WO1991015495A1 - Benzylphosphonic acid tyrosine kinase inhibitors - Google Patents
Benzylphosphonic acid tyrosine kinase inhibitors Download PDFInfo
- Publication number
- WO1991015495A1 WO1991015495A1 PCT/US1991/001731 US9101731W WO9115495A1 WO 1991015495 A1 WO1991015495 A1 WO 1991015495A1 US 9101731 W US9101731 W US 9101731W WO 9115495 A1 WO9115495 A1 WO 9115495A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- phosphite
- phenyl
- formula
- tyrosine kinase
- Prior art date
Links
- 0 C*(C)c1ccccc1 Chemical compound C*(C)c1ccccc1 0.000 description 4
- FGGAVAOTGVJWSB-UHFFFAOYSA-N CC1(COC)CCCCC1 Chemical compound CC1(COC)CCCCC1 FGGAVAOTGVJWSB-UHFFFAOYSA-N 0.000 description 1
- ZXLYYQUMYFHCLQ-UHFFFAOYSA-N CN(C(c1c2cccc1)=O)C2=O Chemical compound CN(C(c1c2cccc1)=O)C2=O ZXLYYQUMYFHCLQ-UHFFFAOYSA-N 0.000 description 1
- WYXVALPCMMZWCG-UHFFFAOYSA-N COCC(CC(N1)=O)CC1=O Chemical compound COCC(CC(N1)=O)CC1=O WYXVALPCMMZWCG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
- C07F9/3882—Arylalkanephosphonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/5537—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom the heteroring containing the structure -C(=O)-N-C(=O)- (both carbon atoms belong to the heteroring)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69105495T DE69105495T2 (en) | 1990-04-02 | 1991-03-14 | BENZYLPHOSPHONIC ACID TYROSINKINAS INHIBITORS. |
EP91907740A EP0526488B1 (en) | 1990-04-02 | 1991-03-14 | Benzylphosphonic acid tyrosine kinase inhibitors |
US07/934,469 US5326905A (en) | 1990-04-02 | 1991-03-14 | Benzylphosphonic acid tyrosine kinase inhibitors |
JP3507239A JPH0662650B2 (en) | 1990-04-02 | 1991-03-14 | Benzylphosphonic acid as a tyrosine kinase inhibitor |
FI924427A FI924427A (en) | 1990-04-02 | 1992-10-01 | BENSYLFOSFONSYRATYROSINKINAS-INHIBITORER |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50318890A | 1990-04-02 | 1990-04-02 | |
US503,188 | 1990-04-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1991015495A1 true WO1991015495A1 (en) | 1991-10-17 |
Family
ID=24001079
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1991/001731 WO1991015495A1 (en) | 1990-04-02 | 1991-03-14 | Benzylphosphonic acid tyrosine kinase inhibitors |
Country Status (12)
Country | Link |
---|---|
US (1) | US5326905A (en) |
EP (1) | EP0526488B1 (en) |
JP (1) | JPH0662650B2 (en) |
AT (1) | ATE114661T1 (en) |
CA (1) | CA2078214C (en) |
DE (1) | DE69105495T2 (en) |
DK (1) | DK0526488T3 (en) |
ES (1) | ES2064101T3 (en) |
FI (1) | FI924427A (en) |
IE (1) | IE64067B1 (en) |
PT (1) | PT97214A (en) |
WO (1) | WO1991015495A1 (en) |
Cited By (96)
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WO1997012903A1 (en) * | 1995-10-04 | 1997-04-10 | Warner-Lambert Company | Compounds, compositions and methods for inhibiting the binding of proteins containing an sh2 domain to cognate phosphorylated proteins |
US5650415A (en) * | 1995-06-07 | 1997-07-22 | Sugen, Inc. | Quinoline compounds |
WO1997048675A1 (en) * | 1996-06-18 | 1997-12-24 | Ortho Pharmaceutical Corporation | 2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents |
US5710173A (en) * | 1995-06-07 | 1998-01-20 | Sugen, Inc. | Thienyl compounds for inhibition of cell proliferative disorders |
US5753715A (en) * | 1995-06-02 | 1998-05-19 | Ortho Pharmaceutical Corporation | 2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents |
US5763470A (en) * | 1995-06-07 | 1998-06-09 | Sugen Inc. | Benzopyran compounds and methods for their use |
US5763441A (en) * | 1992-11-13 | 1998-06-09 | Sugen, Inc. | Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis |
US5773459A (en) * | 1995-06-07 | 1998-06-30 | Sugen, Inc. | Urea- and thiourea-type compounds |
US5792783A (en) * | 1995-06-07 | 1998-08-11 | Sugen, Inc. | 3-heteroaryl-2-indolinone compounds for the treatment of disease |
US5792771A (en) * | 1992-11-13 | 1998-08-11 | Sugen, Inc. | Quinazoline compounds and compositions thereof for the treatment of disease |
US5849742A (en) * | 1992-11-13 | 1998-12-15 | Sugen Inc. | Compounds for the treament of disorders related to vasculogenesis and/or angiogenesis |
US5891917A (en) * | 1995-06-07 | 1999-04-06 | Sugen, Inc. | Certain acrylonitrile-sulfonamide derivatives |
US5981569A (en) * | 1992-11-13 | 1999-11-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease |
