WO1991002716A3 - Hydroxamic acid based collagenase inhibitors - Google Patents
Hydroxamic acid based collagenase inhibitors Download PDFInfo
- Publication number
- WO1991002716A3 WO1991002716A3 PCT/GB1990/001117 GB9001117W WO9102716A3 WO 1991002716 A3 WO1991002716 A3 WO 1991002716A3 GB 9001117 W GB9001117 W GB 9001117W WO 9102716 A3 WO9102716 A3 WO 9102716A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hydroxamic acid
- acid based
- collagenase inhibitors
- based collagenase
- disease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP90911398A EP0489032B1 (en) | 1989-08-24 | 1990-07-20 | Hydroxamic acid based collagenase inhibitors |
US07/820,664 US5453438A (en) | 1989-08-24 | 1990-07-20 | Hydroxamic acid based collagenase inhibitors |
KR1019920700412A KR927003624A (en) | 1989-08-24 | 1990-07-20 | compound |
DE69012575T DE69012575T2 (en) | 1989-08-24 | 1990-07-20 | COLLAGENAS INHIBITORS BASED ON HYDROXAMIC ACID. |
FI920771A FI920771A0 (en) | 1989-08-24 | 1992-02-21 | HYDROXYLAMID BASE COLLAGENASIN INHIBITOR. |
NO92920702A NO920702L (en) | 1989-08-24 | 1992-02-21 | HYDROXAMIC ACID BASED COLLAGENASE INHIBITORS |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8919251.2 | 1989-08-24 | ||
GB898919251A GB8919251D0 (en) | 1989-08-24 | 1989-08-24 | Compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1991002716A2 WO1991002716A2 (en) | 1991-03-07 |
WO1991002716A3 true WO1991002716A3 (en) | 1991-06-27 |
Family
ID=10662057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1990/001117 WO1991002716A2 (en) | 1989-08-24 | 1990-07-20 | Hydroxamic acid based collagenase inhibitors |
Country Status (16)
Country | Link |
---|---|
US (2) | US5453438A (en) |
EP (1) | EP0489032B1 (en) |
JP (1) | JP2871849B2 (en) |
KR (1) | KR927003624A (en) |
AT (1) | ATE111443T1 (en) |
AU (1) | AU639706B2 (en) |
CA (1) | CA2064786A1 (en) |
DE (1) | DE69012575T2 (en) |
DK (1) | DK0489032T3 (en) |
ES (1) | ES2063975T3 (en) |
FI (1) | FI920771A0 (en) |
GB (1) | GB8919251D0 (en) |
NO (1) | NO920702L (en) |
NZ (1) | NZ235050A (en) |
TW (1) | TW202456B (en) |
WO (1) | WO1991002716A2 (en) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8827308D0 (en) * | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
US5268384A (en) * | 1990-11-21 | 1993-12-07 | Galardy Richard E | Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors |
US5892112A (en) * | 1990-11-21 | 1999-04-06 | Glycomed Incorporated | Process for preparing synthetic matrix metalloprotease inhibitors |
EP0520573A1 (en) * | 1991-06-27 | 1992-12-30 | Glaxo Inc. | Cyclic imide derivatives |
ATE150452T1 (en) * | 1992-04-07 | 1997-04-15 | British Biotech Pharm | COLLAGENASE INHIBITORS AND CYTOKINE ACTIVITY INHIBITORS CONTAINING HYDROXAMIC ACID |
GB9211706D0 (en) * | 1992-06-03 | 1992-07-15 | Celltech Ltd | Peptidyl derivatives |
GB9211707D0 (en) * | 1992-06-03 | 1992-07-15 | Celltech Ltd | Peptidyl derivatives |
US5326760A (en) * | 1992-06-29 | 1994-07-05 | Glaxo, Inc. | Aminobutanoic acid compounds having metalloprotease inhibiting properties |
GB9215665D0 (en) * | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
GB9223904D0 (en) * | 1992-11-13 | 1993-01-06 | British Bio Technology | Inhibition of cytokine production |
US5646167A (en) * | 1993-01-06 | 1997-07-08 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamix acids |
