WO1992007254A3 - Use of disulphide bidged substances - Google Patents

Use of disulphide bidged substances Download PDF

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Publication number
WO1992007254A3
WO1992007254A3 PCT/EP1991/001877 EP9101877W WO9207254A3 WO 1992007254 A3 WO1992007254 A3 WO 1992007254A3 EP 9101877 W EP9101877 W EP 9101877W WO 9207254 A3 WO9207254 A3 WO 9207254A3
Authority
WO
WIPO (PCT)
Prior art keywords
substances
bidged
disulphide
bridges
linked
Prior art date
Application number
PCT/EP1991/001877
Other languages
German (de)
French (fr)
Other versions
WO1992007254A2 (en
Inventor
Kurt Lang
Thomas Subkowski
Juergen Schweden
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of WO1992007254A2 publication Critical patent/WO1992007254A2/en
Publication of WO1992007254A3 publication Critical patent/WO1992007254A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The use is disclosed of substances that are linked at the intermolecular level by S-S bridges for producing antibodies, as well as the use of these substances as calibrating substances in molecular weight determination.
PCT/EP1991/001877 1990-10-10 1991-10-01 Use of disulphide bidged substances WO1992007254A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4032127.4 1990-10-10
DE19904032127 DE4032127A1 (en) 1990-10-10 1990-10-10 USE OF DISULFID-BRIDGED PROTEINS AND PEPTIDES

Publications (2)

Publication Number Publication Date
WO1992007254A2 WO1992007254A2 (en) 1992-04-30
WO1992007254A3 true WO1992007254A3 (en) 1992-06-11

Family

ID=6415997

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1991/001877 WO1992007254A2 (en) 1990-10-10 1991-10-01 Use of disulphide bidged substances

Country Status (2)

Country Link
DE (1) DE4032127A1 (en)
WO (1) WO1992007254A2 (en)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507233A (en) * 1981-04-22 1985-03-26 Oriental Yeast Co., Ltd. Colored molecular weight marker
US4713366A (en) * 1985-12-04 1987-12-15 The Ohio State University Research Foundation Antigenic modification of polypeptides
JPH01233297A (en) * 1988-03-15 1989-09-19 Dainippon Pharmaceut Co Ltd Determination of peptide, antibody thereof and endothelin
EP0380443A2 (en) * 1989-01-25 1990-08-01 Ciba-Geigy Ag Monoclonal antibodies specific for thrombin hirudin
EP0384144A1 (en) * 1989-01-26 1990-08-29 Kowa Company, Ltd. Pharmaceutical composition for diseases caused by vasoconstriction
JPH0315752A (en) * 1989-06-13 1991-01-24 Dai Ichi Pure Chem Co Ltd Molecular weight marker
WO1991004045A1 (en) * 1989-09-20 1991-04-04 Board Of Regents, The University Of Texas System Prophylaxis and therapy of acquired immunodeficiency syndrome
EP0438332A1 (en) * 1990-01-16 1991-07-24 Clonatec Peptides issued from the glycoprotein envelope of HIV virus, their uses for the detection of an infection due to these viruses and for the vaccination against AIDS

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507233A (en) * 1981-04-22 1985-03-26 Oriental Yeast Co., Ltd. Colored molecular weight marker
US4713366A (en) * 1985-12-04 1987-12-15 The Ohio State University Research Foundation Antigenic modification of polypeptides
JPH01233297A (en) * 1988-03-15 1989-09-19 Dainippon Pharmaceut Co Ltd Determination of peptide, antibody thereof and endothelin
EP0380443A2 (en) * 1989-01-25 1990-08-01 Ciba-Geigy Ag Monoclonal antibodies specific for thrombin hirudin
EP0384144A1 (en) * 1989-01-26 1990-08-29 Kowa Company, Ltd. Pharmaceutical composition for diseases caused by vasoconstriction
JPH0315752A (en) * 1989-06-13 1991-01-24 Dai Ichi Pure Chem Co Ltd Molecular weight marker
WO1991004045A1 (en) * 1989-09-20 1991-04-04 Board Of Regents, The University Of Texas System Prophylaxis and therapy of acquired immunodeficiency syndrome
EP0438332A1 (en) * 1990-01-16 1991-07-24 Clonatec Peptides issued from the glycoprotein envelope of HIV virus, their uses for the detection of an infection due to these viruses and for the vaccination against AIDS