US6051593A (en) * | 1997-06-20 | 2000-04-18 | Sugen, Inc. | 3-(cycloalkanoheteroarylidenyl)-2- indolinone protein tyrosine kinase inhibitors |
US6093728A (en) * | 1997-09-26 | 2000-07-25 | Asta Medica Aktiengesellschaft | Methods of modulating serine/threonine protein kinase function with azabenzimidazole-based compounds |
US6103728A (en) * | 1995-06-07 | 2000-08-15 | Sugen, Inc. | Quinazolines |
US6114371A (en) * | 1997-06-20 | 2000-09-05 | Sugen, Inc. | 3-(cyclohexanoheteroarylidenyl)-2-indolinone protein tyrosine kinase inhibitors |
US6130238A (en) * | 1997-06-20 | 2000-10-10 | Sugen, Inc. | 3-(cyclohexanoheteroarylidenyl)-2-indolinone protein tyrosine kinase inhibitors |
US6133305A (en) * | 1997-09-26 | 2000-10-17 | Sugen, Inc. | 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity |
US6180631B1 (en) | 1997-10-06 | 2001-01-30 | Asta Medica Aktiengesellschaft | Methods of modulating serine/threonine protein kinase function with 5-azaquinoxaline-based compounds |
US6204267B1 (en) | 1997-05-02 | 2001-03-20 | Sugen, Inc. | Methods of modulating serine/thereonine protein kinase function with quinazoline-based compounds |
US6207401B1 (en) | 1995-12-18 | 2001-03-27 | Sugen, Inc. | Diagnosis and treatment of AUR-1 and/or AUR-2 related disorders |
WO2001027077A2 (en) * | 1999-10-12 | 2001-04-19 | Basf Aktiengesellschaft | Hydroxysulfonylalkylene-, phosphonoalkylene- or difluoro(phosphononon)methyl- substituted benzene, or benzofuran derivatives as non-peptidic cdc25 inhibitors |
US6225346B1 (en) | 1997-10-24 | 2001-05-01 | Sugen, Inc. | Tyrphostin like compounds |
US6228641B1 (en) | 1997-05-20 | 2001-05-08 | Sugen, Inc. | Diagnosis and treatment of PTP04 related disorders |
US6235769B1 (en) | 1997-07-03 | 2001-05-22 | Sugen, Inc. | Methods of preventing and treating neurological disorders with compounds that modulate the function of the C-RET receptor protein tyrosine kinase |
WO2001074369A1 (en) * | 2000-03-31 | 2001-10-11 | Angiogene Pharmaceuticals Ltd. | Divided dose therapies with vascular damaging activity |
US6313158B1 (en) | 1997-06-20 | 2001-11-06 | Sugen, Inc. | Bioavailability of 3-heteroarylidenyl-2-indolinones active as protein tyrosine kinase inhibitors |
US6316603B1 (en) | 1998-09-08 | 2001-11-13 | Agouron Pharmaceuticals, Inc. | Modifications of the VEGF receptor-2 protein and methods of use |
US6316635B1 (en) | 1995-06-07 | 2001-11-13 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
US6316429B1 (en) | 1997-05-07 | 2001-11-13 | Sugen, Inc. | Bicyclic protein kinase inhibitors |
US6329375B1 (en) | 1997-08-05 | 2001-12-11 | Sugen, Inc. | Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors |
US6342593B1 (en) | 1997-06-11 | 2002-01-29 | Sugen, Inc. | Diagnosis and treatment of ALP related disorders |
US6388063B1 (en) | 1997-06-18 | 2002-05-14 | Sugen, Inc. | Diagnosis and treatment of SAD related disorders |
US6395734B1 (en) | 1998-05-29 | 2002-05-28 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
US6465507B2 (en) | 2000-02-28 | 2002-10-15 | Sugen, Inc. | 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors |
US6486185B1 (en) | 1997-05-07 | 2002-11-26 | Sugen, Inc. | 3-heteroarylidene-2-indolinone protein kinase inhibitors |
US6495353B1 (en) | 1998-01-21 | 2002-12-17 | Sugen, Inc. | Human orthologues of wart |
US6514981B1 (en) | 1998-04-02 | 2003-02-04 | Sugen, Inc. | Methods of modulating tyrosine protein kinase function with indolinone compounds |
US6531502B1 (en) | 1998-01-21 | 2003-03-11 | Sugen, Inc. | 3-Methylidenyl-2-indolinone modulators of protein kinase |
US6541504B1 (en) | 2002-04-03 | 2003-04-01 | Allergan Sales, Llc | (3Z)-3-(2,3-dihydro-1H-inden-1-ylidene)-1,3-dihydro-2H-indol-2-ones as kinase inhibitors |
US6559173B1 (en) | 2001-09-27 | 2003-05-06 | Allergan, Inc. | 3-(heteroarylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors |
WO2003042390A1 (en) * | 2001-11-13 | 2003-05-22 | Sugen, Inc. | Mammalian protein phosphatases |
US6642251B1 (en) | 1998-08-31 | 2003-11-04 | Sugen, Inc. | Geometrically restricted 2-indolinone derivatives as modulators of protein kinase activity |
US6656716B1 (en) | 1998-04-14 | 2003-12-02 | Sugen, Inc. | Polypeptide fragments of human PAK5 protein kinase |
US6680335B2 (en) | 1998-09-28 | 2004-01-20 | Sugen, Inc. | Methods of modulating protein tyrosine kinase function with substituted indolinone compounds |
