WO1991018981A3 - Neurotropic growth factors comprising a homeobox peptide - Google Patents

Neurotropic growth factors comprising a homeobox peptide Download PDF

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Publication number
WO1991018981A3
WO1991018981A3 PCT/FR1991/000444 FR9100444W WO9118981A3 WO 1991018981 A3 WO1991018981 A3 WO 1991018981A3 FR 9100444 W FR9100444 W FR 9100444W WO 9118981 A3 WO9118981 A3 WO 9118981A3
Authority
WO
WIPO (PCT)
Prior art keywords
growth factors
homeobox peptide
neurotropic growth
homeobox
peptide
Prior art date
Application number
PCT/FR1991/000444
Other languages
French (fr)
Other versions
WO1991018981A2 (en
Inventor
Alain Joliot
Alain Prochiantz
Original Assignee
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient
Priority to EP91910774A priority Critical patent/EP0485578B1/en
Priority to DE69122472T priority patent/DE69122472T2/en
Priority to BR919105783A priority patent/BR9105783A/en
Publication of WO1991018981A2 publication Critical patent/WO1991018981A2/en
Publication of WO1991018981A3 publication Critical patent/WO1991018981A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
    • C07K14/43581—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies from Drosophila
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Insects & Arthropods (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Novel class of cellular growth factors, active in particular on nerve cells, said factors comprising at least one homeobox peptide, possibly linked to another peptide sequence
PCT/FR1991/000444 1990-06-05 1991-06-05 Neurotropic growth factors comprising a homeobox peptide WO1991018981A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP91910774A EP0485578B1 (en) 1990-06-05 1991-06-05 Neurotropic growth factors comprising a homeobox peptide
DE69122472T DE69122472T2 (en) 1990-06-05 1991-06-05 NEUROTROPIC GROWTH FACTORS CONTAINING A HOMEOBOX PEPTIDE
BR919105783A BR9105783A (en) 1990-06-05 1991-06-05 POLIPEPTIDIO, PROCESS FOR THE GLASS TREATMENT OF NEURONES AND CELLULAR PHARMACEUTICAL COMPOSITES

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9006912A FR2662698A1 (en) 1990-06-05 1990-06-05 New neurotropic growth factors comprising a homeobox peptide
FR90/06912 1990-06-05

Publications (2)

Publication Number Publication Date
WO1991018981A2 WO1991018981A2 (en) 1991-12-12
WO1991018981A3 true WO1991018981A3 (en) 1992-03-19

Family

ID=9397246

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1991/000444 WO1991018981A2 (en) 1990-06-05 1991-06-05 Neurotropic growth factors comprising a homeobox peptide

Country Status (9)

Country Link
EP (1) EP0485578B1 (en)
JP (1) JP3282130B2 (en)
AT (1) ATE143691T1 (en)
BR (1) BR9105783A (en)
DE (1) DE69122472T2 (en)
FR (1) FR2662698A1 (en)
IE (1) IE911914A1 (en)
PT (1) PT97877A (en)
WO (1) WO1991018981A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192312A (en) * 1991-03-05 1993-03-09 Colorado State University Research Foundation Treated tissue for implantation and methods of treatment and use
FR2682875A1 (en) * 1991-10-24 1993-04-30 Fidia France Sarl Use of poly(2-8)- alpha -sialic acid for the regulation of the action of homeo box peptides
GB9422175D0 (en) 1994-11-03 1994-12-21 Univ Dundee Indentification of the p21 waf1-pcna interaction site and therapeutic applications thereof
US5846743A (en) * 1995-02-22 1998-12-08 Brigham And Women's Hospital, Inc. Polyphoshoinositide binding peptides for intracellular drug delivery
GB9519275D0 (en) 1995-09-21 1995-11-22 Univ Dundee Substances and their therapeutic use
GB9521544D0 (en) * 1995-10-20 1995-12-20 Univ Dundee Activation of P53 protein and therapeutic applications thereof
ATE333465T1 (en) 1996-05-08 2006-08-15 Cyclacel Ltd METHODS AND MEANS OF INHIBITING CDK4 ACTIVITY
GB9814527D0 (en) 1998-07-03 1998-09-02 Cyclacel Ltd Delivery system
US6800286B1 (en) 1998-08-19 2004-10-05 The Regents Of The University Of Colorado Chimeric fibroblast growth factor proteins, nucleic acid molecules, and uses thereof
ATE419273T1 (en) 1998-11-13 2009-01-15 Cyclacel Ltd TRANSLOCATION VECTORS DERIVED FROM THE ANTENNAPEDIA HOMEODOMAIN HELIX 3
DE10027777A1 (en) * 2000-06-07 2001-12-13 Otogene Ag Introducing substances into cells of sensory organs, useful for treating degenerative disorders of ear and eye, uses penetratin as transporter molecule
FR2810046B1 (en) * 2000-06-07 2004-09-10 Neurotech PROCESS FOR CONDITIONAL IMMORTALIZATION OF CELLS AND PROTEIN CONSTRUCTIONS FOR ITS IMPLEMENTATION
ES2403558T3 (en) 2004-08-27 2013-05-20 Cyclacel Limited Purine and pyrimidine CDK inhibitors and their use for the treatment of autoimmune diseases
FR2897780B1 (en) * 2006-02-28 2008-05-23 Centre Nat Rech Scient USE OF THE HOMEODOMAINE PROTEIN ENGRAILED AS ANXIOLYTIC
GB0803352D0 (en) 2008-02-22 2008-04-02 Ntnu Technology Transfer As Oligopeptidic compounds and uses thereof
CA2758378A1 (en) 2009-04-14 2010-10-21 Trojan Technologies Ltd. Therapeutic antennapedia-antibody molecules and methods of use thereof
GB201507722D0 (en) 2015-05-06 2015-06-17 Norwegian Univ Sci & Tech Ntnu Anti-bacterial agents and their use in therapy
PL3352777T3 (en) * 2015-09-23 2022-02-07 Centre National De La Recherche Scientifique Engrailed for use in the treatment of dna-damage in a patient suffering from parkinson disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990006757A1 (en) * 1988-12-15 1990-06-28 The Regents Of The University Of California Grafting genetically modified cells to treat diseases of the central nervous system

