WO1991004760A1 - Injection syringe with automatically retractable needle - Google Patents

Injection syringe with automatically retractable needle Download PDF

Info

Publication number
WO1991004760A1
WO1991004760A1 PCT/NL1990/000144 NL9000144W WO9104760A1 WO 1991004760 A1 WO1991004760 A1 WO 1991004760A1 NL 9000144 W NL9000144 W NL 9000144W WO 9104760 A1 WO9104760 A1 WO 9104760A1
Authority
WO
WIPO (PCT)
Prior art keywords
needle
holder
liquid
injection syringe
characterized
Prior art date
Application number
PCT/NL1990/000144
Other languages
French (fr)
Inventor
Abraham Van Den Haak
Original Assignee
Abraham Van Den Haak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NL8902456A priority Critical patent/NL8902456A/en
Priority to NL8902456 priority
Application filed by Abraham Van Den Haak filed Critical Abraham Van Den Haak
Publication of WO1991004760A1 publication Critical patent/WO1991004760A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321Means for protection against accidental injuries by used needles
    • A61M5/322Retractable needles, i.e. disconnected from and withdrawn into the syringe barrel by the piston
    • A61M5/3232Semi-automatic needle retraction, i.e. in which the triggering of the needle retraction requires a deliberate action by the user, e.g. manual release of spring-biased retraction means
    • A61M5/3234Fully automatic, i.e. in which the triggering does not require a deliberate action by the user

Abstract

An injection syringe, at least comprising a piston (2), a liquid holder (1) and a needle (5), where the needle is situated on a needle holder (4) which is displaceable in the liquid holder, and where before use the needle is situated in the liquid holder and can be driven out by displacing the piston, as a result of which the needle holder is clamped, while the needle holder also serves as an auxiliary piston which with the piston bounds a liquid space, according to the invention there is at the other side of the needle holder an expansion agent (8) which becomes active with delayed effect after sliding out of the needle, and is equipped to drive back the needle holder with the needle.

Description

Injection syringe with automatically retractable needle.

The present invention relates to an injection syringe, at least comprising a piston, a liquid holder and a needle, where the needle is situated on a needle holder which is displaceable in the liquid holder, and where before use the needle is situated in the liquid holder and can be driven out by displacing the piston, as a result of which the needle holder is clamped, while the needle holder also serves as an auxiliary piston which with the piston bounds a liquid space. Such an injection syringe is known; in general, after use of the injection syringe the needle with the needle holder can be drawn through an additional action into the liquid holder. Due to the fact that the needle is located in the liquid holder, there is no risk of injury and possible infection arising therefrom after disposal of the injection syringe.

Such needles have a number of disadvantages. The user is in fact required to perform an additional action after use. This can be forgotten, or the injection syringe can be disposed of carelessly. This is mainly the case with non- professional users, and in particular users who are using the injection syringe for administering drugs.

The object of the present invention is to eliminate the above-mentioned disadvantages, and to this end it is characterized in that there is at the other side of the needle holder an expansion agent which becomes active with delayed effect after the sliding out of the needle, and is equipped to drive back the needle holder with the needle. In the case of the injection syringe according to the present invention, it is not necessary after use, i.e. after the injection of a liquid, to perform an additional action in order to draw the needle into the liquid holder. This in fact takes place automatically through the presence of an expansion agent becoming active with delayed effect.

Other features and embodiments of the invention are described in the sub-claims.

A special embodiment of the injection syringe according to the present invention will be explained below by way of example with reference to the appended drawing, in which Figs, la - le show the different steps of use of an injection syringe according to the present invention.

Fig. la shows the injection syringe as it is obtainable. It comprises a liquid holder 1, containing a main piston 2 with piston rod 3. The liquid container 1 also contains a needle holder 4 or auxiliary piston which serves as a needle base for the needle 5. A nose part 6 provided with teeth 7 is pushed onto the needle. These teeth serve to break a holder with an expansion agent 8 at the time of use. Snap grooves 9 and 10 can interact with ribs on the nose part and the needle holder respectively. Snap groove 11 interacts with cams 12 present on the inside of the liquid holder. The whole unit is provided with a closing cap 13. In the figures which follow the same reference numbers indicate the same parts.

Before use, the closing cap 13 is removed first of all, and the main piston 2 is driven in the liquid holder until the ribs present on the nose part 6 and the needle holder 4 snap into the snap grooves. At that moment the situation shown in Figure lb is reached, and the holder of the expansion agent 8 is broken by the teeth 7 present on the nose part 6. This breaking causes the expansion agent to become active with delayed effect, this delay generally amounting to 10 - 12 mins.

