WO1992005278A3 - Method for the determination of the differential expression of mrna for the amyloid precursor protein (app) - Google Patents

Method for the determination of the differential expression of mrna for the amyloid precursor protein (app) Download PDF

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Publication number
WO1992005278A3
WO1992005278A3 PCT/EP1991/001772 EP9101772W WO9205278A3 WO 1992005278 A3 WO1992005278 A3 WO 1992005278A3 EP 9101772 W EP9101772 W EP 9101772W WO 9205278 A3 WO9205278 A3 WO 9205278A3
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WO
WIPO (PCT)
Prior art keywords
app
precursor protein
mrna
amyloid precursor
determination
Prior art date
Application number
PCT/EP1991/001772
Other languages
French (fr)
Other versions
WO1992005278A2 (en
Inventor
Valle Francesco Della
Antonio Morandi
Alessandro Negro
Lanfranco Callegaro
Original Assignee
Fidia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Fidia Spa filed Critical Fidia Spa
Publication of WO1992005278A2 publication Critical patent/WO1992005278A2/en
Publication of WO1992005278A3 publication Critical patent/WO1992005278A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A method is provided for the qualitative and quantitative determination of the expression of the various mRNA's for the human Amyloid Precursor Protein (APP) in human biological tissues, which methodology can be used for a diagnostic test for Alzheimer's Disease.
PCT/EP1991/001772 1990-09-17 1991-09-17 Method for the determination of the differential expression of mrna for the amyloid precursor protein (app) WO1992005278A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT04169190A IT1243515B (en) 1990-09-17 1990-09-17 METHOD FOR DETERMINING THE DIFFERENTIAL EXPRESSION OF MESSANGERS RNA FOR AMYLOID PRECURSOR PROTEIN (AMYLOID PRECURSOR PROTEIN, APP)
IT41691A/90 1990-09-17

Publications (2)

Publication Number Publication Date
WO1992005278A2 WO1992005278A2 (en) 1992-04-02
WO1992005278A3 true WO1992005278A3 (en) 1992-05-14

Family

ID=11253064

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1991/001772 WO1992005278A2 (en) 1990-09-17 1991-09-17 Method for the determination of the differential expression of mrna for the amyloid precursor protein (app)

Country Status (4)

Country Link
CN (1) CN1062925A (en)
AU (1) AU8492591A (en)
IT (1) IT1243515B (en)
WO (1) WO1992005278A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
NZ242955A (en) * 1991-06-13 1995-01-27 Ici Plc Dna containing gene sequences corresponding to sequences causing alzheimers disease, detection, recombinant yeast with such code
CA2129787A1 (en) * 1993-08-27 1995-02-28 Russell G. Higuchi Monitoring multiple amplification reactions simultaneously and analyzing same
EP2933630A3 (en) 2004-06-07 2015-10-28 Fluidigm Corporation Optical lens system and method for microfluidic devices
US7874026B2 (en) 2007-08-24 2011-01-25 Double Space Bed Systems, Inc. System and method for raising and lowering a bed
CN105717182B (en) * 2016-03-10 2018-05-11 中南大学 It is a kind of to be used for synchronous detection amyloid polypeptide monomer and the biology sensor and its construction method of aggregation and application

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Biochemical and Biophysical Research Communications, vol. 157, no. 2, 15 December 1988, S. TANAKA et al.: "Three types anyloid protein precursor mRNA in human brain: their differential expression in Alzheimer's disease", pages 472-479, see whole article *
Biochemical and Biophysical Research Communications, vol. 166, no. 3, 14 February 1990, J. KANG et al.: "Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: PreA4695 mRNA is predominantly produced in rat and human brain", pages 1192-1200, see whole article *
Biochemical and Biophysical Research Communications, vol. 171, no. 1, 31 August 1990, K. YOSHIKAWA et al.: "Neural differentiation increases expression of Alzheimer amyloid protein precursor gene in murine embryonal carcinoma cells", pages 204-209, see whole article *
Cellular and Molecular Neurobiology, vol. 10, no. 4, December 1990, R.J. DONNELLY et al.: "Interleukin-1 stimulates the beta-amyloid precursor protein promoter", pages 485-496, see summary *
FEBS Letters, vol. 241, no. 1,2, December 1988, L. AUTILIO-GAMBETTI et al.: "The amyloid precursor protein of Alzheimer disease is expressed as a 130 kDa polypeptide in various cultured cell types", pages 94-98, see whole article *
Proceedings of the National Academy of Science of USA, vol. 86, October 1989, D. GOLDGABER et al.: "Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells", pages 7606-7610, see whole article (cited in the application) *
Proceedings of the National Academy of Sciences of USA, vol. 88, January 1991, M.J. ADLER et al.: "Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts", pages 16-20, see whole article *
Science, vol. 241, no. 4869, 26 August 1988, M.R. PALMERT et al.: "Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease", pages 1080-1804, see whole article *

Also Published As

Publication number Publication date
CN1062925A (en) 1992-07-22
IT9041691A1 (en) 1992-03-17
AU8492591A (en) 1992-04-15
IT9041691A0 (en) 1990-09-17
WO1992005278A2 (en) 1992-04-02
IT1243515B (en) 1994-06-16

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