US6682921B1 (en) | 1996-08-21 | 2004-01-27 | New York University | Crystals of the tyrosine kinase domain of non-insulin receptor tyrosine kinases |
US6689806B1 (en) | 1999-03-24 | 2004-02-10 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
US6696448B2 (en) | 1996-06-05 | 2004-02-24 | Sugen, Inc. | 3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors |
US6699863B1 (en) | 2002-11-27 | 2004-03-02 | Allergan, Inc. | Kinase inhibitors for the treatment of disease |
US6747025B1 (en) | 2002-11-27 | 2004-06-08 | Allergan, Inc. | Kinase inhibitors for the treatment of disease |
US6765012B2 (en) | 2001-09-27 | 2004-07-20 | Allergan, Inc. | 3-(Arylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors |
US6818440B2 (en) | 1997-04-28 | 2004-11-16 | Sugen, Inc. | Diagnosis and treatment of alk-7 related disorders |
US6835546B1 (en) | 1999-10-22 | 2004-12-28 | Pharmacia & Upjohn Company | Drosophila G protein coupled receptors, nucleic acids, and methods related to the same |
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US6921763B2 (en) | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
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US7091227B2 (en) | 2000-02-07 | 2006-08-15 | Abbott Gmbh & Co. Kg | Benzothiazole derivatives |
US7105562B2 (en) | 2003-08-06 | 2006-09-12 | Sugen, Inc. | Geometrically restricted 3-cyclopentylidene-1,3-dihydroindol-2-ones as potent protein tyrosine kinase inhibitors |
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WO1999045920A2 (en) * | 1998-03-13 | 1999-09-16 | Johns Hopkins University School Of Medicine | The use of a protein tyrosine inhibitor such as genistein in the treatment of diabetic retinopathy or ocular inflammation |
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WO2009091939A1 (en) * | 2008-01-18 | 2009-07-23 | Osi Pharmaceuticals, Inc. | Imidazopyrazinol derivatives for the treatment of cancers |
US20110136993A1 (en) | 2008-08-28 | 2011-06-09 | Dow Global Technologies Llc | Phosphorus-containing compounds and polymeric compositions comprising same |
CA2752826A1 (en) | 2009-04-20 | 2010-10-28 | OSI Pharmaceuticals, LLC | Preparation of c-pyrazine-methylamines |
JP2012526138A (en) * | 2009-05-07 | 2012-10-25 | オーエスアイ・ファーマシューティカルズ,エルエルシー | Use of OSI-906 to treat adrenocortical cancer |
-
1991
- 1991-03-14 CA CA002078214A patent/CA2078214C/en not_active Expired - Fee Related
- 1991-03-14 ES ES91907740T patent/ES2064101T3/en not_active Expired - Lifetime
- 1991-03-14 EP EP91907740A patent/EP0526488B1/en not_active Expired - Lifetime
- 1991-03-14 JP JP3507239A patent/JPH0662650B2/en not_active Expired - Lifetime
- 1991-03-14 DK DK91907740.4T patent/DK0526488T3/en active
- 1991-03-14 DE DE69105495T patent/DE69105495T2/en not_active Expired - Fee Related
- 1991-03-14 AT AT91907740T patent/ATE114661T1/en not_active IP Right Cessation
- 1991-03-14 WO PCT/US1991/001731 patent/WO1991015495A1/en active IP Right Grant
- 1991-03-14 US US07/934,469 patent/US5326905A/en not_active Expired - Lifetime
- 1991-03-28 IE IE103591A patent/IE64067B1/en not_active IP Right Cessation
- 1991-04-01 PT PT97214A patent/PT97214A/en not_active Application Discontinuation
-
1992
- 1992-10-01 FI FI924427A patent/FI924427A/en not_active Application Discontinuation
Non-Patent Citations (2)
Title |
---|
Biohemistry, vol. 28, no. 13, 1989, American Chemical Society, R. Saperstein et al.: "Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells", pages 5694-5701 * |
Chemical Abstracts, vol. 108, no. 23, 6 June 1988, (Columbus, Ohio, US), Y. Okamoto et al.: "Photochemical carbon-phosphorus bond cleavage of some (substituted benzyl)phosphonic acid derivatives", see page 682 * |
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US5763441A (en) * | 1992-11-13 | 1998-06-09 | Sugen, Inc. | Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis |
US5981569A (en) * | 1992-11-13 | 1999-11-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease |
US5849742A (en) * | 1992-11-13 | 1998-12-15 | Sugen Inc. | Compounds for the treament of disorders related to vasculogenesis and/or angiogenesis |
US5792771A (en) * | 1992-11-13 | 1998-08-11 | Sugen, Inc. | Quinazoline compounds and compositions thereof for the treatment of disease |