The injection syringe is now ready to draw up a quantity of liquid to be injected by placing the needle in the liquid to be drawn up and drawing the main piston 3 partially out of the liquid holder. When sufficient liquid is drawn up, something which can be determined by the snap groove 11 and cams 12 or by scale marks placed on a transparent liquid holder, the situation shown in Figure lc is reached. The needle is then taken out of the liquid, and the liquid present in the liquid holder is injected into the body.

Should the injection syringe be disposed of carelessly at this moment, after a limited period of time the expansion agent 8 will expand to the position shown in Figure le. During the expansion the needle holder 4 with the needle 5 is driven back into the liquid holder 1. This movement preferably takes place until the end of the needle 5 has moved past the end of the nose part 6. If the axis of the channel in the nose part now deviates slightly from the longitudinal axis of the liquid holder, it will be impossible to drive out the needle again if there is any attempt at re-use. The interior of the needle end of the liquid holder is advantageously tapered, and the nose part is also tapered, both in such a way that during the sliding out of the needle the nose part is deformed around the needle by the tapered end of the liquid holder. After withdrawal of the needle, the opening in the nose part will consequently essentially close, so that an additional safeguard against re-use is produced.

Another possibility for counteracting the re-use of the injection syringe is to use an expansion agent which hardens after expansion.

It will be clear that the teeth 7, which in the drawing are situated on the nose part 6, could also be located on the inside of the liquid holder near the end of the needle. It is also possible for the teeth to be situated on the needle holder^ and the expansion agent to be provided on the nose part or the liquid holder wall. The expansion agent is preferably a two-component agent. It is composed of, for example, water and polvurethane, the polvurethane being provided with a gelatin skin. When the water holder is now broken, it will take the water some time to dissolve the gelatin skin before it reaches the polvurethane, which water causes to foam. The thickness of the gelatin skin can be set as desired, and thus also the length of the delay time. Another example is a mixture of two substances, one of which produces H' ions, for example sodium bicarbonate, on contact with water, while the other substance, for example citric acid, reacts with these ions, producing gas. The possibilities for the expansion agent given in the figures and the description are only examples. It will be clear that there are further possibilities. For example, the expansion agent can be a gas-forming agent, or possibly a spring held in the tensioned state by a lock, the lock being soluble through a liquid present in a breakable holder.

One or more overflow channels are preferably present at the end of the liquid holder lying opposite the needle end, for the discharge of residual liquid from the liquid space during driving back of the needle. It does happen, in particular in the case of drug users, that two doses are drawn into the injection syringe, following which one dose is used immediately, and the other one later. It can happen here that this user forgets to remove the injection syringe from the body after the first dose. Such overflow channels are provided in order to prevent the second quantity of drug from being injected into the body through the expansion of the expansion agent. It is clear that various variations of the injection syringe according to the present invention are obvious for the expert, such as, for example, an injection syringe without the nose part etc.

Claims

C L A I M S
1. Injection syringe, at least comprising a piston, a liquid holder and a needle, where the needle is situated on a needle holder which is displaceable in the liquid holder, and where before use the needle is situated in the liquid holder and can be driven out by displacing the piston, as a result of which the needle holder is clamped, while the needle holder also serves as an auxiliary piston which with the piston bounds a liquid space, characterized in that there is at the other side of the needle holder an expansion agent which becomes active with delayed effect after sliding out of the needle, and is equipped to drive back the needle holder with the needle.
2. Injection syringe according to Claim 1, characterized in that the expansion agent is a multi-component agent, whose components are provided in one or more holders, and on sliding out of the needle are brought into contact with each other with delayed effect through the breaking of at least one holder.
3. Injection syringe according to Claim 2, characterized in that the expansion agent is located on the needle base, and in that teeth are provided on the inside of the liquid holder near the needle end.
4. Injection syringe according to any of Claims 1 - 3, characterized in that the multi-component agent is composed of water and polvurethane.
5. Injection syringe according to any of the preceding Claims 1 - 4, characterized in that the multi-component agent is composed of water, on the one hand, and a mixture of a substance producing ions, and in particular H' ions, with water, on the other, and a substance reacting with these ions and producing gas.
6. Injection syringe according to any of Claims 2 - 5, characterized in that one component is surrounded by a skin which is soluble in the other component and provides the desired delay.
7. Injection syringe according to any of Claims 1 - 6, characterized in that the needle end of the liquid holder has an opening which is slightly larger than the diameter of the needle, and in that a nose part is present which is slidable over the needle and has an opening which is essentially of the same diameter as the needle, the nose part being held fast in the end of the liquid holder after sliding out of the needle.
8. Injection syringe according to Claim 7, characterized in that the direction of the axis of the channel in the nose part deviates slightly from the axis of the liquid holder.
9. Injection syringe according to Claim 8, characterized in that the interior of the needle end of the liquid holder is tapered, and in that the nose part is also tapered, both in such a way that during the sliding out of the needle the' end of the nose part deforms around the needle and after withdrawal of the needle into the liquid holder the opening in the nose part essentially closes.
10. Injection syringe according to Claim 9, characterized in that the teeth are situated on the nose part.
11. Injection syringe according to Claim 10, characterized in that the expansion agent is a spring held in the tensioned position by a lock, the lock being soluble by a liquid present in a breakable holder.
12. Injection syringe according to one or more of Claims 1 - 11, characterized in that one or more overflow channels are provided at the end of the liquid holder lying opposite the needle end, for the discharge of residual liquid from the liquid space during driving back of the needle.
PCT/NL1990/000144 1989-10-03 1990-10-03 Injection syringe with automatically retractable needle WO1991004760A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
NL8902456A NL8902456A (en) 1989-10-03 1989-10-03 Injection syringe with an automatic retractable needle.
NL8902456 1989-10-03

