WO1990011786A1 - Enzyme containing composition for cleaning contact lenses and method therefor - Google Patents

Enzyme containing composition for cleaning contact lenses and method therefor Download PDF

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Publication number
WO1990011786A1
WO1990011786A1 PCT/SE1990/000227 SE9000227W WO9011786A1 WO 1990011786 A1 WO1990011786 A1 WO 1990011786A1 SE 9000227 W SE9000227 W SE 9000227W WO 9011786 A1 WO9011786 A1 WO 9011786A1
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WO
WIPO (PCT)
Prior art keywords
polymer
terpolymer
membrane
composition according
hydrogen peroxide
Prior art date
Application number
PCT/SE1990/000227
Other languages
French (fr)
Inventor
Lennart Frigren
Christiane Persson
Annika Brantvik
Claes Franzen
Staffan WAXEGÅRD
Lennart Wenngren
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Publication of WO1990011786A1 publication Critical patent/WO1990011786A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/12—Non-macromolecular oxygen-containing compounds, e.g. hydrogen peroxide or ozone
    • A61L12/124—Hydrogen peroxide; Peroxy compounds
    • A61L12/126—Hydrogen peroxide; Peroxy compounds neutralised with catalase or peroxidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres

Definitions

  • Disinfection of contact lenses is mainly carried out by treat ⁇ ing the lenses once a day (or up to once a week) with an aqueous hydrogen peroxide (3 %) solution.
  • the killing effect depends on the concentration of the hydrogen peroxide solu- tion and the time during which the lenses are in contact with the solution. Minimum 1,5 % during minimum 20 minutes is regarded to give a sufficiently killing effect.
  • the removal of the hydrogen peroxide can be carried out in different ways.
  • The-most common way is the use of platinum as a catalyst for the decomposition of hydrogen peroxide and the use of the enzyme catalase for the same purpose.
  • the method based on platinum is carried out in such a way that a plate of platinum is mounted on the bottom of the di ⁇ sinfection vessel.
  • a plate of platinum is mounted on the bottom of the di ⁇ sinfection vessel.
  • the solution of hydrogen peroxide is added the decomposition process starts immediately.
  • Each plate of platinum is intended for three months daily use.
  • a new plate gives a rapid decomposition process, which can je- opardize the killing effect, whereas a plate, which has been used for some time, gives a remarkably reduced decomposition effect with big risk for remaining high concentrations of hydrogen peroxide after the recommended treating time, 6 h. Accordingly the risk of damages on the eye is big.
  • the advantage of the method with the decomposition with pla ⁇ tinum is that it is regarded as easy to use by the user be ⁇ cause disinfection and decomposition is started at the same time and the user needs not do anything with the lenses un- til after 6 h when the process is ready.
  • catalase for the decomposi ⁇ tion of hydrogen peroxide is carried out in such a way that catalase is added either as a solution or in the form of a tablet approximately, 20-30 minutes after the lenses have been placed in 3 % hydrogen .peroxide.
  • the decomposition then starts immediately and goes very rapidly and completely.
  • the disadvantage of the method is that the users consider the method more complicated to use than the method with platinum due to the fact that it requires two operations by the user at two different occasions.
  • An ideal tablet preparation of a hydrogen peroxide inactiva- tor shall thus be able to give a slow decomposition at the beginning and a rapid decomposition after the disinfection is completed.
  • This invention is intended to fulfil the following requirements:
  • a disinfection-process for contact lenses, which when initiated by the user does not require any further acti ⁇ on until the process is complete and the lenses are rea ⁇ dy for use.
  • a predetermined concentration of hydrogen peroxide shall be maintained during a specific period of time in order to secure a complete disinfection.
  • the decomposition rate shall be increased in order to secure that no hydrogen peroxide remains after the desired period of time (during the night).
  • the invention comprises that tablet cores containing a cata ⁇ lytic substance such as catalase, is coated with a membrane, which consists of a water insoluble polymer which contains water soluble particles of a defined size and amount. The particles will be dissolved by the hydrogen peroxide solu ⁇ tion and a macroporous membrane is formed. Hydrogen peroxide penetrates through this membrane and a reaction starts bet- ween the hydrogen peroxide and catalase, whereby hydrogen pe ⁇ roxide decomposes for oxygen and water.
  • a cata ⁇ lytic substance such as catalase
  • the decomposition of the hydrogen peroxide is initially slow, but concurrently with the formation of more oxygen the membrane is expanded by the gas pressure and the penetration capacity of the mem ⁇ brane is increased, whereby catalase is released to the sur ⁇ rounding hydrogen peroxide solution and the reaction rate and the decomposition will increase.
