MX9604367A - Novel hydroxypyridinones. - Google Patents

Novel hydroxypyridinones.

Info

Publication number
MX9604367A
MX9604367A MX9604367A MX9604367A MX9604367A MX 9604367 A MX9604367 A MX 9604367A MX 9604367 A MX9604367 A MX 9604367A MX 9604367 A MX9604367 A MX 9604367A MX 9604367 A MX9604367 A MX 9604367A
Authority
MX
Mexico
Prior art keywords
hydroxypyridinones
novel
iron
hydroxypyridin
warm
Prior art date
Application number
MX9604367A
Other languages
Spanish (es)
Inventor
Paul Zbinden
Original Assignee
Novartis Ag Tambien Denominada
Y O Novartis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag Tambien Denominada, Y O Novartis Inc filed Critical Novartis Ag Tambien Denominada
Publication of MX9604367A publication Critical patent/MX9604367A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The present invention discloses 3-hydroxypyridin-4-ones of formula (I): wherein R1-R4, A and R are as defined in the description. The compounds of the invention have valuable pharmaceutical properties and are specially effective as iron chelators. They can be useful for the treatment of an iron excess in warm-blooded animal bodies.
MX9604367A 1995-09-29 1996-09-26 Novel hydroxypyridinones. MX9604367A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH275995 1995-09-29

Publications (1)

Publication Number Publication Date
MX9604367A true MX9604367A (en) 1997-10-31

Family

ID=4240981

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9604367A MX9604367A (en) 1995-09-29 1996-09-26 Novel hydroxypyridinones.

Country Status (22)

Country Link
US (1) US5688815A (en)
EP (1) EP0768302B1 (en)
JP (1) JPH09124603A (en)
KR (1) KR970015576A (en)
CN (1) CN1151399A (en)
AR (1) AR005419A1 (en)
AT (1) ATE299135T1 (en)
AU (1) AU6584596A (en)
BR (1) BR9603929A (en)
CA (1) CA2186716A1 (en)
CZ (1) CZ284896A3 (en)
DE (1) DE59611243D1 (en)
ES (1) ES2244967T3 (en)
HU (1) HUP9602681A1 (en)
IL (1) IL119316A (en)
MX (1) MX9604367A (en)
NO (1) NO964095L (en)
NZ (1) NZ299452A (en)
PT (1) PT768302E (en)
SA (1) SA96170399B1 (en)
TR (1) TR199600765A2 (en)
ZA (1) ZA968150B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448273B1 (en) 1997-05-29 2002-09-10 Btg International Limited Orally active iron (III) chelators
GB9711093D0 (en) 1997-05-29 1997-07-23 British Tech Group Novel orally active iron (III) chelators
GB9723078D0 (en) * 1997-10-31 1998-01-07 Cerebrus Ltd Chemical compounds
JPH11147377A (en) * 1997-11-18 1999-06-02 Teijin Ltd Biaxially oriented polyester film for heat-sensitive transfer ribbon
ATE384120T1 (en) * 1999-08-27 2008-02-15 Invitrogen Corp METAL BONDING COMPOUNDS AND THEIR USE IN CELL CULTURE MEDIA COMPOSITIONS
US6767741B1 (en) 1999-08-27 2004-07-27 Invitrogen Corporation Metal binding compounds and their use in cell culture medium compositions
US6846915B2 (en) 2001-08-13 2005-01-25 The Regents Of The University Of California Hydroxypyridonate and hydroxypyrimidinone chelating agents
US6426418B1 (en) 2001-11-02 2002-07-30 Apotex, Inc. Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide
WO2003065991A2 (en) * 2002-02-05 2003-08-14 Bristol-Myers Squibb Company N-substituted3-hydroxy-4-pyridinones and pharmaceuticals containing thereof
US20050008699A1 (en) * 2003-07-11 2005-01-13 Fred Wehling Effervescent glucosamine composition
NZ529657A (en) * 2003-11-20 2004-07-30 Apotex Inc Iron chelating cycloalkyl derivatives of 3-hydroxy-4-pyridinones
CA2488034C (en) * 2004-11-19 2009-10-06 Apotex Inc. Process for the manufacture of 3-hydroxy-n-alkyl-1-cycloalkyl-6-alkyl-4-oxo-1,4-dihydropyridine-2-carboxamide and its related analogues
GB0506677D0 (en) * 2005-04-01 2005-05-11 Btg Int Ltd Iron modulators
WO2010011814A1 (en) 2008-07-25 2010-01-28 Smithkline Beecham Corporation Chemical compounds
US20100041653A1 (en) * 2008-08-15 2010-02-18 Burnham Institute For Medical Research Composition and methods for the design and development of metallo-enzyme inhibitors
CN104788367A (en) * 2008-12-11 2015-07-22 盐野义制药株式会社 Processes and intermediates for carbamoylpyridone HIV integrase inhibitors
US8624023B2 (en) 2008-12-11 2014-01-07 Shionogi & Co., Ltd. Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates
TWI518084B (en) 2009-03-26 2016-01-21 鹽野義製藥股份有限公司 Process for pyrone and pyridone derivatives
CN101906069B (en) * 2009-06-02 2012-12-12 首都医科大学 (S)-2-substituted-(3'-acetyl-2'-pyridone-1'-yl) acetic acid as well as preparation method and application thereof
MX2012000247A (en) * 2009-07-03 2012-03-26 Apotex Technologies Inc Fluorinated derivatives of 3-hydroxypyridin-4-ones.
TWI582097B (en) 2010-03-23 2017-05-11 Ｖｉｉｖ醫療保健公司 Process for preparing carbamoylpyridone derivatives and intermediates
WO2012019689A2 (en) * 2010-07-27 2012-02-16 Clariant International Ltd Use of hydroxypyridones or salts thereof for stabilizing hydrogen peroxide or hydrogen peroxide donor substances
CN105017138A (en) * 2015-08-06 2015-11-04 中国科学技术大学 Ethylene-glycol-alcoholized 3-pyridinol-4-ketone compound and preparation method and application thereof
CN110790737B (en) * 2019-11-07 2022-07-22 河南中烟工业有限责任公司 Preparation method of 2, 3-dihydro-3, 5-dihydroxy-6-ethyl-4H-pyran-4-one

