WO1992008697A3 - 9-HALOGEN-11β-HYDROXY PROSTAGLANDIN DERIVATIVE, PROCESS FOR PRODUCING IT AND ITS USE AS A MEDICAMENT - Google Patents
9-HALOGEN-11β-HYDROXY PROSTAGLANDIN DERIVATIVE, PROCESS FOR PRODUCING IT AND ITS USE AS A MEDICAMENT Download PDFInfo
- Publication number
- WO1992008697A3 WO1992008697A3 PCT/DE1991/000881 DE9100881W WO9208697A3 WO 1992008697 A3 WO1992008697 A3 WO 1992008697A3 DE 9100881 W DE9100881 W DE 9100881W WO 9208697 A3 WO9208697 A3 WO 9208697A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- radical
- halogen
- producing
- medicament
- hydroxy prostaglandin
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 150000003254 radicals Chemical class 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- -1 heterocyclic radical Chemical class 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU88726/91A AU650074B2 (en) | 1990-11-09 | 1991-11-08 | 9-halogen-11beta -hydroxy prostaglandin derivative, process for producing it and its use as a medicament |
EP91919671A EP0510154B1 (en) | 1990-11-09 | 1991-11-08 | 9-HALOGEN-11(Beta)-HYDROXY PROSTAGLANDIN DERIVATIVE, PROCESS FOR PRODUCING IT AND ITS USE AS A MEDICAMENT |
DE59105459T DE59105459D1 (en) | 1990-11-09 | 1991-11-08 | 9-HALOGEN-11 (Beta) -HYDROXY-PROSTAGLANDIN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4036140A DE4036140A1 (en) | 1990-11-09 | 1990-11-09 | 9-HALOGEN-11SS-HYDROXY-PROSTAGLANDIN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS |
DEP4036140.3 | 1990-11-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1992008697A2 WO1992008697A2 (en) | 1992-05-29 |
WO1992008697A3 true WO1992008697A3 (en) | 1992-07-23 |
Family
ID=6418184
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE1991/000881 WO1992008697A2 (en) | 1990-11-09 | 1991-11-08 | 9-HALOGEN-11β-HYDROXY PROSTAGLANDIN DERIVATIVE, PROCESS FOR PRODUCING IT AND ITS USE AS A MEDICAMENT |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0510154B1 (en) |
JP (1) | JPH05503713A (en) |
AT (1) | ATE122339T1 (en) |
AU (1) | AU650074B2 (en) |
CA (1) | CA2073462A1 (en) |
DE (2) | DE4036140A1 (en) |
HU (1) | HUT61726A (en) |
WO (1) | WO1992008697A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994005631A1 (en) * | 1992-08-31 | 1994-03-17 | Schering Aktiengesellschaft | 9-chloroprostaglandin esters and amides and their use in the preparation of drugs |
DE4229048A1 (en) * | 1992-08-31 | 1994-03-03 | Schering Ag | New ester(s) of 9-chloro-prostaglandin(s) - useful in treatment of glaucoma and as diuretic agents |
DE4229050A1 (en) * | 1992-08-31 | 1994-03-03 | Schering Ag | New esters and amides of 9-chloro-prostaglandins - useful, e.g., in treatment of glaucoma and as diuretic agents |
AU687906B2 (en) * | 1993-12-15 | 1998-03-05 | Alcon Laboratories, Inc. | Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension |
JP3579448B2 (en) * | 1993-12-29 | 2004-10-20 | 大正製薬株式会社 | Prostaglandin derivatives, salts thereof and uses thereof |
US5807892A (en) * | 1994-09-30 | 1998-09-15 | Alcon Laboratories, Inc. | Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension |
JP2000044477A (en) * | 1998-05-25 | 2000-02-15 | Taisho Pharmaceut Co Ltd | Epilepsy-curing medicine |
DE60043702D1 (en) * | 1999-09-10 | 2010-03-04 | Taisho Pharmaceutical Co Ltd | PROSTAGLANDIN DERIVATIVES |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0030377A1 (en) * | 1979-12-10 | 1981-06-17 | Schering Aktiengesellschaft | 9-Chloro-prostaglandin derivatives, process for their preparation and use as medicines |
WO1989003384A1 (en) * | 1987-10-07 | 1989-04-20 | Pharmacia Ab | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
EP0299914B1 (en) * | 1987-07-17 | 1993-04-07 | Schering Aktiengesellschaft | 9-halogen (z) prostaglandin derivatives, process for their production and their use as medicines |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU624078B2 (en) * | 1987-07-17 | 1992-06-04 | Schering Aktiengesellschaft Berlin Und Bergkamen | 9-halogen-(z)-prostaglandin derivatives, process for manufacturing them, and their use as drugs |
DE4024347A1 (en) * | 1990-07-27 | 1992-01-30 | Schering Ag | CYCLOPENTANE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR PHARMACEUTICAL USE |
-
1990
- 1990-11-09 DE DE4036140A patent/DE4036140A1/en not_active Withdrawn
-
1991
- 1991-11-08 AT AT91919671T patent/ATE122339T1/en not_active IP Right Cessation
- 1991-11-08 CA CA002073462A patent/CA2073462A1/en not_active Abandoned
- 1991-11-08 JP JP3518138A patent/JPH05503713A/en active Pending
- 1991-11-08 HU HU922260A patent/HUT61726A/en unknown
- 1991-11-08 EP EP91919671A patent/EP0510154B1/en not_active Expired - Lifetime
- 1991-11-08 AU AU88726/91A patent/AU650074B2/en not_active Ceased
- 1991-11-08 DE DE59105459T patent/DE59105459D1/en not_active Expired - Lifetime