  • the polymer forming Jhe membrane should have good funifor ⁇ ming and adhesive properties and should be easily soluble in organic solvents, such as acetone and methylene chloride.
  • Suitable polymers are derivatives of cellulose, acrylpoly- mers and vinylpolymers.
  • the coating polymer is a polymer, which contains 80-95 per cent by weight of vinyl chloride, 1-19 per cent by weight vinylacetate and 0-10 per cent vinylalcohol.
  • the coating should also preferably include a plastisizer.
  • the amount of the p astisizer may vary between 30 and 150 per cent by weight of the polymer coating.
  • suitable plastisizers are acetyltributylcitrate, polyethylene glycol , blown castor oil and glyceryltriacetate.
  • the coating can al ⁇ so include sodium bicarbonate as a stabilizing agent.
  • the poreforming substance which is used according to tfie in ⁇ vention should be very water soluble, insoluble in the sol ⁇ vent, which is used for the coating, and toxicologically acceptable in the amounts used.
  • perfered are sugars, such as sucrose and lactose and salts, such as sodium chloride.
  • the particle size of the poreforming substance may vary bet ⁇ ween 0,1 and 100, preferably between 0,5 and 50 urn.
  • the ra- tio between the amount of porecreating substance and coating polymer depends on the desired property. Usually this ratio should exceed 5 and preferably be between 10 and 30.
  • the co ⁇ ating comprises a terpolymer of
  • the amount of plasticizer exceeds 30 per cent by weight of the terpolymer.
  • the amount of plasticizer varies between 50 and 150 per cent by weight of the terpolymer.
  • the ratio porecreating agent to terpolymer should preferably exceed 5. Most preferably this ratio should vary between 10 and 30.
  • the coating thickness depends also on the desired property. It can vary between 5 and 300 ⁇ , preferably between 10 and 200 ⁇ m.
  • the coating procedure according to the invention can prefer ⁇ ably be carried out in the folowing manner:
  • a terpolymer containing (w/w%) 80-95 '/. VC (vinyl- chloride), 1-19 % VAC (vinylacetate), and 1-10 % V0H (vlnylalcohol) is dissolved in a solvent, e.g. acetone, methylenechloride, methylethylketone, or mixtures aceto ⁇ ne and ethanol , acetone and methylenechloride, or the like.
  • a solvent e.g. acetone, methylenechloride, methylethylketone, or mixtures aceto ⁇ ne and ethanol , acetone and methylenechloride, or the like.
  • a suspension of the pore-creating substance is produced as fol ows:
  • the pore-creating particles are ground either by dry milling in a ball mill or by wet-milling in a glass bead milling device to a defined particle size, preferably between 0,5 urn and 50 ⁇ m.
  • the particles are dispersed in solvents or mixtures of solvents, such as those previ ⁇ ously mentioned, and mixed with the terpolymer solution.
  • the ratio between pore-creating substance and terpolymer in the coating fluid is as previously described for the ratio in the coating.
  • the coating fluid may, as previ ⁇ ously stated, include a plasticizer and sodium bicarbonate.
  • the coating fluid in the form of a suspension, is then applied on cores by conventional coating procedure.
  • coating procedures are pan coating, manual or spray-coating, W ⁇ rster coating, and other fluid-bed coating procedures.
  • Coloring matter can also be incorporated in the coating fluid, and insoluble co ⁇ loring materials are preferred.
  • Example 1 The following examples further illustrate the invention but should not be construed as limiting the invention.
  • Example 1 The following examples further illustrate the invention but should not be construed as limiting the invention.
  • Tablets including catalase (commercially available from Allergan) in a sufficient amount for decomposition of 10 ml hydrogen peroxide (3 %) were coated according to the proce ⁇ dure described above with a membrane consisting of 1 mg ter ⁇ polymer of vinylchloride, vinylacetate and vinylalcohol as a water insoluble membrane, 0,2 mg acetyltributylcitrate, 0,1 mg blown castor oil, 5,6 mg saccharose and 0,2 mg sodium bicarbonate. Acetone' as used as a solvent for the coating.
  • the catalase containing tablets from Allergan were coated by a coating fluid having the following composition:

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Oxygen, Ozone, And Oxides In General (AREA)
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Abstract

The invention concerns a composition including a core with a catalytic substance for decomposition of hydrogen peroxide to oxygen and water. The composition is characterized by that the core is surrounded by a membrane, which is expandable in aqueous medium and which comprises of a water insoluble polymer and a water soluble porecreating substance, which is randomly distributed in the polymer, whereby the membrane permeability for the catalitic substance increases concurrently with the expansion of the membrane in the aqueous medium.