EP0689538B1 (en) * | 1993-03-16 | 1998-08-12 | British Biotech Pharmaceuticals Limited | Hydroxamic acid derivatives as metalloproteinase inhibitors |
GB9308695D0 (en) * | 1993-04-27 | 1993-06-09 | Celltech Ltd | Peptidyl derivatives |
DE69419473T2 (en) * | 1993-04-27 | 2000-03-16 | Celltech Therapeutics Ltd | PEPTIDYL DERIVATIVES AS INHIBITORS OF METALLOPROTEINASE |
ES2075797B1 (en) * | 1993-08-18 | 1996-05-16 | British Bio Technology | DERIVATIVES OF THERAPEUTICALLY ACTIVE HYDROXAMIC ACIDS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE. |
ES2075798B1 (en) * | 1993-08-18 | 1996-03-01 | British Bio Technology | DERIVATIVES OF NATURAL AMINO ACIDS AS METALOPROTEINASE INHIBITORS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE. |
US6037472A (en) * | 1993-11-04 | 2000-03-14 | Syntex (U.S.A.) Inc. | Matrix metalloprotease inhibitors |
EP0740652B1 (en) * | 1994-01-20 | 1998-05-06 | British Biotech Pharmaceuticals Limited | Metalloproteinase inhibitors |
GB9501737D0 (en) * | 1994-04-25 | 1995-03-22 | Hoffmann La Roche | Hydroxamic acid derivatives |
US5831004A (en) * | 1994-10-27 | 1998-11-03 | Affymax Technologies N.V. | Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use |
US5840698A (en) * | 1994-10-27 | 1998-11-24 | Affymax Technologies N.V. | Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use |
GB9423914D0 (en) * | 1994-11-26 | 1995-01-11 | British Biotech Pharm | Polyether derivatives as metalloproteinase inhibitors |
US5639746A (en) * | 1994-12-29 | 1997-06-17 | The Procter & Gamble Company | Hydroxamic acid-containing inhibitors of matrix metalloproteases |
US5919940A (en) * | 1995-01-20 | 1999-07-06 | British Biotech Pharmaceuticals Limited | Metalloproteinase inhibitors |
US5672598A (en) * | 1995-03-21 | 1997-09-30 | The Procter & Gamble Company | Lactam-containing hydroxamic acids |
US5917090A (en) * | 1995-06-30 | 1999-06-29 | British Biotech Pharmaceuticals Ltd. | Matrix metalloproteinase inhibitors |
HUP9903863A3 (en) | 1995-11-23 | 2000-11-28 | British Biotech Pharm | Metalloproteinase inhibitors |
KR20000035918A (en) * | 1996-08-28 | 2000-06-26 | 데이비드 엠 모이어 | 1,3-diheterocyclic metalloprotease inhibitors |
CN1228773A (en) * | 1996-08-28 | 1999-09-15 | 普罗克特和甘保尔公司 | Heterocyclic metalloprotease inhibitors |
NZ334254A (en) | 1996-08-28 | 2000-11-24 | Procter & Gamble | Heterocyclic metalloprotease inhibitors |
TR199900399T2 (en) * | 1996-08-28 | 1999-06-21 | The Procter & Gamble Company | Phosphinic acid amides as matrix metalloprotease inhibitors. |
SK284041B6 (en) * | 1996-08-28 | 2004-08-03 | The Procter And Gamble Company | Spirocyclic metalloprotease inhibitors |
US6462023B1 (en) | 1996-09-10 | 2002-10-08 | British Biotech Pharmaceuticals, Ltd. | Cytostatic agents |
IL128337A0 (en) * | 1996-09-10 | 2000-01-31 | British Biotech Pharm | Cytostatic hydroxamic acid derivatives |
US5840974A (en) * | 1996-12-04 | 1998-11-24 | Britisch Biotech Pharmaceuticals, Ltd. | Metalloproteinase inhibitors |
US5985911A (en) * | 1997-01-07 | 1999-11-16 | Abbott Laboratories | C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion |
US5952320A (en) * | 1997-01-07 | 1999-09-14 | Abbott Laboratories | Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion |
NZ503945A (en) | 1997-07-31 | 2002-11-26 | Procter & Gamble | Metalloprotease-inhibiting amide derivatives |
GB9810464D0 (en) * | 1998-05-16 | 1998-07-15 | British Biotech Pharm | Hydroxamic acid derivatives |
US6288261B1 (en) | 1998-12-18 | 2001-09-11 | Abbott Laboratories | Inhibitors of matrix metalloproteinases |
CZ20013176A3 (en) | 1999-03-03 | 2002-04-17 | The Procter & Gamble Company | Compound producing metalloproteinase inhibitor, pharmaceutical preparation, and process for preparing thereof and a medicament |
AU766881B2 (en) * | 1999-08-10 | 2003-10-23 | British Biotech Pharmaceuticals Limited | Antibacterial agents |
GB9929527D0 (en) * | 1999-12-14 | 2000-02-09 | Smithkline Beecham Plc | Novel compounds |
US6797820B2 (en) * | 1999-12-17 | 2004-09-28 | Vicuron Pharmaceuticals Inc. | Succinate compounds, compositions and methods of use and preparation |
AR036053A1 (en) | 2001-06-15 | 2004-08-04 | Versicor Inc | N-FORMIL-HYDROXYLAMINE COMPOUNDS, A PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS |
US6987104B2 (en) | 2001-06-15 | 2006-01-17 | Vicuron Pharmaceuticals Inc. | Pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3341610A1 (en) * | 1982-11-18 | 1984-05-24 | E.R. Squibb & Sons, Inc., Princeton, N.J. | CARBOXY AND SUBSTITUTED CARBOXYALKANOYL AND CYCLOALKANOYL PEPTIDES |
EP0167936A2 (en) * | 1984-07-03 | 1986-01-15 | Microbial Chemistry Research Foundation | Use of actinonin as an immunopotentiator |
EP0214639A2 (en) * | 1985-09-10 | 1987-03-18 | G.D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
EP0274453A2 (en) * | 1987-01-06 | 1988-07-13 | Société anonyme dite: LABORATOIRE ROGER BELLON | Collagenase inhibitor derivatives, their preparation and pharmaceutical compositions containing them |
EP0236872B1 (en) * | 1986-03-11 | 1992-11-25 | F. Hoffmann-La Roche Ag | Hydroxyl amine derivatives, their preparation and use as medicaments |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4105789A (en) * | 1976-05-10 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Carboxyalkylacylamino acids |
IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
US4496540A (en) * | 1982-12-30 | 1985-01-29 | Biomeasure, Inc. | Therapeutic compounds |
US4599361A (en) * | 1985-09-10 | 1986-07-08 | G. D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
-
1989
- 1989-08-24 GB GB898919251A patent/GB8919251D0/en active Pending
-
1990
- 1990-07-20 WO PCT/GB1990/001117 patent/WO1991002716A2/en active IP Right Grant
- 1990-07-20 US US07/820,664 patent/US5453438A/en not_active Expired - Fee Related
- 1990-07-20 AT AT90911398T patent/ATE111443T1/en not_active IP Right Cessation
- 1990-07-20 DK DK90911398.7T patent/DK0489032T3/en active
- 1990-07-20 ES ES90911398T patent/ES2063975T3/en not_active Expired - Lifetime
- 1990-07-20 KR KR1019920700412A patent/KR927003624A/en not_active Application Discontinuation
- 1990-07-20 AU AU60454/90A patent/AU639706B2/en not_active Ceased
- 1990-07-20 CA CA002064786A patent/CA2064786A1/en not_active Abandoned
- 1990-07-20 DE DE69012575T patent/DE69012575T2/en not_active Expired - Fee Related
- 1990-07-20 EP EP90911398A patent/EP0489032B1/en not_active Expired - Lifetime
- 1990-07-20 JP JP2510523A patent/JP2871849B2/en not_active Expired - Fee Related
- 1990-08-01 TW TW079106338A patent/TW202456B/zh active
