 include one or more of lower reaction temperatures, shorter reaction times, lesser amounts of SO3 and the absence of catalysts. Since difluoro-2,5- dihydrothiophene-2,5-dione and tetrafluoro-2,5- dihydrothiophene-2-one are both intermediates in the
10 reaction of hexafluoro-2,5-dihydrothiophene with SO3 to produce difluoromaleic anhydride, reaction of either difluoro-2,5-dihydrothiophene-2,5-dione or tetrafluoro- 2,5-dihydrothiophene-2-one with SO3 under conditions described herein will yield difluoromaleic anhydride.
15 Compounds containing trivalent boron may optionally be added as catalysts to accelerate the formation of difluoromaleic anhydride. They are especially useful at relatively low reaction temperatures. Active catalysts include, but are not limited to trimethyl borate, boron
20 trifluoride, boric oxide and boron trichloride. The amount of boron catalyst used is preferably about 0.5 to about 5 weight percent of the SO3 present.
The reaction to produce difluoromaleic anhydride is run at 25-200°C, preferably 50-100°C. Reaction times
25 typically vary from about 0.5-24 hr., the longer times being needed at lower temperatures. Reactions may be run at atmospheric pressure, but to achieve higher reaction temperatures, the reaction can be run under pressure,' typically up to about 20 atm. A solvent inert
30 to the starting materials and products may be present, but it is preferred to conduct the reaction in the absence of solvent. Water should be excluded to a reasonable extent, thus starting materials should be dry and moist air should be excluded from the reaction. Reaction vessels should be inert to the starting materials and products. Glass and alloys such as stainless steel and Hastelloy®, a trademark of Stoody
Deloro Stellite, Inc., are suitable for reaction vessels.
Products may be isolated by standard methods known to those skilled in the art such as distillation and crystallization. Such methods are illustrated in the Examples. EXAMPLE 1
Preparation of Difluoromaleic Anhydride from Hexafluoro-2.5-dihvdrofuran Sulfur trioxide (336 g, 4.2 mol) was stirred at 25°C while 83 g (0.47 mol) of hexafluoro-2,5- dihydrofuran was distilled in. No interaction was apparent while the temperature dropped to 15°C and the SO3 solidified. Addition of 1 g of trimethyl borate initiate. reaction, which was allowed to progress overnight. Then another 42 g (0.24 mol) of hexafluoro- 2,5-dihydrofuran was added, and the mixture was refluxed for 12 hr. while the temperature rose to 92°C. Distillation afforded, after a large foreshot, 69.0 g (74%) of crude difluoromaleic anhydride, bp 100-125°C. Redistillation gave 50.0 g (53%) of difluoromaleic anhydride, bp 125-126°C. IR (1% in CHCI3) : 1880 (w) , 1815 (s) and 1760 (m) (OO, OC) , 1290 and 1185 cm"1 (C-F) NMR (acetone-dβ) : 19F0 -141.2 (s, =CF) . UV: ε isooctane/235 nm 3,176.
Confirmation of the structure was obtained when the anilide was prepared by adding 2.9 g (0.022 mol) of difluoromaleic anhydride to a solution of 1.9 g (0.020 mol) of aniline in 100 ml of ether. The mixture was stirred for 15 min., filtered, and the filter cake dried to give 4.0 g (88%) of anilide, mp 192-193°C (literature mp 193-195°C) . NMR (acetone-dβ) : 19F0 - 124.9 ( , IF, =CF) , -132.8 (d, JFF4.7 Hz, IF, (=CF) .