Description

ENZYME CONTAINING COMPOSITION FOR CLEANING CONTACT LENSES AND METHOD THEREFORE.
Background
Disinfection of contact lenses is mainly carried out by treat¬ ing the lenses once a day (or up to once a week) with an aqueous hydrogen peroxide (3 %) solution. The killing effect depends on the concentration of the hydrogen peroxide solu- tion and the time during which the lenses are in contact with the solution. Minimum 1,5 % during minimum 20 minutes is regarded to give a sufficiently killing effect.
After the disinfection is completed all hydrogen peroxide must be removed from the lenses in order to avoid that the cornea is damaged. Even as low concentrations of peroxide as 10 pp or less in the lenses can cause severe damages.
The removal of the hydrogen peroxide can be carried out in different ways. The-most common way is the use of platinum as a catalyst for the decomposition of hydrogen peroxide and the use of the enzyme catalase for the same purpose.
The method based on platinum is carried out in such a way that a plate of platinum is mounted on the bottom of the di¬ sinfection vessel. When the solution of hydrogen peroxide is added the decomposition process starts immediately. Each plate of platinum is intended for three months daily use. A new plate gives a rapid decomposition process, which can je- opardize the killing effect, whereas a plate, which has been used for some time, gives a remarkably reduced decomposition effect with big risk for remaining high concentrations of hydrogen peroxide after the recommended treating time, 6 h. Accordingly the risk of damages on the eye is big. The advantage of the method with the decomposition with pla¬ tinum is that it is regarded as easy to use by the user be¬ cause disinfection and decomposition is started at the same time and the user needs not do anything with the lenses un- til after 6 h when the process is ready.
The currently used method with catalase for the decomposi¬ tion of hydrogen peroxide is carried out in such a way that catalase is added either as a solution or in the form of a tablet approximately, 20-30 minutes after the lenses have been placed in 3 % hydrogen .peroxide. The decomposition then starts immediately and goes very rapidly and completely.
The advantages of this method are thus that the concentration of hydrogen peroxide is maintained during the desired period of time so that a safe disinfection is obtained. Furthermore the decomposition of the hydrogen peroxide is complete after the recommended time, which eliminates the risks of damages on the Seye.
The disadvantage of the method is that the users consider the method more complicated to use than the method with platinum due to the fact that it requires two operations by the user at two different occasions.
It follows herefrom that there is a need for a method for disinfecting contact lenses with a safety which can be com¬ pared with the catalase method and simple handling which is comparable with the platinum method.
In prior patents (UK patent 2151039) it has been disclosed a method of making so called controlled release preparation in the form of a tablet of an inactivator for hydrogen peroxi¬ de. The described tablets give a release pattern of the inactivator which is rapid initially and slow at the end of the release period. This is unfavourable as the risk is then big that the concentration of hydrogen peroxide will decrea¬ se rapidly at the beginning, when high concentration is need¬ ed for killing the bacteria. Furthermore the concentration of the hydrogen peroxide will decrease more and more slowly and complete decomposition will occur after a long time and can even be jeopardized within the recommended period of ti¬ me.
An ideal tablet preparation of a hydrogen peroxide inactiva- tor shall thus be able to give a slow decomposition at the beginning and a rapid decomposition after the disinfection is completed.
The invention
This invention is intended to fulfil the following requirements:
- A disinfection-process (for contact lenses), which when initiated by the user does not require any further acti¬ on until the process is complete and the lenses are rea¬ dy for use.
- A predetermined concentration of hydrogen peroxide shall be maintained during a specific period of time in order to secure a complete disinfection. When this point of time has been reached the decomposition rate shall be increased in order to secure that no hydrogen peroxide remains after the desired period of time (during the night).
The invention comprises that tablet cores containing a cata¬ lytic substance such as catalase, is coated with a membrane, which consists of a water insoluble polymer which contains water soluble particles of a defined size and amount. The particles will be dissolved by the hydrogen peroxide solu¬ tion and a macroporous membrane is formed. Hydrogen peroxide penetrates through this membrane and a reaction starts bet- ween the hydrogen peroxide and catalase, whereby hydrogen pe¬ roxide decomposes for oxygen and water. The decomposition of the hydrogen peroxide is initially slow, but concurrently with the formation of more oxygen the membrane is expanded by the gas pressure and the penetration capacity of the mem¬ brane is increased, whereby catalase is released to the sur¬ rounding hydrogen peroxide solution and the reaction rate and the decomposition will increase.
