WO1991010654A1 - Muscarinic receptor antagonists - Google Patents
Muscarinic receptor antagonists Download PDFInfo
- Publication number
- WO1991010654A1 WO1991010654A1 PCT/EP1990/002044 EP9002044W WO9110654A1 WO 1991010654 A1 WO1991010654 A1 WO 1991010654A1 EP 9002044 W EP9002044 W EP 9002044W WO 9110654 A1 WO9110654 A1 WO 9110654A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- formula
- compound
- independently
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Definitions
- This invention relates to certain benzodiazepinone
- the compounds of the invention are muscarinic receptor antagonists which are selective for smooth muscle muscarinic sites over cardiac muscarinic sites and which do not have any significant antihistaminic activity.
- the compounds are useful in the treatment of diseases associated with altered motility and/or tone of smooth muscle which can, for example, be found in the gut, trachea and bladder.
- diseases include irritable bowel syndrome, diverticular disease, urinary
- R 4 is H, halo or C 1 -C 4 alkyl
- R 1 is H or C 1 -C 4 alkyl
- R 2 is H or C 1 -C 4 alkyl
- Y is a direct link, 0 or S;
- n is an integer of from 1 to 4.
- n 2 or 3;
- R 3 is 1- or 2-naphthyl or a group of the formula:-
- R 5 and R 6 are each independently H, C 1 -C 4 alkyl, C 1 -C 4 alkoxy , -(CH 2 ) q OH, halo, trifluoromethyl, cyano,
- R 7 and R 8 are each independently H or C 1 -C 4 alkyl, or
- R 7 is H and R 8 is -SO 2 (C 1 -C 4 alkyl), -CONR 9 R 10 ,
- R 9 and R 10 are each independently H or C 1 -C 4 alkyl
- q 0, 1 or 2;
- Z and Z are each independently 0 or CH 2 ;
- p 1, 2 or 3;
- Het is pyridyl, pyrazinyl or thienyl.
- R 1 is H.
- X is preferably N or CH.
- m is preferably 1, 2 or 3.
- n is preferably 2.
- R 2 is preferably methyl.
- Y is preferably a direct link or 0.
- R 3 is preferably 2-naphthyl, pyridyl or a group of the formula : -
- R 5 and R 6 are each independently H, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halo (preferably chloro), trifluoromethyl, cyano or C 1 -C 4 alkanesulphonamido, and Z 1 is 0 or CH 2 .
- the pharmaceutically acceptable salts of the compounds of formula (I) include acid addition salts such as the hydrochloride, hydrobromide, sulphate or bisulphate, phosphate or hydrogen phosphate, acetate, besylate, citrate, fumarate, gluconate, lactate, maleate, tnesylate, succinate and tartrate salts.
- acid addition salts such as the hydrochloride, hydrobromide, sulphate or bisulphate, phosphate or hydrogen phosphate, acetate, besylate, citrate, fumarate, gluconate, lactate, maleate, tnesylate, succinate and tartrate salts.
- the compounds of the formula (I) can be prepared by the following routes:- Route A
- X, Y, R 1 , R 2 , R 3 , m and n are as defined for formula (I) and Q is a leaving group, e.g. Br, Cl, I, C 1 -C 4 alkanesulfonyloxy (e.g. methanesulfonyloxy), benzenesulfonyloxy, toluenesulfonyloxy (e.g. p-toluenesulfonyloxy) or
- Q is Cl, Br, I or methanesulfonyloxy.
- Q is Br.
- the reaction is preferably carried out in the presence of an acid acceptor such as sodium hydrogen carbonate, sodium or potassium carbonate, triethylamine or pyridine, and in a suitable organic solvent, e.g. acetonitrile, at up to the reflux
- reaction temperatures of 60-120°C are generally desirable and it is most convenient to carry out the reaction under reflux. lodo is often a particularly suitable leaving group but since the starting materials (III) are sometimes most
- reaction can also be carried out using the compound (III) as a chloride or
- the starting materials of the formula (II) are either known compounds or can be prepared by conventional procedures, see e.g.
- R 1 , R 2 , R 3 , X, Y, m and n are as defined for formula (I) and
- the compounds (IV) and (V) are either known (see e.g. GB 1,581,500 and DT-PS 1,936,670) or can be prepared by conventional techniques such as those described in the following Preparations 1 to 3.
- the compounds (VI) are either known or can be prepared conventionally as is illustrated in the following Preparations.
- the selectivity of the compounds as muscarinic receptor antagonists can be measured as follows.
- Dose-response curves to either acetylcholine (ileum) or carbachol (trachea, bladder and right atrium) are determined using a 1-5 minute contact time for each dose of agonist until the maximum response is achieved.
