WO1992006992A3 - New process for biophosphorylating organic compounds - Google Patents
New process for biophosphorylating organic compounds Download PDFInfo
- Publication number
- WO1992006992A3 WO1992006992A3 PCT/US1991/006816 US9106816W WO9206992A3 WO 1992006992 A3 WO1992006992 A3 WO 1992006992A3 US 9106816 W US9106816 W US 9106816W WO 9206992 A3 WO9206992 A3 WO 9206992A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- biophosphorylating
- process include
- organic compounds
- new process
- hydroxyl containing
- Prior art date
Links
- 150000002894 organic compounds Chemical class 0.000 title abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108010049047 Echinocandins Proteins 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 240000005384 Rhizopus oryzae Species 0.000 abstract 1
- 235000013752 Rhizopus oryzae Nutrition 0.000 abstract 1
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 abstract 1
- 230000036983 biotransformation Effects 0.000 abstract 1
- 210000001185 bone marrow Anatomy 0.000 abstract 1
- 210000002216 heart Anatomy 0.000 abstract 1
- 239000004030 hiv protease inhibitor Substances 0.000 abstract 1
- 229960003444 immunosuppressant agent Drugs 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 230000000865 phosphorylative effect Effects 0.000 abstract 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 abstract 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 abstract 1
- 229960002855 simvastatin Drugs 0.000 abstract 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 abstract 1
- 229960002930 sirolimus Drugs 0.000 abstract 1
- MBMQEIFVQACCCH-UHFFFAOYSA-N trans-Zearalenon Natural products O=C1OC(C)CCCC(=O)CCCC=CC2=CC(O)=CC(O)=C21 MBMQEIFVQACCCH-UHFFFAOYSA-N 0.000 abstract 1
- MBMQEIFVQACCCH-QBODLPLBSA-N zearalenone Chemical compound O=C1O[C@@H](C)CCCC(=O)CCC\C=C\C2=CC(O)=CC(O)=C21 MBMQEIFVQACCCH-QBODLPLBSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65525—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a seven-(or more) membered ring
- C07F9/65527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a seven-(or more) membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4501234A JPH06502536A (en) | 1990-10-09 | 1991-09-19 | Novel biological phosphorylation method for organic compounds |
Applications Claiming Priority (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59421490A | 1990-10-09 | 1990-10-09 | |
US59450090A | 1990-10-09 | 1990-10-09 | |
US594,500 | 1990-10-09 | ||
US594,214 | 1990-10-09 | ||
US59589490A | 1990-10-11 | 1990-10-11 | |
US595,894 | 1990-10-11 | ||
US69160791A | 1991-04-26 | 1991-04-26 | |
US07/691,606 US5198421A (en) | 1991-04-26 | 1991-04-26 | Phosphorylated cyclic lipopeptide |
US691,606 | 1991-04-26 | ||
US691,607 | 1991-04-26 | ||
US70138791A | 1991-05-16 | 1991-05-16 | |
US701,387 | 1991-05-16 | ||
US73596391A | 1991-07-25 | 1991-07-25 | |
US735,963 | 1991-07-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1992006992A2 WO1992006992A2 (en) | 1992-04-30 |
WO1992006992A3 true WO1992006992A3 (en) | 1992-06-25 |
Family
ID=27569847
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1991/006816 WO1992006992A2 (en) | 1990-10-09 | 1991-09-19 | New process for biophosphorylating organic compounds |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0552309A1 (en) |
JP (1) | JPH06502536A (en) |
CA (1) | CA2093429A1 (en) |