US5753715A (en) * | 1995-06-02 | 1998-05-19 | Ortho Pharmaceutical Corporation | 2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents |
US6225335B1 (en) | 1995-06-07 | 2001-05-01 | Sugen, Inc. | 3-(4′-bromobenzylindenyl)-2-indolinone and analogues thereof for the treatment of disease |
US5935993A (en) * | 1995-06-07 | 1999-08-10 | Sugen, Inc. | Tyrphostin like compounds |
US5773459A (en) * | 1995-06-07 | 1998-06-30 | Sugen, Inc. | Urea- and thiourea-type compounds |
US5792783A (en) * | 1995-06-07 | 1998-08-11 | Sugen, Inc. | 3-heteroaryl-2-indolinone compounds for the treatment of disease |
US5710173A (en) * | 1995-06-07 | 1998-01-20 | Sugen, Inc. | Thienyl compounds for inhibition of cell proliferative disorders |
US5834504A (en) * | 1995-06-07 | 1998-11-10 | Sugen, Inc. | 3-(2'-halobenzylidenyl)-2-indolinone compounds for the treatment of disease |
US5763470A (en) * | 1995-06-07 | 1998-06-09 | Sugen Inc. | Benzopyran compounds and methods for their use |
US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
US5883113A (en) * | 1995-06-07 | 1999-03-16 | Sugen, Inc. | 3-(4'-Bromobenzylindenyl)-2-indolinone and analogues thereof for the treatment of disease |
US5883116A (en) * | 1995-06-07 | 1999-03-16 | Sugen, Inc. | 3-(2'-alkoxybenzylidenyl)-2-indolinone and analogues thereof for the treatment of disease |
US5886195A (en) * | 1995-06-07 | 1999-03-23 | Sugen, Inc. | Thienyl compounds for inhibition of cell proliferative disorders |
US5886020A (en) * | 1995-06-07 | 1999-03-23 | Sugen, Inc. | 3-(4'-dimethylaminobenzylidenyl)-2-indolinone and analogues thereof for the treatment of disease |
US5891917A (en) * | 1995-06-07 | 1999-04-06 | Sugen, Inc. | Certain acrylonitrile-sulfonamide derivatives |
US6469032B2 (en) | 1995-06-07 | 2002-10-22 | Sugen, Inc. | 3-(4′-bromobenzylindenyl)-2-indolinone and analogues thereof for the treatment of disease |
US5650415A (en) * | 1995-06-07 | 1997-07-22 | Sugen, Inc. | Quinoline compounds |
US6906093B2 (en) | 1995-06-07 | 2005-06-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
US6316635B1 (en) | 1995-06-07 | 2001-11-13 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
US6103728A (en) * | 1995-06-07 | 2000-08-15 | Sugen, Inc. | Quinazolines |
WO1997012903A1 (en) * | 1995-10-04 | 1997-04-10 | Warner-Lambert Company | Compounds, compositions and methods for inhibiting the binding of proteins containing an sh2 domain to cognate phosphorylated proteins |
US7119174B2 (en) | 1995-12-18 | 2006-10-10 | Sugen, Inc. | Diagnosis and treatment of AUR1 and/or AUR2 related disorders |
US6716575B2 (en) | 1995-12-18 | 2004-04-06 | Sugen, Inc. | Diagnosis and treatment of AUR1 and/or AUR2 related disorders |
US6207401B1 (en) | 1995-12-18 | 2001-03-27 | Sugen, Inc. | Diagnosis and treatment of AUR-1 and/or AUR-2 related disorders |
US6696448B2 (en) | 1996-06-05 | 2004-02-24 | Sugen, Inc. | 3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors |
WO1997048675A1 (en) * | 1996-06-18 | 1997-12-24 | Ortho Pharmaceutical Corporation | 2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents |
US6682921B1 (en) | 1996-08-21 | 2004-01-27 | New York University | Crystals of the tyrosine kinase domain of non-insulin receptor tyrosine kinases |
US6818440B2 (en) | 1997-04-28 | 2004-11-16 | Sugen, Inc. | Diagnosis and treatment of alk-7 related disorders |
US6204267B1 (en) | 1997-05-02 | 2001-03-20 | Sugen, Inc. | Methods of modulating serine/thereonine protein kinase function with quinazoline-based compounds |
US6911446B2 (en) | 1997-05-02 | 2005-06-28 | Sugen, Inc. | Methods of modulating serine/threonine protein kinase function with quinazoline-based compounds |
US6316429B1 (en) | 1997-05-07 | 2001-11-13 | Sugen, Inc. | Bicyclic protein kinase inhibitors |
US6683082B2 (en) | 1997-05-07 | 2004-01-27 | Sugen, Inc. | Bicyclic protein kinase inhibitors |
US7189721B2 (en) | 1997-05-07 | 2007-03-13 | Sugen Inc. | Bicyclic protein kinase inhibitors |
US6486185B1 (en) | 1997-05-07 | 2002-11-26 | Sugen, Inc. | 3-heteroarylidene-2-indolinone protein kinase inhibitors |
US6844177B2 (en) | 1997-05-20 | 2005-01-18 | Sugen, Inc. | Diagnosis and treatment of PTP04 related disorders |
US6228641B1 (en) | 1997-05-20 | 2001-05-08 | Sugen, Inc. | Diagnosis and treatment of PTP04 related disorders |
US6849641B1 (en) | 1997-06-11 | 2005-02-01 | Sugen, Inc. | Azaindole tyrosine kinase inhibitors |