- the organ bath is drained and refilled with physiological salt solution containing the lowest dose of the test compound.
- the test compound is allowed to equilibrate with the tissue for 20 minutes and the agonist dose-response curve is repeated until the maximum response is obtained.
- the organ bath is drained and refilled with
- physiological salt solution containing the second concentration of test compound and the above procedure is repeated. Typically four concentrations of the test compound are evaluated on each tissue.
- the concentration of the test compound which causes a doubling of the agonist concentration required to produce the original response is determined (pA 2 value - Arunlakshana and Schild (1959), Brit. J. Pharmacol., 14, 48-58).
- tissue selectivity for muscarinic receptor antagonists is determined.
- Activity against agonist induced bronchoconstriction or gut or bladder contractility in comparison with changes in heart rate is deterimined in the anaesthetised dog. Oral activity is assessed in the conscious dog determining compound effects on, for example, heart rate, pupil diameter and gut motility.
- the dose which causes a doubling of pupil size is determined as well as the dose which inhibits the salivation and tremor responses to intravenous oxotremorine by 50%.
- oral dosages of the compounds will generally be in the range of from 3.5 to 350 mg daily for an average adult patient (70 kg).
- individual tablets or capsules will typically contain from 1 to 250 mg of active compound, in a suitable pharmaceutically acceptable vehicle or carrier for administration singly or in multiple doses, once or several times a day.
- Dosages for intravenous administration will typically be within the range 0.35 to 35 mg per single dose as required.
- the physician will determine the actual dosage which will be most suitable for an individual patient and it will vary with the age, weight and response of the particular patient.
- the above dosages are exemplary of the average case but there can, of course, be individual instances where higher or lower dosage ranges are merited, and such are within the scope of this invention.
- the compounds of the formula (I) can be administered alone, but will generally be administered in admixture with a pharmaceutical carrier selected with regard to the intended route of administration and standard pharmaceutical practice.
- a pharmaceutical carrier selected with regard to the intended route of administration and standard pharmaceutical practice.
- they may be administered orally in the form of tablets containing such excipients as starch or lactose, or in capsules or ovules either alone or in admixture with excipients, or in the form of elixirs of suspensions containing flavouring or colouring agents. They may be injected
- the invention provides a pharmaceutical composition
- a pharmaceutical composition comprising a compound of the formula (I), or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable diluent or carrier.
- the invention also includes a compound of the formula (I) or a pharmaceutically acceptable salt thereof, for use as a
- the invention further includes the use of a compound of the formula (I), or of a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for the treatment of diseases associated with the altered motility and/or tone of smooth muscle, such as irritable bowel syndrome, diverticular disease, urinary incontinence, oesophageal achalasia and chronic obstructive airways disease.
- diseases associated with the altered motility and/or tone of smooth muscle such as irritable bowel syndrome, diverticular disease, urinary incontinence, oesophageal achalasia and chronic obstructive airways disease.
- the invention yet further includes a method of treatment of a human being to cure or prevent a disease associated with the altered motility and/or tone of smooth muscle, such as irritable bowel syndrome, which comprises treating said human being with an effective amount of a compound of the formula (I), or a
- Example 10 appropriate 5-chloroacy1-10,11-dihydrodibenzo[b,e][1,4]diazepin- 6-one with one equivalent of the appropriate arylalkylmethylamine in the presence of two equivalents of sodium hydrogen carbonate using acetonitrile as the solvent.
- the product of Example 10 was characterised as containing 0.10 equivalents of dichloromethane (derived from the chromatography) while the product of Example 8 was characterised as a hydrate.
- the preparation of the starting material for Examples 6-8 is described in Preparation 2 while the preparation of the starting material for Example 9 is described in Preparation 3.
- the starting material for Example 10 was prepared according to German patent no. 1,936,670.
- N-(4-methoxyphenethyl)methylamine (127 mg) in dioxane (15 ml) was heated under reflux for 4 hours and evaporated. The residue was partitioned between water and dichloromethane and the organic layer dried over MgSO 4 and evaporated. The residue was purified by chromatography on silica using dichloromethane plus 0-2% methanol as eluant. Appropriate fractions were combined and evaporated to give the title compound as a pale yellow solid, 182 mg (60%), m.p. 163-164°C, which was characterised as a
- Example 11 were prepared as described for Example 11 by reacting a mixture of 11-acryloyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 11-(3-chloropropionyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]- benzodiazepin-6-one (see Preparation 1) with a slight excess of the appropriate arylalkylmethylamine in the presence of excess sodium hydrogen carbonate using acetonitrile as solvent.
