WO1991019707A3 - Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones - Google Patents
Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones Download PDFInfo
- Publication number
- WO1991019707A3 WO1991019707A3 PCT/US1991/004140 US9104140W WO9119707A3 WO 1991019707 A3 WO1991019707 A3 WO 1991019707A3 US 9104140 W US9104140 W US 9104140W WO 9119707 A3 WO9119707 A3 WO 9119707A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ones
- antiatherosclerotic
- benzoxazine
- benzopyran
- antithrombotic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
- C07D265/22—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP91911326A EP0525123B1 (en) | 1990-06-20 | 1991-06-18 | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
DE69127690T DE69127690T2 (en) | 1990-06-20 | 1991-06-18 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ON AND 2-AMINO-1,3-BENZOXAZINE-4-ON DERIVATIVES |
GR970403134T GR3025485T3 (en) | 1990-06-20 | 1997-11-26 | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54112690A | 1990-06-20 | 1990-06-20 | |
US541,126 | 1990-06-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1991019707A2 WO1991019707A2 (en) | 1991-12-26 |
WO1991019707A3 true WO1991019707A3 (en) | 1992-03-05 |
Family
ID=24158277
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1991/004140 WO1991019707A2 (en) | 1990-06-20 | 1991-06-18 | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0525123B1 (en) |
JP (1) | JPH05509302A (en) |
AT (1) | ATE158288T1 (en) |
AU (1) | AU7998291A (en) |
CA (1) | CA2081577A1 (en) |
DE (1) | DE69127690T2 (en) |
DK (1) | DK0525123T3 (en) |
ES (1) | ES2106783T3 (en) |
GR (1) | GR3025485T3 (en) |
WO (1) | WO1991019707A2 (en) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5474994A (en) * | 1992-05-26 | 1995-12-12 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A |
IT1254469B (en) * | 1992-02-25 | 1995-09-25 | Recordati Chem Pharm | BENZOPYRANIC AND BENZOTHIOPYRANIC DERIVATIVES |
US5605896A (en) * | 1992-02-25 | 1997-02-25 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities |
US5512591A (en) * | 1993-02-18 | 1996-04-30 | President And Fellows Of Harvard College | Treatments for diseases characterized by neovascularization |
US5633274A (en) * | 1993-02-18 | 1997-05-27 | President And Fellows Of Harvard College | Cancer treatments |
US5358959A (en) * | 1993-02-18 | 1994-10-25 | President And Fellows Of Harvard University | Methods for treating arteriosclerosis |
GB9306062D0 (en) * | 1993-03-24 | 1993-05-12 | Lilly Industries Ltd | Pharmaceutical compounds |
EP0619314A1 (en) * | 1993-04-09 | 1994-10-12 | Eli Lilly And Company | 4-Phenyl-4H- naphtho(2,1-b)pyran derivatives and their pharmaceutical use |
US5556871A (en) * | 1995-04-24 | 1996-09-17 | President & Fellows Of Harvard College | Method for treating epithelial precancerous lesions with topical inidazoles |
US6180625B1 (en) | 1998-03-24 | 2001-01-30 | Novo Nordisk A/S | Heterocyclic compounds regulating clotting |
DE19850131A1 (en) * | 1998-10-30 | 2000-05-04 | Merck Patent Gmbh | Chromenon and chromanone derivatives |
WO2000051992A1 (en) * | 1999-03-04 | 2000-09-08 | E.I. Du Pont De Nemours And Company | Fused bicyclic oxazinone and thiazinone fungicides |
JP4820518B2 (en) | 2000-01-24 | 2011-11-24 | アストラゼネカ アクチボラグ | Morpholino-substituted compound therapeutics |
GB0119863D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
GB0119865D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
US7049313B2 (en) | 2002-02-25 | 2006-05-23 | Kudos Pharmaceuticals Ltd. | ATM inhibitors |
US6924376B2 (en) | 2002-04-17 | 2005-08-02 | Cytokinetics, Inc. | Compounds, compositions and methods |
ATE423110T1 (en) | 2002-07-17 | 2009-03-15 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING CELLULAR PROLIFERATIVE DISEASES |
EP1537102A4 (en) | 2002-08-16 | 2010-12-08 | Astrazeneca Ab | Inhibition of phsphoinostide 3-dinase beta |
CN101260104A (en) * | 2002-08-16 | 2008-09-10 | 阿斯利康(瑞典)有限公司 | Inhibition of phosphoinositide 3-kinase beta |
BRPI0409063A (en) * | 2003-04-03 | 2006-03-28 | Semafore Pharmaceuticals Inc | pro pi-3 kinase inhibitor medications |
KR101099409B1 (en) * | 2003-06-06 | 2011-12-27 | 아렉시스 악티에볼라그 | Use of fused heterocyclic compounds as scce inhibitors for the treatment of skin conditions or cancer |