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
Advances in veterinary Science and comparative medicine, Band. 33, 1989 F. Brown: "The Development of Chemically Synthesized Vaccines ", *
Chemical Abstracts, Band 112, no. 11, 12 März 1990, (Columbus, Ohio, US), siehe Seite 823, Zusammenfassung 99269k, & JP, A, 01233297 (Preparation of endothelin and its analogs for immunoassay of endothelin in body fluids) 19 September 1989 *
Chemical Abstracts, Band 114, no. 23, 10 Juni 1991, (Columbus, Ohio, US), siehe Seite 893, Zusammenfassung 229411e, & JP, A, 03015752 (Preparation of S-alkylated reduced form of proteins as molecular weight markers) 1991 *
Chemical Abstracts, Band 114, no. 5, 4 Februar 1991, (Columbus, Ohio, US), Goff, Dane A et al. : "Substituted 2-iminothiolanes: reagents for the preparation of disulfide cross-linked conjugates with increased stability ", siehe Seite 30, Zusammenfassung 35554h, & Bioconjugate chem. 1990, 1( 6), 381- 38 *
Chemical Abstracts, Band 80, no. 19, 13 Mai 1974, (Columbus, Ohio, US), Payne, John W. : "Polymerization of proteins with glutaraldehyde. Soluble molecular-weight markers ", siehe Seite 168, Zusammenfassung 105502v, & Biochem. J. 1973, 135( 4), 867- 87 *
Chemical Abstracts, Band 84, no. 11, 15 März 1976, (Columbus, Ohio, US), Whicher, J. et al. : "Synthesis of polymers of Bence-Jones protein for use as molecular weight markers for sodium dodecyl sulphate-polyacrylamide gel electrophoresis ", siehe Seite 188, Zusammenfassung 71106j, & Clin. chim. Acta 1975, 65( 3), 393- 39 *
Chemical Abstracts, Band 88, no. 25, 19 Juni 1978, (Columbus, Ohio, US), King, Te Piao et al. : "Preparation of protein conjugates via intermolecular disulfide bond formation ", siehe Seite 348, Zusammenfassung 185788w, & Biochemistry 1978, 17( 8), 1499-150 *
Chemical Abstracts, Band 95, no. 9, 31 August 1981, (Columbus, Ohio, US), See, Yew Phew et al. : "Comparison of crosslinked and natural polypeptides as standards for molecular weight determination of large polypeptides (guinea pig thyroglobulin) by SDS-gel electrophoresis ", siehe Seite 380, Zusammenfassung 76316q, & Anal. Biochem. 1981, 114( 2), 377- 38 *
Electrophoresis, Band. 9, 1988 Hiroshi S et al.: "A simple method for preparation of molecular weight marker proteins for sodium dodecyl sulfatepolyacrylamide gel electrophoresis by photopolymerizations of hemoglobin subunits ", *
J. Am. Chem. Soc., Band. 113, 1991 James P. Tam et al: "Disulfide Bond Formation in Peptides by Dimethyl Sulfoxide. Scope andApplications ", *
Methods in Enzymology, Band. 178, 1989 David N. Posnett et al: "Multiple Antigenic Peptide Method for Producing Antipeptide Site-specific Antibodies ", *
Molecular Immunology, Band. 16, 1979 P. Laidler: "The controlled disulphide crosslinking of different proteinsas a method for synthesis of combined protein antigens and copolymers of other design ", *

Also Published As

Publication number Publication date
DE4032127A1 (en) 1992-04-16
WO1992007254A2 (en) 1992-04-30

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