US6987113B2 (en) | 1997-06-11 | 2006-01-17 | Sugen, Inc. | Tyrosine kinase inhibitors |
US7115710B2 (en) | 1997-06-11 | 2006-10-03 | Sugen, Inc. | Diagnosis and treatment of PTP related disorders |
US6342593B1 (en) | 1997-06-11 | 2002-01-29 | Sugen, Inc. | Diagnosis and treatment of ALP related disorders |
US6388063B1 (en) | 1997-06-18 | 2002-05-14 | Sugen, Inc. | Diagnosis and treatment of SAD related disorders |
US6579897B2 (en) | 1997-06-20 | 2003-06-17 | Sugen, Inc. | 3-(cycloalkanoheteroarylidenyl)-2-indolinone protein tyrosine kinase inhibitors |
US6696463B2 (en) | 1997-06-20 | 2004-02-24 | Sugen, Inc. | 3-heteroarylidenyl-2-azaindolinones active as protein tyrosine kinase inhibitors |
US6051593A (en) * | 1997-06-20 | 2000-04-18 | Sugen, Inc. | 3-(cycloalkanoheteroarylidenyl)-2- indolinone protein tyrosine kinase inhibitors |
US6313158B1 (en) | 1997-06-20 | 2001-11-06 | Sugen, Inc. | Bioavailability of 3-heteroarylidenyl-2-indolinones active as protein tyrosine kinase inhibitors |
US6114371A (en) * | 1997-06-20 | 2000-09-05 | Sugen, Inc. | 3-(cyclohexanoheteroarylidenyl)-2-indolinone protein tyrosine kinase inhibitors |
US6130238A (en) * | 1997-06-20 | 2000-10-10 | Sugen, Inc. | 3-(cyclohexanoheteroarylidenyl)-2-indolinone protein tyrosine kinase inhibitors |
US6235769B1 (en) | 1997-07-03 | 2001-05-22 | Sugen, Inc. | Methods of preventing and treating neurological disorders with compounds that modulate the function of the C-RET receptor protein tyrosine kinase |
US6656940B2 (en) | 1997-08-05 | 2003-12-02 | Sugen, Inc. | Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors |
US6329375B1 (en) | 1997-08-05 | 2001-12-11 | Sugen, Inc. | Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors |
US7202265B2 (en) | 1997-08-20 | 2007-04-10 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
US6855723B2 (en) | 1997-09-26 | 2005-02-15 | Zentaris Gmbh | Methods of modulating serine/threonine protein kinase function with azabenzimidazole-based compounds |
BG64784B1 (en) * | 1997-09-26 | 2006-04-28 | Asta Medica Aktiengesellschaft | Azabenzimidazol based compound, process for its preparation and usage for modulating serine/threonine protein kinase function |
US6506763B2 (en) | 1997-09-26 | 2003-01-14 | Sugen, Inc. | 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity |
US6093728A (en) * | 1997-09-26 | 2000-07-25 | Asta Medica Aktiengesellschaft | Methods of modulating serine/threonine protein kinase function with azabenzimidazole-based compounds |
US6133305A (en) * | 1997-09-26 | 2000-10-17 | Sugen, Inc. | 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity |
US6180631B1 (en) | 1997-10-06 | 2001-01-30 | Asta Medica Aktiengesellschaft | Methods of modulating serine/threonine protein kinase function with 5-azaquinoxaline-based compounds |
US6727252B1 (en) | 1997-10-06 | 2004-04-27 | Zentaris Ag | Methods of modulating serine/threonine protein kinase function with 5-azaquinoxaline-based compounds |
BG64969B1 (en) * | 1997-10-06 | 2006-11-30 | Asta Medica Aktiengesellschaft | Methods for the modulation of serin/treonin protein kinase function with compounds based on 5-azaquinoxaline |
US6225346B1 (en) | 1997-10-24 | 2001-05-01 | Sugen, Inc. | Tyrphostin like compounds |
US6531502B1 (en) | 1998-01-21 | 2003-03-11 | Sugen, Inc. | 3-Methylidenyl-2-indolinone modulators of protein kinase |
US6495353B1 (en) | 1998-01-21 | 2002-12-17 | Sugen, Inc. | Human orthologues of wart |
US6514981B1 (en) | 1998-04-02 | 2003-02-04 | Sugen, Inc. | Methods of modulating tyrosine protein kinase function with indolinone compounds |
US6656716B1 (en) | 1998-04-14 | 2003-12-02 | Sugen, Inc. | Polypeptide fragments of human PAK5 protein kinase |
US6680170B2 (en) | 1998-04-14 | 2004-01-20 | Sugen, Inc. | Polynucleotides encoding STE20-related protein kinases and methods of use |
US7119090B2 (en) | 1998-05-29 | 2006-10-10 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
US6395734B1 (en) | 1998-05-29 | 2002-05-28 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
EP2020408A1 (en) | 1998-05-29 | 2009-02-04 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
US6855730B2 (en) | 1998-08-05 | 2005-02-15 | Sugen, Inc. | 3-methylidenyl-2-indolinone modulators of protein kinase |
US6642251B1 (en) | 1998-08-31 | 2003-11-04 | Sugen, Inc. | Geometrically restricted 2-indolinone derivatives as modulators of protein kinase activity |