DE602004026071D1 (en) | 2003-08-13 | 2010-04-29 | Kudos Pharm Ltd | AMINOPYRONE AND ITS USE AS ATM INHIBITORS |
BRPI0515498A (en) | 2004-09-20 | 2008-07-29 | Kudos Pharm Ltd | dna-pk inhibitors |
JP2008529995A (en) | 2005-02-09 | 2008-08-07 | クドス ファーマシューティカルズ リミテッド | ATM inhibitor |
AR053358A1 (en) | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | DNA INHIBITORS - PK |
JPWO2009038064A1 (en) * | 2007-09-19 | 2011-01-06 | 株式会社医薬分子設計研究所 | Heterocyclic derivatives having type I 11β-hydroxysteroid dehydrogenase inhibitory activity |
CA2712022A1 (en) * | 2008-01-25 | 2009-01-30 | Astrazeneca Ab | Enantiomerically pure (-) 2-[1-(7-methyl-2-(morpholin-4-yl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl)ethylamino]benzoic acid, its use in medical therapy, and a pharmaceutical composition comprising it - 026 |
US8399460B2 (en) | 2009-10-27 | 2013-03-19 | Astrazeneca Ab | Chromenone derivatives |
EP2808322B1 (en) * | 2012-01-26 | 2017-08-23 | Daiichi Sankyo Company, Limited | Chromone derivative having osteogenesis promoting effect |
WO2023016521A1 (en) * | 2021-08-12 | 2023-02-16 | 上海赛默罗生物科技有限公司 | Substituted triazole derivative, preparation method therefor, pharmaceutical composition thereof, and use thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4092416A (en) * | 1975-12-09 | 1978-05-30 | Boehringer Mannheim Gmbh | Benzopyrone derivatives exhibiting anti-allergic activity |
EP0248420A2 (en) * | 1986-06-04 | 1987-12-09 | Daiichi Seiyaku Co., Ltd. | Benzopyran derivatives |
WO1990006921A1 (en) * | 1988-12-21 | 1990-06-28 | The Upjohn Company | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
-
1991
- 1991-06-18 CA CA002081577A patent/CA2081577A1/en not_active Abandoned
- 1991-06-18 AU AU79982/91A patent/AU7998291A/en not_active Abandoned
- 1991-06-18 AT AT91911326T patent/ATE158288T1/en not_active IP Right Cessation
- 1991-06-18 ES ES91911326T patent/ES2106783T3/en not_active Expired - Lifetime
- 1991-06-18 EP EP91911326A patent/EP0525123B1/en not_active Expired - Lifetime
- 1991-06-18 DK DK91911326.6T patent/DK0525123T3/en active
- 1991-06-18 DE DE69127690T patent/DE69127690T2/en not_active Expired - Fee Related
- 1991-06-18 JP JP3510888A patent/JPH05509302A/en active Pending
- 1991-06-18 WO PCT/US1991/004140 patent/WO1991019707A2/en active IP Right Grant
-
1997
- 1997-11-26 GR GR970403134T patent/GR3025485T3/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4092416A (en) * | 1975-12-09 | 1978-05-30 | Boehringer Mannheim Gmbh | Benzopyrone derivatives exhibiting anti-allergic activity |
EP0248420A2 (en) * | 1986-06-04 | 1987-12-09 | Daiichi Seiyaku Co., Ltd. | Benzopyran derivatives |
WO1990006921A1 (en) * | 1988-12-21 | 1990-06-28 | The Upjohn Company | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
Non-Patent Citations (3)
Title |
---|
Chemical Abstracts, volume 87, no. 15, 10 October 1977 (Columbus, Ohio, US) A. Ermili et al.: "Chemical and pharmacological research on pyran derivatives. Note VIII. Synthesis of 2-(dialkylamino)-7-methoxychromones and their derivatives", see page 588, abstract 117750g, & Farmaco, Edizione Scientifica 1977, 32(5), 375-387 (cited in the application) * |
European Journal of Medicinal Chemistry, volume 23, no. 3, May-June 1988 (Paris, FR) M. Mazzei et al.: "Synthesis and anti-platelet activity of some 2-(dialkylamino)chromones", pages 237-242, see the whole document (cited in the application) * |
Journal of Heterocyclic Chemistry, volume 18, no. 4, June 1981, Hetero Corp. (Provo, US) J.R. Bantick et al.: "Synthesis of 2-aminochromones. Studies on the nucleophilic displacement of sulphinyl and sulphonyl groups in the 2-position of 5,8-dimethoxychromone", pages 678-684, see the whole article (cited in the application) * |
Also Published As
Publication number | Publication date |
---|---|
GR3025485T3 (en) | 1998-02-27 |
EP0525123B1 (en) | 1997-09-17 |
EP0525123A1 (en) | 1993-02-03 |
DE69127690D1 (en) | 1997-10-23 |
WO1991019707A2 (en) | 1991-12-26 |
AU7998291A (en) | 1992-01-07 |
DE69127690T2 (en) | 1998-02-12 |
JPH05509302A (en) | 1993-12-22 |
ES2106783T3 (en) | 1997-11-16 |
DK0525123T3 (en) | 1998-05-04 |
ATE158288T1 (en) | 1997-10-15 |
CA2081577A1 (en) | 1991-12-21 |
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