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990006757A1 (en) * 1988-12-15 1990-06-28 The Regents Of The University Of California Grafting genetically modified cells to treat diseases of the central nervous system

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
Bio Essays, volume 10, nos. 2,3, février-mars 1989, D.G. Wilkinson: "Homeobox genes and development of the vertebrate CNS", pages 82-85, voir l'article en entier *
Cell, volume 55, 18 novembre 1988, Cell Press, M. Levine et al.: "Homeobox proteins as sequence-specific transcription factors", pages 537-540, voir l'article en entier *
Mol. Cell. Biol., volume 6, no. 12, décembre 1986, American Society for Microbiology, A. Laughon et al.: "Structure of transcripts from the homeotic antennapedia gene of drosophila melanogaster: Two promoters control the major protein-coding region", pages 4676-4689, voir l'article en entier, en particulier figure 8 *
Nature, volume 318, 19/26 décembre 1985, C. Desplan et al.: "The drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity", pages 630-635, voir l'article en entier *
Nucleic Acids Research, volume 17, 1989, IRL Press, D. Acampora et al.: "The human HOX gene familiy", pages 10385-10402, voir l'article en entier (cité dans la demande) *
Proc. Natl. Acad. Sci. USA, volume 83, décembre 1986, Developmental Biology, A. Fainsod et al.: "The homeo domain of a murine protein binds 5' to its own homeo box", pages 9532-9536, voir l'article en entier *
Proc. Natl. Acad. Sci. USA, volume 88, no. 5, mars 1991, Neurobiology, A. Joliot et al.: "Antennapedia homeobox peptide regulates neural morphogenesis", pages 1864-1868, voir l'article en entier *
Proc. Natl. Acad. Sci., volume 86, juin 1989, Neurobiology, P. Ernfors et al.: "A cell line producing recombinant nerve growth factor evokes growth responses in intrinsic and grafted central cholinergic neurons", pages 4756-4760, voir l'article en entier (cité dans la demande) *
The EMBO Journal, volume 7, no. 13, 20 décembre 1988, IRL Press Limited (GB) G. Otting et al.: "Secondary structure determination for the antennapedia homeodomain by nuclear magnetic resonance and evidence for a helix-turn-helix motif", pages 4305-4309, voir l'article en entier (cité dans la demande) *
The EMBO Journal, volume 7, no. 13, 20 décembre 1988, M. M}lLer et al.: "Isolation and sequence-specific DNA binding of the antennapedia homeodomain", pages 4299-4304, voir l'article en entier (cité dans la demande) *
The EMBO Journal, volume 7, no. 7, 1988, IRL Press Ltd, (GB) K.W.Y. Cho et al.: "Differential utilization of the same reading frame in a xenopus homeobox gene encodes two related proteins sharing the same DNA-binding specificity", pages 2139-2149, voir l'article en entier, en particulier figure 5 et page 2144, colonne 1 *

Also Published As

Publication number Publication date
EP0485578B1 (en) 1996-10-02
IE911914A1 (en) 1991-12-18
DE69122472T2 (en) 1997-04-17
WO1991018981A2 (en) 1991-12-12
DE69122472D1 (en) 1996-11-07
JP3282130B2 (en) 2002-05-13
JPH05502885A (en) 1993-05-20
EP0485578A1 (en) 1992-05-20
BR9105783A (en) 1992-07-21
FR2662698B1 (en) 1995-03-24
FR2662698A1 (en) 1991-12-06
ATE143691T1 (en) 1996-10-15
PT97877A (en) 1992-04-30

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