US6316603B1 (en) | 1998-09-08 | 2001-11-13 | Agouron Pharmaceuticals, Inc. | Modifications of the VEGF receptor-2 protein and methods of use |
US6794146B2 (en) | 1998-09-08 | 2004-09-21 | Agouron Pharmaceuticals, Inc. | Modifications of the VEGF receptor-2 protein and methods of use |
US6849721B2 (en) | 1998-09-08 | 2005-02-01 | Agouron Pharmaceuticals, Inc. | Modifications of the VEGF receptor-2 protein and methods of use |
US6784285B1 (en) | 1998-09-08 | 2004-08-31 | Agouron Pharmaceuticals, Inc. | Modifications of the VEGF Receptor-2 Protein and methods of use |
US6753416B2 (en) | 1998-09-08 | 2004-06-22 | Agouron Pharmaceuticals, Inc. | Modifications of the VEGF receptor-2 protein and methods of use |
US6680335B2 (en) | 1998-09-28 | 2004-01-20 | Sugen, Inc. | Methods of modulating protein tyrosine kinase function with substituted indolinone compounds |
US6689806B1 (en) | 1999-03-24 | 2004-02-10 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
US6921763B2 (en) | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
WO2001027077A2 (en) * | 1999-10-12 | 2001-04-19 | Basf Aktiengesellschaft | Hydroxysulfonylalkylene-, phosphonoalkylene- or difluoro(phosphononon)methyl- substituted benzene, or benzofuran derivatives as non-peptidic cdc25 inhibitors |
WO2001027077A3 (en) * | 1999-10-12 | 2002-05-23 | Basf Ag | Hydroxysulfonylalkylene-, phosphonoalkylene- or difluoro(phosphononon)methyl- substituted benzene, or benzofuran derivatives as non-peptidic cdc25 inhibitors |
US6835546B1 (en) | 1999-10-22 | 2004-12-28 | Pharmacia & Upjohn Company | Drosophila G protein coupled receptors, nucleic acids, and methods related to the same |
US7354724B2 (en) | 1999-10-22 | 2008-04-08 | Pharmacia & Upjohn Company | Drosophila G protein coupled receptors, nucleic acids, and methods related to the same |
US6878733B1 (en) | 1999-11-24 | 2005-04-12 | Sugen, Inc. | Formulations for pharmaceutical agents ionizable as free acids or free bases |
US7211600B2 (en) | 1999-12-22 | 2007-05-01 | Sugen Inc. | Methods of modulating c-kit tyrosine protein kinase function with indolinone compounds |
US7091227B2 (en) | 2000-02-07 | 2006-08-15 | Abbott Gmbh & Co. Kg | Benzothiazole derivatives |
US6465507B2 (en) | 2000-02-28 | 2002-10-15 | Sugen, Inc. | 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors |
WO2001074369A1 (en) * | 2000-03-31 | 2001-10-11 | Angiogene Pharmaceuticals Ltd. | Divided dose therapies with vascular damaging activity |
US9775849B2 (en) | 2000-07-05 | 2017-10-03 | Allergan, Inc. | Implants and methods for treating inflammation-mediated conditions of the eye |
US10206934B2 (en) | 2000-07-05 | 2019-02-19 | Allergan, Inc. | Implants and methods for treating inflammation-mediated conditions of the eye |
US9012437B2 (en) | 2000-07-05 | 2015-04-21 | Allergan, Inc. | Implants and methods for treating inflammation-mediated conditions of the eye |
US9592242B2 (en) | 2000-11-29 | 2017-03-14 | Allergan, Inc. | Methods for treating edema in the eye and intraocular implants for use therefor |
US9283178B2 (en) | 2000-11-29 | 2016-03-15 | Allergan, Inc. | Methods for treating edema in the eye and intraocular implants for use therefor |
EP2361990A1 (en) | 2000-12-01 | 2011-08-31 | Response Genetics, Inc. | Method of determining epidermal growth factor receptor and HER2-NEU gene expression and correlation of levels thereof with survival rates |
US7332497B2 (en) | 2001-03-22 | 2008-02-19 | Abbott Gmbh & Co Kg | Pyrazolopyrimidines as therapeutic agents |
US7393870B2 (en) | 2001-09-27 | 2008-07-01 | Allergan, Inc. | 3-(heteroarylamino)methylene-1, 3-dihydro-2H-indol-2-ones as kinase inhibitors |
US7098236B2 (en) | 2001-09-27 | 2006-08-29 | Allergan, Inc. | 3-(arylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors |
US6559173B1 (en) | 2001-09-27 | 2003-05-06 | Allergan, Inc. | 3-(heteroarylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors |
US7015220B2 (en) | 2001-09-27 | 2006-03-21 | Allergan, Inc. | 3-(arylamino)methylene-1, 3-dihydro-2H-indol-2-ones as kinase inhibitors |
US7005444B2 (en) | 2001-09-27 | 2006-02-28 | Allergan, Inc. | 3-(heteroarylamino)methylene-1, 3-dihydro-2H-indol-2-ones as kinase inhibitors |
US7414054B2 (en) | 2001-09-27 | 2008-08-19 | Allergan, Inc. | 3-(arylamino)methylene-1, 3-dihydro-2H-indol-2-ones as kinase inhibitors |