The polymer forming Jhe membrane should have good funifor¬ ming and adhesive properties and should be easily soluble in organic solvents, such as acetone and methylene chloride. Suitable polymers are derivatives of cellulose, acrylpoly- mers and vinylpolymers. Preferably the coating polymer is a polymer, which contains 80-95 per cent by weight of vinyl chloride, 1-19 per cent by weight vinylacetate and 0-10 per cent vinylalcohol.
The coating should also preferably include a plastisizer. The amount of the p astisizer may vary between 30 and 150 per cent by weight of the polymer coating. Examples of suitable plastisizers are acetyltributylcitrate, polyethylene glycol , blown castor oil and glyceryltriacetate. The coating can al¬ so include sodium bicarbonate as a stabilizing agent.
The poreforming substance, which is used according to tfie in¬ vention should be very water soluble, insoluble in the sol¬ vent, which is used for the coating, and toxicologically acceptable in the amounts used. Specifically perfered are sugars, such as sucrose and lactose and salts, such as sodium chloride.
The particle size of the poreforming substance may vary bet¬ ween 0,1 and 100, preferably between 0,5 and 50 urn. The ra- tio between the amount of porecreating substance and coating polymer depends on the desired property. Usually this ratio should exceed 5 and preferably be between 10 and 30. According to a preferred embodiment of the invention the co¬ ating comprises a terpolymer of
A w/w % 80-95 % vinyl chloride B w/w % 1-19 % vinyl acetate C w/w % 1-10 % vinyl alcohol
and a plasticizer whereby the amount of plasticizer exceeds 30 per cent by weight of the terpolymer. Preferably the amount of plasticizer varies between 50 and 150 per cent by weight of the terpolymer. The ratio porecreating agent to terpolymer should preferably exceed 5. Most preferably this ratio should vary between 10 and 30.
In this connection it should be specifically.pointed out that the coatings disclosed in the US patent 4,557,925 can not be used for the purpose of the present invention, as these coatings are not expandable and would therefore not give thte desired H2O2 decomposition profile.
The coating thickness depends also on the desired property. It can vary between 5 and 300 μ , preferably between 10 and 200 μm.
The coating procedure according to the invention can prefer¬ ably be carried out in the folowing manner:
1) A terpolymer containing (w/w%) 80-95 '/. VC (vinyl- chloride), 1-19 % VAC (vinylacetate), and 1-10 % V0H (vlnylalcohol) is dissolved in a solvent, e.g. acetone, methylenechloride, methylethylketone, or mixtures aceto¬ ne and ethanol , acetone and methylenechloride, or the like. 2) A suspension of the pore-creating substance is produced as fol ows:
The pore-creating particles are ground either by dry milling in a ball mill or by wet-milling in a glass bead milling device to a defined particle size, preferably between 0,5 urn and 50 μm. The particles are dispersed in solvents or mixtures of solvents, such as those previ¬ ously mentioned, and mixed with the terpolymer solution.
The ratio between pore-creating substance and terpolymer in the coating fluid is as previously described for the ratio in the coating. The coating fluid may, as previ¬ ously stated, include a plasticizer and sodium bicarbonate.
The coating fluid, in the form of a suspension, is then applied on cores by conventional coating procedure. Examples of such coating procedures are pan coating, manual or spray-coating, Wϋrster coating, and other fluid-bed coating procedures. Coloring matter can also be incorporated in the coating fluid, and insoluble co¬ loring materials are preferred.
■ If a tablet containing catalase, which has been coated as above is placed in 10 ml hydrogen peroxide solution (3 %) sufficiently high concentration of hydrogen peroxide for di¬ sinfection of contact lenses and a complete decomposition of the hydrogen peroxide within 6 hours can be obtained, and this makes this method possible to use for disinfection over night. It 1s, however, also possible as is clearly demon¬ strated by Figure 2 that an essentially complete decomposi¬ tion can be obtained within two hours by using the composi¬ tion according to the Invention. It is believed that com- plete decomposition can be obtained within even shorter time if the coating is further modified.
The following examples further illustrate the invention but should not be construed as limiting the invention. Example 1
Tablets including catalase (commercially available from Allergan) in a sufficient amount for decomposition of 10 ml hydrogen peroxide (3 %) were coated according to the proce¬ dure described above with a membrane consisting of 1 mg ter¬ polymer of vinylchloride, vinylacetate and vinylalcohol as a water insoluble membrane, 0,2 mg acetyltributylcitrate, 0,1 mg blown castor oil, 5,6 mg saccharose and 0,2 mg sodium bicarbonate. Acetone' as used as a solvent for the coating.
10 of these tablets were tested as follows in order to de¬ termine the effectiveness in destroying hydrogen peroxide. 10 ml of a 3 % (w/v) aqueous solution of hydrogen peroxide was held at room temperature. The tablet was introduced into the solution and periodic determinations of the H2O2 con¬ centration were made. The results of these determinations are summarized in Figure 1.
Example 2
The catalase containing tablets from Allergan were coated by a coating fluid having the following composition:
mg/tab]_et
terpolymer (VC)m, (VAC)n, (V0H)0 0,61 m=31, n=l, 0=2 saccharose 11,4 acetyl tributyl citrate 0,35 blown castor oil 0,26 sodium bicarbonate 0,39 acetone ad
The coated tablets were tested to determine the effective¬ ness as in example 1 and the results are summarized in Figure 2.