Publications (1)

Publication Number Publication Date
WO1991004760A1 true WO1991004760A1 (en) 1991-04-18

Family

ID=19855388

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL1990/000144 WO1991004760A1 (en) 1989-10-03 1990-10-03 Injection syringe with automatically retractable needle

Country Status (3)

Country Link
AU (1) AU6620590A (en)
NL (1) NL8902456A (en)
WO (1) WO1991004760A1 (en)

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0479217A1 (en) * 1990-10-02 1992-04-08 Patrick Lamoni Single-use syringe with security means preventing its re-use
WO1992016248A1 (en) * 1991-03-24 1992-10-01 Milian Instruments S.A. Syringe adaptor
WO1993013817A1 (en) * 1990-07-24 1993-07-22 Gilman, Paxton & Seid Partnership Syringe with extendable and retractable needle
EP0582849A1 (en) * 1992-08-12 1994-02-16 Brice Somers Syringe
WO1998034659A1 (en) * 1997-02-07 1998-08-13 Ellingsen, Olav Self-destructing hypodermic syringe
WO1998044971A1 (en) * 1997-04-03 1998-10-15 L.O.M. Laboratories Inc. Syringe with pneumatically retractable needle
WO1999025401A1 (en) * 1997-11-05 1999-05-27 Lifecare As Arrangement in a needle holder for a self-destructing syringe
GB2397767A (en) * 2002-12-17 2004-08-04 Pa Consulting Services Injection device
EP1957134A2 (en) * 2005-12-05 2008-08-20 Becton, Dickinson and Company, Wagner, Jaconda Cutting element for a retracting needle syringe
US7648483B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems and methods for medicament delivery
US7648482B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems, and methods for medicament delivery
US7731690B2 (en) 2004-11-22 2010-06-08 Intelliject, Inc. Devices, systems and methods for medicament delivery
US7731686B2 (en) 2005-02-01 2010-06-08 Intelliject, Inc. Devices, systems and methods for medicament delivery
US7749194B2 (en) 2005-02-01 2010-07-06 Intelliject, Inc. Devices, systems, and methods for medicament delivery
US7811259B2 (en) 2004-09-03 2010-10-12 L.O.M. Laboratories Inc. Single-use pneumatic safety syringe providing gas-driven needle retraction
US7947017B2 (en) 2004-11-22 2011-05-24 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8206360B2 (en) 2005-02-01 2012-06-26 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8231573B2 (en) 2005-02-01 2012-07-31 Intelliject, Inc. Medicament delivery device having an electronic circuit system
WO2012162821A1 (en) * 2011-05-31 2012-12-06 L.O.M. Laboratories Inc. Modular gas-actuated retractable needle assembly
US8627816B2 (en) 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US8932252B2 (en) 2005-02-01 2015-01-13 Kaleo, Inc. Medical injector simulation device
US8939943B2 (en) 2011-01-26 2015-01-27 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US9084849B2 (en) 2011-01-26 2015-07-21 Kaleo, Inc. Medicament delivery devices for administration of a medicament within a prefilled syringe
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
US9522235B2 (en) 2012-05-22 2016-12-20 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
US9555191B2 (en) 2007-01-22 2017-01-31 Kaleo, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
US10195364B2 (en) 2014-03-26 2019-02-05 L.O.M. Laboratories Inc. Gas release cell