- the products of Examples 23-28 were characterised as hemihydrates.
- the N-(4-methanesulphonamidophenethyl)methylamine used in Example 30 was prepared as described in EP-A-245,997.
- Phosphorus tribromide (3.5 ml) was added, dropwise, to a solution of 5-(2-hydroxyethyl)indane (14.0 g) (FR-A-2139628) in carbon tetrachloride (100 ml). The mixture was stirred at room temperature for 0.5 hour and then heated under reflux for 2 hours. Ice (100 g) was added and the mixture partitioned between dichloromethane and 10% aqueous sodium carbonate solution. The layers were separated and the aqueous layer extracted wilth dichloromethane (2 x 100 ml).
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT91900776T ATE101599T1 (en) | 1990-01-06 | 1990-11-28 | MUSCARINE RECEPTOR ANTAGONISTS. |
JP3501208A JPH0692376B2 (en) | 1990-01-06 | 1990-11-28 | Muscarinic receptor antagonist |
DE69006745T DE69006745T2 (en) | 1990-01-06 | 1990-11-28 | MUSCARINE RECEPTOR ANTAGONISTS. |
FI922346A FI922346A0 (en) | 1990-01-06 | 1992-05-22 | MUSCARINRECEPTORANTAGONISTER. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909000302A GB9000302D0 (en) | 1990-01-06 | 1990-01-06 | Muscarinic receptor antagonists |
GB9000302.1 | 1990-01-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1991010654A1 true WO1991010654A1 (en) | 1991-07-25 |
Family
ID=10668923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1990/002044 WO1991010654A1 (en) | 1990-01-06 | 1990-11-28 | Muscarinic receptor antagonists |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0508995B1 (en) |
JP (1) | JPH0692376B2 (en) |
AT (1) | ATE101599T1 (en) |
CA (1) | CA2069931C (en) |
DE (1) | DE69006745T2 (en) |
DK (1) | DK0508995T3 (en) |
ES (1) | ES2062755T3 (en) |
FI (1) | FI922346A0 (en) |
GB (1) | GB9000302D0 (en) |
IE (1) | IE63685B1 (en) |
PT (1) | PT96420B (en) |
WO (1) | WO1991010654A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0515796A1 (en) * | 1991-05-25 | 1992-12-02 | ARZNEIMITTELWERK DRESDEN GmbH | 5-Aminoacyl-5,10-dihydro-11H-dibenzo(b,e)(1,4)diazepin-11-ones, processes for their preparation, and their use as medicaments |
WO1994022861A1 (en) * | 1993-04-05 | 1994-10-13 | Pharmaceutical Discovery Corporation | PYRIDO[2,3-b][1,4]BENZODIAZEPINONES AS M2 RECEPTOR LIGAND FOR THE TREATMENT OF NEUROLOGICAL DISORDERS |
WO1996013488A1 (en) * | 1994-10-31 | 1996-05-09 | Yamanouchi Pharmaceutical Co., Ltd. | Novel benzodiazepinone derivative and medicinal composition thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1581500A (en) * | 1977-05-31 | 1980-12-17 | Thomae Gmbh Dr K | Pyridobenzodiazepines |
EP0346744A1 (en) * | 1988-06-15 | 1989-12-20 | Dr. Karl Thomae GmbH | Condensed diazepinones, process for their preparation and medicaments containing them |
-
1990
- 1990-01-06 GB GB909000302A patent/GB9000302D0/en active Pending
- 1990-11-28 AT AT91900776T patent/ATE101599T1/en not_active IP Right Cessation
- 1990-11-28 ES ES91900776T patent/ES2062755T3/en not_active Expired - Lifetime
- 1990-11-28 DE DE69006745T patent/DE69006745T2/en not_active Expired - Fee Related
- 1990-11-28 CA CA002069931A patent/CA2069931C/en not_active Expired - Fee Related
- 1990-11-28 JP JP3501208A patent/JPH0692376B2/en not_active Expired - Lifetime
- 1990-11-28 DK DK91900776.5T patent/DK0508995T3/en active
- 1990-11-28 EP EP91900776A patent/EP0508995B1/en not_active Expired - Lifetime
- 1990-11-28 WO PCT/EP1990/002044 patent/WO1991010654A1/en active IP Right Grant
-
1991
- 1991-01-04 PT PT96420A patent/PT96420B/en not_active IP Right Cessation
- 1991-01-04 IE IE1791A patent/IE63685B1/en not_active IP Right Cessation
-
1992
- 1992-05-22 FI FI922346A patent/FI922346A0/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1581500A (en) * | 1977-05-31 | 1980-12-17 | Thomae Gmbh Dr K | Pyridobenzodiazepines |