US6765012B2 (en) | 2001-09-27 | 2004-07-20 | Allergan, Inc. | 3-(Arylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors |
WO2003042390A1 (en) * | 2001-11-13 | 2003-05-22 | Sugen, Inc. | Mammalian protein phosphatases |
US6541504B1 (en) | 2002-04-03 | 2003-04-01 | Allergan Sales, Llc | (3Z)-3-(2,3-dihydro-1H-inden-1-ylidene)-1,3-dihydro-2H-indol-2-ones as kinase inhibitors |
US7060844B2 (en) | 2002-04-03 | 2006-06-13 | Allergan, Inc. | (3Z)-3-(2,3-dihydro-1H-inden-1-ylidene)-1,3-dihydro-2H-indol-2-ones as kinase inhibitors |
US7709455B2 (en) | 2002-06-05 | 2010-05-04 | Genentech, Inc. | Compositions and methods for liver growth and liver protection |
EP2430923A1 (en) | 2002-06-05 | 2012-03-21 | Genentech, Inc. | Compositions and methods for liver growth and liver protection |
US7700571B2 (en) | 2002-06-05 | 2010-04-20 | Genentech, Inc. | Compositions and methods for liver growth and liver protection |
US8993573B2 (en) | 2002-08-02 | 2015-03-31 | Ab Science | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
US8835435B2 (en) | 2002-08-02 | 2014-09-16 | Ab Science | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
US8450302B2 (en) | 2002-08-02 | 2013-05-28 | Ab Science | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
US6699863B1 (en) | 2002-11-27 | 2004-03-02 | Allergan, Inc. | Kinase inhibitors for the treatment of disease |
US7531665B2 (en) | 2002-11-27 | 2009-05-12 | Allergan, Inc. | Kinase inhibitors for the treatment of disease |
US6747025B1 (en) | 2002-11-27 | 2004-06-08 | Allergan, Inc. | Kinase inhibitors for the treatment of disease |
US10702539B2 (en) | 2003-01-09 | 2020-07-07 | Allergan, Inc. | Ocular implant made by a double extrusion process |
US9192511B2 (en) | 2003-01-09 | 2015-11-24 | Allergan, Inc. | Ocular implant made by a double extrusion process |
US10076526B2 (en) | 2003-01-09 | 2018-09-18 | Allergan, Inc. | Ocular implant made by a double extrusion process |
EP2476667A2 (en) | 2003-02-26 | 2012-07-18 | Sugen, Inc. | Aminoheteroaryl compounds as protein kinase inhibitors |
US7157577B2 (en) | 2003-03-07 | 2007-01-02 | Sugen Inc. | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors |
US7105562B2 (en) | 2003-08-06 | 2006-09-12 | Sugen, Inc. | Geometrically restricted 3-cyclopentylidene-1,3-dihydroindol-2-ones as potent protein tyrosine kinase inhibitors |
US8110591B2 (en) | 2003-10-23 | 2012-02-07 | Ab Science | 2-aminoaryloxazole compounds as tyrosine kinase inhibitors |
EP2305682A1 (en) | 2004-04-02 | 2011-04-06 | OSI Pharmaceuticals, Inc. | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors |
EP2308879A1 (en) | 2004-04-02 | 2011-04-13 | OSI Pharmaceuticals, Inc. | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors |
US8895049B2 (en) | 2004-04-30 | 2014-11-25 | Allergan, Inc. | Extended release biodegradable ocular implants |
US10154960B2 (en) | 2004-04-30 | 2018-12-18 | Allergan, Inc. | Extended release biodegradable ocular implants |
US8974812B2 (en) | 2004-04-30 | 2015-03-10 | Allergan, Inc. | Extended release biodegradable ocular implants |
US8685435B2 (en) | 2004-04-30 | 2014-04-01 | Allergan, Inc. | Extended release biodegradable ocular implants |
US10874605B2 (en) | 2004-04-30 | 2020-12-29 | Allergan, Inc. | Extended release biodegradable ocular implants |
EP2777693A1 (en) | 2004-04-30 | 2014-09-17 | Allergan, Inc. | Biodegradable ocular implants with long-term release characteristics |
US8911768B2 (en) | 2004-04-30 | 2014-12-16 | Allergan, Inc. | Methods for treating retinopathy with extended therapeutic effect |
WO2006012422A1 (en) | 2004-07-20 | 2006-02-02 | Osi Pharmaceuticals, Inc. | Imidazopyrazine as tyrosine kinase inhibitors |
US8658659B2 (en) | 2005-04-04 | 2014-02-25 | Ab Science | Substituted oxazole derivatives and their use as tyrosine kinase inhibitors |
WO2007064993A2 (en) | 2005-12-02 | 2007-06-07 | Osi Pharmaceuticals, Inc. | Bicyclic protein kinase inhibitors |
US8338415B2 (en) | 2006-01-24 | 2012-12-25 | Allergan, Inc. | Substituted 3-(5-membered unsaturated heterocyclyl-1, 3-dihydro-indol-2-one's and derivatives thereof as kinase inhibitors |
US8877923B2 (en) | 2006-01-24 | 2014-11-04 | Allergan, Inc. | Substituted 3-(5-membered unsaturated heterocyclyl-1, 3-dihydro-indol-2-ones and derivatives thereof as kinase inhibitors |
