WO1990000401A3 - Inhibiteurs de protease neutre stimulant l'innervation de fibres musculaires - Google Patents

Inhibiteurs de protease neutre stimulant l'innervation de fibres musculaires Download PDF

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Publication number
WO1990000401A3
WO1990000401A3 PCT/GB1989/000878 GB8900878W WO9000401A3 WO 1990000401 A3 WO1990000401 A3 WO 1990000401A3 GB 8900878 W GB8900878 W GB 8900878W WO 9000401 A3 WO9000401 A3 WO 9000401A3
Authority
WO
WIPO (PCT)
Prior art keywords
innervation
promoting
neutral protease
muscle fibers
protease inhibitors
Prior art date
Application number
PCT/GB1989/000878
Other languages
English (en)
Other versions
WO1990000401A2 (fr
Inventor
Gerda Vrbova
Theresa Jane Fisher
Original Assignee
Univ London
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ London filed Critical Univ London
Publication of WO1990000401A2 publication Critical patent/WO1990000401A2/fr
Publication of WO1990000401A3 publication Critical patent/WO1990000401A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Procédé stimulant la formation de synapses et l'innervaton (et notamment la réinnervation) de fibres musculaires, consistant à administer un inhibiteur de protéase neutre activée par le calcium (CANP) pour obtenir une concentration efficace dudit inhibiteur dans la zone d'un muscle au moins partiellement dépourvue de terminaisons nerveuses. On décrit également des préparations destinées à être utilisées par ce procédé.
PCT/GB1989/000878 1988-07-05 1989-07-04 Inhibiteurs de protease neutre stimulant l'innervation de fibres musculaires WO1990000401A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8815962.9 1988-07-05
GB888815962A GB8815962D0 (en) 1988-07-05 1988-07-05 Pharmaceutical preparation & method for promoting reinnervation of muscle fibers

Publications (2)

Publication Number Publication Date
WO1990000401A2 WO1990000401A2 (fr) 1990-01-25
WO1990000401A3 true WO1990000401A3 (fr) 1990-03-22

Family

ID=10639884

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1989/000878 WO1990000401A2 (fr) 1988-07-05 1989-07-04 Inhibiteurs de protease neutre stimulant l'innervation de fibres musculaires

Country Status (2)

Country Link
GB (1) GB8815962D0 (fr)
WO (1) WO1990000401A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR1001044B (el) * 1991-06-03 1993-04-28 Logothetou Rella Eleni Μηχανισμός διή?ησης νεοπλασματικών κυττάρων και η χρήση του αναστολέα της Ca2+ -εξαρτώμενης ουδέτερης πρωτεάσης για την παρασκευή φαρμακευτικών αντικαρκινικών συν?έσεων.
WO1998038990A1 (fr) * 1997-03-07 1998-09-11 Hoechst Marion Roussel, Inc. Methode de traitement d'un trauma associe a des lesions du cerveau, de la moelle epiniere ou de nerfs peripheriques au moyen de carbobenzyloxy phenylalaninals di- et tri-pepetidiques n-proteges
FR2778851B1 (fr) * 1998-05-19 2002-07-26 Aetsrn Composition a base d'inhibiteurs de cysteine-proteases pour retarder la senescence, l'autodestruction et l'hemolyse des erythrocytes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0100673A2 (fr) * 1982-08-02 1984-02-15 The Research Foundation Of State University Of New York Méthode pour favoriser la régénération des fibres nerveuses

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0100673A2 (fr) * 1982-08-02 1984-02-15 The Research Foundation Of State University Of New York Méthode pour favoriser la régénération des fibres nerveuses

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Developmental Brain Research, Vol. 28, 1986, Elsevier Science Publishers B.V. (Biomedical Division), A.L. CONNOLD et al.: "Effect of Low Calcium and Protease Inhibitors on Synapse Elimination During Postnatal Development in Ther at Soleus Muscle", pages 99-107, see the whole article *
Developmental Brain Research, Vol. 33, 1987, Elsevier Science Publishers B.V. (Biomedical Division), G.J. SWANSON et al.: "Effects of Low Calcium and Inhibition of Calciumactivated Neutral Protease (CANP) on Mature Nerve Terminal Structure in the Rat Sternocostalis Muscle", pages 199-203 see the whole article *
Experimental Neurology, Vol. 91, 1986, Academic Press Inc., K. KOMATSU et al.: "Beneficial Effect of New Thiol Protease Inhibitors, Epoxide Derivatives, on Dystrophic Mice", pages 23-29 *
Proc. Natl. Acad. Sci. USA, Vol. 78, No. 12, December 1981, J. HOLLENBERG SHER et al.:"Successful Treatment of Murine Muscular Dystrophy with the Proteinase inhibitor Leupeptin", pages 7742-7744 *

Also Published As

Publication number Publication date
WO1990000401A2 (fr) 1990-01-25
GB8815962D0 (en) 1988-08-10

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