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3306290A (en) * 1964-02-14 1967-02-28 Harold S Weltman Automatically retractable needle syringe
WO1988008314A1 (en) * 1987-04-22 1988-11-03 The Johns Hopkins University Single-use, self-annulling injection syringe

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3306290A (en) * 1964-02-14 1967-02-28 Harold S Weltman Automatically retractable needle syringe
WO1988008314A1 (en) * 1987-04-22 1988-11-03 The Johns Hopkins University Single-use, self-annulling injection syringe

Cited By (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013817A1 (en) * 1990-07-24 1993-07-22 Gilman, Paxton & Seid Partnership Syringe with extendable and retractable needle
EP0479217A1 (en) * 1990-10-02 1992-04-08 Patrick Lamoni Single-use syringe with security means preventing its re-use
WO1992016248A1 (en) * 1991-03-24 1992-10-01 Milian Instruments S.A. Syringe adaptor
EP0582849A1 (en) * 1992-08-12 1994-02-16 Brice Somers Syringe
WO1998034659A1 (en) * 1997-02-07 1998-08-13 Ellingsen, Olav Self-destructing hypodermic syringe
US5868713A (en) * 1997-04-03 1999-02-09 L.O.M. Laboratories Inc. Pneumatic retractable syringe
WO1998044971A1 (en) * 1997-04-03 1998-10-15 L.O.M. Laboratories Inc. Syringe with pneumatically retractable needle
WO1999025401A1 (en) * 1997-11-05 1999-05-27 Lifecare As Arrangement in a needle holder for a self-destructing syringe
AU2003294124B2 (en) * 2002-12-17 2009-11-26 Cilag Gmbh International Injection device
GB2397767A (en) * 2002-12-17 2004-08-04 Pa Consulting Services Injection device
GB2397767B (en) * 2002-12-17 2006-07-05 Pa Consulting Services Injection device
US9192732B2 (en) 2004-09-03 2015-11-24 L.O.M. Laboratories Inc. Single use pneumatic safety syringe providing gas-driven needle retraction
US8167848B2 (en) 2004-09-03 2012-05-01 L.O.M. Laboratories Inc. Single-use pneumatic safety syringe providing gas-driven needle retraction
US9649450B2 (en) 2004-09-03 2017-05-16 L.O.M. Laboratories Inc. Single use pneumatic safety syringe providing gas-driven needle retraction
US7811259B2 (en) 2004-09-03 2010-10-12 L.O.M. Laboratories Inc. Single-use pneumatic safety syringe providing gas-driven needle retraction
US9408983B2 (en) 2004-09-03 2016-08-09 L.O.M. Laboratories Inc. Single-use pneumatic safety syringe providing gas-driven needle retraction
US8523810B2 (en) 2004-09-03 2013-09-03 L.O.M. Laboratories Inc. Single-use pneumatic safety syringe providing gas-driven needle retraction
US9352091B2 (en) 2004-11-22 2016-05-31 Kaleo, Inc. Devices, systems and methods for medicament delivery
US9833573B2 (en) 2004-11-22 2017-12-05 Kaleo, Inc. Devices, systems and methods for medicament delivery
US7918823B2 (en) 2004-11-22 2011-04-05 Intelliject, Inc. Devices, systems and methods for medicament delivery
US7947017B2 (en) 2004-11-22 2011-05-24 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8016788B2 (en) 2004-11-22 2011-09-13 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8105281B2 (en) 2004-11-22 2012-01-31 Intelliject, Inc. Devices, systems and methods for medicament delivery
US9149579B2 (en) 2004-11-22 2015-10-06 Kaleo, Inc. Devices, systems and methods for medicament delivery
US7648482B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems, and methods for medicament delivery
US10071203B2 (en) 2004-11-22 2018-09-11 Kaleo, Inc. Devices, systems and methods for medicament delivery
US9056170B2 (en) 2004-11-22 2015-06-16 Kaleo, Inc. Devices, systems and methods for medicament delivery
US8920377B2 (en) 2004-11-22 2014-12-30 Kaleo, Inc. Devices, systems and methods for medicament delivery
US8313466B2 (en) 2004-11-22 2012-11-20 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8425462B2 (en) 2004-11-22 2013-04-23 Intelliject, Inc. Devices, systems, and methods for medicament delivery
US8361029B2 (en) 2004-11-22 2013-01-29 Intelliject, Llc Devices, systems and methods for medicament delivery
US7648483B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8608698B2 (en) 2004-11-22 2013-12-17 Intelliject, Inc. Devices, systems and methods for medicament delivery
US7731690B2 (en) 2004-11-22 2010-06-08 Intelliject, Inc. Devices, systems and methods for medicament delivery
US9737669B2 (en) 2004-11-22 2017-08-22 Kaleo, Inc. Devices, systems and methods for medicament delivery