Claims

C L A I M S
1. Composition including a core with a catalytic substance for decomposition of hydrogen peroxide to oxygen and wa¬ ter, characterized by that the core is surrounded by a membrane, which is expandable in aqueous medium and which comprises of a water insoluble polymer and a water soluble porecreating substance, which is randomly dist- ributed in the polymer, whereby the membrane permeabili¬ ty for the catalytic substance increases concurrently with the expansion of the membrane in the aqueous medium.
2. Composition according to claim 1, characterized that the polymer is a terpolymer of vinyl chloride, vinyl acetate and vinyl alcohol and the polymer coating also includes a plasticizer whereby the amount of plasticizer exceeds 30 per cent by weight of the terpolymer.
3. Composition according to claim 1 and 2, characterized by in that the amount of plasticizer varies between 50 and 150 per cent by weight of the terpolymer.
4. Composition according to preceeding claims, characteriz- ed in that the weight ratio porecreating agent to ter¬ polymer exceeds 5.
5. Composition according to any of the claims, characteriz¬ ed in that the weight ratio porecreating agent to terpolymer varies between 10 and 30.
6. Composition according to any of the claims 1-5, charac¬ terized by that it includes catalase as catalytic sub¬ stance.
7. Method for cleaning and disinfecting contact lenses, characterized by that the lenses together with a compo¬ sition according to claim 1-5 are suspended in an aqueous solution of H202, which during an initial period con- tains H202 in an amount effective for cleaning and di¬ sinfection and after less than 8 hours, preferably less than 6 hours, includes less than 10 ppm H202.
8. Method according to claim 7 characterized in that the aqueous of H202 'includes less than 10 ppm H202 after less than 4 preferably less than 2 hours.
PCT/SE1990/000227 1989-04-10 1990-04-05 Enzyme containing composition for cleaning contact lenses and method therefor WO1990011786A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8901279A SE8901279D0 (en) 1989-04-10 1989-04-10 COMPOSITION
SE8901279-3 1989-04-10