- 1990-08-24 NZ NZ235050A patent/NZ235050A/en unknown
-
1992
- 1992-02-21 NO NO92920702A patent/NO920702L/en unknown
- 1992-02-21 FI FI920771A patent/FI920771A0/en not_active Application Discontinuation
-
1995
- 1995-04-05 US US08/417,095 patent/US5910609A/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3341610A1 (en) * | 1982-11-18 | 1984-05-24 | E.R. Squibb & Sons, Inc., Princeton, N.J. | CARBOXY AND SUBSTITUTED CARBOXYALKANOYL AND CYCLOALKANOYL PEPTIDES |
EP0167936A2 (en) * | 1984-07-03 | 1986-01-15 | Microbial Chemistry Research Foundation | Use of actinonin as an immunopotentiator |
EP0214639A2 (en) * | 1985-09-10 | 1987-03-18 | G.D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
EP0236872B1 (en) * | 1986-03-11 | 1992-11-25 | F. Hoffmann-La Roche Ag | Hydroxyl amine derivatives, their preparation and use as medicaments |
EP0274453A2 (en) * | 1987-01-06 | 1988-07-13 | Société anonyme dite: LABORATOIRE ROGER BELLON | Collagenase inhibitor derivatives, their preparation and pharmaceutical compositions containing them |
Non-Patent Citations (6)
Title |
---|
Biochemical and Biophysical Research Communications, vol. 125, no. 1, 30 November 1984, editors E. Carafoli, Academic Press Inc., (Harcourt Brace Jovanovich, Publishers), (San Diego, US), H.N. Weller et al.: "Design of conformationally constrained angiotensin-converting enzyme inhibitors", pages 82-89 * |
Chemical Abstracts, vol. 102, 1985, (Columbus, Ohio, US), T. Amamoto et al.: "Effect of E-64, thiol protease inhibitor, on the secondary anti-SRBC response in vitro", see page 461 * |
Chemical Abstracts, vol. 70, 1969, (Columbus, Ohio, US), M.M. Attwood: "Mode of action of actinonin", page 157 * |
Journal of the Chemical Society, Perkin Transactions 1, 1975, J.J. Gordon et al.: "Studies concerning the antibiotic actinonin. Part I. The constitution of actinonin. A natural hydroxamic acid with antibviotic acitivity", pages 819-825, see compound XVIII. * |
Journal of the Chemical Society, Perkin Transactions 1, 1975, J.P. Devlin et al.: "Studies concerning the antibiotic actinonin. Part V. Synthesis of structural analogues of actinonin by the anhydride-ester method", pages 846-848 * |
Journal of the Chemical Society, Perkin Transactions 1, 1975, N.H. Anderson et al.: "Studies concerning the antibiotic actinonin, Part II. Total synthesis of actinonin and some structural analogues by the isomaleimide method", pages 825-830, see table 2, compound XXVII, CN=56439-48-6 * |
Also Published As
Publication number | Publication date |
---|---|
EP0489032B1 (en) | 1994-09-14 |
TW202456B (en) | 1993-03-21 |
JPH05501864A (en) | 1993-04-08 |
CA2064786A1 (en) | 1991-02-25 |
NZ235050A (en) | 1991-12-23 |
AU6045490A (en) | 1991-04-03 |
FI920771A0 (en) | 1992-02-21 |
GB8919251D0 (en) | 1989-10-04 |
NO920702L (en) | 1992-04-23 |
EP0489032A1 (en) | 1992-06-10 |
DE69012575D1 (en) | 1994-10-20 |
WO1991002716A2 (en) | 1991-03-07 |
JP2871849B2 (en) | 1999-03-17 |
ATE111443T1 (en) | 1994-09-15 |
DK0489032T3 (en) | 1995-01-30 |
AU639706B2 (en) | 1993-08-05 |
NO920702D0 (en) | 1992-02-21 |
KR927003624A (en) | 1992-12-18 |
US5910609A (en) | 1999-06-08 |
DE69012575T2 (en) | 1995-03-30 |
ES2063975T3 (en) | 1995-01-16 |
US5453438A (en) | 1995-09-26 |
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