EP0346744A1 (en) * | 1988-06-15 | 1989-12-20 | Dr. Karl Thomae GmbH | Condensed diazepinones, process for their preparation and medicaments containing them |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0515796A1 (en) * | 1991-05-25 | 1992-12-02 | ARZNEIMITTELWERK DRESDEN GmbH | 5-Aminoacyl-5,10-dihydro-11H-dibenzo(b,e)(1,4)diazepin-11-ones, processes for their preparation, and their use as medicaments |
WO1994022861A1 (en) * | 1993-04-05 | 1994-10-13 | Pharmaceutical Discovery Corporation | PYRIDO[2,3-b][1,4]BENZODIAZEPINONES AS M2 RECEPTOR LIGAND FOR THE TREATMENT OF NEUROLOGICAL DISORDERS |
US5712269A (en) * | 1993-04-05 | 1998-01-27 | Pharmaceutical Discovery Corporation | M2 receptor ligand for the treatment of neurological disorders |
AU688318B2 (en) * | 1993-04-05 | 1998-03-12 | Mannkind Corporation | M2 receptor ligand for the treatment of neurological disorders |
EP1120416A1 (en) * | 1993-04-05 | 2001-08-01 | Pharmaceutical Discovery Corporation | Pyrido[2.3-b][1,4]benzodiazepinones as M2 receptor ligand for the treatment of neurological disorders |
WO1996013488A1 (en) * | 1994-10-31 | 1996-05-09 | Yamanouchi Pharmaceutical Co., Ltd. | Novel benzodiazepinone derivative and medicinal composition thereof |
Also Published As
Publication number | Publication date |
---|---|
CA2069931A1 (en) | 1991-07-07 |
DE69006745T2 (en) | 1994-06-01 |
PT96420A (en) | 1991-10-15 |
FI922346A (en) | 1992-05-22 |
DK0508995T3 (en) | 1994-03-21 |
IE63685B1 (en) | 1995-05-31 |
EP0508995A1 (en) | 1992-10-21 |
FI922346A0 (en) | 1992-05-22 |
EP0508995B1 (en) | 1994-02-16 |
IE910017A1 (en) | 1991-07-17 |
ATE101599T1 (en) | 1994-03-15 |
JPH05501711A (en) | 1993-04-02 |
CA2069931C (en) | 1997-08-26 |
DE69006745D1 (en) | 1994-03-24 |
ES2062755T3 (en) | 1994-12-16 |
JPH0692376B2 (en) | 1994-11-16 |
PT96420B (en) | 1997-05-28 |
GB9000302D0 (en) | 1990-03-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0505377B1 (en) | Muscarinic receptor antagonists | |
WO1992005172A2 (en) | Muscarinic receptor antagonists | |
US5418229A (en) | Muscarinic receptor antagonists | |
WO1991009013A1 (en) | Muscarinic receptor antagonists | |
EP0510003B1 (en) | Piperidine and pyrrolidine derivatives | |
WO1993003015A1 (en) | Heteroalkoxy benzazepines | |
CS247094B2 (en) | Preparation method of 5,11-dihydro-11-(((methyl-4-piperidinyl)amino)carbonyl)-6h-dibenz(b,e)-azepin-6-on | |
FI94131C (en) | Process for the preparation of therapeutically active R (-) - 3-quinuclidinol derivatives | |
WO1991010647A1 (en) | Muscarinic receptor antagonists | |
FI75818C (en) | Process for the preparation of substituting dibenzodiazepinones | |
EP0441852B1 (en) | Muscarinic receptor antagonists | |
EP0508995B1 (en) | Muscarinic receptor antagonists | |
US4616023A (en) | Pharmaceutical compositions of 4-(dibenzo-[a,d]cycloalkenyl)piperazine compounds and methods | |
EP1053235A1 (en) | Oxazole derivatives as serotonin-1a receptor agonists | |
US5932594A (en) | Muscarinic receptor antagonists | |
US5639748A (en) | 6,9-disubstituted benzazepines having α-adrenoceptor blocking activity | |
US4337260A (en) | Imidazopyridine-spiro-piperidine compounds | |
US5300516A (en) | Muscarinic receptor antagonists | |
MXPA98004749A (en) | Use of compounds to reduce glucose in blood and / or inhibit the secretion, circulation or effect of antagonising peptides in the insul |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): CA FI JP US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LU NL SE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2069931 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 922346 Country of ref document: FI |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1991900776 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1991900776 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 1991900776 Country of ref document: EP |