EXAMPLE 2 Preparation of Difluoromaleic Anhydride 5 f om Hexafluoro-2,5-dihvdrothiophβne
Commercial sulfur trioxide (176 g, 2.20 mol) was treated cautiously with 2.0 g of trimethyl borate, and the mixture was stirred while 72.9 g (0.38 mol) of hexafluoro-2,5-dihydrothiophene was added over 30 min. 10 A mildly exothermic reaction caused reflux. The mixture was stirred 1 hr. while the temperature came down and then was heated to 60°C where a second exotherm was accompanied with pronounced gassing. A sample of the off-gases was shown by IR to be SO2 with a minor amount 15 of FSO2OSO2F present. Reaction was continued at 60-65°C until gas evolution subsided, then at reflux for 2 hr. while the pot temperature fell from 90°C to 80°C. Distillation gave a large foreshot, bp 40-100°C followed by 37.0 g (73%) of crude difluoromaleic anhydride, bp 20 100-125°C, nearly pure by GC. The IR spectrum was substantially the same as that of a known sample.
EXAMPLE 3 Preparation of Tetra luoro-2.5-dihvdro- thiophene-2-one and Difluoro-2.5- 25 tiihytirPthiPPhene-2 ,5-d pne
Sulfur trioxide (128.0 g, 1.60 mol) was added rapidly to 77.6 g (0.40 mol) of hexafluoro-2,5- dihydrothiophene. After an initial exotherm, the mixture was refluxed for 30 min. and fractionated to 30 give 121.9 g, bp 42-55°C, shown to be mainly pyrosulfuryl fluoride by 19F NMR, and 29.5 g of crude tetrafluoro-2,5-dihydrothiophene, bp 77-85°C. Redistillation of this product afforded 16.9 g (25%) of tetrafluoro-2,5-dihydrothiophene-2-one, bp 83°C. IR 35 (CCI4) : 1755 (OO) and 1740 cm"1(OC) . NMR (CCI4) : 19F0 -92.0 (d of d, JFF14.7, 5.5 Hz, 2F, CF2) , -133.5 (q, JFF14.3 Hz, IF, CF), -144.3 (d of t, JFF13.9, 5.5 Hz, IF, CF) . MS: m/e 171.9615 (M+; calcd for C4F4OS, 171.9606), 143.9664 (M+ -CO; cald, 143,9657), 121.9641 (M+ -CF2; calcd, 121.9638) . Anal. Calcd for C4F4OS: C, 27.91; S, 18.63 Found: C, 28.27; S, 19.16.
Further distillation of the reaction mixture afforded 32.6 g of crude difluoro-2,5-dihydrothiophene- 2,5-dione bp 80-86°C (100 mm), which solidified on standing. Recrystallization from hexane/ether followed by sublimation at 45-50°C (10 mm) gave 12.7 g of nearly colorless difluoro-2,5-dihydrothiophene-2,5-dione, mp 57-58°C. Evaporation of the filtrate and sublimation at 40°C (10 mm) gave an additional 4.7 g of difluoro-2,5- dihydrothiophene-2,5-dione, mp 52-56°C, for a total yield of 17.4 g (29%). An analytical sample, mp 58-59°C, was prepared by sublimation at 30°C (10 mm) . IR (CCI4) : 1760 (w) and 1715 (s) cm'1 (OO and OC) . NMR (CCI4) : 19F0 -132.2 (s, CF) . Anal. Calcd for C4F202S: C, 32.00; S, 21.36. Found: C, 32.81; S, 21.64.
Although preferred embodiments of the invention have been described hereinabove, it is to be understood that there is no attempt to limit the invention to the precise constructions herein disclosed, and it is to be further understood that the right is reserved to all changes coming within the scope of the invention as defined by the appended claims.