US8865682B2 (en) | 2006-01-24 | 2014-10-21 | Allergan, Inc. | Substituted 3-(5-membered unsaturated heterocyclyl-1, 3-dihydro-indol-2-one's and derivatives thereof as kinase inhibitors |
US8367664B2 (en) | 2006-01-24 | 2013-02-05 | Allergan, Inc. | Substituted 3-(5-membered unsaturated heterocyclyl-1, 3-dihydro-indol-2-one's and derivatives thereof as kinase inhibitors |
US9758509B2 (en) | 2006-01-24 | 2017-09-12 | Allergan, Inc. | Substituted 3-(5-membered unsaturated heterocyclyl-1, 3-dihydro-indol-2-one's and derivatives thereof as kinase inhibitors |
US9657005B2 (en) | 2006-01-24 | 2017-05-23 | Allergan, Inc. | Substituted 3-(5-membered unsaturated heterocyclyl-1, 3-dihydro-indol-2-one's and derivatives thereof as kinase inhibitors |
US8455535B2 (en) | 2006-03-22 | 2013-06-04 | Allergan, Inc. | Heteroaryl dihydroindolones as kinase inhibitors |
US7977351B2 (en) | 2006-03-22 | 2011-07-12 | Allergan, Inc. | Heteroaryl dihydroindolones as kinase inhibitors |
WO2008061236A2 (en) | 2006-11-16 | 2008-05-22 | Allergan, Inc. | Sulfoximines as kinase inhibitors |
US8663915B2 (en) | 2007-04-13 | 2014-03-04 | Agency For Science, Technology And Research | Methods of controlling tumorigenesis and diagnosing the risk thereof |
US8956655B2 (en) | 2007-05-24 | 2015-02-17 | Allergan, Inc. | Biodegradable drug delivery system |
US8231892B2 (en) | 2007-05-24 | 2012-07-31 | Allergan, Inc. | Biodegradable drug delivery system |
US8969313B2 (en) | 2007-11-02 | 2015-03-03 | Agency For Science, Technology And Research | Methods and compounds for preventing and treating a tumour |
US8809534B2 (en) | 2009-09-03 | 2014-08-19 | Allergan, Inc. | Compounds as tyrosine kinase modulators |
WO2011029001A1 (en) | 2009-09-03 | 2011-03-10 | Allergan, Inc. | Compounds as tyrosine kinase modulators |
US9340555B2 (en) | 2009-09-03 | 2016-05-17 | Allergan, Inc. | Compounds as tyrosine kinase modulators |
US9328103B2 (en) | 2009-09-03 | 2016-05-03 | Allergan, Inc. | Compounds as tyrosine kinase modulators |
US9725433B2 (en) | 2009-09-03 | 2017-08-08 | Allergan, Inc. | Compounds as tyrosine kinase modulators |
WO2011028995A1 (en) | 2009-09-03 | 2011-03-10 | Allergan, Inc. | Compounds as tyrosine kinase modulators |
US8614234B2 (en) | 2009-09-03 | 2013-12-24 | Allergan, Inc. | Compounds as tyrosine kinase modulators |
US9475801B2 (en) | 2009-09-03 | 2016-10-25 | Allergan, Inc. | Compounds as tyrosine kinase modulators |
US10221192B2 (en) | 2009-09-03 | 2019-03-05 | Allergan, Inc. | Compounds as tyrosine kinase modulators |
US9265739B2 (en) | 2010-06-02 | 2016-02-23 | The Trustees Of The University Of Pennsylvania | Methods and use of compounds that bind to HER2/neu receptor complex |
US8993634B2 (en) | 2010-06-02 | 2015-03-31 | The Trustees Of The University Of Pennsylvania | Methods and use of compounds that bind to Her2/neu receptor complex |
WO2013062843A1 (en) | 2011-10-20 | 2013-05-02 | Allergan, Inc. | Pyridine- sulfoximines as tyrosine kinase inhibitors |
WO2014033281A1 (en) | 2012-08-31 | 2014-03-06 | Westfaelische Wilhelms-Universitaet Muenster | Methods and peptides for preventing and treating a bcr-abl and a c-abl associated disease |
US11285212B2 (en) | 2013-03-01 | 2022-03-29 | California Institute Of Technology | Targeted nanoparticles |
US10717825B2 (en) | 2015-07-01 | 2020-07-21 | California Instite of Technology | Cationic mucic acid polymer-based delivery system |
US11041050B2 (en) | 2015-07-01 | 2021-06-22 | California Institute Of Technology | Cationic mucic acid polymer-based delivery systems |
WO2020178230A1 (en) * | 2019-03-04 | 2020-09-10 | Merck Patent Gmbh | Ligands for nano-sized materials |
Also Published As
Publication number | Publication date |
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DE69105495D1 (en) | 1995-01-12 |
EP0526488A1 (en) | 1993-02-10 |
FI924427A0 (en) | 1992-10-01 |
US5326905A (en) | 1994-07-05 |
DE69105495T2 (en) | 1995-04-06 |
PT97214A (en) | 1992-01-31 |
JPH0662650B2 (en) | 1994-08-17 |
CA2078214C (en) | 1995-03-28 |
DK0526488T3 (en) | 1995-04-24 |
FI924427A (en) | 1992-10-01 |
ATE114661T1 (en) | 1994-12-15 |
JPH05502452A (en) | 1993-04-28 |
EP0526488B1 (en) | 1994-11-30 |
IE64067B1 (en) | 1995-07-12 |
IE911035A1 (en) | 1991-10-09 |
ES2064101T3 (en) | 1995-01-16 |
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