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EP (1) EP0461202A1 (en)
JP (1) JPH04506159A (en)
AU (1) AU5528490A (en)
SE (1) SE8901279D0 (en)
WO (1) WO1990011786A1 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0426489A2 (en) * 1989-11-03 1991-05-08 Allergan, Inc. Hydrogen peroxide destroying compositions and methods of using same
WO1992011041A1 (en) * 1990-12-20 1992-07-09 Allergan, Inc. Hydrogen peroxide destroying compositions and methods of making and using same
EP0517758A4 (en) * 1990-02-27 1992-10-03 Allergan Inc Hydrogen peroxide destroying compositions and methods of making and using same.
EP0514311A1 (en) * 1991-05-07 1992-11-19 Dirygesa, S.L. Procedure for disinfecting and cleaning contact lenses
EP0517749A1 (en) * 1990-02-27 1992-12-16 Allergan, Inc. Hydrogen peroxide destroying compositions and methods of using same
WO1994014479A1 (en) * 1992-12-28 1994-07-07 Bausch & Lomb Incorporated Controlled release composition for active substances into an aqueous medium
EP1050313A1 (en) * 1993-02-12 2000-11-08 Allergan, Inc. Compositions and methods for destroying hydrogen peroxide
US6382408B1 (en) 1997-12-12 2002-05-07 Synoptik A/S Container for timed release of substances

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2151039A (en) * 1983-12-06 1985-07-10 Contactasol Ltd Contact lenses cleaned with hydrogen peroxide
EP0209071A1 (en) * 1985-07-10 1987-01-21 Ciba-Geigy Ag Cleaning set for contact lenses
EP0265253A2 (en) * 1986-10-24 1988-04-27 Kingston Technologies, Inc. Stabilized dispersed enzyme
WO1989000045A1 (en) * 1987-06-30 1989-01-12 Riker Laboratories, Incorporated Pellets with enzymatically controlled drug release

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3524659C2 (en) * 1985-07-10 1999-02-18 Novartis Ag Contact lens care kit

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2151039A (en) * 1983-12-06 1985-07-10 Contactasol Ltd Contact lenses cleaned with hydrogen peroxide
EP0209071A1 (en) * 1985-07-10 1987-01-21 Ciba-Geigy Ag Cleaning set for contact lenses
EP0265253A2 (en) * 1986-10-24 1988-04-27 Kingston Technologies, Inc. Stabilized dispersed enzyme
WO1989000045A1 (en) * 1987-06-30 1989-01-12 Riker Laboratories, Incorporated Pellets with enzymatically controlled drug release

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0426489A2 (en) * 1989-11-03 1991-05-08 Allergan, Inc. Hydrogen peroxide destroying compositions and methods of using same
EP0426489A3 (en) * 1989-11-03 1992-05-13 Allergan, Inc. Hydrogen peroxide destroying compositions and methods of using same
EP0517749A1 (en) * 1990-02-27 1992-12-16 Allergan, Inc. Hydrogen peroxide destroying compositions and methods of using same
EP0517758A4 (en) * 1990-02-27 1992-10-03 Allergan Inc Hydrogen peroxide destroying compositions and methods of making and using same.
EP0517758A1 (en) * 1990-02-27 1992-12-16 Allergan, Inc. Hydrogen peroxide destroying compositions and methods of making and using same
EP0517749A4 (en) * 1990-02-27 1993-01-20 Allergan, Inc. Hydrogen peroxide destroying compositions and methods of using same
US5312588A (en) * 1990-02-27 1994-05-17 Allergan, Inc. Hydrogen peroxide destroying compositions and methods of making and using same
WO1992011041A1 (en) * 1990-12-20 1992-07-09 Allergan, Inc. Hydrogen peroxide destroying compositions and methods of making and using same
EP0514311A1 (en) * 1991-05-07 1992-11-19 Dirygesa, S.L. Procedure for disinfecting and cleaning contact lenses
ES2041561A1 (en) * 1991-05-07 1993-11-16 Dirygesa Sl Procedure for disinfecting and cleaning contact lenses.
WO1994014479A1 (en) * 1992-12-28 1994-07-07 Bausch & Lomb Incorporated Controlled release composition for active substances into an aqueous medium
AU676268B2 (en) * 1992-12-28 1997-03-06 Bausch & Lomb Incorporated Controlled release composition for active substances into anaqueous medium
US5645848A (en) * 1992-12-28 1997-07-08 Bausch & Lomb Incorporated Controlled release composition for active substances into an aqueous medium
EP1050313A1 (en) * 1993-02-12 2000-11-08 Allergan, Inc. Compositions and methods for destroying hydrogen peroxide
US6382408B1 (en) 1997-12-12 2002-05-07 Synoptik A/S Container for timed release of substances

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EP0461202A1 (en) 1991-12-18
SE8901279D0 (en) 1989-04-10
JPH04506159A (en) 1992-10-29
AU5528490A (en) 1990-11-05

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