Family Cites Families (14)

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DE1518098A1 (en) * 1963-09-19 1969-04-10 Pfizer & Co C Process for the preparation of pyromeconic acid derivatives
GB2118176B (en) * 1982-03-24 1985-12-04 Nat Res Dev Pharmaceutical compositions
GB8308054D0 (en) * 1983-03-24 1983-05-05 Hider R C Pharmaceutical compositions
US4908371A (en) * 1987-11-10 1990-03-13 Ciba-Geigy Corporation Esterified hydroxy dihydropyridinones for treating diseases associated with trivalent metal ion overload
ATE98631T1 (en) * 1988-01-20 1994-01-15 Ciba Geigy Ag PROCESSES FOR PRODUCTION OF COMPLEX CONNECTIONS.
WO1989009211A1 (en) * 1988-03-31 1989-10-05 The Royal Free Hospital School Of Medicine Process for producing pyrid-4-ones
US4980371A (en) * 1988-12-21 1990-12-25 Merrell Dow Pharmaceuticals Antiretroviral furan ketones
US5112968A (en) * 1989-07-28 1992-05-12 E. R. Squibb & Sons, Inc. Monobactam hydrazide derivatives
GB9100465D0 (en) * 1991-01-09 1991-02-20 Hider Robert C Pharmaceutical compositions
GB9209078D0 (en) * 1992-04-27 1992-06-10 Hider Robert C Pharmaceutical compositions
CA2100623A1 (en) * 1992-07-17 1994-01-18 Michiyuki Sendai Cephem compounds, their production and use
GB9216506D0 (en) * 1992-08-04 1992-09-16 Rice Evans Catherine A Improvements in or relating to the treatment of sickle cell disease
GB9217099D0 (en) * 1992-08-12 1992-09-23 British Tech Group Pharmaceutical compositions
US5789426A (en) * 1995-01-20 1998-08-04 Cornell Research Foundation, Inc. Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation

Also Published As

Publication number Publication date
KR970015576A (en) 1997-04-28
DE59611243D1 (en) 2005-08-11
JPH09124603A (en) 1997-05-13
ATE299135T1 (en) 2005-07-15
CZ284896A3 (en) 1997-04-16
AU6584596A (en) 1997-04-10
NO964095L (en) 1997-04-01
TR199600765A2 (en) 1997-05-21
EP0768302A2 (en) 1997-04-16
CN1151399A (en) 1997-06-11
IL119316A (en) 2000-08-13
ZA968150B (en) 1997-04-01
US5688815A (en) 1997-11-18
PT768302E (en) 2005-11-30
NZ299452A (en) 1998-06-26
CA2186716A1 (en) 1997-03-30
EP0768302A3 (en) 1998-02-25
ES2244967T3 (en) 2005-12-16
SA96170399B1 (en) 2007-01-20
HUP9602681A1 (en) 1997-09-29
EP0768302B1 (en) 2005-07-06
BR9603929A (en) 1998-06-09
NO964095D0 (en) 1996-09-27
IL119316A0 (en) 1996-12-05
HU9602681D0 (en) 1996-11-28
AR005419A1 (en) 1999-06-23

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