WO1991007967A3 - Method of preventing or limiting reperfusion damage - Google Patents

Method of preventing or limiting reperfusion damage

Info

Publication number
WO1991007967A3
WO1991007967A3 PCT/EP1990/001985 EP9001985W WO9107967A3 WO 1991007967 A3 WO1991007967 A3 WO 1991007967A3 EP 9001985 W EP9001985 W EP 9001985W WO 9107967 A3 WO9107967 A3 WO 9107967A3
Authority
WO
WIPO (PCT)
Prior art keywords
preventing
reperfusion
heart
alkylpiperazinealkanamide
limiting
Prior art date
Application number
PCT/EP1990/001985
Other languages
French (fr)
Other versions
WO1991007967A2 (en
Inventor
Belle Herman Van
Laerhoven Willy J C Van
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Priority to CA002044143A priority Critical patent/CA2044143C/en
Priority to SU905001085A priority patent/RU2093156C1/en
Priority to AT90917677T priority patent/ATE102831T1/en
Priority to DE69007471T priority patent/DE69007471T2/en
Publication of WO1991007967A2 publication Critical patent/WO1991007967A2/en
Priority to NO912511A priority patent/NO304519B1/en
Publication of WO1991007967A3 publication Critical patent/WO1991007967A3/en
Priority to FI913433A priority patent/FI109694B/en
Priority to HK115095A priority patent/HK115095A/en
Priority to NO19982078A priority patent/NO311701B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A61K38/166—Streptokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Protection Of Pipes Against Damage, Friction, And Corrosion (AREA)
  • Dicing (AREA)
  • Branch Pipes, Bends, And The Like (AREA)
  • Suspension Of Electric Lines Or Cables (AREA)
  • Golf Clubs (AREA)
  • Professional, Industrial, Or Sporting Protective Garments (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
  • Paper (AREA)
  • External Artificial Organs (AREA)

Abstract

The use of an N-alkylpiperazinealkanamide for preventing and/or limiting reperfusion damage upon reperfusion of an organ or muscular tissue, particularly in a patient undergoing thrombolysis or reperfusion of the heart after open heart surgery or after receiving a donor heart. The use of an N-alkylpiperazinealkanamide for preventing and/or limiting reperfusion damage upon reperfusion of a transplanted heart. The use of an N-alkylpiperazinealkanamide for storing a heart for transplantation for at least 24 hours in a cold cardioplegic solution. Compositions comprising an effective reperfusion damage preventing and/or limiting amount of an N-aryl-piperazinealkanamide derivative and optionally further comprising a thrombolytic agent and/or cyclodextrin or an ether derivative thereof. Processes for preparing such compositions. Novel N-alkylpiperazinealkanamide compounds and a process for preparing said compounds.
PCT/EP1990/001985 1989-11-22 1990-11-19 Method of preventing or limiting reperfusion damage WO1991007967A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA002044143A CA2044143C (en) 1989-11-22 1990-11-19 Method of preventing or limiting reperfusion damage
SU905001085A RU2093156C1 (en) 1989-11-22 1990-11-19 L-(-)-2-(aminocarbonyl)-n-(4-amino-2,6-dichlorophenyl)-4-[5,5- -bis-(4-fluorophenyl)-pentyl]-1-piperazine acetamide, its pharmaceutically acceptable salt or hydrate, a method of its synthesis and an agent for donor heart storage
AT90917677T ATE102831T1 (en) 1989-11-22 1990-11-19 METHODS TO PREVENT OR LIMIT REPERFUSION INJURY.
DE69007471T DE69007471T2 (en) 1989-11-22 1990-11-19 METHOD FOR PREVENTING OR LIMITING REPERFUSION DAMAGE.
NO912511A NO304519B1 (en) 1989-11-22 1991-06-26 Preparation of (1) - (-) - 2- (aminocarbonyl) -N- (4-amino-2,6-dichlorophenyl) -4- [5,5-bis (4-fluorophenyl) pentyl] -1-piperazine acetamide
FI913433A FI109694B (en) 1989-11-22 1991-07-16 A process for the preparation of a therapeutically useful (1) - (-) - 2- (aminocarbonyl) -N- (4-amino-2,6-dichlorophenyl) -4- [5,5-bis (4-fluorophenyl) pentyl] -1- for the preparation of piperazine acetamide
HK115095A HK115095A (en) 1989-11-22 1995-07-13 Method of preventing or limiting reperfusion damage
NO19982078A NO311701B1 (en) 1989-11-22 1998-05-07 Method of protecting a donor heart for transplantation and using an N-aryl-piperazine alkanamide compound for this purpose

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44014289A 1989-11-22 1989-11-22
US440,142 1989-11-22
SG118494A SG118494G (en) 1989-11-22 1994-08-20 Method of preventing or limiting reperfusion damage

Publications (2)

Publication Number Publication Date
WO1991007967A2 WO1991007967A2 (en) 1991-06-13
WO1991007967A3 true WO1991007967A3 (en) 1991-07-11

Family

ID=26664237

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1990/001985 WO1991007967A2 (en) 1989-11-22 1990-11-19 Method of preventing or limiting reperfusion damage

Country Status (22)