US7749194B2 (en) 2005-02-01 2010-07-06 Intelliject, Inc. Devices, systems, and methods for medicament delivery
US10099023B2 (en) 2005-02-01 2018-10-16 Kaleo, Inc. Devices, systems and methods for medicament delivery
US8690827B2 (en) 2005-02-01 2014-04-08 Kaleo, Inc. Devices, systems, and methods for medicament delivery
US8899987B2 (en) 2005-02-01 2014-12-02 Kaleo, Inc. Simulated medicament delivery device having an electronic circuit system
US8231573B2 (en) 2005-02-01 2012-07-31 Intelliject, Inc. Medicament delivery device having an electronic circuit system
US8920367B2 (en) 2005-02-01 2014-12-30 Kaleo, Inc. Devices, systems and methods for medicament delivery
US8926594B2 (en) 2005-02-01 2015-01-06 Kaleo, Inc. Devices, systems and methods for medicament delivery
US8932252B2 (en) 2005-02-01 2015-01-13 Kaleo, Inc. Medical injector simulation device
US9805620B2 (en) 2005-02-01 2017-10-31 Kaleo, Inc. Medical injector simulation device
US10076611B2 (en) 2005-02-01 2018-09-18 Kaleo, Inc. Medicament delivery device having an electronic circuit system
US9022980B2 (en) 2005-02-01 2015-05-05 Kaleo, Inc. Medical injector simulation device
US8206360B2 (en) 2005-02-01 2012-06-26 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8172082B2 (en) 2005-02-01 2012-05-08 Intelliject, Inc. Devices, systems and methods for medicament delivery
US9724471B2 (en) 2005-02-01 2017-08-08 Kaleo, Inc. Devices, systems, and methods for medicament delivery
US9867938B2 (en) 2005-02-01 2018-01-16 Kaleo, Inc. Devices, systems and methods for medicament delivery
US7731686B2 (en) 2005-02-01 2010-06-08 Intelliject, Inc. Devices, systems and methods for medicament delivery
US9238108B2 (en) 2005-02-01 2016-01-19 Kaleo, Inc. Medicament delivery device having an electronic circuit system
US9259539B2 (en) 2005-02-01 2016-02-16 Kaleo, Inc. Devices, systems and methods for medicament delivery
US9278182B2 (en) 2005-02-01 2016-03-08 Kaleo, Inc. Devices, systems and methods for medicament delivery
US8123719B2 (en) 2005-02-01 2012-02-28 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8544645B2 (en) 2005-02-01 2013-10-01 Intelliject, Inc. Devices, systems and methods for medicament delivery
EP1957134A4 (en) * 2005-12-05 2010-09-29 Becton Dickinson Co Cutting element for a retracting needle syringe
EP1957134A2 (en) * 2005-12-05 2008-08-20 Becton, Dickinson and Company, Wagner, Jaconda Cutting element for a retracting needle syringe
US9555191B2 (en) 2007-01-22 2017-01-31 Kaleo, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
US8939943B2 (en) 2011-01-26 2015-01-27 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US9814838B2 (en) 2011-01-26 2017-11-14 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US10183116B2 (en) 2011-01-26 2019-01-22 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
US9173999B2 (en) 2011-01-26 2015-11-03 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
US9084849B2 (en) 2011-01-26 2015-07-21 Kaleo, Inc. Medicament delivery devices for administration of a medicament within a prefilled syringe
US10238806B2 (en) 2011-01-26 2019-03-26 Kaleo, Inc. Medicament delivery devices for administration of a medicament within a prefilled syringe
US8627816B2 (en) 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US9474869B2 (en) 2011-02-28 2016-10-25 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US9022022B2 (en) 2011-02-28 2015-05-05 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US10143792B2 (en) 2011-02-28 2018-12-04 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
WO2012162821A1 (en) * 2011-05-31 2012-12-06 L.O.M. Laboratories Inc. Modular gas-actuated retractable needle assembly
CN103648559A (en) * 2011-05-31 2014-03-19 L.O.M.实验室股份有限公司 Modular gas-actuated retractable needle assembly
US10226583B2 (en) 2012-05-22 2019-03-12 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
US9522235B2 (en) 2012-05-22 2016-12-20 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
US10195364B2 (en) 2014-03-26 2019-02-05 L.O.M. Laboratories Inc. Gas release cell
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
US10220158B2 (en) 2014-07-18 2019-03-05 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone

Also Published As

Publication number Publication date
AU6620590A (en) 1991-04-28
NL8902456A (en) 1991-05-01

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