WO (1) | WO1992006992A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5493107A (en) * | 1993-05-07 | 1996-02-20 | Digicomp Research Corporation | Shelf price label and product placement verification method and apparatus |
ES2065290B1 (en) * | 1993-07-29 | 1995-11-01 | Consejo Superior Investigacion | USE OF ENZYMATIC INHIBITORS FOR THE TREATMENT OF DISEASES CAUSED BY PARASITES. |
PT864653E (en) * | 1997-03-11 | 2004-08-31 | Aventis Pharma Inc | PROCESS FOR PREPARATION OF 4- (4- (4- (HYDROXIDIFENYL) -1-PIPERIDINYL) -1-HYDROXIBUTIL) -ALFA, ALPHA-DIMETHYLPHENYL ACETATE AND PHOSPHORYLED DERIVATIVES |
EP1478648B1 (en) * | 2002-02-01 | 2014-04-30 | ARIAD Pharmaceuticals, Inc. | Phosphorus-containing compounds and uses thereof |
AU2003901812A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphates of secondary alcohols |
DE102005056669A1 (en) | 2005-11-28 | 2007-05-31 | Basf Ag | Fermentative preparation of organic compounds, useful for making, e.g. amino acids or enzymes, using a starch source from which non-starch solids have not been removed, hydrolyzed and enzymatically converted to monosaccharides |
CN103330694A (en) | 2006-11-14 | 2013-10-02 | 阿里亚德医药股份有限公司 | Oral formulations |
KR20190017074A (en) * | 2013-08-19 | 2019-02-19 | 알이지 라이프 사이언시스, 엘엘씨 | Production of partially refined waste glycerol |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0192091A2 (en) * | 1985-01-29 | 1986-08-27 | Asahi Denka Kogyo Kabushiki Kaisha | Metal salts of organic phosphates and antihyperlipemic agents containing them |
EP0337714A2 (en) * | 1988-04-12 | 1989-10-18 | Merck & Co. Inc. | HIV protease inhibitors useful for the treatment of aids |
EP0405997A1 (en) * | 1989-06-30 | 1991-01-02 | Merck & Co. Inc. | Antibiotic agent |
EP0434365A2 (en) * | 1989-12-18 | 1991-06-26 | Merck & Co. Inc. | HIV protease inhibitors useful for the treatment of aids |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6058084A (en) * | 1983-09-08 | 1985-04-04 | Akira Endo | Physiologically active substance |
-
1991
- 1991-09-19 CA CA002093429A patent/CA2093429A1/en not_active Abandoned
- 1991-09-19 WO PCT/US1991/006816 patent/WO1992006992A2/en active Application Filing
- 1991-09-19 JP JP4501234A patent/JPH06502536A/en active Pending
- 1991-09-19 EP EP92901105A patent/EP0552309A1/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0192091A2 (en) * | 1985-01-29 | 1986-08-27 | Asahi Denka Kogyo Kabushiki Kaisha | Metal salts of organic phosphates and antihyperlipemic agents containing them |
EP0337714A2 (en) * | 1988-04-12 | 1989-10-18 | Merck & Co. Inc. | HIV protease inhibitors useful for the treatment of aids |
EP0405997A1 (en) * | 1989-06-30 | 1991-01-02 | Merck & Co. Inc. | Antibiotic agent |
EP0434365A2 (en) * | 1989-12-18 | 1991-06-26 | Merck & Co. Inc. | HIV protease inhibitors useful for the treatment of aids |
Non-Patent Citations (2)
Title |
---|
Journal of Antibiotics, vol. 38, no. 3, March 1985, (Tokyo, JP), A. ENDO et al.: "Microbial phosphorylation of compactin (ML-236B) and related compounds", pages 328-332, see the whole document * |
Patent Abstracts of Japan, vol. 9, no. 188 (C-295)[1911], 3 August 1985, & JP,A,60058084 (AKIRA ENDOU) 4 April 1985, see abstract * |
Also Published As
Publication number | Publication date |
---|---|
CA2093429A1 (en) | 1992-04-10 |
JPH06502536A (en) | 1994-03-24 |
WO1992006992A2 (en) | 1992-04-30 |
EP0552309A1 (en) | 1993-07-28 |
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