Claims

CLAIMS What is claimed is:
1. A process for the production of difluoromaleic anhydride, comprising, reacting sulfur trioxide with a fluorinated precursor selected from the group consisting of hexafluoro-2,5-dihydrofuran, hexafluoro-2,5- dihydrothiophene, difluor o-2,5-dihydrothiophene-2,5- dione and tetrafluor o-2,5-dihydrothiophene-2-one.
2. The process of Claim 1 wherein the molar ratio of said sulfur trioxide to said fluorinated precursor is at least about 3.
3. The process of Claim 2 wherein said molar ratio is about 3 to about 10.
4. The process of Claim 1 wherein the temperature is about 25°C to about 200°C.
5. The process of Claim 4 wherein the temperature is about 50°C to about 100°C.
6. The process of Claim 3 wherein the temperature is about 25°C to about 200°C.
7. The process of Claim 6 wherein the temperature is about 50°C to about 100°C.
8. The process of Claim 1 wherein a compound containing trivalent boron is present as a catalyst.
9. The process of Claim 8 wherein the amount of said catalyst present is about 0.5% to 5% by weight of said sulfur trioxide.
10. The process of Claim 8 wherein said catalyst is selected from the group consisting of trimethyl borate, boron trifluoride, boric oxide and boron trichloride.
11. The process of Claim 3 wherein a compound containing trivalent boron is present as a catalyst.
12. The process of Claim 11 wherein the amount of said catalyst present is about 0.5% to 5% by weight of said sulfur trioxide. *
13. The process of Claim 11 wherein said catalyst
5 is selected from the group consisting of trimethyl " borate, boron trifluoride, boric oxide and boron trichloride.
14. The process of Claim 8 wherein the temperature is about 25°C to about 200°C. 10
15. The process of Claim 14 wherein the temperature is about 50°C to about 100°C.
16. The process of Claim 11 wherein the temperature is about 25°C to about 200°C.
17. The process of Claim 16 wherein the 15 temperature is about 50°C to about 100°C.
18 . The process of Claim 12 wherein the temperature is about 25°C to about 200°C.
19. The process of Claim 18 wherein the temperature is about 50°C to about 100°C.
20 20. The process of Claim 1 wherein said sulfur trioxide is added as oleum.
21. The process of Claim 3 wherein said sulfur trioxide is added as oleum.
22. The process of Claim 1 wherein the pressure is 25 about 1 to about 20 atmospheres.
23. The compound difluoro-2,5-dihydrothiophene- 2,5-dione.
24. The compound tetrafluoro-2,5-dihydrothiophene- 2-one.
30
35
PCT/US1990/006693 1990-11-15 1990-11-15 Process for the preparation of difluoromaleic anhydride and intermediate compounds produced thereby WO1992008710A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP3500581A JPH06501675A (en) 1990-11-15 1990-11-15 Method for producing difluoromaleic anhydride and intermediate compound for producing the same
EP90917387A EP0557272B1 (en) 1990-11-15 1990-11-15 Process for the preparation of difluoromaleic anhydride and intermediate compounds produced thereby
DE69017720T DE69017720T2 (en) 1990-11-15 1990-11-15 METHOD FOR PRODUCING DIFLUORMALIC ACID ANHYDRIDE AND INTERMEDIATE PRODUCTS PRODUCED THEREOF.
PCT/US1990/006693 WO1992008710A1 (en) 1990-11-15 1990-11-15 Process for the preparation of difluoromaleic anhydride and intermediate compounds produced thereby
CA002095641A CA2095641A1 (en) 1990-11-15 1990-11-15 Process or the preparation of difluoromaleic anhydride and intermediate compounds produced thereby

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PCT/US1990/006693 WO1992008710A1 (en) 1990-11-15 1990-11-15 Process for the preparation of difluoromaleic anhydride and intermediate compounds produced thereby
CA002095641A CA2095641A1 (en) 1990-11-15 1990-11-15 Process or the preparation of difluoromaleic anhydride and intermediate compounds produced thereby

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4446646A1 (en) * 1994-12-19 1996-06-20 Teledrive Telematik Im Verkehr Motor vehicle unit for system for collecting tolls automatically

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1282893A (en) * 1961-02-27 1962-01-27 Inst Chemii Ogolnej Process for obtaining nicotinic and isonicotinic acids from pyridine bases as well as from chinoline and its derivatives
DE1290551B (en) * 1965-06-22 1969-03-13 Hoechst Ag Process for the preparation of 3, 4-dichlorothiacyclopentene-2, 5-dione
US4067887A (en) * 1976-08-12 1978-01-10 Vadim Dmitrievich Simonov Method of preparing dichloromaleic anhydride

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1282893A (en) * 1961-02-27 1962-01-27 Inst Chemii Ogolnej Process for obtaining nicotinic and isonicotinic acids from pyridine bases as well as from chinoline and its derivatives
DE1290551B (en) * 1965-06-22 1969-03-13 Hoechst Ag Process for the preparation of 3, 4-dichlorothiacyclopentene-2, 5-dione
US4067887A (en) * 1976-08-12 1978-01-10 Vadim Dmitrievich Simonov Method of preparing dichloromaleic anhydride

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Journal of the Chemical Society (C), 1971, W.J. Feast et al.: "Fluorination of Perchloro-2,5-dihydrofuran", pages 769-772 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4446646A1 (en) * 1994-12-19 1996-06-20 Teledrive Telematik Im Verkehr Motor vehicle unit for system for collecting tolls automatically

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