Country Link
EP (2) EP0577171B1 (en)
JP (1) JP2574585B2 (en)
KR (1) KR0165686B1 (en)
AT (2) ATE102831T1 (en)
AU (1) AU632888B2 (en)
CA (1) CA2044143C (en)
CY (1) CY1869A (en)
DE (2) DE69033926T2 (en)
DK (2) DK0577171T3 (en)
ES (2) ES2173883T3 (en)
FI (1) FI109694B (en)
HK (1) HK115095A (en)
HU (1) HU215847B (en)
IE (1) IE65121B1 (en)
IL (1) IL96390A (en)
NO (2) NO304519B1 (en)
NZ (1) NZ236168A (en)
PT (2) PT95959B (en)
RU (1) RU2093156C1 (en)
SG (1) SG118494G (en)
WO (1) WO1991007967A2 (en)
ZA (1) ZA909345B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9202266D0 (en) * 1992-07-31 1992-07-31 Kabi Pharmacia Ab NOVEL PIPERAZINE CARBOXAMIDES
SE9504661D0 (en) 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
US6683100B2 (en) 1999-01-19 2004-01-27 Novartis Ag Organic compounds
US6194181B1 (en) 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
SE9904674D0 (en) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904673D0 (en) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0001209D0 (en) 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
WO2002094794A1 (en) 2001-05-18 2002-11-28 Astrazeneca Ab 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders
SE0203303D0 (en) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203300D0 (en) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203302D0 (en) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
WO2005047274A1 (en) * 2003-11-12 2005-05-26 Dr. Reddy's Laboratories, Inc. Preparation of escitalopram
KR101234421B1 (en) 2004-08-02 2013-02-18 아스트라제네카 아베 Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
FR2946340B1 (en) 2009-06-05 2011-06-24 Galderma Res & Dev NOVEL N-PHENYL ACETAMIA, INHIBITORS OF ENZYME SOAT-1, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME
KR101900124B1 (en) 2014-06-25 2018-09-18 전남대학교산학협력단 Compositon for abalone exfoliation agent
KR101644299B1 (en) 2014-07-22 2016-08-02 주식회사 엔바이로젠 Compositon for abalone exfoliation agent comprising schizandra chinensis extract and allilum hookeri extract

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068544A2 (en) * 1981-06-23 1983-01-05 Janssen Pharmaceutica N.V. Novel N-aryl-piperazinealkanamides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ223847A (en) * 1987-04-01 1989-12-21 Janssen Pharmaceutica Nv Substituted piperazine derivatives and pharmaceutical compositions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068544A2 (en) * 1981-06-23 1983-01-05 Janssen Pharmaceutica N.V. Novel N-aryl-piperazinealkanamides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Br. J. Pharmacol, vol. 99, Proc. Suppl., 1990, (GB), C.L. Wainwright et al.: "The effects of a nkucleoside transport inhibitor, R75231, on ischaemic arrhythmias in anaesthetised pigs" *
European Journal of Pharmacology - Molecular Pharmacology Section, vol. 172, 1989, Elsevier Science Publishers B.V. (Biomedical Division), (Amsterdam, NL), A.P. IJzerman et al.: "Inhibition or nucleoside transport by a new series of compounds related to lidoflazine and mioflazine", pages 273-281 *
J. Mol. Cell. Cardiol., vol. 21, suppl. 2, 1989, (London, GB), H. van Belle et al.: "Normothermic global ischemia in the isolated working rabbit heart the effect of different drugs on functional recovery and on the release of inarganic phosphate lactic acid nucleosides and norepinephrine", page *

Also Published As

Publication number Publication date
NO304519B1 (en) 1999-01-04
IE65121B1 (en) 1995-10-04
HU215847B (en) 1999-04-28
NZ236168A (en) 1993-05-26
AU632888B2 (en) 1993-01-14
FI109694B (en) 2002-09-30
DK0455789T3 (en) 1994-04-05
CA2044143C (en) 2002-11-19
NO982078D0 (en) 1998-05-07
RU2093156C1 (en) 1997-10-20
EP0577171A2 (en) 1994-01-05
PT102145A (en) 1999-10-29
SG118494G (en) 1994-11-25
DE69007471T2 (en) 1994-06-23
ES2053208T3 (en) 1994-07-16
IL96390A (en) 1995-06-29
ES2173883T3 (en) 2002-11-01
NO311701B1 (en) 2002-01-14
EP0455789A1 (en) 1991-11-13
HU9102436D0 (en) 1991-12-30
PT95959B (en) 1998-08-31
ATE213943T1 (en) 2002-03-15
ATE102831T1 (en) 1994-04-15
DE69033926D1 (en) 2002-04-11
DE69033926T2 (en) 2002-10-24
PT95959A (en) 1991-09-13
PT102145B (en) 2002-06-28
CY1869A (en) 1996-04-05
NO982078L (en) 1991-08-26
EP0455789B1 (en) 1994-03-16
IL96390A0 (en) 1991-08-16
NO912511L (en) 1991-08-26
CA2044143A1 (en) 1991-05-23
EP0577171A3 (en) 1994-06-29
HUT58709A (en) 1992-03-30
EP0577171B1 (en) 2002-03-06
AU6876391A (en) 1991-06-26
IE904209A1 (en) 1991-05-22
DE69007471D1 (en) 1994-04-21
ZA909345B (en) 1992-08-26
DK0577171T3 (en) 2002-06-03
NO912511D0 (en) 1991-06-26
KR0165686B1 (en) 1999-01-15
FI913433A0 (en) 1991-07-16
WO1991007967A2 (en) 1991-06-13
JP2574585B2 (en) 1997-01-22
KR920700644A (en) 1992-08-10
HK115095A (en) 1995-07-21

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