WO1990009399A1 - New neurotrophic factor - Google Patents

New neurotrophic factor Download PDF

Info

Publication number
WO1990009399A1
WO1990009399A1 PCT/JP1990/000154 JP9000154W WO9009399A1 WO 1990009399 A1 WO1990009399 A1 WO 1990009399A1 JP 9000154 W JP9000154 W JP 9000154W WO 9009399 A1 WO9009399 A1 WO 9009399A1
Authority
WO
WIPO (PCT)
Prior art keywords
neurotrophic factor
ntf
new neurotrophic
substance
new
Prior art date
Application number
PCT/JP1990/000154
Other languages
French (fr)
Japanese (ja)
Inventor
Taiji Kato
Ryo Tanaka
Original Assignee
Ono Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co., Ltd. filed Critical Ono Pharmaceutical Co., Ltd.
Publication of WO1990009399A1 publication Critical patent/WO1990009399A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators

Abstract

This invention relates to a new neurotrophic factor (NTF) isolated and purified from the block of neurofibromata obtained from the patients suffering from the von Recklinghausen disease. The NTF has a polypeptide portion of a molecular weight of 3.000 ± 500 and is a substance which is thermally stable and sensitive to trypsin and proteinase K. This substance promotes the extension of axons of the neurons of a cerebral cortex in a culture medium of a concentration of 1 to 50 ng/ml.
PCT/JP1990/000154 1989-02-15 1990-02-08 New neurotrophic factor WO1990009399A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1/33630 1989-02-15
JP3363089 1989-02-15

Publications (1)

Publication Number Publication Date
WO1990009399A1 true WO1990009399A1 (en) 1990-08-23

Family

ID=12391772

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1990/000154 WO1990009399A1 (en) 1989-02-15 1990-02-08 New neurotrophic factor

Country Status (1)

Country Link
WO (1) WO1990009399A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534615A (en) * 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US5571675A (en) * 1994-04-25 1996-11-05 Genentech, Inc. Detection and amplification of candiotrophin-1(cardiac hypertrophy factor)
US6472585B1 (en) 1994-04-25 2002-10-29 Genentech, Inc. Cardiotrophin-1 defective mouse
US7258983B2 (en) 1994-04-25 2007-08-21 Genentech, Inc. Cardiotrophin-1 compositions and methods for the treatment of tumor

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BRIAN RES., Vol. 336, No. 2, (1985), A.R. SCHONFELD et al.: "Neuronotrophic factors: effects on central cholinergic regeneration in vivo", pp. 297-301. *
DEV. BIOL., Vol. 112, No. 2, (1985), RONALD. M. LINDSAY et al.: "Placode and Neural Crest-Derived Sensory Neurons are Responsive at Early Developmental Stages to Brain-Derived Neurotrophic Factor", pp. 319-328. *
NEUROCHEM. INT., Vol. 13, No. 2, (1988), KANATO YAMAGATA et al.: "Characterization and Partial Purification of a Neurotrophic Factor for Cerebrocortical Neurons from Chicken Cerebral Extract", pp. 153-158. *
PROC. NATL. ACAD. SCI. USA, Vol. 81, No. 4, (1984), HANS WERNER MUELLER et al.: "Neurotrophic factor for central neurons", pp. 1248-1252. *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534615A (en) * 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US5571675A (en) * 1994-04-25 1996-11-05 Genentech, Inc. Detection and amplification of candiotrophin-1(cardiac hypertrophy factor)
US5624806A (en) * 1994-04-25 1997-04-29 Genentech, Inc. Antibodies to cardiac hypertrophy factor and uses thereof
US5627073A (en) * 1994-04-25 1997-05-06 Genentech, Inc. Hybridomas producing antibodies to cardiac hypertrophy factor
US5679545A (en) * 1994-04-25 1997-10-21 Genentech, Inc. Gene encoding cardiac hypertrophy factor
US5723585A (en) * 1994-04-25 1998-03-03 Genentech, Inc. Method of purifying cardiac hypertrophy factor
US6117650A (en) * 1994-04-25 2000-09-12 Genentech, Inc. Assay for cardiac hypertrophy
US6472585B1 (en) 1994-04-25 2002-10-29 Genentech, Inc. Cardiotrophin-1 defective mouse
US7258983B2 (en) 1994-04-25 2007-08-21 Genentech, Inc. Cardiotrophin-1 compositions and methods for the treatment of tumor

Similar Documents

Publication Publication Date Title
EP1361229A3 (en) Use of Tyrosine Kinase (PYK2) to produce antibodies
DE4392749T1 (en) Purified forms of Dnase
EP0385060A3 (en) Purified ciliary neurotrophic factor
AU1170588A (en) Methods and deoxyribonucleic acid for the preparation of tissue factor protein
DE69526120T2 (en) USE OF NEBIVOLOL AS AN ANTI-ATHEROGENIC AGENT
AU4727889A (en) A novel purified thrombomodulin-like glycoprotein obtained from urine.
WO1991004316A3 (en) Ciliary neurotrophic factor
DE3884680D1 (en) Outer membrane protein F from Pseudomonas aeruginosa.
WO1990009399A1 (en) New neurotrophic factor
EP0773290A3 (en) Novel LDL receptor analog protein and the gene coding therefor
ATE147076T1 (en) PHYSOSTIGMINE DERIVATIVES, THEIR USE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM
AU4868490A (en) 3- or 4-substituted oxotremorine derivatives
ATE300554T1 (en) CONNECTIVE TISSUE GROWTH FACTOR 3.
FI894592A (en) DIAGNOSTISERING AV OEVERFLOEDIG FETMA FOERORSAKAD AV GENETISK FOERORSAKAD OEFERFLOEDIG FETMA.
Faravelli et al. Personality features of patients with panic anxiety.
WO1998001149A3 (en) Variants of human ciliary neurotrophic factor (hcntf) with a range of action different from that of the wild-type molecule
ATE128867T1 (en) USE OF 3-ARYL-5-ALKYLTHIO-4H-1,2,4-TRIAZOLES FOR THE TREATMENT OF SUPERREFLEXES RESULTING FROM SPINAL CORD TRAUMA.
IT8819454A0 (en) SPECIAL WHEELCHAIR FOR WALKING OF SERIOUSLY DISABLED PEOPLE INJURED IN MOTOR FUNCTIONS, BALANCE, COORDINATION OR SUFFERING FROM SPASTIC TETRAPARESIS, AND FOR REHABILITATION IN TRAUMAS OF THE SPINAL COLUMN.
IT8820679V0 (en) SPECIAL WHEELCHAIR FOR THE DEAMBULATION OF SERIOUS HANDICAPPED PEOPLE IN THE MOTOR FUNCTIONS, BALANCE, OR COORDINATION OF AFFECTED BY SPASTIC TETRAPARESIS AND FOR THE REHABILITATION IN THE TRAUMA OF THE VERTEBRAL COLUMN.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): CA JP KR US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB IT LU NL SE

NENP Non-entry into the national phase

Ref country code: CA