- 1991-11-08 WO PCT/DE1991/000881 patent/WO1992008697A2/en active IP Right Grant
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0030377A1 (en) * | 1979-12-10 | 1981-06-17 | Schering Aktiengesellschaft | 9-Chloro-prostaglandin derivatives, process for their preparation and use as medicines |
EP0299914B1 (en) * | 1987-07-17 | 1993-04-07 | Schering Aktiengesellschaft | 9-halogen (z) prostaglandin derivatives, process for their production and their use as medicines |
WO1989003384A1 (en) * | 1987-10-07 | 1989-04-20 | Pharmacia Ab | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
Non-Patent Citations (1)
Title |
---|
Prostaglandins, Band 11, Nr. 1, Januar 1976; W.L. MILLER et a.: "Relative biological activity of certain prostaglandis and their enantiomers", Seiten 77-84, siehe Seite 80, Tabelle 1 * |
Also Published As
Publication number | Publication date |
---|---|
EP0510154B1 (en) | 1995-05-10 |
DE59105459D1 (en) | 1995-06-14 |
EP0510154A1 (en) | 1992-10-28 |
AU650074B2 (en) | 1994-06-09 |
ATE122339T1 (en) | 1995-05-15 |
JPH05503713A (en) | 1993-06-17 |
AU8872691A (en) | 1992-06-11 |
HUT61726A (en) | 1993-03-01 |
WO1992008697A2 (en) | 1992-05-29 |
CA2073462A1 (en) | 1992-05-10 |
HU9202260D0 (en) | 1992-10-28 |
DE4036140A1 (en) | 1992-05-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69109631D1 (en) | 2-Substituted adenosine derivatives and pharmaceutical compositions for use against infectious diseases. | |
CA2036876A1 (en) | Derivatives having a naphthalenic structure; process for preparing the same and pharmaceutical compositions containing them | |
ATE120644T1 (en) | USE OF 1,3-OXATHIOL ANALOGUES OF NUCLEOSIDES FOR PRODUCING A MEDICINAL PRODUCT FOR THE TREATMENT OF HEPATITIS-B. | |
DK132789A (en) | 9-HALOGEN (Z) PROSTAGLAND INGREDIENTS, PROCEDURES FOR THEIR PREPARATION AND THEIR USE AS A MEDICINE | |
NO930511L (en) | ORTO-SUBSTITUTED BENZOYLGUANIDINES, PROCEDURES FOR THE PREPARATION OF THEM, THEIR USE AS DIAGNOSTIC SUMMARY OF MEDICINAL PRODUCTS CONTAINING THEM | |
LU91943I2 (en) | Tafluprost and its pharmaceutically acceptable derivatives (SAFLUTAN®) | |
HU9201116D0 (en) | Piperidine derivatives, process for their production, and medical preparations containing such compounds | |
HUT59394A (en) | Process for producing piperazine derivatives and pharmaceutical compositions comprising same | |
AU650074B2 (en) | 9-halogen-11beta -hydroxy prostaglandin derivative, process for producing it and its use as a medicament | |
GR3002415T3 (en) | Esters of cyclopropanecarboxylic acids related to pyrethric acid, process for their preparation and their use as parasiticides | |
BR9611871B1 (en) | diaminopyrimidines, intermediate compounds for their synthesis, as well as medicinal products containing them. | |
AU2636988A (en) | New 2-(piperazinyl)-2-substituted flavonoid derivatives, processes for preparing them and pharmaceutical compositions containing them | |
AU541413B2 (en) | 2-(1,4-benzodioxan-2-ylalicyl)imidazoles | |
DE3876711D1 (en) | PIPERIDINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS A MEDICINAL PRODUCT. | |
ATE183190T1 (en) | ERYTHROMYCIN DERIVATIVES, THEIR PROCESS FOR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS | |
AU562182B2 (en) | Bicyclo(4,2,0)1,3,5-octatriene derivatives | |
JPS57188566A (en) | 2-(3-(3-indolyl)-2-amino-propionyloxy)acetic acid derivative, manufacture and medicine containing same | |
ES2060150T3 (en) | NEW DERIVATIVES OF LEUCOTRENE-B4, PROCEDURE FOR ITS PREPARATION AND ITS USE AS MEDICINES. | |
ES2009553A6 (en) | 2,3-Dihydro-2-oxo-3-benzofuranyl acetic-acid derivatives and pharmaceutical compositions containing them. | |
GR74116B (en) | ||
HU9200931D0 (en) | Process for the production of medical preparations containing 4,9,11-triene-steroides | |
ATE181331T1 (en) | SALMYCINES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT | |
FR2629456B1 (en) | ACID DERIVATIVES 7- (1-IMIDAZOLYL), 1,4-DIHYDRO-4-OXO-6,8-DIFLUORO-1-CYCLOPROPYL-3-QUINOLEINCARBOXYLIC, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS | |
JO1697B1 (en) | Pyridine derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AU CA HU JP US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): AT BE CH DE DK ES FR GB GR IT LU NL SE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2073462 Country of ref document: CA |
|
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AU CA HU JP US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): AT BE CH DE DK ES FR GB GR IT LU NL SE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1991919671 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1991919671 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 1991919671 Country of ref document: EP |